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Aliases for SLC37A3 Gene

Aliases for SLC37A3 Gene

  • Solute Carrier Family 37 Member 3 2 3 4 5
  • Solute Carrier Family 37, Member 3 2
  • SPX3 4

External Ids for SLC37A3 Gene

Previous GeneCards Identifiers for SLC37A3 Gene

  • GC07M138305
  • GC07M139363
  • GC07M139440
  • GC07M139486
  • GC07M139680
  • GC07M139993
  • GC07M134326

Summaries for SLC37A3 Gene

GeneCards Summary for SLC37A3 Gene

SLC37A3 (Solute Carrier Family 37 Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is SLC37A1.

Additional gene information for SLC37A3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A3 Gene

Genomics for SLC37A3 Gene

GeneHancer (GH) Regulatory Elements for SLC37A3 Gene

Promoters and enhancers for SLC37A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I140397 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 570.8 +6.2 6217 1.8 PKNOX1 ARNT ARID4B SIN3A DMAP1 POLR2B ZNF213 ZNF143 SP3 MXD4 SLC37A3 RAB19 RNA5SP248
GH07I140403 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 560.2 +0.2 155 1.2 PKNOX1 SIN3A ETS1 NCOA2 ZNF335 ZNF366 SCRT2 ZNF143 THAP11 ZNF362 SLC37A3 RAB19
GH07I139773 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 26.5 +628.2 628202 5.5 HDGF PKNOX1 SIN3A ZNF2 IRF4 YY1 ZNF143 ZNF207 FOS KLF13 TBXAS1 HIPK2 SLC37A3 LUC7L2 ZC3HAV1L PARP12 PIR36040
GH07I141013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.1 -609.9 -609899 2.6 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 NBN MRPS33 SLC37A3 TAS2R6P TAS2R5 TMEM178B BRAF NDUFB2-AS1 NDUFB2 CCT4P1 LOC105375536
GH07I140058 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 22.8 +343.0 342987 5.1 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF143 FOS PARP12 SLC37A3 LUC7L2 UBN2 GC07P140023 GC07P140024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC37A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC37A3 gene promoter:

Genomic Locations for SLC37A3 Gene

Genomic Locations for SLC37A3 Gene
chr7:140,293,693-140,404,433
(GRCh38/hg38)
Size:
110,741 bases
Orientation:
Minus strand
chr7:139,993,493-140,104,233
(GRCh37/hg19)

Genomic View for SLC37A3 Gene

Genes around SLC37A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC37A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC37A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A3 Gene

Proteins for SLC37A3 Gene

  • Protein details for SLC37A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCC5-SPX3_HUMAN
    Recommended name:
    Sugar phosphate exchanger 3
    Protein Accession:
    Q8NCC5
    Secondary Accessions:
    • Q6PIU7
    • Q86SS4
    • Q9BQG7

    Protein attributes for SLC37A3 Gene

    Size:
    494 amino acids
    Molecular mass:
    54486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC37A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC37A3 Gene

Post-translational modifications for SLC37A3 Gene

  • Glycosylation at posLast=5858 and posLast=266266

No data available for DME Specific Peptides for SLC37A3 Gene

Domains & Families for SLC37A3 Gene

Gene Families for SLC37A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC37A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCC5

UniProtKB/Swiss-Prot:

SPX3_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A3: view

Function for SLC37A3 Gene

Phenotypes From GWAS Catalog for SLC37A3 Gene

Gene Ontology (GO) - Molecular Function for SLC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061513 NOT glucose 6-phosphate:inorganic phosphate antiporter activity IDA 21949678
genes like me logo Genes that share ontologies with SLC37A3: view
genes like me logo Genes that share phenotypes with SLC37A3: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A3 Gene

Localization for SLC37A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC37A3 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC37A3: view

Pathways & Interactions for SLC37A3 Gene

SuperPathways for SLC37A3 Gene

No Data Available

Interacting Proteins for SLC37A3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321498%0d%0a9606.ENSP00000356903%0d%0a9606.ENSP00000338703%0d%0a9606.ENSP00000386935%0d%0a
Selected Interacting proteins: Q8NCC5-SPX3_HUMAN ENSP00000321498 for SLC37A3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015760 NOT glucose-6-phosphate transport IDA 21949678
GO:0035435 NOT phosphate ion transmembrane transport IDA 21949678
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC37A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A3 Gene

