Aliases for SLC35E3 Gene

Aliases for SLC35E3 Gene

  • Solute Carrier Family 35 Member E3 2 3 4 5
  • BLOV1 2 3 4
  • Bladder Cancer-Overexpressed Gene 1 Protein 3 4
  • Solute Carrier Family 35, Member E3 2
  • Solute Carrier Family 35, Member E2 3
  • SLC35E3 5

External Ids for SLC35E3 Gene

Previous GeneCards Identifiers for SLC35E3 Gene

  • GC12P068856
  • GC12P067426
  • GC12P069139
  • GC12P066190

Summaries for SLC35E3 Gene

GeneCards Summary for SLC35E3 Gene

SLC35E3 (Solute Carrier Family 35 Member E3) is a Protein Coding gene. Diseases associated with SLC35E3 include Congenital Disorder Of Glycosylation, Type Iic and Glioblastoma Multiforme. An important paralog of this gene is SLC35D2.

UniProtKB/Swiss-Prot Summary for SLC35E3 Gene

Additional gene information for SLC35E3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35E3 Gene

Genomics for SLC35E3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC35E3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35E3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35E3

Top Transcription factor binding sites by QIAGEN in the SLC35E3 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • Arnt
  • ATF6
  • C/EBPbeta
  • GATA-1
  • HOXA3
  • ISGF-3
  • POU3F1

Genomic Locations for SLC35E3 Gene

Genomic Locations for SLC35E3 Gene
chr12:68,746,125-68,793,964
(GRCh38/hg38)
Size:
47,840 bases
Orientation:
Plus strand
chr12:69,139,886-69,187,508
(GRCh37/hg19)
Size:
47,623 bases
Orientation:
Plus strand

Genomic View for SLC35E3 Gene

Genes around SLC35E3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E3 Gene

Proteins for SLC35E3 Gene

  • Protein details for SLC35E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z769-S35E3_HUMAN
    Recommended name:
    Solute carrier family 35 member E3
    Protein Accession:
    Q7Z769
    Secondary Accessions:
    • A8K0T0
    • Q0P5Y5
    • Q9P0V1

    Protein attributes for SLC35E3 Gene

    Size:
    313 amino acids
    Molecular mass:
    35066 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF73127.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for SLC35E3 Gene

Post-translational modifications for SLC35E3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E3 Gene

No data available for DME Specific Peptides for SLC35E3 Gene

Domains & Families for SLC35E3 Gene

Gene Families for SLC35E3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35E3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E3 Gene

GenScript: Design optimal peptide antigens:
  • Bladder cancer-overexpressed gene 1 protein (S35E3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z769

UniProtKB/Swiss-Prot:

S35E3_HUMAN :
  • Belongs to the TPT transporter family. SLC35E subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E3: view

Function for SLC35E3 Gene

Molecular function for SLC35E3 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Phenotypes From GWAS Catalog for SLC35E3 Gene

Gene Ontology (GO) - Molecular Function for SLC35E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005338 nucleotide-sugar transmembrane transporter activity IBA 21873635
GO:0015297 antiporter activity IBA 21873635
GO:0022857 transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC35E3: view
genes like me logo Genes that share phenotypes with SLC35E3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35E3

CRISPR Products

miRNA for SLC35E3 Gene

miRTarBase miRNAs that target SLC35E3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35E3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E3 Gene

Localization for SLC35E3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E3 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E3 gene
Compartment Confidence
golgi apparatus 3
plasma membrane 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC35E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35E3 Gene

Pathways & Interactions for SLC35E3 Gene

PathCards logo

SuperPathways for SLC35E3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015931 nucleobase-containing compound transport IEA --
GO:0055085 transmembrane transport IEA --
GO:1901264 carbohydrate derivative transport IEA --
genes like me logo Genes that share ontologies with SLC35E3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35E3 Gene

Drugs & Compounds for SLC35E3 Gene

No Compound Related Data Available

Transcripts for SLC35E3 Gene

mRNA/cDNA for SLC35E3 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35E3

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E3 Gene

No ASD Table

Relevant External Links for SLC35E3 Gene

GeneLoc Exon Structure for
SLC35E3

Expression for SLC35E3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35E3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35E3 Gene

This gene is overexpressed in Retina (60.8) and Placenta (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35E3 Gene



Protein tissue co-expression partners for SLC35E3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35E3

SOURCE GeneReport for Unigene cluster for SLC35E3 Gene:

Hs.506011

Evidence on tissue expression from TISSUES for SLC35E3 Gene

  • Nervous system(4.4)
  • Pancreas(4)
  • Heart(2.4)
  • Stomach(2.3)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with SLC35E3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E3 Gene

Orthologs for SLC35E3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC35E3 30 31
  • 99.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC35E3 30 31
  • 92.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC35E3 30 31
  • 91.35 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC35E3 31
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc35e3 30
  • 89.88 (n)
Mouse
(Mus musculus)
Mammalia Slc35e3 30 17 31
  • 89.46 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SLC35E3 30 31
  • 76.63 (n)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8418 30
Zebrafish
(Danio rerio)
Actinopterygii slc35e3 30 31
  • 72.52 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5791 30
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT2G28315 30
  • 43.2 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0628200 30
  • 45.9 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 61 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
-- 31
  • 37 (a)
OneToMany
Species where no ortholog for SLC35E3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC35E3 Gene

ENSEMBL:
Gene Tree for SLC35E3 (if available)
TreeFam:
Gene Tree for SLC35E3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35E3: view image

Paralogs for SLC35E3 Gene

Pseudogenes.org Pseudogenes for SLC35E3 Gene

genes like me logo Genes that share paralogs with SLC35E3: view

Variants for SLC35E3 Gene

Additional dbSNP identifiers (rs#s) for SLC35E3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC35E3 Gene

Variant ID Type Subtype PubMed ID
esv3629857 CNV loss 21293372
nsv522941 CNV gain 19592680
nsv759 CNV deletion 18451855

Variation tolerance for SLC35E3 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35E3 Gene

Human Gene Mutation Database (HGMD)
SLC35E3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35E3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35E3 Gene

Disorders for SLC35E3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC35E3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type iic
  • rhs
glioblastoma multiforme
  • adult glioblastoma multiforme
bladder cancer
  • bladder cancer, somatic
malignant mesenchymoma
  • sarcoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SLC35E3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35E3 Gene

Publications for SLC35E3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer. (PMID: 28589857) Shivakumar M … Kim D (BMC medical genomics 2017) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for SLC35E3 Gene

Sources for SLC35E3 Gene