Aliases for SLC41A2 Gene

Aliases for SLC41A2 Gene

  • Solute Carrier Family 41 Member 2 2 3 4 5
  • Solute Carrier Family 41 (Magnesium Transporter), Member 2 2 3
  • Solute Carrier Family 41, Member 2 2
  • SLC41A1-Like 1 3
  • SLC41A1-L1 3

External Ids for SLC41A2 Gene

Previous GeneCards Identifiers for SLC41A2 Gene

  • GC12M103701
  • GC12M103702
  • GC12M105197
  • GC12M102256

Summaries for SLC41A2 Gene

GeneCards Summary for SLC41A2 Gene

SLC41A2 (Solute Carrier Family 41 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A1.

UniProtKB/Swiss-Prot Summary for SLC41A2 Gene

Additional gene information for SLC41A2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC41A2 Gene

Genomics for SLC41A2 Gene

GeneHancer (GH) Regulatory Elements for SLC41A2 Gene

Promoters and enhancers for SLC41A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J104957 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 757.7 +0.3 270 4.1 CTCF RBPJ SMARCE1 USF2 NR2F6 ETV6 ELF1 L3MBTL2 RAD21 MAX SLC41A2 C12orf45 piR-33422-093
GH12J104985 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 15.4 -28.3 -28257 2.8 SIN3A SP1 ZBTB6 POLR2A ZNF362 MYC NFYC HLF L3MBTL2 RAD21 C12orf45 HSALNG0093675 LOC105369952 SLC41A2 WASHC4 RPL18AP3 NFYB ALDH1L2 piR-37937
GH12J104930 Enhancer 1 FANTOM5 Ensembl 18.4 +28.0 28043 2.6 SP1 JUND ETV6 RELA ELF3 MLLT1 ZNF687 CREM ZNF644 ZBTB33 SLC41A2 WASHC4 TDG CHST11 piR-33422-093
GH12J104890 Enhancer 1 FANTOM5 Ensembl 17.4 +69.9 69944 5.2 ZNF362 ZNF121 BCL6B MAFK SP7 ZIC2 ZBTB8A ZNF639 ZEB2 ZNF148 SLC41A2 C12orf45 WASHC4 CHST11 piR-48222-098 piR-33303-054
GH12J104763 Enhancer 0.8 Ensembl ENCODE 15.4 +195.2 195243 5 RELA IKZF1 IKZF2 ZSCAN4 ZNF316 CBFB EED RUNX3 TRIM24 JUNB SLC41A2 CHST11 APPL2 WASHC4 lnc-CHST11-2 lnc-C12orf45-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC41A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC41A2 gene promoter:
  • AREB6
  • E4BP4
  • Hlf
  • Nkx2-5
  • POU6F1 (c2)
  • S8
  • TBP

Genomic Locations for SLC41A2 Gene

Genomic Locations for SLC41A2 Gene
chr12:104,802,553-104,958,744
(GRCh38/hg38)
Size:
156,192 bases
Orientation:
Minus strand
chr12:105,196,331-105,352,522
(GRCh37/hg19)
Size:
156,192 bases
Orientation:
Minus strand

Genomic View for SLC41A2 Gene

Genes around SLC41A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC41A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC41A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A2 Gene

Proteins for SLC41A2 Gene

  • Protein details for SLC41A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JW4-S41A2_HUMAN
    Recommended name:
    Solute carrier family 41 member 2
    Protein Accession:
    Q96JW4
    Secondary Accessions:
    • Q3KP68
    • Q9H0E5

    Protein attributes for SLC41A2 Gene

    Size:
    573 amino acids
    Molecular mass:
    62473 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36734.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI06872.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI06873.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55402.1; Type=Frameshift; Positions=69, 101, 103; Evidence={ECO:0000305}; Sequence=CAB66762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC41A2 Gene

Post-translational modifications for SLC41A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC41A2 Gene

Domains & Families for SLC41A2 Gene

Gene Families for SLC41A2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC41A2 Gene

Suggested Antigen Peptide Sequences for SLC41A2 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 41 member 2 (S41A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96JW4

UniProtKB/Swiss-Prot:

S41A2_HUMAN :
  • Belongs to the SLC41A transporter family.
Family:
  • Belongs to the SLC41A transporter family.
genes like me logo Genes that share domains with SLC41A2: view

Function for SLC41A2 Gene

Molecular function for SLC41A2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a plasma-membrane magnesium transporter.

