Aliases for SLC37A2 Gene

Aliases for SLC37A2 Gene

  • Solute Carrier Family 37 Member 2 2 3 4 5
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 2 2 3
  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 2 2 3
  • Glucose-6-Phosphate Exchanger SLC37A2 3 4
  • Sugar Phosphate Exchanger 2 3
  • FLJ00171 2
  • Pp11662 3
  • SLC37A2 5
  • SPX2 3

External Ids for SLC37A2 Gene

Previous GeneCards Identifiers for SLC37A2 Gene

  • GC11P126446
  • GC11P124966
  • GC11P124470
  • GC11P124438
  • GC11P124933
  • GC11P120875

Summaries for SLC37A2 Gene

GeneCards Summary for SLC37A2 Gene

SLC37A2 (Solute Carrier Family 37 Member 2) is a Protein Coding gene. Diseases associated with SLC37A2 include Caffey Disease and Van Den Ende-Gupta Syndrome. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A1.

UniProtKB/Swiss-Prot Summary for SLC37A2 Gene

  • Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC37A2 Gene

Genomics for SLC37A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC37A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC37A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC37A2

Top Transcription factor binding sites by QIAGEN in the SLC37A2 gene promoter:
  • C/EBPbeta
  • NF-kappaB
  • NF-kappaB1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for SLC37A2 Gene

Latest Assembly
chr11:125,063,067-125,090,516
(GRCh38/hg38)
Size:
27,450 bases
Orientation:
Plus strand

Previous Assembly
chr11:124,933,201-124,960,412
(GRCh37/hg19 by Entrez Gene)
Size:
27,212 bases
Orientation:
Plus strand

chr11:124,932,963-124,959,131
(GRCh37/hg19 by Ensembl)
Size:
26,169 bases
Orientation:
Plus strand

Genomic View for SLC37A2 Gene

Genes around SLC37A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC37A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC37A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A2 Gene

Proteins for SLC37A2 Gene

  • Protein details for SLC37A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TED4-G6PT3_HUMAN
    Recommended name:
    Glucose-6-phosphate exchanger SLC37A2
    Protein Accession:
    Q8TED4
    Secondary Accessions:
    • A8K2P9
    • Q6P599
    • Q7Z7P8
    • Q8TEM2

    Protein attributes for SLC37A2 Gene

    Size:
    501 amino acids
    Molecular mass:
    54436 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB84926.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC37A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC37A2 Gene

Post-translational modifications for SLC37A2 Gene

  • Glycosylation at Asn53, Asn62, and Asn68
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC37A2 Gene

No data available for DME Specific Peptides for SLC37A2 Gene

Domains & Families for SLC37A2 Gene

Gene Families for SLC37A2 Gene

Protein Domains for SLC37A2 Gene

Suggested Antigen Peptide Sequences for SLC37A2 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 37 member 2 (SPX2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TED4

UniProtKB/Swiss-Prot:

G6PT3_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A2: view

Function for SLC37A2 Gene

Molecular function for SLC37A2 Gene

UniProtKB/Swiss-Prot Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate but not by chlorogenic acid.

Phenotypes From GWAS Catalog for SLC37A2 Gene

Gene Ontology (GO) - Molecular Function for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
GO:0061513 glucose 6-phosphate:inorganic phosphate antiporter activity IBA,IDA 21949678
genes like me logo Genes that share ontologies with SLC37A2: view
genes like me logo Genes that share phenotypes with SLC37A2: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC37A2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC37A2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A2 Gene

Localization for SLC37A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A2 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC37A2 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA,IDA 21949678
genes like me logo Genes that share ontologies with SLC37A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC37A2 Gene

Pathways & Interactions for SLC37A2 Gene

PathCards logo

SuperPathways for SLC37A2 Gene

No Data Available

Interacting Proteins for SLC37A2 Gene

Gene Ontology (GO) - Biological Process for SLC37A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0015760 glucose-6-phosphate transport TAS --
GO:0035435 phosphate ion transmembrane transport IBA,IDA 21949678
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC37A2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A2 Gene

