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Aliases for SLC35G1 Gene

Aliases for SLC35G1 Gene

  • Solute Carrier Family 35 Member G1 2 3 4 5
  • Transmembrane Protein 20 2 3 4
  • Partner Of STIM1 3 4
  • C10orf60 3 4
  • TMEM20 3 4
  • POST 3 4
  • Solute Carrier Family 35, Member G1 2

External Ids for SLC35G1 Gene

Previous HGNC Symbols for SLC35G1 Gene

  • TMEM20

Previous GeneCards Identifiers for SLC35G1 Gene

  • GC10P095653

Summaries for SLC35G1 Gene

Entrez Gene Summary for SLC35G1 Gene

  • This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]

GeneCards Summary for SLC35G1 Gene

SLC35G1 (Solute Carrier Family 35 Member G1) is a Protein Coding gene. An important paralog of this gene is SLC35G4.

UniProtKB/Swiss-Prot for SLC35G1 Gene

  • May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.

Additional gene information for SLC35G1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35G1 Gene

Genomics for SLC35G1 Gene

GeneHancer (GH) Regulatory Elements for SLC35G1 Gene

Promoters and enhancers for SLC35G1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J093893 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 617 +1.4 1445 8.8 ZFX ZNF148 NKRF POLR2A ZNF687 ZSCAN21 ZBTB7A SP7 KLF14 PRDM1 SLC35G1 FRA10AC1 LGI1 MYOF PIPSL
GH10J093854 Enhancer 0.8 Ensembl ENCODE 27.2 -38.1 -38053 3 SP1 PRDM1 SCRT2 JUND SCRT1 YY1 GABPA RCOR1 HNF4A FOS SLC35G1 RAB11AP1 LOC105378437
GH10J093841 Enhancer 0.5 ENCODE 25 -51.9 -51874 0.2 SP1 POLR2A ETS1 NANOG POU5F1 SLC35G1 RAB11AP1 LOC105378437
GH10J093870 Enhancer 0.9 Ensembl ENCODE 11.4 -21.4 -21437 3.7 BACH1 MAFK NFE2L2 POLR2A HDAC1 ZNF316 CEBPB SOX6 NFE2 EP300 SLC35G1 RAB11AP1 LOC105378437
GH10J093945 Enhancer 0.6 Ensembl ENCODE 15.5 +53.0 53017 2.8 POLR2A USF1 L3MBTL2 SLC35G1 PLCE1 PIPSL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35G1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC35G1 Gene

Genomic Locations for SLC35G1 Gene
chr10:93,893,973-93,956,062
(GRCh38/hg38)
Size:
62,090 bases
Orientation:
Plus strand
chr10:95,653,730-95,715,819
(GRCh37/hg19)
Size:
62,090 bases
Orientation:
Plus strand

Genomic View for SLC35G1 Gene

Genes around SLC35G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G1 Gene

Proteins for SLC35G1 Gene

  • Protein details for SLC35G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3R5-S35G1_HUMAN
    Recommended name:
    Solute carrier family 35 member G1
    Protein Accession:
    Q2M3R5
    Secondary Accessions:
    • Q86YG5
    • Q8NBA5

    Protein attributes for SLC35G1 Gene

    Size:
    365 amino acids
    Molecular mass:
    39836 Da
    Quaternary structure:
    • Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1.

    Alternative splice isoforms for SLC35G1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35G1 Gene

Post-translational modifications for SLC35G1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC35G1 Gene

Domains & Families for SLC35G1 Gene

Gene Families for SLC35G1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35G1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35G1 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 20 (B7ZKP1_HUMAN)
  • Transmembrane protein 20, isoform CRA_a (D3DR41_HUMAN)
  • Transmembrane protein 20 (TMM20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2M3R5

UniProtKB/Swiss-Prot:

S35G1_HUMAN :
  • Belongs to the TMEM20 family.
Family:
  • Belongs to the TMEM20 family.
genes like me logo Genes that share domains with SLC35G1: view

Function for SLC35G1 Gene

Molecular function for SLC35G1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.

