Aliases for SLC41A1 Gene

Aliases for SLC41A1 Gene

  • Solute Carrier Family 41 Member 1 2 3 4 5
  • Solute Carrier Family 41 (Magnesium Transporter), Member 1 2 3
  • MgtE 3

External Ids for SLC41A1 Gene

Previous GeneCards Identifiers for SLC41A1 Gene

  • GC01M201219
  • GC01M202119
  • GC01M202935
  • GC01M202489
  • GC01M204025
  • GC01M205758
  • GC01M176922

Summaries for SLC41A1 Gene

GeneCards Summary for SLC41A1 Gene

SLC41A1 (Solute Carrier Family 41 Member 1) is a Protein Coding gene. Diseases associated with SLC41A1 include Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia and Nephronophthisis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC41A2.

UniProtKB/Swiss-Prot Summary for SLC41A1 Gene

  • Acts as a magnesium transporter that is responsive to magnesium balance.

Additional gene information for SLC41A1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC41A1 Gene

Genomics for SLC41A1 Gene

GeneHancer (GH) Regulatory Elements for SLC41A1 Gene

Promoters and enhancers for SLC41A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J205809 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.3 1259 4.6 ZNF217 EP300 CTCF ZSCAN5C NRF1 USF1 SP1 PHF8 ZFX ZNF639 ENSG00000286619 SLC41A1 lnc-SLC41A1-1 PM20D1 MAPKAPK2 lnc-RAB29-1
GH01J205849 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -36.3 -36342 1.4 NR2F2 ZNF316 POLR2A FOS TCF7L2 NFYB RXRA NFYA SP1 PM20D1 SLC41A1 RAB29 lnc-SLC41A1-2 ENSG00000286619
GH01J205786 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 +26.6 26594 1.6 NRF1 CTBP1 ZNF316 MAX ZNF592 TBP NFE2 KDM4B EHMT2 MNT RAB29 PM20D1 SLC41A1 NUCKS1 SLC26A9 lnc-RAB29-1 piR-37170-008
GH01J205919 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 -106.1 -106078 1.9 ZNF217 CTCF GABPA REST RAD21 TRIM22 SMC3 CTBP1 RBM25 DEK SLC26A9 SLC41A1 AVPR1B ENSG00000226780 RAB29 piR-52079-021 lnc-RHEX-6
GH01J205923 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 -111.4 -111442 3.6 FOS ZNF639 ZIC2 EP300 ATF2 WT1 FOSL2 CEBPB ZBTB1 ZFHX2 SLC41A1 PM20D1 AVPR1B ENSG00000226780 MFSD4A CTSE RAB29 RNU6-418P SLC26A9 piR-52079-021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC41A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC41A1

Top Transcription factor binding sites by QIAGEN in the SLC41A1 gene promoter:
  • CBF(2)
  • CBF-A
  • E47
  • Egr-3
  • STAT1
  • STAT1alpha
  • STAT1beta
  • Tal-1

Genomic Locations for SLC41A1 Gene

Genomic Locations for SLC41A1 Gene
24,667 bases
Minus strand
24,656 bases
Minus strand

Genomic View for SLC41A1 Gene

Genes around SLC41A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC41A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC41A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC41A1 Gene

Proteins for SLC41A1 Gene

  • Protein details for SLC41A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 41 member 1
    Protein Accession:
    Secondary Accessions:
    • Q63HJ4
    • Q658Z5
    • Q659A4
    • Q6MZK2

    Protein attributes for SLC41A1 Gene

    513 amino acids
    Molecular mass:
    54901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC41A1 Gene

Post-translational modifications for SLC41A1 Gene

  • Ubiquitination at Lys170
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC41A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC41A1 Gene

Domains & Families for SLC41A1 Gene

Gene Families for SLC41A1 Gene

Protein Domains for SLC41A1 Gene

Suggested Antigen Peptide Sequences for SLC41A1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ46190 fis, clone TESTI4005399, highly similar to Homo sapiens solute carrier family 41, member 1 (SLC41A1), mRNA (B2RMP2_HUMAN)
  • Solute carrier family 41 member 1 (S41A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC41A transporter family.
  • Belongs to the SLC41A transporter family.
genes like me logo Genes that share domains with SLC41A1: view

Function for SLC41A1 Gene

Molecular function for SLC41A1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a magnesium transporter that is responsive to magnesium balance.

