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Aliases for SLC36A4 Gene

Aliases for SLC36A4 Gene

  • Solute Carrier Family 36 Member 4 2 3 4 5
  • Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 4 2 3
  • PAT4 3 4
  • Proton-Coupled Amino Acid Transporter 4 3
  • Proton/Amino Acid Transporter 4 4

External Ids for SLC36A4 Gene

Previous GeneCards Identifiers for SLC36A4 Gene

  • GC11M093065
  • GC11M092569
  • GC11M092520
  • GC11M092880
  • GC11M088965
  • GC11M093208
  • GC11M093321
  • GC11M093322

Summaries for SLC36A4 Gene

Entrez Gene Summary for SLC36A4 Gene

  • SLC36A4 belongs to the SLC36 family of amino acid transporters based on sequence similarity with other family members (e.g., SLC36A1; MIM 606561). SLC36 proteins contain about 500 amino acids and have 9 to 11 transmembrane domains. Unlike other SLC36 family members, which are proton-coupled amino acid transporters, SLC36A4 is a high-affinity/low-capacity non-proton-coupled amino acid transporter (Pillai and Meredith, 2011 [PubMed 21097500]).[supplied by OMIM, Feb 2011]

GeneCards Summary for SLC36A4 Gene

SLC36A4 (Solute Carrier Family 36 Member 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include symporter activity and amino acid transmembrane transporter activity. An important paralog of this gene is SLC36A1.

UniProtKB/Swiss-Prot for SLC36A4 Gene

  • Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.

Additional gene information for SLC36A4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC36A4 Gene

Genomics for SLC36A4 Gene

GeneHancer (GH) Regulatory Elements for SLC36A4 Gene

Promoters and enhancers for SLC36A4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J093541 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.1 -344.6 -344586 3.1 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 ZNF766 CBX5 SMCO4 SLC36A4 MED17 ANKRD49 MRE11 SNORA1 CEP295 ENSG00000255445 HEPHL1 C11orf54
GH11J093196 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 664 +0.3 305 2.3 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 FOS KLF13 SLC36A4 CEP295 MED17 ENSG00000255445 SNORA1 ENSG00000280379
GH11J093523 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.3 -327.2 -327234 4.4 HDGF PKNOX1 FOXA2 RAD21 RARA YY1 BCLAF1 IKZF2 RUNX3 EGR2 SMCO4 SLC36A4 GPR83 DEUP1 MED17 SRP14P2 GC11M093919
GH11J092380 Enhancer 0.6 ENCODE 11.2 +817.1 817092 1.3 ZNF473 ZBTB21 JUN ZFP37 SALL2 ZNF398 ZEB2 ATF2 ZEB1 HIC1 SLC36A4 PGAM1P9 ENSG00000254705 FAT3
GH11J093071 Enhancer 0.8 ENCODE dbSUPER 7 +124.8 124784 2.9 STAT1 USF1 NANOG MAX USF2 ZNF623 SP1 POLR2A POU5F1 ENSG00000278892 SLC36A4 ENSG00000279304
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC36A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC36A4 gene promoter:
  • RP58
  • Tal-1beta
  • E47
  • E4BP4
  • Sox5
  • ATF
  • HFH-3
  • FOXI1
  • Nkx6-1

Genomic Locations for SLC36A4 Gene

Genomic Locations for SLC36A4 Gene
53,805 bases
Minus strand
53,790 bases
Minus strand

Genomic View for SLC36A4 Gene

Genes around SLC36A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC36A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC36A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC36A4 Gene

Proteins for SLC36A4 Gene

  • Protein details for SLC36A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proton-coupled amino acid transporter 4
    Protein Accession:
    Secondary Accessions:
    • Q86X30
    • Q8IVM5
    • Q8N8S6

    Protein attributes for SLC36A4 Gene

    504 amino acids
    Molecular mass:
    56157 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAC82496.1; Type=Frameshift; Positions=358, 361, 363, 366, 370, 373, 376, 387, 396, 458, 487; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC36A4 Gene


neXtProt entry for SLC36A4 Gene

Post-translational modifications for SLC36A4 Gene

  • Glycosylation at posLast=495495 and isoforms=2197
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC36A4 Gene

Domains & Families for SLC36A4 Gene

Gene Families for SLC36A4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC36A4 Gene


Suggested Antigen Peptide Sequences for SLC36A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amino acid/polyamine transporter 2 family.
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC36A4: view

Function for SLC36A4 Gene

Molecular function for SLC36A4 Gene

UniProtKB/Swiss-Prot Function:
Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.1 uM for L-proline {ECO:0000269 PubMed:21097500}; KM=1.7 uM for L-tryptophan {ECO:0000269 PubMed:21097500}; pH dependence: Optimum pH is 7.4 (for proline transport). {ECO:0000269 PubMed:21097500};

Phenotypes From GWAS Catalog for SLC36A4 Gene

Gene Ontology (GO) - Molecular Function for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IBA --
GO:0015180 L-alanine transmembrane transporter activity IDA 21097500
GO:0015193 L-proline transmembrane transporter activity IDA 21097500
GO:0015196 L-tryptophan transmembrane transporter activity IDA 21097500
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC36A4: view
genes like me logo Genes that share phenotypes with SLC36A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC36A4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC36A4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC36A4 Gene