Phenotypes From GWAS Catalog for SLC35G1 Gene

Gene Ontology (GO) - Molecular Function for SLC35G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22084111
genes like me logo Genes that share ontologies with SLC35G1: view

Phenotypes for SLC35G1 Gene

genes like me logo Genes that share phenotypes with SLC35G1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35G1

CRISPR Products

miRNA for SLC35G1 Gene

miRTarBase miRNAs that target SLC35G1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35G1

Clone Products

  • Applied Biological Materials (abm): Clones for SLC35G1 - Now 50% OFF >
  • * SLC35G1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SLC35G1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35G1 Gene

Localization for SLC35G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35G1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC35G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IBA,IDA 22084111
GO:0005886 plasma membrane IBA,IDA 22084111
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC35G1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35G1 Gene

Pathways & Interactions for SLC35G1 Gene

PathCards logo

SuperPathways for SLC35G1 Gene

No Data Available

Interacting Proteins for SLC35G1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400932%0d9606.ENSP00000072644%0d9606.ENSP00000295887%0d9606.ENSP00000419879%0d9606.ENSP00000243253%0d9606.ENSP00000298428%0d
Selected Interacting proteins: ENSP00000400932 Q2M3R5-S35G1_HUMAN for SLC35G1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC35G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051480 regulation of cytosolic calcium ion concentration IBA,IMP 22084111
GO:1990034 calcium ion export across plasma membrane IMP 22084111
genes like me logo Genes that share ontologies with SLC35G1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35G1 Gene

Drugs & Compounds for SLC35G1 Gene

No Compound Related Data Available

Transcripts for SLC35G1 Gene

Unigene Clusters for SLC35G1 Gene

Solute carrier family 35, member G1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35G1

Clone Products

  • Applied Biological Materials (abm): Clones for SLC35G1 - Now 50% OFF >
  • * SLC35G1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SLC35G1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for SLC35G1 Gene

GeneLoc Exon Structure for
SLC35G1
ECgene alternative splicing isoforms for
SLC35G1

Expression for SLC35G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35G1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35G1 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35G1 Gene



Protein tissue co-expression partners for SLC35G1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35G1 Gene:

SLC35G1

SOURCE GeneReport for Unigene cluster for SLC35G1 Gene:

Hs.632085

mRNA Expression by UniProt/SwissProt for SLC35G1 Gene:

Q2M3R5-S35G1_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SLC35G1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC35G1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35G1 Gene

Orthologs for SLC35G1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM20 35 34
  • 99.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35g1 17 35 34
  • 81.96 (n)
dog
(Canis familiaris)
Mammalia SLC35G1 35 34
  • 80.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35g1 34
  • 79.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35G1 35
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM20 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35G1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35G1 35 34
  • 73.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35G1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35g1 34
  • 66.25 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100001920 34
  • 61.85 (n)
SLC35G1 35
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001214 34
  • 50.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5281 35 34
  • 49.66 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPL264C 34
  • 45.37 (n)
-- 35
  • 23 (a)
OneToMany
-- 35
  • 19 (a)
OneToMany
-- 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7107 35
  • 35 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
Species where no ortholog for SLC35G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35G1 Gene

ENSEMBL:
Gene Tree for SLC35G1 (if available)
TreeFam:
Gene Tree for SLC35G1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35G1: view image

Paralogs for SLC35G1 Gene

Paralogs for SLC35G1 Gene

(1) SIMAP similar genes for SLC35G1 Gene using alignment to 2 proteins:

  • S35G1_HUMAN
  • S4R2Y7_HUMAN
genes like me logo Genes that share paralogs with SLC35G1: view

Variants for SLC35G1 Gene

Sequence variations from dbSNP and Humsavar for SLC35G1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs144043787 uncertain-significance, Malignant tumor of prostate 93,900,819(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs1000202563 -- 93,902,045(+) C/A 3_prime_UTR_variant, intron_variant
rs1000215809 -- 93,913,519(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000256166 -- 93,911,598(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000332610 -- 93,904,872(+) G/A genic_downstream_transcript_variant, intron_variant

Variation tolerance for SLC35G1 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35G1 Gene

Disorders for SLC35G1 Gene

Additional Disease Information for SLC35G1

No disorders were found for SLC35G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35G1 Gene

Publications for SLC35G1 Gene

  1. Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae. (PMID: 21569384) Västermark Å … Schiöth HB (BMC evolutionary biology 2011) 2 3 58
  2. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. (PMID: 22084111) Krapivinsky G … Clapham DE (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLC35G1 Gene

Sources for SLC35G1 Gene

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