Phenotypes From GWAS Catalog for SLC41A1 Gene

Gene Ontology (GO) - Molecular Function for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity IEA --
GO:0015095 magnesium ion transmembrane transporter activity IDA 18367447
GO:0022857 transmembrane transporter activity IMP 22031603
GO:0061768 magnesium:sodium antiporter activity IMP 22031603
GO:0072509 divalent inorganic cation transmembrane transporter activity ISS --
genes like me logo Genes that share ontologies with SLC41A1: view
genes like me logo Genes that share phenotypes with SLC41A1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC41A1 Gene

Localization for SLC41A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC41A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC41A1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IDA 23661805
genes like me logo Genes that share ontologies with SLC41A1: view

Pathways & Interactions for SLC41A1 Gene

genes like me logo Genes that share pathways with SLC41A1: view

Interacting Proteins for SLC41A1 Gene


Gene Ontology (GO) - Biological Process for SLC41A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0010961 cellular magnesium ion homeostasis IMP 22031603
GO:0015693 magnesium ion transport IMP 22031603
GO:0035725 sodium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC41A1: view

No data available for SIGNOR curated interactions for SLC41A1 Gene

Drugs & Compounds for SLC41A1 Gene

(1) Drugs for SLC41A1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with SLC41A1: view

Transcripts for SLC41A1 Gene

mRNA/cDNA for SLC41A1 Gene

14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC41A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - - - -
SP3: -

Relevant External Links for SLC41A1 Gene

GeneLoc Exon Structure for

Expression for SLC41A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC41A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC41A1 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.9) and Heart - Atrial Appendage (x4.9).

Protein differential expression in normal tissues from HIPED for SLC41A1 Gene

This gene is overexpressed in Nasal epithelium (58.2) and Breast (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC41A1 Gene

Protein tissue co-expression partners for SLC41A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC41A1

SOURCE GeneReport for Unigene cluster for SLC41A1 Gene:


mRNA Expression by UniProt/SwissProt for SLC41A1 Gene:

Tissue specificity: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.

Evidence on tissue expression from TISSUES for SLC41A1 Gene

  • Muscle(4.4)
  • Nervous system(2.9)
  • Heart(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with SLC41A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC41A1 Gene

Orthologs for SLC41A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC41A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC41A1 31 30
  • 99.74 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 98 (a)
-- 31
  • 85 (a)
(Monodelphis domestica)
Mammalia SLC41A1 31
  • 95 (a)
(Canis familiaris)
Mammalia SLC41A1 31 30
  • 93.5 (n)
(Rattus norvegicus)
Mammalia Slc41a1 30
  • 92.2 (n)
(Mus musculus)
Mammalia Slc41a1 17 31 30
  • 91.73 (n)
(Bos Taurus)
Mammalia SLC41A1 31 30
  • 90.38 (n)
(Gallus gallus)
Aves SLC41A1 31 30
  • 78.88 (n)
(Anolis carolinensis)
Reptilia SLC41A1 31
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc41a1 30
  • 70.7 (n)
Str.15281 30
(Danio rerio)
Actinopterygii slc41a1 31 30
  • 74.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33181 31
  • 29 (a)
(Caenorhabditis elegans)
Secernentea K07H8.2 31 30
  • 52.61 (n)
ZK185.2 31
  • 34 (a)
ZK1053.6 31
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 57 (a)
Species where no ortholog for SLC41A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC41A1 Gene

Gene Tree for SLC41A1 (if available)
Gene Tree for SLC41A1 (if available)
Evolutionary constrained regions (ECRs) for SLC41A1: view image

Paralogs for SLC41A1 Gene

Paralogs for SLC41A1 Gene

(2) SIMAP similar genes for SLC41A1 Gene using alignment to 2 proteins:

  • S41A1_HUMAN
genes like me logo Genes that share paralogs with SLC41A1: view

Variants for SLC41A1 Gene

Additional dbSNP identifiers (rs#s) for SLC41A1 Gene

Variation tolerance for SLC41A1 Gene

Residual Variation Intolerance Score: 8.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC41A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for SLC41A1 Gene

Disorders for SLC41A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC41A1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC41A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC41A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC41A1 Gene

Publications for SLC41A1 Gene

  1. The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. (PMID: 12810078) Wabakken T … Aasheim HC (Biochemical and biophysical research communications 2003) 2 3 4 23 54
  2. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. (PMID: 21738487) Do CB … Eriksson N (PLoS genetics 2011) 3 41 54
  3. Genetic variability at the PARK16 locus. (PMID: 20683486) Tucci A … Paisán-Ruiz C (European journal of human genetics : EJHG 2010) 3 41 54
  4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PMID: 19915576) Satake W … Toda T (Nature genetics 2009) 3 41 54
  5. SLC41A1 is a novel mammalian Mg2+ carrier. (PMID: 18367447) Kolisek M … Schweigel M (The Journal of biological chemistry 2008) 2 3 54

Products for SLC41A1 Gene

Sources for SLC41A1 Gene