Aliases for SLC35G3 Gene

Aliases for SLC35G3 Gene

  • Solute Carrier Family 35 Member G3 2 3 4 5
  • Transmembrane Protein 21A 2 3 4
  • Acyl-Malonyl-Condensing Enzyme 1 3 4
  • TMEM21A 3 4
  • AMAC1 3 4
  • Solute Carrier Family 35, Member G3 2
  • Acyl-Malonyl Condensing Enzyme 1 2
  • Protein AMAC1 3
  • FLJ40154 2
  • SLC35G3 5

External Ids for SLC35G3 Gene

Previous HGNC Symbols for SLC35G3 Gene

  • TMEM21A
  • AMAC1

Previous GeneCards Identifiers for SLC35G3 Gene

  • GC17M033520

Summaries for SLC35G3 Gene

GeneCards Summary for SLC35G3 Gene

SLC35G3 (Solute Carrier Family 35 Member G3) is a Protein Coding gene. Diseases associated with SLC35G3 include Keratolytic Winter Erythema and Pyruvate Dehydrogenase E1-Alpha Deficiency. An important paralog of this gene is SLC35G5.

Additional gene information for SLC35G3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35G3 Gene

Genomics for SLC35G3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC35G3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35G3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35G3

Genomic Locations for SLC35G3 Gene

Latest Assembly
chr17:35,192,520-35,194,523
(GRCh38/hg38)
Size:
2,004 bases
Orientation:
Minus strand

Previous Assembly
chr17:33,519,539-33,521,412
(GRCh37/hg19 by Entrez Gene)
Size:
1,874 bases
Orientation:
Minus strand

chr17:33,519,539-33,521,412
(GRCh37/hg19 by Ensembl)
Size:
1,874 bases
Orientation:
Minus strand

Genomic View for SLC35G3 Gene

Genes around SLC35G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G3 Gene

Proteins for SLC35G3 Gene

  • Protein details for SLC35G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N808-S35G3_HUMAN
    Recommended name:
    Solute carrier family 35 member G3
    Protein Accession:
    Q8N808
    Secondary Accessions:
    • B9EGE9

    Protein attributes for SLC35G3 Gene

    Size:
    338 amino acids
    Molecular mass:
    35381 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

neXtProt entry for SLC35G3 Gene

Post-translational modifications for SLC35G3 Gene

No Post-translational modifications

Other Protein References for SLC35G3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35G3 Gene

Domains & Families for SLC35G3 Gene

Gene Families for SLC35G3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35G3 Gene

InterPro:
Blocks:
  • Protein of unknown function DUF6

Suggested Antigen Peptide Sequences for SLC35G3 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 21A (AMAC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N808

UniProtKB/Swiss-Prot:

S35G3_HUMAN :
  • Belongs to the SLC35G solute transporter family.
Family:
  • Belongs to the SLC35G solute transporter family.
genes like me logo Genes that share domains with SLC35G3: view

Function for SLC35G3 Gene

Phenotypes From GWAS Catalog for SLC35G3 Gene

genes like me logo Genes that share phenotypes with SLC35G3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35G3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35G3 Gene

Localization for SLC35G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G3 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35G3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC35G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC35G3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35G3 Gene

Pathways & Interactions for SLC35G3 Gene

PathCards logo

SuperPathways for SLC35G3 Gene

No Data Available

Interacting Proteins for SLC35G3 Gene

Gene Ontology (GO) - Biological Process for SLC35G3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35G3 Gene

Drugs & Compounds for SLC35G3 Gene

No Compound Related Data Available

Transcripts for SLC35G3 Gene

mRNA/cDNA for SLC35G3 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35G3

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G3 Gene

No ASD Table

Relevant External Links for SLC35G3 Gene

GeneLoc Exon Structure for
SLC35G3

Expression for SLC35G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35G3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC35G3 Gene

This gene is overexpressed in Testis (x42.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35G3

SOURCE GeneReport for Unigene cluster for SLC35G3 Gene:

Hs.514814

mRNA Expression by UniProt/SwissProt for SLC35G3 Gene:

Q8N808-S35G3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with SLC35G3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35G3 Gene

Orthologs for SLC35G3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC35G3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC35G5 30
  • 93 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 81 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Slc35g3 30
  • 77 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 69 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 53 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii slc35g2a 30
  • 23 (a)
ManyToMany
slc35g2b 30
  • 23 (a)
ManyToMany
Species where no ortholog for SLC35G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC35G3 Gene

ENSEMBL:
Gene Tree for SLC35G3 (if available)
TreeFam:
Gene Tree for SLC35G3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35G3: view image
Alliance of Genome Resources:
Additional Orthologs for SLC35G3

Paralogs for SLC35G3 Gene

Paralogs for SLC35G3 Gene

(3) SIMAP similar genes for SLC35G3 Gene using alignment to 1 proteins:

  • S35G3_HUMAN

Pseudogenes.org Pseudogenes for SLC35G3 Gene

genes like me logo Genes that share paralogs with SLC35G3: view

Variants for SLC35G3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC35G3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC35G3 Gene

Variant ID Type Subtype PubMed ID
dgv569e214 CNV gain 21293372
esv3640443 CNV loss 21293372
esv3892998 CNV loss 25118596
nsv2037 CNV deletion 18451855
nsv962311 CNV duplication 23825009

Variation tolerance for SLC35G3 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.93; 67.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35G3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35G3
Leiden Open Variation Database (LOVD)
SLC35G3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35G3 Gene

Disorders for SLC35G3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC35G3 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC35G3

genes like me logo Genes that share disorders with SLC35G3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35G3 Gene

Publications for SLC35G3 Gene

  1. Emergence of primate genes by retrotransposon-mediated sequence transduction. (PMID: 17101974) Xing J … Batzer MA (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for SLC35G3 Gene

Sources for SLC35G3 Gene