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This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013] See more...
Aliases for SLC35C2 Gene
Aliases for SLC35C2 Gene
External Ids for SLC35C2 Gene
- HGNC: 17117
- Entrez Gene: 51006
- Ensembl: ENSG00000080189
- UniProtKB: Q9NQQ7
Previous HGNC Symbols for SLC35C2 Gene
- C20orf5
- OVCOV1
Previous GeneCards Identifiers for SLC35C2 Gene
- GC20M045616
- GC20M045663
- GC20M044411
- GC20M044978
- GC20M041719
Summaries for SLC35C2 Gene
-
This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]
GeneCards Summary for SLC35C2 Gene
SLC35C2 (Solute Carrier Family 35 Member C2) is a Protein Coding gene. Diseases associated with SLC35C2 include Dicarboxylic Aminoaciduria and Hydranencephaly. An important paralog of this gene is SLC35E2B.
UniProtKB/Swiss-Prot Summary for SLC35C2 Gene
-
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
Additional gene information for SLC35C2 Gene
- HGNC(17117)
- Entrez Gene(51006)
- Ensembl(ENSG00000080189)
- UniProtKB(Q9NQQ7)
- Open Targets Platform(ENSG00000080189)
- Search for SLC35C2 at DataMed
- Search for SLC35C2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35C2 Gene
Genomics for SLC35C2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC35C2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC35C2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35C2
- Top Transcription factor binding sites by QIAGEN in the SLC35C2 gene promoter:
-
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- POU2F1
- POU2F1a
- Sox9
- Zic1
- Zic3
Genomic Locations for SLC35C2 Gene
Genomic Locations for SLC35C2 Gene
- chr20:46,345,980-46,364,458
- (GRCh38/hg38)
- Size:
- 18,479 bases
- Orientation:
- Minus strand
- chr20:44,978,167-44,993,064
- (GRCh37/hg19)
- Size:
- 14,898 bases
- Orientation:
- Minus strand
Genomic View for SLC35C2 Gene
Genes around SLC35C2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by HGNC
- 20q13.12 by Entrez Gene
- 20q13.12 by Ensembl
SLC35C2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC35C2 Gene
Proteins for SLC35C2 Gene
-
Protein details for SLC35C2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQQ7-S35C2_HUMAN
- Recommended name:
- Solute carrier family 35 member C2
- Protein Accession:
- Q9NQQ7
- B7Z6V6
- E1P5T0
- Q53GK3
- Q5JW05
- Q96CJ8
- Q9Y304
Protein attributes for SLC35C2 Gene
- Size:
- 365 amino acids
- Molecular mass:
- 40432 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD27724.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for SLC35C2 Gene
Post-translational modifications for SLC35C2 Gene
Other Protein References for SLC35C2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SLC35C2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SLC35C2
- Novus Biologicals Antibodies for SLC35C2
- Invitrogen Antibodies for SLC35C2 (AFLGC-SLC35C2)
-
Boster Bio Antibodies for SLC35C2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC35C2
- Origene Custom Protein Services for SLC35C2
No data available for DME Specific Peptides for SLC35C2 Gene
Domains & Families for SLC35C2 Gene
Gene Families for SLC35C2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC35C2 Gene
- InterPro:
- Blocks:
-
- Short-chain dehydrogenase/reductase SDR
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC35C2 Gene
- GenScript: Design optimal peptide antigens:
-
- Ovarian cancer-overexpressed gene 1 protein (S35C2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQQ7- Family:
-
- Belongs to the TPT transporter family. SLC35C subfamily.
Function for SLC35C2 Gene
Molecular function for SLC35C2 Gene
- UniProtKB/Swiss-Prot Function:
- May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
- UniProtKB/Swiss-Prot Induction:
- In hypoxic trophoblast cells.
