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Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
SLC39A6 (Solute Carrier Family 39 Member 6) is a Protein Coding gene. Diseases associated with SLC39A6 include Acrodermatitis Enteropathica, Zinc-Deficiency Type and Breast Cancer. Among its related pathways are Metal ion SLC transporters and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005385 | zinc ion transmembrane transporter activity | IDA | 15642354 |
GO:0046873 | metal ion transmembrane transporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IDA | 15642354 |
GO:0009986 | cell surface | HDA | 19581412 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metal ion SLC transporters |
.38
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2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
3 | NRF2 pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006829 | zinc ion transport | IEA | -- |
GO:0006882 | cellular zinc ion homeostasis | IDA | 15642354 |
GO:0030001 | metal ion transport | IEA | -- |
GO:0055085 | transmembrane transport | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC39A6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC39A6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC39A6 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc39a6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Slc39a6 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC39A6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC39A6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SLC39A6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC39A6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100487349 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | slc39a6 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | foi 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1789528 | - | p.Glu119Asp |
Disorder | Aliases | PubMed IDs |
---|---|---|
acrodermatitis enteropathica, zinc-deficiency type |
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|
breast cancer |
|
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