This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010] See more...

Aliases for SLC39A2 Gene

Aliases for SLC39A2 Gene

  • Solute Carrier Family 39 Member 2 2 3 4 5
  • Solute Carrier Family 39 (Zinc Transporter), Member 2 2 3
  • Zrt- And Irt-Like Protein 2 3 4
  • Zinc Transporter ZIP2 3 4
  • ZIP-2 3 4
  • ZIP2 3 4
  • 6A1 3 4
  • Zinc Uptake Transporter 2 3
  • ETI-1 3
  • Eti-1 4
  • HZIP2 4

External Ids for SLC39A2 Gene

Previous GeneCards Identifiers for SLC39A2 Gene

  • GC14P018839
  • GC14P015254
  • GC14P019457
  • GC14P020537
  • GC14P021467
  • GC14P001588
  • GC14P021029
  • GC14P021041
  • GC14P021115
  • GC14P021122
  • GC14P021128
  • GC14P021048
  • GC14P021054
  • GC14P021066
  • GC14P021074
  • GC14P021083
  • GC14P021090
  • GC14P021100
  • GC14P021107

Summaries for SLC39A2 Gene

Entrez Gene Summary for SLC39A2 Gene

  • This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]

GeneCards Summary for SLC39A2 Gene

SLC39A2 (Solute Carrier Family 39 Member 2) is a Protein Coding gene. Diseases associated with SLC39A2 include Carotid Artery Disease and Acrodermatitis Enteropathica, Zinc-Deficiency Type. Among its related pathways are Metal ion SLC transporters and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A1.

UniProtKB/Swiss-Prot Summary for SLC39A2 Gene

  • Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.

Gene Wiki entry for SLC39A2 Gene

Additional gene information for SLC39A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC39A2 Gene

Genomics for SLC39A2 Gene

GeneHancer (GH) Regulatory Elements for SLC39A2 Gene

Promoters and enhancers for SLC39A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC39A2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC39A2

Top Transcription factor binding sites by QIAGEN in the SLC39A2 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5b)

Genomic Locations for SLC39A2 Gene

Genomic Locations for SLC39A2 Gene
chr14:20,999,255-21,001,875
(GRCh38/hg38)
Size:
2,621 bases
Orientation:
Plus strand
chr14:21,467,414-21,470,034
(GRCh37/hg19)
Size:
2,621 bases
Orientation:
Plus strand

Genomic View for SLC39A2 Gene

Genes around SLC39A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A2 Gene

Proteins for SLC39A2 Gene

  • Protein details for SLC39A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP94-S39A2_HUMAN
    Recommended name:
    Zinc transporter ZIP2
    Protein Accession:
    Q9NP94
    Secondary Accessions:
    • B2RC76
    • G3V5X2
    • Q4QQJ1
    • Q4V9S4
    • Q96JT6
    • Q9UD20

    Protein attributes for SLC39A2 Gene

    Size:
    309 amino acids
    Molecular mass:
    32742 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Zinc uptake is inhibited at pH levels below 7.0 and is stimulated at higher pH and is significantly inhibited by Cu(2+), Co(2+) and Mn(2+) ions. Not inhibited by Fe(2+).

    Alternative splice isoforms for SLC39A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A2 Gene

Post-translational modifications for SLC39A2 Gene

No Post-translational modifications

Other Protein References for SLC39A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC39A2 Gene

Domains & Families for SLC39A2 Gene

Gene Families for SLC39A2 Gene

Protein Domains for SLC39A2 Gene

Blocks:
  • Zinc transporter ZIP
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A2 Gene

GenScript: Design optimal peptide antigens:
  • Zrt- and Irt-like protein 2 (S39A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NP94

UniProtKB/Swiss-Prot:

S39A2_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A2: view

Function for SLC39A2 Gene

Molecular function for SLC39A2 Gene

UniProtKB/Swiss-Prot Function:
Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
UniProtKB/Swiss-Prot Induction:
Shows a dramatic induction in normal epithelial cells contact inhibition.

