Aliases for SLC38A3 Gene

Aliases for SLC38A3 Gene

  • Solute Carrier Family 38 Member 3 2 3 4 5
  • G17 2 3 4
  • SN1 2 3 4
  • Sodium-Coupled Neutral Amino Acid Transporter 3 3 4
  • Na(+)-Coupled Neutral Amino Acid Transporter 3 3 4
  • N-System Amino Acid Transporter 1 3 4
  • System N Amino Acid Transporter 1 3 4
  • SNAT3 3 4
  • NAT1 3 4
  • System N1 Na+ And H+-Coupled Glutamine Transporter 3
  • Solute Carrier Family 38, Member 3 2
  • SLC38A3 5

External Ids for SLC38A3 Gene

Previous GeneCards Identifiers for SLC38A3 Gene

  • GC03M049728
  • GC03M049898
  • GC03P050097
  • GC03P050201
  • GC03P050217
  • GC03P050244

Summaries for SLC38A3 Gene

GeneCards Summary for SLC38A3 Gene

SLC38A3 (Solute Carrier Family 38 Member 3) is a Protein Coding gene. Diseases associated with SLC38A3 include Dissociative Disorder and Sarcocystosis. Among its related pathways are Proximal tubule bicarbonate reclamation and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include symporter activity and L-alanine transmembrane transporter activity. An important paralog of this gene is SLC38A5.

UniProtKB/Swiss-Prot Summary for SLC38A3 Gene

  • Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.

Gene Wiki entry for SLC38A3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC38A3 Gene

Genomics for SLC38A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC38A3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC38A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC38A3

Top Transcription factor binding sites by QIAGEN in the SLC38A3 gene promoter:
  • ATF
  • c-Ets-1
  • C/EBPalpha
  • Egr-3
  • GATA-2
  • HOXA5
  • NF-AT
  • p53
  • Pbx1a

Genomic Locations for SLC38A3 Gene

Latest Assembly
chr3:50,205,246-50,221,486
(GRCh38/hg38)
Size:
16,241 bases
Orientation:
Plus strand

Previous Assembly
chr3:50,242,704-50,258,918
(GRCh37/hg19 by Entrez Gene)
Size:
16,215 bases
Orientation:
Plus strand

chr3:50,242,679-50,258,411
(GRCh37/hg19 by Ensembl)
Size:
15,733 bases
Orientation:
Plus strand

Genomic View for SLC38A3 Gene

Genes around SLC38A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A3 Gene

Proteins for SLC38A3 Gene

  • Protein details for SLC38A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99624-S38A3_HUMAN
    Recommended name:
    Sodium-coupled neutral amino acid transporter 3
    Protein Accession:
    Q99624
    Secondary Accessions:
    • B2R8Q0
    • Q6IB34

    Protein attributes for SLC38A3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55773 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC38A3 Gene

Post-translational modifications for SLC38A3 Gene

  • Glycosylation at Asn74, Asn247, Asn248, Asn252, and Asn323
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC38A3 Gene

No data available for DME Specific Peptides for SLC38A3 Gene

Domains & Families for SLC38A3 Gene

Gene Families for SLC38A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC38A3 Gene

InterPro:

Suggested Antigen Peptide Sequences for SLC38A3 Gene

GenScript: Design optimal peptide antigens:
  • System N amino acid transporter 1 (S38A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99624

UniProtKB/Swiss-Prot:

S38A3_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A3: view

Function for SLC38A3 Gene

Molecular function for SLC38A3 Gene

UniProtKB/Swiss-Prot Function:
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.

Phenotypes From GWAS Catalog for SLC38A3 Gene

Gene Ontology (GO) - Molecular Function for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005290 L-histidine transmembrane transporter activity IEA,IDA 10823827
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015180 L-alanine transmembrane transporter activity IDA 10823827
GO:0015182 L-asparagine transmembrane transporter activity IBA,IDA 10823827
GO:0015186 L-glutamine transmembrane transporter activity IEA,IDA 10823827
genes like me logo Genes that share ontologies with SLC38A3: view
genes like me logo Genes that share phenotypes with SLC38A3: view

miRNA for SLC38A3 Gene

miRTarBase miRNAs that target SLC38A3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC38A3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC38A3 Gene

Localization for SLC38A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC38A3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC38A3: view

Pathways & Interactions for SLC38A3 Gene

genes like me logo Genes that share pathways with SLC38A3: view

Gene Ontology (GO) - Biological Process for SLC38A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA 21873635
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport TAS --
GO:0006867 asparagine transport IBA,IDA 10823827
genes like me logo Genes that share ontologies with SLC38A3: view

