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Aliases for SLC39A9 Gene

Aliases for SLC39A9 Gene

  • Solute Carrier Family 39 Member 9 2 3 4 5
  • Zrt- And Irt-Like Protein 9 3 4
  • ZIP-9 3 4
  • ZIP9 3 4
  • Solute Carrier Family 39 (Zinc Transporter), Member 9 3
  • Solute Carrier Family 39, Member 9 2
  • Zinc Transporter SLC39A9 3
  • Zinc Transporter ZIP9 3

External Ids for SLC39A9 Gene

Previous GeneCards Identifiers for SLC39A9 Gene

  • GC00U913003
  • GC14P067856
  • GC14P067857
  • GC14P068935
  • GC14P069865
  • GC14P050033

Summaries for SLC39A9 Gene

GeneCards Summary for SLC39A9 Gene

SLC39A9 (Solute Carrier Family 39 Member 9) is a Protein Coding gene. Among its related pathways are Metal ion SLC transporters and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include metal ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for SLC39A9 Gene

  • May act as a zinc-influx transporter.

Additional gene information for SLC39A9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A9 Gene

Genomics for SLC39A9 Gene

GeneHancer (GH) Regulatory Elements for SLC39A9 Gene

Promoters and enhancers for SLC39A9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I069396 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.9 916 4.5 PKNOX1 CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ERH SLC39A9 SRSF5 DDX18P1 DCAF5 RPL7AP6 GALNT16 PLEKHD1
GH14I069267 Enhancer 0.9 Ensembl ENCODE 10.3 -129.5 -129530 2.6 ZSCAN4 YBX1 GLI4 CDC5L ZKSCAN1 ZNF664 ZFHX2 CTBP1 ZNF207 EGR2 ERH SRSF5 RPL7AP6 DDX18P1 SUSD6 DCAF5 EXD2 SLC39A9 GALNT16 ACTN1
GH14I069460 Enhancer 0.8 ENCODE 10.9 +62.3 62274 0.2 ELF3 MEIS2 CTCF PKNOX1 ATF1 ZBTB21 JUN SIN3A BRCA1 RAD21 PLEKHD1 GALNT16 ERH SLC39A9
GH14I069423 Enhancer 0.7 ENCODE 11.7 +26.5 26505 1.2 SOX13 GATAD2A FOXA2 SAP130 TEAD1 FOXA3 CEBPG HMG20A PPARG FOXA1 GALNT16 SLC39A9 ERH PLEKHD1
GH14I069439 Enhancer 0.5 Ensembl 16 +42.0 41986 0.8 ZSCAN5C PRDM10 MYC SP7 SLC39A9 GALNT16 PLEKHD1 ERH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC39A9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC39A9 gene promoter:

Genomic Locations for SLC39A9 Gene

Genomic Locations for SLC39A9 Gene
70,389 bases
Plus strand

Genomic View for SLC39A9 Gene

Genes around SLC39A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A9 Gene

Proteins for SLC39A9 Gene

  • Protein details for SLC39A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter ZIP9
    Protein Accession:
    Secondary Accessions:
    • G3V5J8
    • Q53HN3
    • Q5MJQ0
    • Q6P2Q1
    • Q86WY2

    Protein attributes for SLC39A9 Gene

    307 amino acids
    Molecular mass:
    32251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A9 Gene


neXtProt entry for SLC39A9 Gene

Post-translational modifications for SLC39A9 Gene

  • Glycosylation at isoforms=2, 329 and isoforms=2241
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC39A9 Gene

Domains & Families for SLC39A9 Gene

Gene Families for SLC39A9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC39A9 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZIP transporter (TC 2.A.5) family.
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A9: view

Function for SLC39A9 Gene

Molecular function for SLC39A9 Gene

UniProtKB/Swiss-Prot Function:
May act as a zinc-influx transporter.

