SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008] See more...

Aliases for SLC43A1 Gene

Aliases for SLC43A1 Gene

  • Solute Carrier Family 43 Member 1 2 3 4 5
  • Solute Carrier Family 43 (Amino Acid System L Transporter), Member 1 2 3
  • Large Neutral Amino Acids Transporter Small Subunit 3 3 4
  • Prostate Cancer Overexpressed Gene 1 Protein 3 4
  • L-Type Amino Acid Transporter 3 3 4
  • POV1 3 4
  • LAT3 3 4
  • PB39 3 4
  • Prostate Cancer Overexpressed Gene 1 2
  • R00504 3

External Ids for SLC43A1 Gene

Previous HGNC Symbols for SLC43A1 Gene

  • POV1

Previous GeneCards Identifiers for SLC43A1 Gene

  • GC11M057502
  • GC11M057027
  • GC11M057008
  • GC11M057252
  • GC11M053600
  • GC11M057736
  • GC11M058190

Summaries for SLC43A1 Gene

Entrez Gene Summary for SLC43A1 Gene

  • SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC43A1 Gene

SLC43A1 (Solute Carrier Family 43 Member 1) is a Protein Coding gene. Diseases associated with SLC43A1 include Prostate Cancer and Seminoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Amino acid transport across the plasma membrane. Gene Ontology (GO) annotations related to this gene include neutral amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC43A2.

UniProtKB/Swiss-Prot Summary for SLC43A1 Gene

  • Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.

Gene Wiki entry for SLC43A1 Gene

Additional gene information for SLC43A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC43A1 Gene

Genomics for SLC43A1 Gene

GeneHancer (GH) Regulatory Elements for SLC43A1 Gene

Promoters and enhancers for SLC43A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057513 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.8 779 4 SMARCE1 USF2 HDAC2 NR2F6 MYC L3MBTL2 MAX MNT ZNF148 ELF3 SLC43A1 TIMM10 SMTNL1 RF00019-015
GH11J057431 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +82.6 82579 7.2 MLX SMARCE1 RBPJ NR2F6 ATF1 CREB1 RUNX1 MIXL1 MYC L3MBTL2 SLC43A3 HSALNG0084275 RTN4RL2 PRG2 TIMM10 P2RX3 SSRP1 SLC43A1 SERPING1 UBE2L6
GH11J057481 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 12.3 +32.5 32451 2.7 MYC ETV6 RAD21 CTCF CREM KLF14 IKZF1 GLIS2 ZIC2 BACH1 TIMM10 RTN4RL2 RN7SKP259 SLC43A1 P2RX3 SSRP1 SLC43A3 ENSG00000254979 UBE2L6 HSALNG0084279
GH11J057402 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +107.9 107879 13 ZNF24 SMARCE1 MYC CC2D1A ETV6 RELA HLF L3MBTL2 MAX TEAD4 JX952206 lnc-SLC43A3-1 SSRP1 SLC43A3 PRG2 RTN4RL2 ZDHHC5 P2RX3 CTNND1 CLP1
GH11J057679 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 9.6 -164.5 -164534 2.6 TEAD4 SP1 CBFA2T2 IKZF1 RXRA PKNOX1 JUND GABPA FOSL1 NCOR1 ZDHHC5 YPEL4 MED19 CLP1 ENSG00000254602 BTBD18 CTNND1 SERPING1 SLC43A1 ENSG00000255299
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC43A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC43A1 gene promoter:
  • aMEF-2
  • AREB6
  • ATF
  • E47
  • GATA-2
  • MEF-2
  • MEF-2A
  • N-Myc
  • RORalpha2

Genomic Locations for SLC43A1 Gene

Genomic Locations for SLC43A1 Gene
chr11:57,484,531-57,515,780
(GRCh38/hg38)
Size:
31,250 bases
Orientation:
Minus strand
chr11:57,252,004-57,283,259
(GRCh37/hg19)
Size:
31,256 bases
Orientation:
Minus strand

Genomic View for SLC43A1 Gene

Genes around SLC43A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC43A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC43A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC43A1 Gene

Proteins for SLC43A1 Gene

  • Protein details for SLC43A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75387-LAT3_HUMAN
    Recommended name:
    Large neutral amino acids transporter small subunit 3
    Protein Accession:
    O75387

    Protein attributes for SLC43A1 Gene

    Size:
    559 amino acids
    Molecular mass:
    61477 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors.

    Alternative splice isoforms for SLC43A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC43A1 Gene

Post-translational modifications for SLC43A1 Gene

  • Glycosylation at Asn57, Asn212, and Asn229
  • Ubiquitination at Lys264
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC43A1 Gene

Domains & Families for SLC43A1 Gene

Gene Families for SLC43A1 Gene

Protein Domains for SLC43A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC43A1 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 43 member 1 (LAT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75387

UniProtKB/Swiss-Prot:

LAT3_HUMAN :
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
Family:
  • Belongs to the SLC43A transporter (TC 2.A.1.44) family.
genes like me logo Genes that share domains with SLC43A1: view

Function for SLC43A1 Gene

Molecular function for SLC43A1 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.

