Aliases for SLC35E2A Gene

Aliases for SLC35E2A Gene

  • Solute Carrier Family 35 Member E2A 2 3 4 5
  • Solute Carrier Family 35 Member E2 2 3
  • SLC35E2 3 4
  • Solute Carrier Family 35, Member E2 2

External Ids for SLC35E2A Gene

Previous HGNC Symbols for SLC35E2A Gene

  • SLC35E2

Summaries for SLC35E2A Gene

GeneCards Summary for SLC35E2A Gene

SLC35E2A (Solute Carrier Family 35 Member E2A) is a Protein Coding gene. An important paralog of this gene is SLC35E2B.

UniProtKB/Swiss-Prot Summary for SLC35E2A Gene

Additional gene information for SLC35E2A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35E2A Gene

Genomics for SLC35E2A Gene

GeneHancer (GH) Regulatory Elements for SLC35E2A Gene

Promoters and enhancers for SLC35E2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35E2A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35E2A

Genomic Locations for SLC35E2A Gene

Genomic Locations for SLC35E2A Gene
chr1:1,724,838-1,745,999
(GRCh38/hg38)
Size:
21,162 bases
Orientation:
Minus strand
chr1:1,656,277-1,677,438
(GRCh37/hg19)
Size:
21,162 bases
Orientation:
Minus strand

Genomic View for SLC35E2A Gene

Genes around SLC35E2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E2A Gene

Proteins for SLC35E2A Gene

  • Protein details for SLC35E2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CK97-S35E2_HUMAN
    Recommended name:
    Solute carrier family 35 member E2A
    Protein Accession:
    P0CK97
    Secondary Accessions:
    • B3KWR0
    • O75035
    • Q2TAY8
    • Q569F8
    • Q5CZA4
    • Q5QPR8
    • Q9Y3J8

    Protein attributes for SLC35E2A Gene

    Size:
    266 amino acids
    Molecular mass:
    29079 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35E2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E2A Gene

Post-translational modifications for SLC35E2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35E2A Gene

Domains & Families for SLC35E2A Gene

Gene Families for SLC35E2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SLC35E2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E2A Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 35 member E2 (S35E2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CK97

UniProtKB/Swiss-Prot:

S35E2_HUMAN :
  • Belongs to the TPT transporter family. SLC35E subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E2A: view

Function for SLC35E2A Gene

Molecular function for SLC35E2A Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Phenotypes From GWAS Catalog for SLC35E2A Gene

Gene Ontology (GO) - Molecular Function for SLC35E2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015297 antiporter activity IBA 21873635
GO:0022857 transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC35E2A: view

Phenotypes for SLC35E2A Gene

genes like me logo Genes that share phenotypes with SLC35E2A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35E2A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35E2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC35E2A Gene

Localization for SLC35E2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E2A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E2A gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35E2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E2A: view

Pathways & Interactions for SLC35E2A Gene

PathCards logo

SuperPathways for SLC35E2A Gene

No Data Available

Interacting Proteins for SLC35E2A Gene

Selected Interacting proteins: P0CK97-S35E2_HUMAN for SLC35E2A Gene via IID

Symbol External ID(s) Details
ELAVL1
;

Gene Ontology (GO) - Biological Process for SLC35E2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35E2A: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35E2A Gene

Drugs & Compounds for SLC35E2A Gene

No Compound Related Data Available

Transcripts for SLC35E2A Gene

mRNA/cDNA for SLC35E2A Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35E2A

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E2A Gene

No ASD Table

Relevant External Links for SLC35E2A Gene

GeneLoc Exon Structure for
SLC35E2A

Expression for SLC35E2A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35E2A

Evidence on tissue expression from TISSUES for SLC35E2A Gene

  • Nervous system(4.6)
  • Lung(2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E2A Gene

Orthologs for SLC35E2A Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35E2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35E2 30
  • 99.32 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35E2 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e2b 30
  • 65.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14621 31
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 10 (a)
OneToMany
Species where no ortholog for SLC35E2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC35E2A Gene

ENSEMBL:
Gene Tree for SLC35E2A (if available)
TreeFam:
Gene Tree for SLC35E2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35E2A: view image

Paralogs for SLC35E2A Gene

genes like me logo Genes that share paralogs with SLC35E2A: view

Variants for SLC35E2A Gene

Additional dbSNP identifiers (rs#s) for SLC35E2A Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC35E2A Gene

Variant ID Type Subtype PubMed ID
dgv2e214 CNV loss 21293372
dgv3e212 CNV loss 25503493
dgv3n67 CNV gain 20364138
dgv40n54 CNV loss 21841781
dgv41n54 CNV loss 21841781
dgv42n54 CNV loss 21841781
dgv4e212 CNV gain 25503493
dgv5e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
dgv9n100 CNV loss 25217958
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv2764265 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3550788 CNV deletion 23714750
esv3567896 CNV gain 25503493
esv3585010 CNV loss 21293372
esv3585015 CNV gain 21293372
esv3891747 CNV loss 25118596
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1076312 CNV duplication 25765185
nsv1160797 CNV duplication 26073780
nsv1160864 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv436343 CNV deletion 17901297
nsv442858 CNV gain+loss 18776908
nsv482937 CNV loss 15286789
nsv545027 CNV loss 21841781
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv545032 CNV loss 21841781
nsv545040 CNV loss 21841781
nsv822475 CNV gain 20364138
nsv822697 CNV loss 20364138
nsv822809 CNV loss 20364138
nsv834091 CNV loss 17160897
nsv945747 CNV duplication 23825009
nsv950521 CNV deletion 24416366

Variation tolerance for SLC35E2A Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35E2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35E2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35E2A Gene

Disorders for SLC35E2A Gene

Additional Disease Information for SLC35E2A

No disorders were found for SLC35E2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E2A Gene

Publications for SLC35E2A Gene

  1. YY1 binds to the E3' enhancer and inhibits the expression of the immunoglobulin κ gene via epigenetic modifications. (PMID: 30098214) Zhou X … Wang X (Immunology 2018) 3 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for SLC35E2A Gene

Sources for SLC35E2A Gene