Aliases for SLC38A10 Gene

Aliases for SLC38A10 Gene

  • Solute Carrier Family 38 Member 10 2 3 4 5
  • Putative Sodium-Coupled Neutral Amino Acid Transporter 10 3 4
  • PP1744 2 3
  • Solute Carrier Family 38, Member 10 2
  • SLC38A10 5
  • MGC15523 2

External Ids for SLC38A10 Gene

Previous GeneCards Identifiers for SLC38A10 Gene

  • GC17M076834
  • GC17M079218
  • GC17M074654

Summaries for SLC38A10 Gene

GeneCards Summary for SLC38A10 Gene

SLC38A10 (Solute Carrier Family 38 Member 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity. An important paralog of this gene is SLC38A2.

UniProtKB/Swiss-Prot Summary for SLC38A10 Gene

Gene Wiki entry for SLC38A10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC38A10 Gene

Genomics for SLC38A10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC38A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC38A10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC38A10

Top Transcription factor binding sites by QIAGEN in the SLC38A10 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • ATF
  • FOXO4
  • GATA-2
  • GR
  • GR-alpha
  • HEN1

Genomic Locations for SLC38A10 Gene

Latest Assembly
50,737 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
50,497 bases
Minus strand

(GRCh37/hg19 by Ensembl)
50,548 bases
Minus strand

Genomic View for SLC38A10 Gene

Genes around SLC38A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC38A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC38A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC38A10 Gene

Proteins for SLC38A10 Gene

  • Protein details for SLC38A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 10
    Protein Accession:
    Secondary Accessions:
    • Q6ZRC5
    • Q8NA99
    • Q96C66

    Protein attributes for SLC38A10 Gene

    1119 amino acids
    Molecular mass:
    119762 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG17235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC38A10 Gene


neXtProt entry for SLC38A10 Gene

Post-translational modifications for SLC38A10 Gene

  • Glycosylation at Ser429, Ser524, Ser795, Ser802, Ser806, Thr886, Thr902, Thr904, Ser905, Thr921, Ser965, Ser997, and Ser1106
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC38A10 Gene

Domains & Families for SLC38A10 Gene

Gene Families for SLC38A10 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC38A10 Gene


Suggested Antigen Peptide Sequences for SLC38A10 Gene

GenScript: Design optimal peptide antigens:
  • SLC38A10 protein (Q8WW39_HUMAN)
  • Putative sodium-coupled neutral amino acid transporter 10 (S38AA_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid/polyamine transporter 2 family.
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC38A10: view

Function for SLC38A10 Gene

Molecular function for SLC38A10 Gene

UniProtKB/Swiss-Prot Function:
Putative sodium-dependent amino acid/proton antiporter.

Phenotypes From GWAS Catalog for SLC38A10 Gene

Gene Ontology (GO) - Molecular Function for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC38A10: view
genes like me logo Genes that share phenotypes with SLC38A10: view

Animal Models for SLC38A10 Gene

MGI Knock Outs for SLC38A10:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC38A10

miRNA for SLC38A10 Gene

miRTarBase miRNAs that target SLC38A10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC38A10

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC38A10 Gene

Localization for SLC38A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC38A10 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC38A10 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
nucleus 2
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC38A10: view

Pathways & Interactions for SLC38A10 Gene

PathCards logo

SuperPathways for SLC38A10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC38A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA 21873635
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006865 amino acid transport IEA --
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with SLC38A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC38A10 Gene

Drugs & Compounds for SLC38A10 Gene

(1) Additional Compounds for SLC38A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Na(+)
  • Na+
  • SODIUM ion
  • Sodium(1+)
genes like me logo Genes that share compounds with SLC38A10: view

Transcripts for SLC38A10 Gene

mRNA/cDNA for SLC38A10 Gene

18 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC38A10

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A10 Gene

No ASD Table

Relevant External Links for SLC38A10 Gene

GeneLoc Exon Structure for

Expression for SLC38A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC38A10 Gene

