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SLC37A1 Gene(Protein Coding)

Solute Carrier Family 37 Member 1

GCID:
GC21P042499
GIFtS:
43
Genes Participants
UDN Logo

Aliases for SLC37A1 Gene

Aliases for SLC37A1 Gene

  • Solute Carrier Family 37 Member 1 2 3 4 5
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 1 2 3
  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 1 2 3
  • Glycerol-3-Phosphate Permease 3 4
  • G-3-P Permease 3 4
  • G3PP 3 4
  • Glucose-6-Phosphate Exchanger SLC37A1 3
  • Glycerol-3-Phosphate Transporter 3
  • G-3-P Transporter 3

External Ids for SLC37A1 Gene

Previous GeneCards Identifiers for SLC37A1 Gene

  • GC21P040467
  • GC21P042814
  • GC21P042828
  • GC21P042807
  • GC21P043918
  • GC21P029337

Summaries for SLC37A1 Gene

Entrez Gene Summary for SLC37A1 Gene

  • The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SLC37A1 Gene

SLC37A1 (Solute Carrier Family 37 Member 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A2.

UniProtKB/Swiss-Prot for SLC37A1 Gene

  • Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Additional gene information for SLC37A1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC37A1 Gene

Genomics for SLC37A1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SLC37A1 Gene

Promoters and enhancers for SLC37A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH21I042499 Promoter 0.9 EPDnew 550.8 +3.6 3615 0.1 AFF1 L3MBTL2 NRF1 ZNF76 DEAF1 ZIC2 ZFHX2 IKZF1 ZNF143 PRDM10 SLC37A1 LOC101930094 ENSG00000231867
GH21I042500 Promoter 0.6 EPDnew 550.8 +4.9 4932 0.1 ADNP SLC37A1 LOC101930094 ENSG00000231867
GH21I042512 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 41.4 +20.1 20108 6.7 HDGF PKNOX1 CLOCK NEUROD1 SIN3A BRCA1 ZNF121 GLIS2 ZNF207 FOS SLC37A1 ENSG00000235772 RSPH1 PKNOX1 TFF2 ENSG00000227698 ENSG00000231867
GH21I042490 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 29 -2.1 -2149 7.4 HDGF PKNOX1 ATF1 ARID4B NEUROD1 SIN3A YY1 GLIS2 ELK1 ZNF143 RSPH1 SLC37A1 ENSG00000235772 WDR4 PRDM15 LOC101930094 RNU6-1149P
GH21I042522 Enhancer 1.3 Ensembl ENCODE dbSUPER 43.7 +30.0 30011 6.5 HDGF ATF1 FEZF1 ZNF48 YY1 ATF7 RUNX3 RXRA JUNB REST SLC37A1 ENSG00000235772 RSPH1 LOC101930094 TFF2 ENSG00000231867
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC37A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC37A1 gene promoter:

Genomic Locations for SLC37A1 Gene

Genomic Locations for SLC37A1 Gene
chr21:42,496,008-42,581,440
(GRCh38/hg38)
Size:
85,433 bases
Orientation:
Plus strand
chr21:43,916,118-44,001,550
(GRCh37/hg19)

Genomic View for SLC37A1 Gene

Genes around SLC37A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC37A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC37A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SLC37A1 Gene

Proteins for SLC37A1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SLC37A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57057-G6PT2_HUMAN
    Recommended name:
    Glucose-6-phosphate exchanger SLC37A1
    Protein Accession:
    P57057
    Secondary Accessions:
    • D3DSJ7
    • Q9HAQ1

    Protein attributes for SLC37A1 Gene

    Size:
    533 amino acids
    Molecular mass:
    57648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC37A1 Gene

Protein Expression for SLC37A1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SLC37A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC37A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC37A1 Gene

Domains & Families for SLC37A1 Gene

Gene Families for SLC37A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC37A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC37A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57057

UniProtKB/Swiss-Prot:

G6PT2_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A1: view

Function for SLC37A1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SLC37A1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate but not by chlorogenic acid.
UniProtKB/Swiss-Prot Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Phenotypes From GWAS Catalog for SLC37A1 Gene

Gene Ontology (GO) - Molecular Function for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0061513 glucose 6-phosphate:inorganic phosphate antiporter activity IDA 21949678
genes like me logo Genes that share ontologies with SLC37A1: view
genes like me logo Genes that share phenotypes with SLC37A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC37A1

miRNA for SLC37A1 Gene

miRTarBase miRNAs that target SLC37A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC37A1 Gene

Localization for SLC37A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC37A1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 21949678
genes like me logo Genes that share ontologies with SLC37A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC37A1 Gene

Pathways & Interactions for SLC37A1 Gene

SuperPathways for SLC37A1 Gene

PathCards logo More details on SuperPathways for SLC37A1
No Data Available

Interacting Proteins for SLC37A1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000344648%0d%0a9606.ENSP00000356903%0d%0a9606.ENSP00000386935%0d%0a9606.ENSP00000338703%0d%0a9606.ENSP00000369816%0d%0a
Selected Interacting proteins: ENSP00000344648 P57057-G6PT2_HUMAN for SLC37A1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015760 glucose-6-phosphate transport TAS --
GO:0035435 phosphate ion transmembrane transport IDA 21949678
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC37A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A1 Gene

Drugs & Compounds for SLC37A1 Gene

Products:

