Aliases for SLC40A1 Gene
External Ids for SLC40A1 Gene
Previous HGNC Symbols for SLC40A1 Gene
Previous GeneCards Identifiers for SLC40A1 Gene
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC40A1 Gene
SLC40A1 (Solute Carrier Family 40 Member 1) is a Protein Coding gene. Diseases associated with SLC40A1 include Hemochromatosis, Type 4 and Hemochromatosis, Type 1. Among its related pathways are Mineral absorption and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include iron ion transmembrane transporter activity.
UniProtKB/Swiss-Prot Summary for SLC40A1 Gene
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).