Localization for SLC36A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC36A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC36A4 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 2
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005774 vacuolar membrane IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC36A4: view

Pathways & Interactions for SLC36A4 Gene

SuperPathways for SLC36A4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC36A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006865 amino acid transport IEA --
GO:0015808 L-alanine transport IDA 21097500
GO:0015824 proline transport IDA 21097500
GO:0015827 tryptophan transport IDA 21097500
genes like me logo Genes that share ontologies with SLC36A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC36A4 Gene

Drugs & Compounds for SLC36A4 Gene

No Compound Related Data Available

Transcripts for SLC36A4 Gene

mRNA/cDNA for SLC36A4 Gene

Unigene Clusters for SLC36A4 Gene

Solute carrier family 36 (proton/amino acid symporter), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC36A4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC36A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - -
SP2: - - -

Relevant External Links for SLC36A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC36A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC36A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC36A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC36A4 Gene:


SOURCE GeneReport for Unigene cluster for SLC36A4 Gene:


Evidence on tissue expression from TISSUES for SLC36A4 Gene

  • Muscle(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SLC36A4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC36A4 Gene

Orthologs for SLC36A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC36A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC36A4 34 33
  • 99.74 (n)
(Canis familiaris)
Mammalia SLC36A4 34 33
  • 92.31 (n)
(Bos Taurus)
Mammalia SLC36A4 34 33
  • 91.65 (n)
(Mus musculus)
Mammalia Slc36a4 16 34 33
  • 83.67 (n)
(Ornithorhynchus anatinus)
Mammalia SLC36A4 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Slc36a4 33
  • 81.97 (n)
(Monodelphis domestica)
Mammalia SLC36A4 34
  • 75 (a)
(Gallus gallus)
Aves SLC36A4 34 33
  • 72.81 (n)
(Anolis carolinensis)
Reptilia SLC36A4 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc36a4 33
  • 66.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32457 33
(Danio rerio)
Actinopterygii slc36a4 34 33
  • 59.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13384 34 33
  • 51.06 (n)
CG16700 34
  • 32 (a)
CG7888 34
  • 32 (a)
CG8785 34
  • 31 (a)
path 34
  • 30 (a)
CG1139 34
  • 30 (a)
CG43693 34
  • 28 (a)
CG4991 34
  • 27 (a)
CG32081 34
  • 27 (a)
CG32079 34
  • 25 (a)
CG12943 34
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008490 33
  • 48.66 (n)
(Caenorhabditis elegans)
Secernentea T27A1.5 34
  • 32 (a)
Y43F4B.7 34
  • 30 (a)
H32K16.1 34
  • 27 (a)
C44B7.6 34
  • 26 (a)
Y38H6C.17 34
  • 25 (a)
F59B2.2 34
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT4 34 33
  • 48.24 (n)
AVT3 34
  • 15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13277g 33
  • 46.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER380C 33
  • 45.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for SLC36A4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC36A4 Gene

Gene Tree for SLC36A4 (if available)
Gene Tree for SLC36A4 (if available)
Evolutionary constrained regions (ECRs) for SLC36A4: view image

Paralogs for SLC36A4 Gene

Paralogs for SLC36A4 Gene

(3) SIMAP similar genes for SLC36A4 Gene using alignment to 3 proteins:

  • S36A4_HUMAN
  • E9PN09_HUMAN
genes like me logo Genes that share paralogs with SLC36A4: view

Variants for SLC36A4 Gene

Sequence variations from dbSNP and Humsavar for SLC36A4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000063508 -- 93,191,714(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000076210 -- 93,171,908(-) T/C intron_variant
rs1000149545 -- 93,172,184(-) G/A intron_variant
rs1000243005 -- 93,152,638(-) T/C intron_variant
rs1000342341 -- 93,145,390(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC36A4 Gene

Variant ID Type Subtype PubMed ID
nsv818858 CNV loss 17921354
nsv525304 CNV loss 19592680
nsv510593 OTHER complex 20534489
nsv435 CNV deletion 18451855
nsv1039134 CNV loss 25217958
esv33564 CNV loss 17666407
esv2759853 CNV loss 17122850
dgv2094n54 CNV loss 21841781
dgv1253n100 CNV loss 25217958

Variation tolerance for SLC36A4 Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC36A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC36A4 Gene

Disorders for SLC36A4 Gene

Additional Disease Information for SLC36A4

No disorders were found for SLC36A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC36A4 Gene

Publications for SLC36A4 Gene

  1. SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. (PMID: 21097500) Pillai SM … Meredith D (The Journal of biological chemistry 2011) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. (PMID: 26434594) Fan SJ … Goberdhan DC (Oncogene 2016) 3 58
  4. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. (PMID: 23506890) Schiöth HB … Fredriksson R (Molecular aspects of medicine 2013) 3 58
  5. Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. (PMID: 23719583) Kerns SL … Ostrer H (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013) 3 58

Products for SLC36A4 Gene

Sources for SLC36A4 Gene

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