  1. Drug

(1) Additional Compounds for SLC37A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC37A1: view

Transcripts for SLC37A1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SLC37A1 Gene

(12) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(151) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC37A1 Gene

Solute carrier family 37 (glycerol-3-phosphate transporter), member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A1 Gene

No ASD Table

Relevant External Links for SLC37A1 Gene

GeneLoc Exon Structure for
SLC37A1
ECgene alternative splicing isoforms for
SLC37A1

Expression for SLC37A1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC37A1 Gene

mRNA expression in normal human tissues for SLC37A1 Gene
mRNA expression by BioGPS for SLC37A1 GenemRNA expression by GTEx for SLC37A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC37A1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC37A1 Gene



Protein tissue co-expression partners for SLC37A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC37A1 Gene:

SLC37A1

SOURCE GeneReport for Unigene cluster for SLC37A1 Gene:

Hs.547009

mRNA Expression by UniProt/SwissProt for SLC37A1 Gene:

P57057-G6PT2_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.

Evidence on tissue expression from TISSUES for SLC37A1 Gene

  • Gall bladder(2)
genes like me logo Genes that share expression patterns with SLC37A1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC37A1 Gene

Orthologs for SLC37A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SLC37A1 33 34
  • 99.44 (n)
dog
(Canis familiaris)
 Mammalia SLC37A1 33 34
  • 86.38 (n)
cow
(Bos Taurus)
 Mammalia SLC37A1 33 34
  • 84.74 (n)
mouse
(Mus musculus)
 Mammalia Slc37a1 33 16 34
  • 83.24 (n)
rat
(Rattus norvegicus)
 Mammalia Slc37a1 33
  • 83.05 (n)
oppossum
(Monodelphis domestica)
 Mammalia SLC37A1 34
  • 81 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia SLC37A1 34
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SLC37A1 33 34
  • 70.15 (n)
lizard
(Anolis carolinensis)
 Reptilia SLC37A1 34
  • 76 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii slc37a1 33 34
  • 65.33 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG10069 35
  • 44 (a)
MFS16 34
  • 41 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea T10C6.6b 35
  • 31 (a)
T10C6.6a 35
  • 30 (a)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT4G17550 33
  • 50.43 (n)
rice
(Oryza sativa)
 Liliopsida Os02g0652800 33
  • 54.88 (n)
barley
(Hordeum vulgare)
 Liliopsida Hv.12156 33
corn
(Zea mays)
 Liliopsida Zm.13067 33
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.9170 34
  • 50 (a)
 OneToMany
Species where no ortholog for SLC37A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC37A1 Gene

ENSEMBL:
Gene Tree for SLC37A1 (if available)
TreeFam:
Gene Tree for SLC37A1 (if available)

Paralogs for SLC37A1 Gene

Paralogs for SLC37A1 Gene

(2) SIMAP similar genes for SLC37A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC37A1: view

Variants for SLC37A1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for SLC37A1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000018467 -- 42,529,975(+) C/G intron_variant
rs1000023546 -- 42,570,332(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000074876 -- 42,543,943(+) G/C intron_variant
rs1000098294 -- 42,513,134(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000164827 -- 42,506,639(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC37A1 Gene

Variant ID Type Subtype PubMed ID
dgv7861n54 CNV loss 21841781
dgv7862n54 CNV gain+loss 21841781
dgv7863n54 CNV gain+loss 21841781
dgv7864n54 CNV gain 21841781
esv2153018 CNV deletion 18987734
esv25213 CNV loss 19812545
esv2723551 CNV deletion 23290073
esv2723552 CNV deletion 23290073
esv2723553 CNV deletion 23290073
esv2723554 CNV deletion 23290073
esv2723555 CNV deletion 23290073
esv2723556 CNV deletion 23290073
esv2723557 CNV deletion 23290073
esv2723558 CNV deletion 23290073
esv2723559 CNV deletion 23290073
esv2723560 CNV deletion 23290073
esv3400425 CNV insertion 20981092
esv3557769 CNV deletion 23714750
esv3647082 CNV loss 21293372
esv4794 CNV loss 18987735
nsv1139030 CNV deletion 24896259
nsv187256 CNV deletion 16902084
nsv3533 CNV deletion 18451855
nsv521904 CNV loss 19592680
nsv522001 CNV gain 19592680
nsv587633 CNV gain 21841781
nsv587634 CNV gain 21841781
nsv587636 CNV gain 21841781
nsv587647 CNV loss 21841781
nsv587648 CNV loss 21841781
nsv834103 CNV gain 17160897
nsv953633 CNV deletion 24416366

Variation tolerance for SLC37A1 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC37A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC37A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A1 Gene

Disorders for SLC37A1 Gene

Additional Disease Information for SLC37A1

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC37A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC37A1 Gene

Publications for SLC37A1 Gene

  1. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. (PMID: 11112347) Bartoloni L … Antonarakis SE (Genomics 2000) 2 3 4 22 58
  2. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan CJ … Chou JY (PloS one 2011) 3 4 58
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D … Wilkins JA (Journal of mass spectrometry : JMS 2010) 3 58
  5. Simulation of spontaneous substrate binding revealing the binding pathway and mechanism and initial conformational response of GlpT. (PMID: 20058936) Enkavi G … Tajkhorshid E (Biochemistry 2010) 22 58

Products for SLC37A1 Gene

Sources for SLC37A1 Gene

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