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Aliases for SLC35F3 Gene

Aliases for SLC35F3 Gene

  • Solute Carrier Family 35 Member F3 2 3 4 5
  • Solute Carrier Family 35, Member F3 2

External Ids for SLC35F3 Gene

Previous GeneCards Identifiers for SLC35F3 Gene

  • GC01P231124
  • GC01P230347
  • GC01P232107
  • GC01P234040
  • GC01P204531

Summaries for SLC35F3 Gene

GeneCards Summary for SLC35F3 Gene

SLC35F3 (Solute Carrier Family 35 Member F3) is a Protein Coding gene. An important paralog of this gene is SLC35F4.

UniProtKB/Swiss-Prot for SLC35F3 Gene

  • May be a thiamine transporter.

Additional gene information for SLC35F3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F3 Gene

Genomics for SLC35F3 Gene

GeneHancer (GH) Regulatory Elements for SLC35F3 Gene

Promoters and enhancers for SLC35F3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I233904 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.5 503 2.2 RB1 ARNT KLF17 SIN3A ZNF2 ZNF335 ZNF366 ZNF143 ZNF280D ZBTB11 PIR54761 SLC35F3 NTPCR RPS7P3 GC01P233935 GC01M233807
GH01I234213 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.1 +309.5 309457 0.9 CTCF KLF1 ZSCAN4 ZNF133 ZIC2 ZNF335 GLIS2 ZBTB48 PATZ1 ZNF214 ENSG00000233332 SLC35F3 LINC01354 RAC1P7
GH01I234313 Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.5 +410.1 410084 3.5 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 RXRA SP5 MXD4 MIER2 SLC35F3 ENSG00000236358 RPS15P2 COA6 LOC101927765 LOC102724100 IRF2BP2 MIR4671
GH01I234261 Enhancer 0.6 ENCODE 14.5 +357.8 357762 1.3 NR4A1 PYGO2 GTF2A2 ZNF354B TEAD3 ZNF664 MEF2D CEBPA SMAD4 BCL6 LOC105373206 SLC35F3 RPS7P3 IRF2BP2 GC01P234267
GH01I234320 Enhancer 0.6 ENCODE 10.5 +416.0 416018 0.2 SOX13 RXRA SAP130 EBF1 RARA TEAD3 RFX3 HNF4A RPS15P2 ENSG00000236358 LOC101927765 COA6 LOC102724100 SLC35F3 MIR4671
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35F3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35F3 gene promoter:

Genomic Locations for SLC35F3 Gene

Genomic Locations for SLC35F3 Gene
419,807 bases
Plus strand

Genomic View for SLC35F3 Gene

Genes around SLC35F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F3 Gene

Proteins for SLC35F3 Gene

  • Protein details for SLC35F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative thiamine transporter SLC35F3
    Protein Accession:
    Secondary Accessions:
    • Q5TDD6
    • Q8N9C9

    Protein attributes for SLC35F3 Gene

    421 amino acids
    Molecular mass:
    46817 Da
    Quaternary structure:
    No Data Available
    • Promotes thiamine uptake when expressed in E.coli. Individuals with blood hypertension and a SLC35F3 risk allele T/T homozygosity (intronic variant rs17514104) show a significant reduction in blood thiamine content.

    Alternative splice isoforms for SLC35F3 Gene


neXtProt entry for SLC35F3 Gene

Post-translational modifications for SLC35F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35F3 Gene

Domains & Families for SLC35F3 Gene

Gene Families for SLC35F3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35F3 Gene

Suggested Antigen Peptide Sequences for SLC35F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC35F solute transporter family.
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F3: view

Function for SLC35F3 Gene

Molecular function for SLC35F3 Gene

UniProtKB/Swiss-Prot Function:
May be a thiamine transporter.

Phenotypes From GWAS Catalog for SLC35F3 Gene

Phenotypes for SLC35F3 Gene

genes like me logo Genes that share phenotypes with SLC35F3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35F3

miRNA for SLC35F3 Gene

miRTarBase miRNAs that target SLC35F3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F3 Gene

Localization for SLC35F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35F3 gene
Compartment Confidence
plasma membrane 3
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35F3: view

Pathways & Interactions for SLC35F3 Gene

SuperPathways for SLC35F3 Gene

No Data Available

Interacting Proteins for SLC35F3 Gene

Gene Ontology (GO) - Biological Process for SLC35F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015888 thiamine transport IDA 24509276
genes like me logo Genes that share ontologies with SLC35F3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F3 Gene

Drugs & Compounds for SLC35F3 Gene

No Compound Related Data Available

Transcripts for SLC35F3 Gene

mRNA/cDNA for SLC35F3 Gene

Unigene Clusters for SLC35F3 Gene

Solute carrier family 35, member F3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F3 Gene

No ASD Table

Relevant External Links for SLC35F3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35F3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC35F3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0), Brain - Cerebellum (x5.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Frontal Cortex (BA9) (x4.4).

