The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, ... See more...

Aliases for SLC37A1 Gene

Aliases for SLC37A1 Gene

  • Solute Carrier Family 37 Member 1 2 3 4 5
  • Solute Carrier Family 37 (Glycerol-3-Phosphate Transporter), Member 1 2 3
  • Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 1 2 3
  • Glucose-6-Phosphate Exchanger SLC37A1 3 4
  • Glycerol-3-Phosphate Permease 3 4
  • G-3-P Permease 3 4
  • G3PP 3 4
  • Glycerol-3-Phosphate Transporter 3
  • G-3-P Transporter 3

External Ids for SLC37A1 Gene

Previous GeneCards Identifiers for SLC37A1 Gene

  • GC21P040467
  • GC21P042814
  • GC21P042828
  • GC21P042807
  • GC21P043918
  • GC21P029337
  • GC21P042499
  • GC21P042502
  • GC21P042506

Summaries for SLC37A1 Gene

Entrez Gene Summary for SLC37A1 Gene

  • The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SLC37A1 Gene

SLC37A1 (Solute Carrier Family 37 Member 1) is a Protein Coding gene. Diseases associated with SLC37A1 include Glycerol Kinase Deficiency and Deafness, Autosomal Recessive 8. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC37A2.

UniProtKB/Swiss-Prot Summary for SLC37A1 Gene

  • Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Additional gene information for SLC37A1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC37A1 Gene

Genomics for SLC37A1 Gene

GeneHancer (GH) Regulatory Elements for SLC37A1 Gene

Promoters and enhancers for SLC37A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC37A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC37A1

Top Transcription factor binding sites by QIAGEN in the SLC37A1 gene promoter:
  • ATF6
  • C/EBPalpha
  • Elk-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • LCR-F1
  • p53

Genomic Locations for SLC37A1 Gene

Genomic Locations for SLC37A1 Gene
chr21:42,496,008-42,581,440
(GRCh38/hg38)
Size:
85,433 bases
Orientation:
Plus strand
chr21:43,916,118-44,001,550
(GRCh37/hg19)
Size:
85,433 bases
Orientation:
Plus strand

Genomic View for SLC37A1 Gene

Genes around SLC37A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC37A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC37A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC37A1 Gene

Proteins for SLC37A1 Gene

  • Protein details for SLC37A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57057-G6PT2_HUMAN
    Recommended name:
    Glucose-6-phosphate exchanger SLC37A1
    Protein Accession:
    P57057
    Secondary Accessions:
    • D3DSJ7
    • Q9HAQ1

    Protein attributes for SLC37A1 Gene

    Size:
    533 amino acids
    Molecular mass:
    57648 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC37A1 Gene

Post-translational modifications for SLC37A1 Gene

  • Glycosylation at Asn81 and Asn263
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC37A1 Gene

Domains & Families for SLC37A1 Gene

Gene Families for SLC37A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC37A1 Gene

Blocks:
  • GlpT transporter
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC37A1 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 37 member 1 (GLPT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57057

UniProtKB/Swiss-Prot:

G6PT2_HUMAN :
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
Family:
  • Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
genes like me logo Genes that share domains with SLC37A1: view

Function for SLC37A1 Gene

Molecular function for SLC37A1 Gene

UniProtKB/Swiss-Prot Function:
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by vanadate but not by chlorogenic acid.

Phenotypes From GWAS Catalog for SLC37A1 Gene

Gene Ontology (GO) - Molecular Function for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
GO:0061513 glucose 6-phosphate:inorganic phosphate antiporter activity IDA 21949678
genes like me logo Genes that share ontologies with SLC37A1: view
genes like me logo Genes that share phenotypes with SLC37A1: view

Animal Models for SLC37A1 Gene

MGI Knock Outs for SLC37A1:
  • Slc37a1 Slc37a1<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC37A1

CRISPR Products

miRNA for SLC37A1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC37A1 Gene

Localization for SLC37A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC37A1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC37A1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 21949678
genes like me logo Genes that share ontologies with SLC37A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC37A1 Gene

Pathways & Interactions for SLC37A1 Gene

PathCards logo

SuperPathways for SLC37A1 Gene

No Data Available

Interacting Proteins for SLC37A1 Gene

;

Gene Ontology (GO) - Biological Process for SLC37A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0015760 glucose-6-phosphate transport TAS --
GO:0035435 phosphate ion transmembrane transport IDA 21949678
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC37A1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC37A1 Gene

Drugs & Compounds for SLC37A1 Gene

(1) Additional Compounds for SLC37A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC37A1: view

Transcripts for SLC37A1 Gene

mRNA/cDNA for SLC37A1 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC37A1 Gene

No ASD Table

Relevant External Links for SLC37A1 Gene

GeneLoc Exon Structure for
SLC37A1

Expression for SLC37A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC37A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC37A1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC37A1 Gene



Protein tissue co-expression partners for SLC37A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC37A1

SOURCE GeneReport for Unigene cluster for SLC37A1 Gene:

Hs.547009

mRNA Expression by UniProt/SwissProt for SLC37A1 Gene:

P57057-G6PT2_HUMAN
Tissue specificity: Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen.

