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Aliases for SLC38A7 Gene

Aliases for SLC38A7 Gene

  • Solute Carrier Family 38 Member 7 2 3 4 5
  • SNAT7 3 4
  • Putative Sodium-Coupled Neutral Amino Acid Transporter 7 3
  • Solute Carrier Family 38, Member 7 2
  • Amino Acid Transporter 3

External Ids for SLC38A7 Gene

Previous GeneCards Identifiers for SLC38A7 Gene

  • GC16M057258
  • GC16M044565

Summaries for SLC38A7 Gene

GeneCards Summary for SLC38A7 Gene

SLC38A7 (Solute Carrier Family 38 Member 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include L-glutamate transmembrane transporter activity and L-serine transmembrane transporter activity. An important paralog of this gene is SLC38A8.

UniProtKB/Swiss-Prot for SLC38A7 Gene

  • Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.

Additional gene information for SLC38A7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC38A7 Gene

Genomics for SLC38A7 Gene

GeneHancer (GH) Regulatory Elements for SLC38A7 Gene

Promoters and enhancers for SLC38A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I058683 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557 +0.6 567 1.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF143 FOS NFYC ZHX2 MXD4 SLC38A7 CNOT1 SETD6 GOT2 ENSG00000245768 RNU6-1155P
GH16I058731 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.4 -48.3 -48340 3.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 GOT2 ENSG00000245768 GC16M058732 CNOT1 CSNK2A2 LOC101927556 SLC38A7
GH16I058755 Enhancer 1 Ensembl ENCODE 7.3 -71.3 -71254 1.6 ELF3 FOXA2 ARID4B ZNF2 IRF4 RAD21 ARID2 ZNF143 THAP11 DEK GOT2 SLC38A7 GC16M058744 RN7SL143P RNU6-1155P ENSG00000245768
GH16I058661 Enhancer 1 Ensembl ENCODE 5.8 +23.7 23703 0.4 ELF3 CTCF PKNOX1 ZBTB6 SAP130 ARID4B RAD21 RFX5 TEAD3 FOSL1 SLC38A7 CNOT1
GH16I058366 Enhancer 1.3 FANTOM5 Ensembl ENCODE 3.2 +318.7 318674 0.5 HDAC1 PKNOX1 ATF1 INSM2 ZNF335 ZNF366 FOS ZEB2 ZNF843 MAFF PIR48676 GINS3 PRSS54 SLC38A7 GC16M058378 RNU6-269P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC38A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC38A7 gene promoter:

Genomic Locations for SLC38A7 Gene

Genomic Locations for SLC38A7 Gene
chr16:58,665,109-58,685,104
(GRCh38/hg38)
Size:
19,996 bases
Orientation:
Minus strand
chr16:58,699,013-58,719,008
(GRCh37/hg19)

Genomic View for SLC38A7 Gene

Genes around SLC38A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A7 Gene

Proteins for SLC38A7 Gene

  • Protein details for SLC38A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVC3-S38A7_HUMAN
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 7
    Protein Accession:
    Q9NVC3
    Secondary Accessions:
    • Q53GJ9
    • Q9H9I5

    Protein attributes for SLC38A7 Gene

    Size:
    462 amino acids
    Molecular mass:
    49966 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC38A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC38A7 Gene

Post-translational modifications for SLC38A7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC38A7 Gene

Domains & Families for SLC38A7 Gene

Gene Families for SLC38A7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC38A7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC38A7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVC3

UniProtKB/Swiss-Prot:

S38A7_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A7: view

Function for SLC38A7 Gene

Molecular function for SLC38A7 Gene

UniProtKB/Swiss-Prot Function:
Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.

