Aliases for SLC38A1 Gene
External Ids for SLC38A1 Gene
Previous GeneCards Identifiers for SLC38A1 Gene
Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC38A1 Gene
SLC38A1 (Solute Carrier Family 38 Member 1) is a Protein Coding gene. Diseases associated with SLC38A1 include Klatskin's Tumor and Persistent Fetal Circulation Syndrome. Among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include neutral amino acid transmembrane transporter activity and amino acid:sodium symporter activity. An important paralog of this gene is SLC38A4.
UniProtKB/Swiss-Prot Summary for SLC38A1 Gene
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.