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The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
SLC37A1 (Solute Carrier Family 37 Member 1) is a Protein Coding gene. Diseases associated with SLC37A1 include Glycerol Kinase Deficiency and Deafness, Autosomal Recessive 8. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015297 | antiporter activity | IEA | -- |
GO:0022857 | transmembrane transporter activity | IEA | -- |
GO:0061513 | glucose 6-phosphate:inorganic phosphate antiporter activity | IDA | 21949678 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030176 | integral component of endoplasmic reticulum membrane | IDA | 21949678 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008643 | carbohydrate transport | IEA | -- |
GO:0015760 | glucose-6-phosphate transport | TAS | -- |
GO:0035435 | phosphate ion transmembrane transport | IDA | 21949678 |
GO:0055085 | transmembrane transport | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC37A1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC37A1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC37A1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Slc37a1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc37a1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SLC37A1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC37A1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SLC37A1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC37A1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | slc37a1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10069 32 |
|
|
|
MFS16 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | T10C6.6b 32 |
|
|
|
T10C6.6a 32 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G17550 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0652800 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.12156 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.13067 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9170 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711678 | Benign: not provided | 42,565,848(+) | A/T | MISSENSE_VARIANT | |
716647 | Benign: not provided | 42,564,801(+) | G/A | INTRON_VARIANT | |
727488 | Benign: not provided | 42,542,412(+) | C/T | SYNONYMOUS_VARIANT | |
769135 | Benign: not provided | 42,564,800(+) | C/T | INTRON_VARIANT | |
777310 | Benign: not provided | 42,539,566(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
glycerol kinase deficiency |
|
|
deafness, autosomal recessive 8 |
|
|
glycogen storage disease ia |
|
|
glycogen storage disease |
|
|