Protein differential expression in normal tissues from HIPED for SLC35F3 Gene

This gene is overexpressed in Testis (6.7) and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35F3 Gene

Protein tissue co-expression partners for SLC35F3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35F3 Gene:


SOURCE GeneReport for Unigene cluster for SLC35F3 Gene:


Evidence on tissue expression from TISSUES for SLC35F3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SLC35F3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35F3 Gene

Orthologs for SLC35F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35F3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35F3 33 34
  • 99.75 (n)
(Bos Taurus)
Mammalia SLC35F3 33 34
  • 92.79 (n)
(Canis familiaris)
Mammalia SLC35F3 33 34
  • 92.71 (n)
(Monodelphis domestica)
Mammalia SLC35F3 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Slc35f3 33
  • 87.06 (n)
(Mus musculus)
Mammalia Slc35f3 33 16 34
  • 86.75 (n)
(Ornithorhynchus anatinus)
Mammalia SLC35F3 34
  • 81 (a)
(Gallus gallus)
Aves SLC35F3 33 34
  • 80.78 (n)
(Anolis carolinensis)
Reptilia SLC35F3 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491052 33
  • 69.3 (n)
(Danio rerio)
Actinopterygii slc35f3b 33 34
  • 70.04 (n)
slc35f3a 34
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42322 33 34
  • 48.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004544 33
  • 45.69 (n)
(Caenorhabditis elegans)
Secernentea Y73B6BL.31 33 34
  • 50.65 (n)
Species where no ortholog for SLC35F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35F3 Gene

Gene Tree for SLC35F3 (if available)
Gene Tree for SLC35F3 (if available)

Paralogs for SLC35F3 Gene

Paralogs for SLC35F3 Gene

(1) SIMAP similar genes for SLC35F3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC35F3: view

Variants for SLC35F3 Gene

Sequence variations from dbSNP and Humsavar for SLC35F3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000022366 -- 233,968,677(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000049168 -- 234,004,030(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000053797 -- 233,995,726(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000059931 -- 234,017,333(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000082166 -- 234,266,297(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35F3 Gene

Variant ID Type Subtype PubMed ID
dgv109n67 CNV loss 20364138
dgv56e201 CNV deletion 23290073
dgv585n100 CNV gain 25217958
dgv857n54 CNV loss 21841781
esv1005100 CNV gain 20482838
esv1716945 CNV insertion 17803354
esv24323 CNV loss 19812545
esv2656563 CNV deletion 23128226
esv2659243 CNV deletion 23128226
esv2666716 CNV deletion 23128226
esv2725118 CNV deletion 23290073
esv2725129 CNV deletion 23290073
esv2725141 CNV deletion 23290073
esv2725185 CNV deletion 23290073
esv2725196 CNV deletion 23290073
esv2762225 CNV loss 21179565
esv2846791 CNV deletion 24192839
esv3334867 CNV duplication 20981092
esv33370 CNV loss 17666407
esv33741 CNV loss 17666407
esv3548578 CNV deletion 23714750
esv3578480 CNV loss 25503493
esv3589157 CNV loss 21293372
esv3589159 CNV loss 21293372
esv3589161 CNV loss 21293372
esv3589164 CNV loss 21293372
esv3589165 CNV loss 21293372
esv4582 CNV loss 18987735
esv7223 CNV loss 19470904
esv990606 CNV gain 20482838
nsv1012676 CNV gain 25217958
nsv1068616 CNV deletion 25765185
nsv1116627 CNV tandem duplication 24896259
nsv159799 CNV deletion 16902084
nsv475392 CNV novel sequence insertion 20440878
nsv477055 CNV novel sequence insertion 20440878
nsv479135 CNV novel sequence insertion 20440878
nsv481199 CNV novel sequence insertion 20440878
nsv4899 CNV insertion 18451855
nsv506983 OTHER sequence alteration 20534489
nsv509657 CNV insertion 20534489
nsv512759 CNV insertion 21212237
nsv519237 CNV loss 19592680
nsv522312 CNV loss 19592680
nsv549364 CNV loss 21841781
nsv549367 CNV loss 21841781
nsv549368 CNV loss 21841781
nsv549369 CNV loss 21841781
nsv819148 CNV loss 19587683
nsv827342 CNV loss 20364138
nsv832892 CNV loss 17160897
nsv832903 CNV loss 17160897
nsv945375 CNV duplication 23825009
nsv953973 CNV deletion 24416366

Variation tolerance for SLC35F3 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35F3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35F3 Gene

Disorders for SLC35F3 Gene

Additional Disease Information for SLC35F3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC35F3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F3 Gene

Publications for SLC35F3 Gene

  1. Genetic implication of a novel thiamine transporter in human hypertension. (PMID: 24509276) Zhang K … O'Connor DT (Journal of the American College of Cardiology 2014) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58

Products for SLC35F3 Gene

Sources for SLC35F3 Gene

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