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Aliases for SLC35E4 Gene

Aliases for SLC35E4 Gene

  • Solute Carrier Family 35 Member E4 2 3 5
  • Solute Carrier Family 35, Member E4 2

External Ids for SLC35E4 Gene

Previous GeneCards Identifiers for SLC35E4 Gene

  • GC22P029357
  • GC22P029347
  • GC22P029358
  • GC22P031031
  • GC22P013994

Summaries for SLC35E4 Gene

GeneCards Summary for SLC35E4 Gene

SLC35E4 (Solute Carrier Family 35 Member E4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35E4 Gene

  • Putative transporter.

Additional gene information for SLC35E4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E4 Gene

Genomics for SLC35E4 Gene

GeneHancer (GH) Regulatory Elements for SLC35E4 Gene

Promoters and enhancers for SLC35E4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I030634 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 562.3 +0.4 377 4 PKNOX1 ZFP64 SIN3A ZNF2 IRF4 GLIS2 GATA2 ARID2 ZNF207 ZNF143 SLC35E4 TCN2 PES1 OSM SMTN CCDC157 TBC1D10A DUSP18 SF3A1 GC22P030639
GH22I030666 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 18.8 +32.1 32078 2.1 HDGF ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 KLF7 ATF7 SP3 PIR46747 PIR40493 DUSP18 ENSG00000250318 SLC35E4 OSBP2
GH22I030589 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -44.3 -44252 2.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 PES1 TCN2 LINC01521 RNF215 SLC35E4 ENSG00000223831 GAL3ST1
GH22I030716 Enhancer 1.2 FANTOM5 Ensembl ENCODE 15.4 +83.2 83158 4.2 HDAC1 MEIS2 USF1 JUN TEAD4 ZSCAN4 BATF TCF12 CTBP1 EGR1 OSBP2 SLC35E4 DUSP18 MIR3200
GH22I030572 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 11.3 -61.1 -61069 4.5 CTCF DRAP1 TFAP4 SAP130 ARID4B BACH1 SIN3A ZMYM3 ZNF48 HIC1 GAL3ST1 SLC35E4 PES1 SEC14L6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35E4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35E4 gene promoter:

Genomic Locations for SLC35E4 Gene

Genomic Locations for SLC35E4 Gene
chr22:30,635,652-30,669,016
(GRCh38/hg38)
Size:
33,365 bases
Orientation:
Plus strand
chr22:31,031,639-31,065,003
(GRCh37/hg19)

Genomic View for SLC35E4 Gene

Genes around SLC35E4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E4 Gene

Proteins for SLC35E4 Gene

  • Protein details for SLC35E4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICL7-S35E4_HUMAN
    Recommended name:
    Solute carrier family 35 member E4
    Protein Accession:
    Q6ICL7
    Secondary Accessions:
    • Q567P0

    Protein attributes for SLC35E4 Gene

    Size:
    350 amino acids
    Molecular mass:
    36747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35E4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E4 Gene

Post-translational modifications for SLC35E4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E4 Gene

No data available for DME Specific Peptides for SLC35E4 Gene

Domains & Families for SLC35E4 Gene

Gene Families for SLC35E4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35E4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ICL7

UniProtKB/Swiss-Prot:

S35E4_HUMAN :
  • Belongs to the TPT transporter family. SLC35E subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E4: view

Function for SLC35E4 Gene

Molecular function for SLC35E4 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Phenotypes From GWAS Catalog for SLC35E4 Gene

genes like me logo Genes that share phenotypes with SLC35E4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E4 Gene

Localization for SLC35E4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E4 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E4: view

Pathways & Interactions for SLC35E4 Gene

SuperPathways for SLC35E4 Gene

No Data Available

Interacting Proteins for SLC35E4 Gene

Gene Ontology (GO) - Biological Process for SLC35E4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35E4 Gene

Drugs & Compounds for SLC35E4 Gene

No Compound Related Data Available

Transcripts for SLC35E4 Gene

Unigene Clusters for SLC35E4 Gene

Solute carrier family 35, member E4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E4 Gene

No ASD Table

Relevant External Links for SLC35E4 Gene

GeneLoc Exon Structure for
SLC35E4
ECgene alternative splicing isoforms for
SLC35E4

Expression for SLC35E4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35E4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35E4 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC35E4 Gene:

SLC35E4

SOURCE GeneReport for Unigene cluster for SLC35E4 Gene:

Hs.660384

Evidence on tissue expression from TISSUES for SLC35E4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC35E4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E4 Gene

Orthologs for SLC35E4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35E4 33 34
  • 98.29 (n)
dog
(Canis familiaris)
Mammalia SLC35E4 33 34
  • 87.71 (n)
cow
(Bos Taurus)
Mammalia SLC35E4 33 34
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Slc35e4 33 16 34
  • 82.86 (n)
rat
(Rattus norvegicus)
Mammalia Slc35e4 33
  • 82.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35E4 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35E4 33 34
  • 73.58 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35E4 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e4 33
  • 57.44 (n)
zebrafish
(Danio rerio)
Actinopterygii slc35e4 33 34
  • 60.84 (n)
rice
(Oryza sativa)
Liliopsida Os05g0121900 33
  • 46.03 (n)
Species where no ortholog for SLC35E4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E4 Gene

ENSEMBL:
Gene Tree for SLC35E4 (if available)
TreeFam:
Gene Tree for SLC35E4 (if available)

Paralogs for SLC35E4 Gene

No data available for Paralogs for SLC35E4 Gene

Variants for SLC35E4 Gene

Sequence variations from dbSNP and Humsavar for SLC35E4 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000095639 -- 30,652,366(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000148986 -- 30,660,115(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000354461 -- 30,666,697(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000356204 -- 30,661,694(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000447800 -- 30,652,679(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35E4 Gene

Variant ID Type Subtype PubMed ID
esv2675394 CNV deletion 23128226
esv3647565 CNV loss 21293372
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv829172 CNV gain 20364138
nsv834175 CNV gain 17160897

Variation tolerance for SLC35E4 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35E4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35E4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E4 Gene

Disorders for SLC35E4 Gene

Additional Disease Information for SLC35E4

No disorders were found for SLC35E4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E4 Gene

Publications for SLC35E4 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SLC35E4 Gene

Sources for SLC35E4 Gene

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