Gene Ontology (GO) - Molecular Function for SLC39A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IMP 20148757
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A2: view
genes like me logo Genes that share phenotypes with SLC39A2: view

Animal Models for SLC39A2 Gene

MGI Knock Outs for SLC39A2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC39A2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC39A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC39A2 Gene

Localization for SLC39A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC39A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0005887 integral component of plasma membrane TAS 10681536
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IDA 14612438
genes like me logo Genes that share ontologies with SLC39A2: view

Pathways & Interactions for SLC39A2 Gene

genes like me logo Genes that share pathways with SLC39A2: view

Gene Ontology (GO) - Biological Process for SLC39A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006829 zinc ion transport TAS 10681536
GO:0030001 metal ion transport IEA --
GO:0055085 transmembrane transport IEA --
GO:0071577 zinc ion transmembrane transport IBA 21873635
genes like me logo Genes that share ontologies with SLC39A2: view

No data available for SIGNOR curated interactions for SLC39A2 Gene

Drugs & Compounds for SLC39A2 Gene

(1) Drugs for SLC39A2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC39A2: view

Transcripts for SLC39A2 Gene

mRNA/cDNA for SLC39A2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC39A2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3:

Relevant External Links for SLC39A2 Gene

GeneLoc Exon Structure for
SLC39A2

Expression for SLC39A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC39A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.9), Skin - Not Sun Exposed (Suprapubic) (x14.4), Esophagus - Mucosa (x7.9), and Vagina (x5.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC39A2

SOURCE GeneReport for Unigene cluster for SLC39A2 Gene:

Hs.175783

mRNA Expression by UniProt/SwissProt for SLC39A2 Gene:

Q9NP94-S39A2_HUMAN
Tissue specificity: Expressed only in prostate and uterine epithelial cells.
genes like me logo Genes that share expression patterns with SLC39A2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A2 Gene

Orthologs for SLC39A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC39A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC39A2 31 30
  • 99.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC39A2 31 30
  • 83.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a2 17 31 30
  • 81.34 (n)
rat
(Rattus norvegicus)
Mammalia Slc39a2 30
  • 80.58 (n)
dog
(Canis familiaris)
Mammalia SLC39A2 31 30
  • 79.61 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC39A2 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A2 31
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC39A2 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496006 30
  • 54.31 (n)
zebrafish
(Danio rerio)
Actinopterygii slc39a1 31
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4334 31
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F31C3.4 31
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ZIP2 30
  • 40.61 (n)
rice
(Oryza sativa)
Liliopsida Os01g0972200 30
  • 44 (n)
Species where no ortholog for SLC39A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC39A2 Gene

ENSEMBL:
Gene Tree for SLC39A2 (if available)
TreeFam:
Gene Tree for SLC39A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC39A2: view image

Paralogs for SLC39A2 Gene

Paralogs for SLC39A2 Gene

(2) SIMAP similar genes for SLC39A2 Gene using alignment to 1 proteins:

  • S39A2_HUMAN
genes like me logo Genes that share paralogs with SLC39A2: view

Variants for SLC39A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC39A2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs2234633 - p.Leu48Pro
rs2234634 - p.Met80Val
rs2234636 - p.Phe115Leu
rs2234637 - p.His154Tyr
rs6413532 - p.Gly129Glu

Additional dbSNP identifiers (rs#s) for SLC39A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC39A2 Gene

Variant ID Type Subtype PubMed ID
esv2759972 CNV gain+loss 17122850
nsv428293 CNV gain+loss 18775914
nsv470622 CNV loss 18288195
nsv563847 CNV loss 21841781
nsv832740 CNV gain 17160897

Variation tolerance for SLC39A2 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC39A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC39A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A2 Gene

Disorders for SLC39A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC39A2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
carotid artery disease
  • disorder of carotid artery
acrodermatitis enteropathica, zinc-deficiency type
  • aez
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC39A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC39A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC39A2 Gene

Publications for SLC39A2 Gene

  1. Functional expression of the human hZIP2 zinc transporter. (PMID: 10681536) Gaither LA … Eide DJ (The Journal of biological chemistry 2000) 2 3 4 54
  2. [Subtraction cloning of growth arrest inducible genes in normal human epithelial cells]. (PMID: 7751801) Yamaguchi S (Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan 1995) 2 3 4 54
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41 54
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41 54
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 41 54

Products for SLC39A2 Gene

Sources for SLC39A2 Gene