Phenotypes From GWAS Catalog for SLC39A9 Gene

Gene Ontology (GO) - Molecular Function for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

Phenotypes for SLC39A9 Gene

genes like me logo Genes that share phenotypes with SLC39A9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A9

CRISPR Products

miRNA for SLC39A9 Gene

miRTarBase miRNAs that target SLC39A9

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A9 Gene

Localization for SLC39A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A9 gene
Compartment Confidence
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

Pathways & Interactions for SLC39A9 Gene

SuperPathways for SLC39A9 Gene

SuperPathway Contained pathways
1 NRF2 pathway
2 Metal ion SLC transporters
genes like me logo Genes that share pathways with SLC39A9: view

Pathways by source for SLC39A9 Gene

2 BioSystems pathways for SLC39A9 Gene

Interacting Proteins for SLC39A9 Gene

Gene Ontology (GO) - Biological Process for SLC39A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0030001 metal ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC39A9: view

No data available for SIGNOR curated interactions for SLC39A9 Gene

Drugs & Compounds for SLC39A9 Gene

No Compound Related Data Available

Transcripts for SLC39A9 Gene

Unigene Clusters for SLC39A9 Gene

Solute carrier family 39 (zinc transporter), member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for SLC39A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC39A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC39A9 Gene

Protein differential expression in normal tissues from HIPED for SLC39A9 Gene

This gene is overexpressed in Lung (11.4), Frontal cortex (11.0), and Kidney (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC39A9 Gene:


SOURCE GeneReport for Unigene cluster for SLC39A9 Gene:


Evidence on tissue expression from TISSUES for SLC39A9 Gene

  • Intestine(4.2)
  • Skin(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC39A9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A9 Gene

Orthologs for SLC39A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC39A9 33 34
  • 99.57 (n)
(Monodelphis domestica)
Mammalia SLC39A9 34
  • 94 (a)
(Canis familiaris)
Mammalia SLC39A9 33 34
  • 93.16 (n)
(Rattus norvegicus)
Mammalia Slc39a9 33
  • 91.95 (n)
(Bos Taurus)
Mammalia SLC39A9 33 34
  • 91.42 (n)
(Mus musculus)
Mammalia Slc39a9 33 16 34
  • 89.69 (n)
(Ornithorhynchus anatinus)
Mammalia SLC39A9 34
  • 71 (a)
(Gallus gallus)
Aves SLC39A9 33 34
  • 81.09 (n)
(Anolis carolinensis)
Reptilia SLC39A9 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a9 33
  • 74.04 (n)
Str.2106 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16284 33
(Danio rerio)
Actinopterygii slc39a9 33 34
  • 72.75 (n)
wufc56g12 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009188 33
  • 58.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2177 33 34
  • 57.85 (n)
(Caenorhabditis elegans)
Secernentea T01D3.5 33 34
  • 54.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4940 33
Species where no ortholog for SLC39A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A9 Gene

Gene Tree for SLC39A9 (if available)
Gene Tree for SLC39A9 (if available)

Paralogs for SLC39A9 Gene

No data available for Paralogs for SLC39A9 Gene

Variants for SLC39A9 Gene

Sequence variations from dbSNP and Humsavar for SLC39A9 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000017124 -- 69,443,298(+) A/G intron_variant
rs1000069566 -- 69,443,623(+) C/T intron_variant
rs1000074215 -- 69,416,485(+) C/G intron_variant
rs1000091488 -- 69,435,213(+) A/G intron_variant
rs1000111538 -- 69,439,981(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A9 Gene

Variant ID Type Subtype PubMed ID
dgv1930n100 CNV gain 25217958
esv3634836 CNV gain 21293372
nsv456335 CNV gain 19166990
nsv526398 CNV loss 19592680
nsv564967 CNV gain 21841781

Variation tolerance for SLC39A9 Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC39A9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A9 Gene

Disorders for SLC39A9 Gene

Additional Disease Information for SLC39A9

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC39A9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A9 Gene

Publications for SLC39A9 Gene

  1. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Membrane androgen receptor characteristics of human ZIP9 (SLC39A) zinc transporter in prostate cancer cells: Androgen-specific activation and involvement of an inhibitory G protein in zinc and MAP kinase signaling. (PMID: 28219737) Thomas P … Dong J (Molecular and cellular endocrinology 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SLC39A9 Gene

Sources for SLC39A9 Gene

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