Evidence on tissue expression from TISSUES for SLC37A1 Gene

  • Gall bladder(2)
genes like me logo Genes that share expression patterns with SLC37A1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC37A1 Gene

Orthologs for SLC37A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC37A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC37A1 31 30
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC37A1 31 30
  • 86.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC37A1 31 30
  • 84.74 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc37a1 17 31 30
  • 83.24 (n)
rat
(Rattus norvegicus)
Mammalia Slc37a1 30
  • 83.05 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC37A1 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC37A1 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC37A1 31 30
  • 70.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC37A1 31
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc37a1 31 30
  • 65.33 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10069 32
  • 44 (a)
MFS16 31
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T10C6.6b 32
  • 31 (a)
T10C6.6a 32
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17550 30
  • 50.43 (n)
rice
(Oryza sativa)
Liliopsida Os02g0652800 30
  • 54.88 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.12156 30
corn
(Zea mays)
Liliopsida Zm.13067 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9170 31
  • 50 (a)
OneToMany
Species where no ortholog for SLC37A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC37A1 Gene

ENSEMBL:
Gene Tree for SLC37A1 (if available)
TreeFam:
Gene Tree for SLC37A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC37A1: view image

Paralogs for SLC37A1 Gene

(2) SIMAP similar genes for SLC37A1 Gene using alignment to 1 proteins:

  • GLPT_HUMAN
genes like me logo Genes that share paralogs with SLC37A1: view

Variants for SLC37A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC37A1 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
711678 Benign: not provided 42,565,848(+) A/T MISSENSE_VARIANT
716647 Benign: not provided 42,564,801(+) G/A INTRON_VARIANT
727488 Benign: not provided 42,542,412(+) C/T SYNONYMOUS_VARIANT
769135 Benign: not provided 42,564,800(+) C/T INTRON_VARIANT
777310 Benign: not provided 42,539,566(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SLC37A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC37A1 Gene

Variant ID Type Subtype PubMed ID
dgv7861n54 CNV loss 21841781
dgv7862n54 CNV gain+loss 21841781
dgv7863n54 CNV gain+loss 21841781
dgv7864n54 CNV gain 21841781
esv2153018 CNV deletion 18987734
esv25213 CNV loss 19812545
esv2723551 CNV deletion 23290073
esv2723552 CNV deletion 23290073
esv2723553 CNV deletion 23290073
esv2723554 CNV deletion 23290073
esv2723555 CNV deletion 23290073
esv2723556 CNV deletion 23290073
esv2723557 CNV deletion 23290073
esv2723558 CNV deletion 23290073
esv2723559 CNV deletion 23290073
esv2723560 CNV deletion 23290073
esv3400425 CNV insertion 20981092
esv3557769 CNV deletion 23714750
esv3647082 CNV loss 21293372
esv4794 CNV loss 18987735
nsv1139030 CNV deletion 24896259
nsv187256 CNV deletion 16902084
nsv3533 CNV deletion 18451855
nsv521904 CNV loss 19592680
nsv522001 CNV gain 19592680
nsv587633 CNV gain 21841781
nsv587634 CNV gain 21841781
nsv587636 CNV gain 21841781
nsv587647 CNV loss 21841781
nsv587648 CNV loss 21841781
nsv834103 CNV gain 17160897
nsv953633 CNV deletion 24416366

Variation tolerance for SLC37A1 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC37A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC37A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC37A1 Gene

Disorders for SLC37A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC37A1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC37A1

genes like me logo Genes that share disorders with SLC37A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC37A1 Gene

Publications for SLC37A1 Gene

  1. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. (PMID: 11112347) Bartoloni L … Antonarakis SE (Genomics 2000) 2 3 4 23 54
  2. SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. (PMID: 21949678) Pan CJ … Chou JY (PloS one 2011) 3 4 54
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 54
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D … Wilkins JA (Journal of mass spectrometry : JMS 2010) 3 54

Products for SLC37A1 Gene

  • Biorbyt antibodies for SLC37A1

Sources for SLC37A1 Gene