Phenotypes From GWAS Catalog for SLC38A7 Gene

Gene Ontology (GO) - Molecular Function for SLC38A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005290 L-histidine transmembrane transporter activity IBA --
GO:0005313 L-glutamate transmembrane transporter activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0015179 L-amino acid transmembrane transporter activity ISS --
GO:0015180 L-alanine transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC38A7: view
genes like me logo Genes that share phenotypes with SLC38A7: view

Animal Model Products

CRISPR Products

miRNA for SLC38A7 Gene

miRTarBase miRNAs that target SLC38A7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A7 Gene

Localization for SLC38A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A7 Gene

Membrane; Multi-pass membrane protein. Note=In neurons, located in soma and axons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC38A7 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC38A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon ISS --
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with SLC38A7: view

Pathways & Interactions for SLC38A7 Gene

SuperPathways for SLC38A7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC38A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport ISS --
GO:0006865 amino acid transport IEA --
GO:0006867 asparagine transport IBA --
genes like me logo Genes that share ontologies with SLC38A7: view

No data available for Pathways by source and SIGNOR curated interactions for SLC38A7 Gene

Drugs & Compounds for SLC38A7 Gene

No Compound Related Data Available

Transcripts for SLC38A7 Gene

Unigene Clusters for SLC38A7 Gene

Solute carrier family 38, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - - -
SP12:
SP13: - -
SP14: - -

ExUns: 14 ^ 15 ^ 16a · 16b · 16c · 16d
SP1: -
SP2: - -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SLC38A7 Gene

GeneLoc Exon Structure for
SLC38A7
ECgene alternative splicing isoforms for
SLC38A7

Expression for SLC38A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC38A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A7 Gene

This gene is overexpressed in Testis (x4.3).

Protein differential expression in normal tissues from HIPED for SLC38A7 Gene

This gene is overexpressed in Testis (23.5), Placenta (21.2), Blymphocyte (7.9), and Retina (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC38A7 Gene



Protein tissue co-expression partners for SLC38A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC38A7 Gene:

SLC38A7

SOURCE GeneReport for Unigene cluster for SLC38A7 Gene:

Hs.10499

Evidence on tissue expression from TISSUES for SLC38A7 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with SLC38A7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC38A7 Gene

Orthologs for SLC38A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC38A7 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia SLC38A7 33 34
  • 90.98 (n)
cow
(Bos Taurus)
Mammalia SLC38A7 33 34
  • 90.91 (n)
mouse
(Mus musculus)
Mammalia Slc38a7 33 16 34
  • 89.25 (n)
rat
(Rattus norvegicus)
Mammalia Slc38a7 33
  • 88.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC38A7 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC38A7 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC38A7 33 34
  • 79.52 (n)
lizard
(Anolis carolinensis)
Reptilia SLC38A7 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc38a7 33
  • 66.74 (n)
zebrafish
(Danio rerio)
Actinopterygii slc38a7 33 34
  • 70.14 (n)
wufi23b07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5352 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT6 34 36
  • 20 (a)
ManyToMany
AVT5 34
  • 19 (a)
ManyToMany
AVT7 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
Species where no ortholog for SLC38A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC38A7 Gene

ENSEMBL:
Gene Tree for SLC38A7 (if available)
TreeFam:
Gene Tree for SLC38A7 (if available)

Paralogs for SLC38A7 Gene

Paralogs for SLC38A7 Gene

(1) SIMAP similar genes for SLC38A7 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SLC38A7: view

Variants for SLC38A7 Gene

Sequence variations from dbSNP and Humsavar for SLC38A7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000099399 -- 58,667,152(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000168079 -- 58,675,416(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000197987 -- 58,670,913(-) G/A genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000206610 -- 58,670,599(-) C/T genic_downstream_transcript_variant, intron_variant
rs1001420860 -- 58,665,744(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC38A7 Gene

Variant ID Type Subtype PubMed ID
nsv528513 CNV loss 19592680
nsv511049 OTHER complex 20534489
nsv510686 CNV deletion 20534489
nsv509623 CNV insertion 20534489
esv2758650 CNV loss 17122850

Variation tolerance for SLC38A7 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC38A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC38A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A7 Gene

Disorders for SLC38A7 Gene

Additional Disease Information for SLC38A7

No disorders were found for SLC38A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A7 Gene

Publications for SLC38A7 Gene

  1. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58

Products for SLC38A7 Gene

Sources for SLC38A7 Gene

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