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Aliases for SLC41A2 Gene

Aliases for SLC41A2 Gene

  • Solute Carrier Family 41 Member 2 2 3 5
  • Solute Carrier Family 41 (Magnesium Transporter), Member 2 2 3
  • Solute Carrier Family 41, Member 2 2
  • SLC41A1-Like 1 3
  • SLC41A1-L1 3

External Ids for SLC41A2 Gene

Previous GeneCards Identifiers for SLC41A2 Gene

  • GC12M103701
  • GC12M103702
  • GC12M105197
  • GC12M102256

Summaries for SLC41A2 Gene

GeneCards Summary for SLC41A2 Gene

SLC41A2 (Solute Carrier Family 41 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A1.

UniProtKB/Swiss-Prot for SLC41A2 Gene

  • Acts as a plasma-membrane magnesium transporter.

Additional gene information for SLC41A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC41A2 Gene

Genomics for SLC41A2 Gene

GeneHancer (GH) Regulatory Elements for SLC41A2 Gene

Promoters and enhancers for SLC41A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I104957 Promoter/Enhancer 1.5 Ensembl ENCODE 557.8 -0.1 -129 3.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF766 FOS KLF13 SLC41A2 C12orf45 KRT18P20
GH12I104928 Promoter 0.5 EPDnew 550.3 +30.1 30078 0.1 SLC41A2 GC12M104943 GC12M104883
GH12I104985 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.4 -28.0 -28017 2.3 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF48 YY1 C12orf45 LOC105369952 SLC41A2 NFYB ALDH1L2 PIR60982 GC12M104965
GH12I104747 Enhancer 1 Ensembl ENCODE dbSUPER 15.7 +209.0 209034 4.2 MAFG EBF1 IRF4 ZNF316 ZNF184 IKZF1 SCRT2 HMBOX1 ETV6 NFE2 SLC41A2 WASHC4 GC12P104758 PIR42556 CHST11
GH12I105031 Enhancer 0.6 Ensembl 17.6 -72.6 -72557 0.6 JUNB ELF1 ATF2 ZNF217 IKZF1 MLLT1 ETV6 RUNX3 SLC41A2 PIR40149 C12orf45 ALDH1L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC41A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC41A2 gene promoter:

Genomic Locations for SLC41A2 Gene

Genomic Locations for SLC41A2 Gene
156,192 bases
Minus strand

Genomic View for SLC41A2 Gene

Genes around SLC41A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC41A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC41A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A2 Gene

Proteins for SLC41A2 Gene

  • Protein details for SLC41A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 41 member 2
    Protein Accession:
    Secondary Accessions:
    • Q3KP68
    • Q9H0E5

    Protein attributes for SLC41A2 Gene

    573 amino acids
    Molecular mass:
    62473 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36734.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI06872.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI06873.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55402.1; Type=Frameshift; Positions=69, 101, 103; Evidence={ECO:0000305}; Sequence=CAB66762.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC41A2 Gene

Post-translational modifications for SLC41A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC41A2 Gene

Domains & Families for SLC41A2 Gene

Gene Families for SLC41A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC41A2 Gene

Suggested Antigen Peptide Sequences for SLC41A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC41A transporter family.
  • Belongs to the SLC41A transporter family.
genes like me logo Genes that share domains with SLC41A2: view

Function for SLC41A2 Gene

Molecular function for SLC41A2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a plasma-membrane magnesium transporter.

Gene Ontology (GO) - Molecular Function for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity IEA --
GO:0015095 magnesium ion transmembrane transporter activity TAS --
GO:0072509 divalent inorganic cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

Phenotypes for SLC41A2 Gene

genes like me logo Genes that share phenotypes with SLC41A2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC41A2 Gene

Localization for SLC41A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC41A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC41A2 Gene

Pathways & Interactions for SLC41A2 Gene

genes like me logo Genes that share pathways with SLC41A2: view

Interacting Proteins for SLC41A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000258538 Q96JW4-S41A2_HUMAN for SLC41A2 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for SLC41A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0055085 transmembrane transport IBA --
GO:0070838 divalent metal ion transport IEA --
genes like me logo Genes that share ontologies with SLC41A2: view

No data available for SIGNOR curated interactions for SLC41A2 Gene

Drugs & Compounds for SLC41A2 Gene

(1) Drugs for SLC41A2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
genes like me logo Genes that share compounds with SLC41A2: view

Transcripts for SLC41A2 Gene

Unigene Clusters for SLC41A2 Gene

Solute carrier family 41, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A2 Gene

No ASD Table

Relevant External Links for SLC41A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC41A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC41A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A2 Gene

This gene is overexpressed in Liver (x7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC41A2 Gene

Protein tissue co-expression partners for SLC41A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC41A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC41A2 Gene:


Evidence on tissue expression from TISSUES for SLC41A2 Gene

  • Skin(4.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with SLC41A2: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC41A2 Gene

Orthologs for SLC41A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC41A2 33 34
  • 99.71 (n)
(Bos Taurus)
Mammalia SLC41A2 33 34
  • 91.97 (n)
(Canis familiaris)
Mammalia SLC41A2 33 34
  • 91.51 (n)
(Monodelphis domestica)
Mammalia SLC41A2 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SLC41A2 34
  • 88 (a)
(Mus musculus)
Mammalia Slc41a2 33 16 34
  • 84.03 (n)
(Rattus norvegicus)
Mammalia Slc41a2 33
  • 83.03 (n)
(Gallus gallus)
Aves SLC41A2 33 34 34
  • 79.87 (n)
(Anolis carolinensis)
Reptilia SLC41A2 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a2 33
  • 74.12 (n)
Str.4263 33
(Danio rerio)
Actinopterygii slc41a2b 34
  • 68 (a)
LOC566242 33
  • 66.27 (n)
SLC41A2 (2 of 2) 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33181 33 34
  • 48.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000663 33
  • 48.28 (n)
(Caenorhabditis elegans)
Secernentea K07H8.2 34
  • 42 (a)
ZK185.2 34
  • 34 (a)
ZK1053.6 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
Species where no ortholog for SLC41A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A2 Gene

Gene Tree for SLC41A2 (if available)
Gene Tree for SLC41A2 (if available)

Paralogs for SLC41A2 Gene

Paralogs for SLC41A2 Gene

(2) SIMAP similar genes for SLC41A2 Gene using alignment to 9 proteins: Pseudogenes for SLC41A2 Gene

genes like me logo Genes that share paralogs with SLC41A2: view

Variants for SLC41A2 Gene

Sequence variations from dbSNP and Humsavar for SLC41A2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005611 -- 104,928,785(-) ACACA/ACA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000013041 -- 104,831,738(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000015644 -- 104,835,252(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000067864 -- 104,834,950(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000082940 -- 104,842,494(-) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC41A2 Gene

Variant ID Type Subtype PubMed ID
dgv302e214 CNV gain 21293372
dgv303e214 CNV gain 21293372
esv3427923 CNV insertion 20981092
esv3580450 CNV loss 25503493
esv3630652 CNV gain 21293372
nsv832505 CNV gain 17160897

Variation tolerance for SLC41A2 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC41A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC41A2 Gene

Disorders for SLC41A2 Gene

Additional Disease Information for SLC41A2

No disorders were found for SLC41A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC41A2 Gene

Publications for SLC41A2 Gene

  1. SLC41A2 encodes a plasma-membrane Mg2+ transporter. (PMID: 16984228) Sahni J … Scharenberg AM (The Biochemical journal 2007) 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 58

Products for SLC41A2 Gene

Sources for SLC41A2 Gene

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