Drugs & Compounds for SLC37A2 Gene

No Compound Related Data Available

Transcripts for SLC37A2 Gene

mRNA/cDNA for SLC37A2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC37A2

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for SLC37A2 Gene

GeneLoc Exon Structure for
SLC37A2

Expression for SLC37A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC37A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC37A2 Gene

This gene is overexpressed in Adrenal Gland (x10.2), Skin - Sun Exposed (Lower leg) (x5.9), Minor Salivary Gland (x4.8), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for SLC37A2 Gene

This gene is overexpressed in Breast (25.0), Monocytes (19.1), Cervix (15.0), and Adrenal (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC37A2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC37A2

SOURCE GeneReport for Unigene cluster for SLC37A2 Gene:

Hs.352661

mRNA Expression by UniProt/SwissProt for SLC37A2 Gene:

Q8TED4-G6PT3_HUMAN
Tissue specificity: Detected in intestine and pancreas. Lower expression is also detected in liver and kidney.

Evidence on tissue expression from TISSUES for SLC37A2 Gene

  • Nervous system(4.3)
  • Spleen(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with SLC37A2: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC37A2 Gene

Orthologs for SLC37A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC37A2 30 31
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC37A2 30 31
  • 87.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC37A2 30 31
  • 85.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc37a2 30
  • 85.25 (n)
Mouse
(Mus musculus)
Mammalia Slc37a2 30 17 31
  • 84.59 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 79 (a)
OneToMany
-- 31
  • 72 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A2 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC37A2 31
  • 74 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC37A2 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc37a2 30
  • 66.32 (n)
Str.7479 30
Zebrafish
(Danio rerio)
Actinopterygii slc37a2 30 31
  • 68.85 (n)
OneToOne
wufv35a12 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006413 30
  • 58.37 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta MFS16 30 31
  • 57.21 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PS3 30
  • 52.66 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9801 30
Soybean
(Glycine max)
eudicotyledons Gma.3539 30
Rice
(Oryza sativa)
Liliopsida Os04g0555300 30
  • 55.8 (n)
Wheat
(Triticum aestivum)
Liliopsida Ta.11166 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9170 31
  • 53 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3087 30
Species where no ortholog for SLC37A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Worm (Caenorhabditis elegans)

Evolution for SLC37A2 Gene

ENSEMBL:
Gene Tree for SLC37A2 (if available)
TreeFam:
Gene Tree for SLC37A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC37A2: view image

Paralogs for SLC37A2 Gene

(2) SIMAP similar genes for SLC37A2 Gene using alignment to 2 proteins:

  • SPX2_HUMAN
  • E9PRJ4_HUMAN
genes like me logo Genes that share paralogs with SLC37A2: view

Variants for SLC37A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC37A2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs34485243 - p.Gly268Ser
rs55752830 - p.Ile96Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC37A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC37A2 Gene

Variant ID Type Subtype PubMed ID
nsv1054682 CNV gain 25217958
nsv520010 CNV loss 19592680
nsv525136 CNV loss 19592680
nsv527157 CNV loss 19592680
nsv952754 CNV deletion 24416366

Variation tolerance for SLC37A2 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.12; 80.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC37A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC37A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A2 Gene

Disorders for SLC37A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC37A2 Gene - From: COP

Disorder Aliases PubMed IDs
caffey disease
  • cafyd
van den ende-gupta syndrome
  • vdegs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC37A2

genes like me logo Genes that share disorders with SLC37A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC37A2 Gene

Publications for SLC37A2 Gene

  1. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan CJ … Chou JY (PloS one 2011) 3 4
  2. Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. (PMID: 30880002) Villani A … Peri F (Developmental cell 2019) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M … Yates JR (Journal of proteome research 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for SLC37A2 Gene

  • Biorbyt antibodies for SLC37A2

Sources for SLC37A2 Gene