Drugs & Compounds for SLC37A3 Gene

No Compound Related Data Available

Transcripts for SLC37A3 Gene

Unigene Clusters for SLC37A3 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b · 16c ·
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7: - - - - - - -
SP8:
SP9: - -

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SLC37A3 Gene

GeneLoc Exon Structure for
SLC37A3
ECgene alternative splicing isoforms for
SLC37A3

Expression for SLC37A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC37A3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC37A3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC37A3 Gene:

SLC37A3

SOURCE GeneReport for Unigene cluster for SLC37A3 Gene:

Hs.446021

mRNA Expression by UniProt/SwissProt for SLC37A3 Gene:

Q8NCC5-SPX3_HUMAN
Tissue specificity: Expressed in liver, kidney, intestine and pancreas.

Evidence on tissue expression from TISSUES for SLC37A3 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SLC37A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC37A3 Gene

Orthologs for SLC37A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC37A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC37A3 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia SLC37A3 33 34
  • 89.41 (n)
cow
(Bos Taurus)
Mammalia SLC37A3 33 34
  • 88.19 (n)
mouse
(Mus musculus)
Mammalia Slc37a3 33 16 34
  • 86.17 (n)
rat
(Rattus norvegicus)
Mammalia Slc37a3 33
  • 85.43 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC37A3 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A3 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A3 33 34
  • 75.26 (n)
lizard
(Anolis carolinensis)
Reptilia SLC37A3 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc37a3 33
  • 67.84 (n)
zebrafish
(Danio rerio)
Actinopterygii SLC37A3 34
  • 67 (a)
OneToOne
LOC100331554 33
  • 66.67 (n)
worm
(Caenorhabditis elegans)
Secernentea T11G6.2 33 34
  • 53.18 (n)
T11G6.3 34
  • 42 (a)
OneToMany
T10C6.6 34
  • 41 (a)
OneToMany
T11G6.4 34
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
Species where no ortholog for SLC37A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC37A3 Gene

ENSEMBL:
Gene Tree for SLC37A3 (if available)
TreeFam:
Gene Tree for SLC37A3 (if available)

Paralogs for SLC37A3 Gene

Paralogs for SLC37A3 Gene

genes like me logo Genes that share paralogs with SLC37A3: view

Variants for SLC37A3 Gene

Sequence variations from dbSNP and Humsavar for SLC37A3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000047037 -- 140,389,637(-) C/T intron_variant
rs1000138083 -- 140,390,432(-) A/G intron_variant
rs1000143169 -- 140,350,728(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000152851 -- 140,397,827(-) G/A intron_variant
rs1000234230 -- 140,370,377(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC37A3 Gene

Variant ID Type Subtype PubMed ID
nsv957032 CNV insertion 24416366
nsv522190 CNV gain 19592680
nsv478214 CNV novel sequence insertion 20440878
nsv473636 CNV novel sequence insertion 20440878
nsv1117763 CNV deletion 24896259
nsv1026255 CNV gain 25217958
nsv1022919 CNV gain 25217958
esv3615229 CNV loss 21293372
esv3615228 CNV gain 21293372
esv3615227 CNV gain 21293372
esv3572169 CNV loss 25503493
esv3572168 CNV loss 25503493
esv3411273 CNV insertion 20981092
esv2762706 CNV loss 21179565
esv2735212 CNV deletion 23290073
esv1579138 CNV insertion 17803354
esv1228695 CNV insertion 17803354

Variation tolerance for SLC37A3 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.29; 90.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC37A3 Gene

Human Gene Mutation Database (HGMD)
SLC37A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC37A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A3 Gene

Disorders for SLC37A3 Gene

Additional Disease Information for SLC37A3

No disorders were found for SLC37A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC37A3 Gene

Publications for SLC37A3 Gene

  1. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan CJ … Chou JY (PloS one 2011) 3 4 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (PMID: 21752829) Palmieri M … Ballabio A (Human molecular genetics 2011) 3 58

Products for SLC37A3 Gene

Sources for SLC37A3 Gene

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