Gene Ontology (GO) - Molecular Function for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity IEA --
GO:0072509 divalent inorganic cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC41A2: view
genes like me logo Genes that share phenotypes with SLC41A2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC41A2 Gene

Localization for SLC41A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC41A2 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC41A2 Gene

Pathways & Interactions for SLC41A2 Gene

genes like me logo Genes that share pathways with SLC41A2: view

Interacting Proteins for SLC41A2 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q96JW4-S41A2_HUMAN ENSP00000258538 for SLC41A2 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0070838 divalent metal ion transport IEA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

No data available for SIGNOR curated interactions for SLC41A2 Gene

Drugs & Compounds for SLC41A2 Gene

(1) Drugs for SLC41A2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with SLC41A2: view

Transcripts for SLC41A2 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A2 Gene

No ASD Table

Relevant External Links for SLC41A2 Gene

GeneLoc Exon Structure for
SLC41A2
ECgene alternative splicing isoforms for
SLC41A2

Expression for SLC41A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC41A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A2 Gene

This gene is overexpressed in Liver (x7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC41A2 Gene



Protein tissue co-expression partners for SLC41A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC41A2 Gene:

SLC41A2

SOURCE GeneReport for Unigene cluster for SLC41A2 Gene:

Hs.577463

Evidence on tissue expression from TISSUES for SLC41A2 Gene

  • Skin(4.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with SLC41A2: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC41A2 Gene

Orthologs for SLC41A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC41A2 33 32
  • 99.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC41A2 33 32
  • 91.97 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC41A2 33 32
  • 91.51 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC41A2 33
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC41A2 33
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc41a2 17 33 32
  • 84.03 (n)
rat
(Rattus norvegicus)
Mammalia Slc41a2 32
  • 83.03 (n)
chicken
(Gallus gallus)
Aves SLC41A2 33 33 32
  • 79.87 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SLC41A2 33
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a2 32
  • 74.12 (n)
Str.4263 32
zebrafish
(Danio rerio)
Actinopterygii slc41a2b 33
  • 68 (a)
OneToMany
LOC566242 32
  • 66.27 (n)
SLC41A2 (2 of 2) 33
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG33181 33 32
  • 48.48 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000663 32
  • 48.28 (n)
worm
(Caenorhabditis elegans)
Secernentea K07H8.2 33
  • 42 (a)
ManyToMany
ZK185.2 33
  • 34 (a)
ManyToMany
ZK1053.6 33
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 54 (a)
OneToMany
Species where no ortholog for SLC41A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A2 Gene

ENSEMBL:
Gene Tree for SLC41A2 (if available)
TreeFam:
Gene Tree for SLC41A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC41A2: view image

Paralogs for SLC41A2 Gene

Paralogs for SLC41A2 Gene

(2) SIMAP similar genes for SLC41A2 Gene using alignment to 9 proteins:

  • S41A2_HUMAN
  • C9J2P6_HUMAN
  • C9JA64_HUMAN
  • C9JCR2_HUMAN
  • C9JDQ2_HUMAN
  • C9JIL4_HUMAN
  • C9JKF2_HUMAN
  • C9JYJ7_HUMAN
  • H7BZT9_HUMAN

Pseudogenes.org Pseudogenes for SLC41A2 Gene

genes like me logo Genes that share paralogs with SLC41A2: view

Variants for SLC41A2 Gene

Sequence variations from dbSNP and Humsavar for SLC41A2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005611 -- 104,928,785(-) ACACA/ACA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000013041 -- 104,831,738(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000015644 -- 104,835,252(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000067864 -- 104,834,950(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000082940 -- 104,842,494(-) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC41A2 Gene

Variant ID Type Subtype PubMed ID
dgv302e214 CNV gain 21293372
dgv303e214 CNV gain 21293372
esv3427923 CNV insertion 20981092
esv3580450 CNV loss 25503493
esv3630652 CNV gain 21293372
nsv832505 CNV gain 17160897

Variation tolerance for SLC41A2 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC41A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC41A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC41A2 Gene

Disorders for SLC41A2 Gene

Additional Disease Information for SLC41A2

No disorders were found for SLC41A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC41A2 Gene

Publications for SLC41A2 Gene

  1. SLC41A2 encodes a plasma-membrane Mg2+ transporter. (PMID: 16984228) Sahni J … Scharenberg AM (The Biochemical journal 2007) 4 23 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 56
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  5. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 56

Products for SLC41A2 Gene

Sources for SLC41A2 Gene