Phenotypes From GWAS Catalog for SLC43A1 Gene

Gene Ontology (GO) - Molecular Function for SLC43A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015175 neutral amino acid transmembrane transporter activity IBA,IDA 12930836
GO:0015179 L-amino acid transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC43A1: view
genes like me logo Genes that share phenotypes with SLC43A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC43A1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC43A1 Gene

Localization for SLC43A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC43A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC43A1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC43A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 12930836
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC43A1: view

Pathways & Interactions for SLC43A1 Gene

genes like me logo Genes that share pathways with SLC43A1: view

Gene Ontology (GO) - Biological Process for SLC43A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006865 amino acid transport TAS --
GO:0015804 neutral amino acid transport IDA,IBA 12930836
GO:0055085 transmembrane transport IEA --
GO:1902475 L-alpha-amino acid transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC43A1: view

No data available for SIGNOR curated interactions for SLC43A1 Gene

Drugs & Compounds for SLC43A1 Gene

(1) Additional Compounds for SLC43A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with SLC43A1: view

Transcripts for SLC43A1 Gene

mRNA/cDNA for SLC43A1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12:

ExUns: 21a · 21b · 21c ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLC43A1 Gene

GeneLoc Exon Structure for
SLC43A1
ECgene alternative splicing isoforms for
SLC43A1

Expression for SLC43A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC43A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC43A1 Gene

This gene is overexpressed in Pancreas (x13.1) and Liver (x8.3).

Protein differential expression in normal tissues from HIPED for SLC43A1 Gene

This gene is overexpressed in Pancreas (37.2), Fetal Liver (16.0), and Liver (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC43A1 Gene



Protein tissue co-expression partners for SLC43A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC43A1 Gene:

SLC43A1

SOURCE GeneReport for Unigene cluster for SLC43A1 Gene:

Hs.591952

mRNA Expression by UniProt/SwissProt for SLC43A1 Gene:

O75387-LAT3_HUMAN
Tissue specificity: In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.

Evidence on tissue expression from TISSUES for SLC43A1 Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with SLC43A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC43A1 Gene

Orthologs for SLC43A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC43A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC43A1 32
  • 90.05 (n)
dog
(Canis familiaris)
Mammalia SLC43A1 33 32
  • 88.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc43a1 17 33 32
  • 84.2 (n)
rat
(Rattus norvegicus)
Mammalia Slc43a1 32
  • 84.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC43A1 33
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC43A1 33
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC43A1 33
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc43a1 32
  • 62.35 (n)
zebrafish
(Danio rerio)
Actinopterygii slc43a1b 33 32
  • 65.7 (n)
OneToMany
slc43a1a 33
  • 60 (a)
OneToMany
wufi47a12 32
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 33
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 39 (a)
OneToMany
Species where no ortholog for SLC43A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC43A1 Gene

ENSEMBL:
Gene Tree for SLC43A1 (if available)
TreeFam:
Gene Tree for SLC43A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC43A1: view image

Paralogs for SLC43A1 Gene

Paralogs for SLC43A1 Gene

(2) SIMAP similar genes for SLC43A1 Gene using alignment to 7 proteins:

  • LAT3_HUMAN
  • E9PJ68_HUMAN
  • E9PJT8_HUMAN
  • E9PKZ5_HUMAN
  • E9PR87_HUMAN
  • E9PRF0_HUMAN
  • H0YEH0_HUMAN
genes like me logo Genes that share paralogs with SLC43A1: view

Variants for SLC43A1 Gene

Sequence variations from dbSNP and Humsavar for SLC43A1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000013983 -- 57,496,429(-) T/A intron_variant
rs1000068436 -- 57,499,842(-) C/A intron_variant
rs1000200734 -- 57,489,920(-) G/A intron_variant
rs1000332266 -- 57,497,233(-) G/A intron_variant
rs1000343231 -- 57,504,057(-) C/T intron_variant

Variation tolerance for SLC43A1 Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC43A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC43A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC43A1 Gene

Disorders for SLC43A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC43A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
seminoma
  • seminoma, pure
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC43A1

genes like me logo Genes that share disorders with SLC43A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC43A1 Gene

Publications for SLC43A1 Gene

  1. cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer. (PMID: 9722952) Cole KA … Emmert-Buck MR (Genomics 1998) 2 3 4 23 56
  2. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. (PMID: 12930836) Babu E … Endou H (The Journal of biological chemistry 2003) 3 4 23 56
  3. Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma. (PMID: 9255310) Chuaqui RF … Emmert-Buck MR (Urology 1997) 2 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. New insights into testicular germ cell tumorigenesis from gene expression profiling. (PMID: 11956097) Skotheim RI … Kallioniemi A (Cancer research 2002) 3 4 56

Products for SLC43A1 Gene

  • Boster Bio Antibodies for SLC43A1
  • Boster Bio ELISA Kits for SLC43A1

Sources for SLC43A1 Gene