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Aliases for SLC35E1 Gene

Aliases for SLC35E1 Gene

  • Solute Carrier Family 35 Member E1 2 3 5
  • Solute Carrier Family 35, Member E1 2

External Ids for SLC35E1 Gene

Previous GeneCards Identifiers for SLC35E1 Gene

  • GC19M016507
  • GC19M016523
  • GC19M016522
  • GC19M016660
  • GC19M016229

Summaries for SLC35E1 Gene

GeneCards Summary for SLC35E1 Gene

SLC35E1 (Solute Carrier Family 35 Member E1) is a Protein Coding gene. An important paralog of this gene is SLC35E2B.

UniProtKB/Swiss-Prot for SLC35E1 Gene

  • Putative transporter.

Additional gene information for SLC35E1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E1 Gene

Genomics for SLC35E1 Gene

GeneHancer (GH) Regulatory Elements for SLC35E1 Gene

Promoters and enhancers for SLC35E1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I016568 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 191 7.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B GC19P019771 SLC35E1 LOC105372295 TMEM38A C19orf44 CHERP RN7SL146P ENSG00000141979 SMIM7 EPS15L1
GH19I016626 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 -56.1 -56134 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B MED26 LOC105372296 ENSG00000141979 SMIM7 C19orf44 ENSG00000269578 COLGALT1 HAUS8 CHERP SLC35E1
GH19I016593 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -22.1 -22092 2.1 HDGF RB1 BACH1 EBF1 BATF ZIC2 RELA ZFHX2 NFATC1 ETV6 C19orf44 SLC35E1 RN7SL146P CHERP ENSG00000141979 MED26 KLF2 GC19M016221 ENSG00000268087 ENSG00000268790
GH19I016607 Enhancer 1.2 Ensembl ENCODE dbSUPER 12 -36.0 -35973 1.7 PKNOX1 ARNT INSM2 FEZF1 ZNF2 RAD21 ZNF366 ZSCAN5C RUNX3 ZNF362 C19orf44 EPS15L1 MED26 CALR3 SLC35E1 SMIM7 TMEM38A CHERP RN7SL146P CPAMD8
GH19I016611 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.7 -39.7 -39664 1.7 CTCF ZBTB6 CEBPG RAD21 ZFHX2 VEZF1 EGR2 ZNF654 RXRA REST ENSG00000268087 ENSG00000279977 C19orf44 CALR3 SLC35E1 CHERP RN7SL146P SMIM7 TMEM38A EPS15L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35E1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35E1 gene promoter:

Genomic Locations for SLC35E1 Gene

Genomic Locations for SLC35E1 Gene
22,552 bases
Minus strand

Genomic View for SLC35E1 Gene

Genes around SLC35E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E1 Gene

Proteins for SLC35E1 Gene

  • Protein details for SLC35E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member E1
    Protein Accession:
    Secondary Accessions:
    • Q8NBQ2
    • Q96JV7

    Protein attributes for SLC35E1 Gene

    410 amino acids
    Molecular mass:
    44773 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14557.1; Type=Frameshift; Positions=372, 384; Evidence={ECO:0000305}; Sequence=AAH62562.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55306.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55410.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35E1 Gene


neXtProt entry for SLC35E1 Gene

Post-translational modifications for SLC35E1 Gene

  • Ubiquitination at isoforms=2345, isoforms=2358, and isoforms=2367
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC35E1 Gene

No data available for DME Specific Peptides for SLC35E1 Gene

Domains & Families for SLC35E1 Gene

Gene Families for SLC35E1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35E1 Gene


Suggested Antigen Peptide Sequences for SLC35E1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPT transporter family. SLC35E subfamily.
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E1: view

Function for SLC35E1 Gene

Molecular function for SLC35E1 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Phenotypes From GWAS Catalog for SLC35E1 Gene

genes like me logo Genes that share phenotypes with SLC35E1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35E1

miRNA for SLC35E1 Gene

miRTarBase miRNAs that target SLC35E1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E1 Gene

Localization for SLC35E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E1: view

Pathways & Interactions for SLC35E1 Gene

SuperPathways for SLC35E1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SLC35E1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35E1 Gene

Drugs & Compounds for SLC35E1 Gene

No Compound Related Data Available

Transcripts for SLC35E1 Gene

Unigene Clusters for SLC35E1 Gene

Solute carrier family 35, member E1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -

Relevant External Links for SLC35E1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35E1 Gene

This gene is overexpressed in Placenta (13.3), Breast (7.3), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC35E1 Gene

Protein tissue co-expression partners for SLC35E1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35E1 Gene:


SOURCE GeneReport for Unigene cluster for SLC35E1 Gene:


Evidence on tissue expression from TISSUES for SLC35E1 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with SLC35E1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E1 Gene

Orthologs for SLC35E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35E1 33 34
  • 99.82 (n)
(Canis familiaris)
Mammalia SLC35E1 33 34
  • 92.5 (n)
(Bos Taurus)
Mammalia SLC35E1 33 34
  • 90.66 (n)
(Mus musculus)
Mammalia Slc35e1 33 16 34
  • 86.67 (n)
(Ornithorhynchus anatinus)
Mammalia SLC35E1 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Slc35e1 33
  • 85.63 (n)
(Monodelphis domestica)
Mammalia SLC35E1 34
  • 79 (a)
(Gallus gallus)
Aves SLC35E1 33 34
  • 77.78 (n)
(Anolis carolinensis)
Reptilia SLC35E1 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e1 33
  • 74.13 (n)
Str.215 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11369 33
(Danio rerio)
Actinopterygii slc35e1 33 34
  • 70.51 (n)
Dr.3762 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000544 33
  • 58.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14621 33 34
  • 57.08 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR543C 33
  • 47.49 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08569g 33
  • 40.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLY41 33
  • 38.65 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GPT1 33
  • 47.17 (n)
(Oryza sativa)
Liliopsida Os08g0187800 33
  • 45.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05453 33
  • 47.62 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC83.11 33
  • 40.14 (n)
Species where no ortholog for SLC35E1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E1 Gene

Gene Tree for SLC35E1 (if available)
Gene Tree for SLC35E1 (if available)

Paralogs for SLC35E1 Gene

Paralogs for SLC35E1 Gene

(1) SIMAP similar genes for SLC35E1 Gene using alignment to 4 proteins: Pseudogenes for SLC35E1 Gene

genes like me logo Genes that share paralogs with SLC35E1: view

Variants for SLC35E1 Gene

Sequence variations from dbSNP and Humsavar for SLC35E1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000004711 -- 16,574,019(-) C/G upstream_transcript_variant
rs1000093968 -- 16,571,540(-) A/G coding_sequence_variant, missense_variant
rs1000141944 -- 16,574,272(-) T/A upstream_transcript_variant
rs1000257632 -- 16,570,946(-) A/C intron_variant
rs1000286888 -- 16,564,772(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35E1 Gene

Variant ID Type Subtype PubMed ID
nsv510757 CNV deletion 20534489

Variation tolerance for SLC35E1 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E1 Gene

Disorders for SLC35E1 Gene

Additional Disease Information for SLC35E1

No disorders were found for SLC35E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E1 Gene

Publications for SLC35E1 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for SLC35E1 Gene

Sources for SLC35E1 Gene

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