Aliases for SLC35E2B Gene

Aliases for SLC35E2B Gene

  • Solute Carrier Family 35 Member E2B 2 3 4 5
  • Solute Carrier Family 35, Member E2B 2
  • SLC35E2B 5
  • KIAA0447 4
  • SLC35E2 3

External Ids for SLC35E2B Gene

Previous GeneCards Identifiers for SLC35E2B Gene

  • GC01M001595
  • GC01M000871
  • GC01M001596
  • GC01M001597
  • GC01M001600
  • GC01M001604
  • GC01M001609

Summaries for SLC35E2B Gene

GeneCards Summary for SLC35E2B Gene

SLC35E2B (Solute Carrier Family 35 Member E2B) is a Protein Coding gene. An important paralog of this gene is SLC35E2A.

UniProtKB/Swiss-Prot Summary for SLC35E2B Gene

Additional gene information for SLC35E2B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35E2B Gene

Genomics for SLC35E2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC35E2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35E2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35E2B

Genomic Locations for SLC35E2B Gene

Genomic Locations for SLC35E2B Gene
33,267 bases
Minus strand
31,305 bases
Minus strand

Genomic View for SLC35E2B Gene

Genes around SLC35E2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E2B Gene

Proteins for SLC35E2B Gene

  • Protein details for SLC35E2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member E2B
    Protein Accession:
    Secondary Accessions:
    • B3KWR0
    • O75035
    • Q2TAY8
    • Q569F8
    • Q5CZA4
    • Q9Y3J8

    Protein attributes for SLC35E2B Gene

    405 amino acids
    Molecular mass:
    43777 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA32292.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for SLC35E2B Gene

Post-translational modifications for SLC35E2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E2B Gene

No data available for DME Specific Peptides for SLC35E2B Gene

Domains & Families for SLC35E2B Gene

Gene Families for SLC35E2B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35E2B Gene


Suggested Antigen Peptide Sequences for SLC35E2B Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 35 member E2B (S352B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPT transporter family. SLC35E subfamily.
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E2B: view

Function for SLC35E2B Gene

Molecular function for SLC35E2B Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Phenotypes From GWAS Catalog for SLC35E2B Gene

Gene Ontology (GO) - Molecular Function for SLC35E2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IBA 21873635
GO:0022857 transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC35E2B: view
genes like me logo Genes that share phenotypes with SLC35E2B: view

Animal Model Products

CRISPR Products

miRNA for SLC35E2B Gene

miRTarBase miRNAs that target SLC35E2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35E2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E2B Gene

Localization for SLC35E2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E2B Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E2B gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35E2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E2B: view

Pathways & Interactions for SLC35E2B Gene

PathCards logo

SuperPathways for SLC35E2B Gene

No Data Available

Interacting Proteins for SLC35E2B Gene

Gene Ontology (GO) - Biological Process for SLC35E2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001835 blastocyst hatching IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35E2B: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35E2B Gene

Drugs & Compounds for SLC35E2B Gene

No Compound Related Data Available

Transcripts for SLC35E2B Gene

mRNA/cDNA for SLC35E2B Gene

15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35E2B

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E2B Gene

No ASD Table

Relevant External Links for SLC35E2B Gene

GeneLoc Exon Structure for

Expression for SLC35E2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35E2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35E2B Gene

This gene is overexpressed in Heart (52.7) and Retina (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35E2B Gene

Protein tissue co-expression partners for SLC35E2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35E2B

SOURCE GeneReport for Unigene cluster for SLC35E2B Gene:


Evidence on tissue expression from TISSUES for SLC35E2B Gene

  • Nervous system(4.8)
  • Spleen(4.3)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with SLC35E2B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E2B Gene

Orthologs for SLC35E2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35E2B 31
  • 100 (a)
(Canis familiaris)
Mammalia SLC35E2B 30 31
  • 83.66 (n)
(Bos Taurus)
Mammalia SLC35E2B 31
  • 83 (a)
SLC35E2 30
  • 82.1 (n)
(Mus musculus)
Mammalia Slc35e2 30 17 31
  • 81.35 (n)
(Rattus norvegicus)
Mammalia Slc35e2b 30
  • 81.11 (n)
(Ornithorhynchus anatinus)
Mammalia SLC35E2B 31
  • 78 (a)
(Monodelphis domestica)
Mammalia SLC35E2B 31
  • 76 (a)
(Gallus gallus)
Aves SLC35E2B 30 31
  • 73.83 (n)
(Anolis carolinensis)
Reptilia SLC35E2B 31
  • 81 (a)
(Danio rerio)
Actinopterygii LOC100331662 30
  • 71.43 (n)
SLC35E2B 31
  • 64 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG14621 31
  • 23 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G17630 30
  • 42.57 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
Species where no ortholog for SLC35E2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC35E2B Gene

Gene Tree for SLC35E2B (if available)
Gene Tree for SLC35E2B (if available)
Evolutionary constrained regions (ECRs) for SLC35E2B: view image

Paralogs for SLC35E2B Gene

(2) SIMAP similar genes for SLC35E2B Gene using alignment to 2 proteins:

  • S352B_HUMAN
  • L8E7I2_HUMAN
genes like me logo Genes that share paralogs with SLC35E2B: view

Variants for SLC35E2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35E2B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs778277949 Uncertain Significance: Severe Myopia 1,668,369(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SLC35E2B Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC35E2B Gene

Variant ID Type Subtype PubMed ID
dgv16e59 CNV duplication 20981092
dgv2e199 CNV deletion 23128226
dgv37n54 CNV loss 21841781
dgv38n54 CNV gain 21841781
dgv39n54 CNV loss 21841781
dgv3e212 CNV loss 25503493
dgv3n67 CNV gain 20364138
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
esv1758309 CNV deletion 17803354
esv2677252 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3550788 CNV deletion 23714750
esv3551899 CNV deletion 23714750
esv3553010 CNV deletion 23714750
esv3575582 CNV gain 25503493
esv3577686 CNV loss 25503493
esv3585007 CNV loss 21293372
esv3585008 CNV loss 21293372
esv3585009 CNV gain 21293372
esv3585010 CNV loss 21293372
esv3585011 CNV loss 21293372
esv3585012 CNV gain 21293372
esv3891747 CNV loss 25118596
esv6099 CNV gain 19470904
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv482937 CNV loss 15286789
nsv545017 CNV loss 21841781
nsv545018 CNV loss 21841781
nsv545022 CNV loss 21841781
nsv545026 CNV loss 21841781
nsv545027 CNV loss 21841781
nsv545030 CNV gain 21841781
nsv945745 CNV duplication 23825009
nsv947410 CNV duplication 23825009
nsv950516 CNV deletion 24416366

Variation tolerance for SLC35E2B Gene

Gene Damage Index Score: 1.83; 34.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35E2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E2B Gene

Disorders for SLC35E2B Gene

No disorders were found for SLC35E2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E2B Gene

Publications for SLC35E2B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for SLC35E2B Gene

Sources for SLC35E2B Gene