Protein differential expression in normal tissues from HIPED for SLC38A10 Gene

This gene is overexpressed in Adrenal (34.3), Pancreas (8.2), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC38A10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC38A10

SOURCE GeneReport for Unigene cluster for SLC38A10 Gene:


Evidence on tissue expression from TISSUES for SLC38A10 Gene

  • Liver(4.3)
  • Muscle(4.3)
  • Skin(2.5)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with SLC38A10: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC38A10 Gene

Orthologs for SLC38A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC38A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC38A10 29
  • 97.62 (n)
(Ornithorhynchus anatinus)
Mammalia SLC38A10 30
  • 90 (a)
(Bos Taurus)
Mammalia SLC38A10 29 30
  • 79.58 (n)
(Canis familiaris)
Mammalia SLC38A10 29 30
  • 78.49 (n)
(Mus musculus)
Mammalia Slc38a10 29 16 30
  • 76.66 (n)
(Rattus norvegicus)
Mammalia Slc38a10 29
  • 76.23 (n)
(Monodelphis domestica)
Mammalia SLC38A10 30
  • 59 (a)
(Gallus gallus)
Aves SLC38A10 29 30
  • 64.94 (n)
(Anolis carolinensis)
Reptilia SLC38A10 30
  • 52 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc38a10 29
  • 66.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69139 29
(Danio rerio)
Actinopterygii slc38a10 30
  • 44 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG30394 30
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y51F10.4 29 30
  • 45.55 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT2 30
  • 20 (a)
AVT5 32
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 48 (a)
Species where no ortholog for SLC38A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC38A10 Gene

Gene Tree for SLC38A10 (if available)
Gene Tree for SLC38A10 (if available)
Evolutionary constrained regions (ECRs) for SLC38A10: view image
Alliance of Genome Resources:
Additional Orthologs for SLC38A10

Paralogs for SLC38A10 Gene

genes like me logo Genes that share paralogs with SLC38A10: view

Variants for SLC38A10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC38A10 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2725405 -- p.Ala831Gly
rs35546507 -- p.Lys559Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC38A10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC38A10 Gene

Variant ID Type Subtype PubMed ID
dgv46n68 CNV loss 17160897
esv26223 CNV gain+loss 19812545
esv2716444 CNV deletion 23290073
esv2716445 CNV deletion 23290073
esv2758707 CNV gain 17122850
esv3357817 CNV duplication 20981092
esv3554878 CNV deletion 23714750
esv3641394 CNV loss 21293372
esv3893051 CNV gain 25118596
esv987875 CNV insertion 20482838
esv997494 CNV insertion 20482838
nsv1064123 CNV gain 25217958
nsv1142232 CNV tandem duplication 24896259
nsv1160499 CNV deletion 26073780
nsv2161 CNV insertion 18451855
nsv428351 CNV gain 18775914
nsv457971 CNV loss 19166990
nsv470619 CNV loss 18288195
nsv509677 CNV insertion 20534489
nsv576172 CNV loss 21841781
nsv828128 CNV loss 20364138
nsv952389 CNV deletion 24416366

Variation tolerance for SLC38A10 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.46; 99.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC38A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC38A10 Gene

Disorders for SLC38A10 Gene

Additional Disease Information for SLC38A10

No disorders were found for SLC38A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC38A10 Gene

Publications for SLC38A10 Gene

  1. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin AI … Ukraintseva SV (Aging 2010) 3 40
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. (PMID: 31024071) Guard SE … Old WM (Scientific reports 2019) 3
  4. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. (PMID: 30862715) Liu C … Buckhaults PJ (Cancer research 2019) 3
  5. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease. (PMID: 31524172) Hashimoto M … Tjernberg LO (Journal of Alzheimer's disease : JAD 2019) 3

Products for SLC38A10 Gene

Sources for SLC38A10 Gene