No data available for SIGNOR curated interactions for SLC38A3 Gene

Drugs & Compounds for SLC38A3 Gene

(7) Drugs for SLC38A3 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Asparagine Approved, Investigational Nutra Target, inhibitor 40
L-Glutamine Approved, Investigational Nutra Transporter, substrate 0
Histidine Investigational Nutra Target 67
[<sup>14</sup>C]glutamine Pharma 0
[<sup>3</sup>H]glutamine Pharma 0

(1) Additional Compounds for SLC38A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
  • Sodium(1+)
7440-23-5
genes like me logo Genes that share compounds with SLC38A3: view

Transcripts for SLC38A3 Gene

mRNA/cDNA for SLC38A3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC38A3

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for SLC38A3 Gene

GeneLoc Exon Structure for
SLC38A3

Expression for SLC38A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC38A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC38A3 Gene

This gene is overexpressed in Liver (x23.8) and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for SLC38A3 Gene

This gene is overexpressed in Fetal Liver (23.3), Frontal cortex (16.0), Liver (10.9), and Retina (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC38A3 Gene



Protein tissue co-expression partners for SLC38A3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC38A3

SOURCE GeneReport for Unigene cluster for SLC38A3 Gene:

Hs.76460

Evidence on tissue expression from TISSUES for SLC38A3 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with SLC38A3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC38A3 Gene

Orthologs for SLC38A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC38A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC38A3 29
  • 99.6 (n)
Dog
(Canis familiaris)
Mammalia SLC38A3 29
  • 90.54 (n)
Cow
(Bos Taurus)
Mammalia SLC38A3 29
  • 89.09 (n)
Rat
(Rattus norvegicus)
Mammalia Slc38a3 29
  • 87.81 (n)
Mouse
(Mus musculus)
Mammalia Slc38a3 29 16
  • 87.21 (n)
Chicken
(Gallus gallus)
Aves SLC38A3 29
  • 78.33 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc38a3 29
  • 72.45 (n)
Zebrafish
(Danio rerio)
Actinopterygii slc38a5b 29
  • 65.73 (n)
wufc48a10 29
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G38820 29
  • 41.05 (n)
Rice
(Oryza sativa)
Liliopsida Os06g0275800 29
  • 44.68 (n)
Species where no ortholog for SLC38A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC38A3 Gene

ENSEMBL:
Gene Tree for SLC38A3 (if available)
TreeFam:
Gene Tree for SLC38A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC38A3: view image
Alliance of Genome Resources:
Additional Orthologs for SLC38A3

Paralogs for SLC38A3 Gene

(5) SIMAP similar genes for SLC38A3 Gene using alignment to 1 proteins:

  • S38A3_HUMAN
genes like me logo Genes that share paralogs with SLC38A3: view

Variants for SLC38A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC38A3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1352789248 Uncertain Significance: Short stature 50,218,664(+) C/A
NM_006841.6(SLC38A3):c.1108C>A (p.Arg370Ser)
MISSENSE
rs587595868 Uncertain Significance: Short stature 50,220,103(+) C/A
NM_006841.6(SLC38A3):c.1441C>A (p.Leu481Met)
MISSENSE
rs780109786 Uncertain Significance: Short stature 50,217,469(+) T/C
NM_006841.6(SLC38A3):c.686T>C (p.Ile229Thr)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC38A3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC38A3 Gene

Variant ID Type Subtype PubMed ID
dgv602n27 CNV loss 19166990
dgv8316n54 CNV loss 21841781
dgv8317n54 CNV loss 21841781
esv2759148 CNV loss 17122850
esv3381149 CNV insertion 20981092
esv3596139 CNV loss 21293372
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv515986 CNV loss 19592680
nsv523560 CNV loss 19592680
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834690 CNV loss 17160897
nsv834692 CNV loss 17160897
nsv954855 CNV deletion 24416366

Additional Variant Information for SLC38A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC38A3
Leiden Open Variation Database (LOVD)
SLC38A3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SLC38A3 Gene

Disorders for SLC38A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC38A3 Gene - From: COP

Disorder Aliases PubMed IDs
dissociative disorder
  • dissociative disease
sarcocystosis
  • sarcosporidiosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC38A3

genes like me logo Genes that share disorders with SLC38A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC38A3 Gene

Publications for SLC38A3 Gene

  1. Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter. (PMID: 10823827) Fei YJ … Ganapathy V (The Journal of biological chemistry 2000) 2 3 4
  2. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. (PMID: 10619430) Chaudhry FA … Edwards RH (Cell 1999) 2 3 22
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4
  4. Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (PMID: 16432833) Kholodnyuk ID … Imreh S (International journal of cancer 2006) 3 22
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SLC38A3 Gene

  • Biorbyt antibodies for SLC38A3

Sources for SLC38A3 Gene