Phenotypes From GWAS Catalog for SLC35C2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015297 | antiporter activity | IBA | 21873635 |
| GO:0022857 | transmembrane transporter activity | IBA | 21873635 |
Phenotypes for SLC35C2 Gene
- MGI mutant phenotypes for SLC35C2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC35C2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability ratio
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Mitotic spindle defects
Animal Models for SLC35C2 Gene
- MGI Knock Outs for SLC35C2:
-
- Slc35c2 Slc35c2<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC35C2 - Select products 50% OFF >
- * SLC35C2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC35C2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC35C2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC35C2
miRNA for SLC35C2 Gene
- miRTarBase miRNAs that target SLC35C2
-
- mmu-miR-136-5p (MIRT015042)
- hsa-miR-6739-5p (MIRT455865)
- hsa-miR-6733-5p (MIRT455866)
- hsa-miR-3153 (MIRT455867)
- hsa-miR-4763-3p (MIRT455868)
- hsa-miR-1207-5p (MIRT455869)
- hsa-miR-4755-3p (MIRT455870)
- hsa-miR-4673 (MIRT455871)
- hsa-miR-4645-5p (MIRT455872)
- hsa-miR-4692 (MIRT455873)
- hsa-miR-4514 (MIRT455874)
- hsa-miR-5584-5p (MIRT455875)
- hsa-miR-940 (MIRT455876)
- hsa-miR-6893-5p (MIRT455877)
- hsa-miR-6808-5p (MIRT455878)
- hsa-miR-4428 (MIRT455879)
- hsa-miR-651-3p (MIRT455880)
- hsa-miR-7109-5p (MIRT483281)
- hsa-miR-4665-5p (MIRT483282)
- hsa-miR-1275 (MIRT483283)
- hsa-miR-1587 (MIRT483284)
- hsa-miR-3620-5p (MIRT483285)
- hsa-miR-4472 (MIRT483286)
- hsa-miR-4447 (MIRT483287)
- hsa-miR-92a-2-5p (MIRT483288)
- hsa-miR-4483 (MIRT483289)
- hsa-miR-1293 (MIRT483290)
- hsa-miR-6766-5p (MIRT483291)
- hsa-miR-6756-5p (MIRT483292)
- hsa-miR-6745 (MIRT483293)
- hsa-miR-363-5p (MIRT483294)
- hsa-miR-5010-5p (MIRT483295)
- hsa-miR-7111-5p (MIRT483296)
- hsa-miR-4525 (MIRT483297)
- hsa-miR-6870-5p (MIRT483298)
- hsa-miR-5698 (MIRT483299)
- hsa-miR-4723-5p (MIRT483300)
- hsa-miR-625-5p (MIRT483301)
- hsa-miR-6825-5p (MIRT483302)
- hsa-miR-4741 (MIRT483303)
- hsa-miR-4675 (MIRT483304)
- hsa-miR-762 (MIRT483305)
- hsa-miR-5001-5p (MIRT483306)
- hsa-miR-4492 (MIRT483307)
- hsa-miR-4498 (MIRT483308)
- hsa-miR-6829-5p (MIRT483309)
- hsa-miR-4656 (MIRT483310)
- hsa-miR-7106-5p (MIRT483311)
- hsa-miR-6827-5p (MIRT483312)
- hsa-miR-5787 (MIRT483313)
- hsa-miR-4505 (MIRT483314)
- hsa-miR-765 (MIRT483315)
- hsa-miR-5589-5p (MIRT483316)
- hsa-miR-6133 (MIRT483317)
- hsa-miR-6130 (MIRT483318)
- hsa-miR-6129 (MIRT483319)
- hsa-miR-6127 (MIRT483320)
- hsa-miR-4510 (MIRT483321)
- hsa-miR-4419a (MIRT483322)
- hsa-miR-4784 (MIRT483323)
- hsa-miR-3150b-3p (MIRT483324)
- hsa-miR-1233-3p (MIRT483325)
- hsa-miR-4687-5p (MIRT483326)
- hsa-miR-6776-5p (MIRT483327)
- hsa-miR-6873-5p (MIRT483328)
- hsa-miR-5096 (MIRT528439)
- hsa-miR-218-5p (MIRT528440)
- hsa-miR-636 (MIRT528441)
- hsa-miR-205-3p (MIRT528442)
- hsa-miR-892a (MIRT528443)
- hsa-miR-323a-3p (MIRT528444)
- hsa-miR-4290 (MIRT569288)
- hsa-miR-4667-3p (MIRT569289)
- hsa-miR-4668-5p (MIRT615579)
- hsa-miR-3613-3p (MIRT615580)
- hsa-miR-4422 (MIRT615581)
- hsa-miR-548e-5p (MIRT615582)
- hsa-miR-520e (MIRT625853)
- hsa-miR-520d-3p (MIRT625854)
- hsa-miR-520c-3p (MIRT625855)
- hsa-miR-520b (MIRT625856)
- hsa-miR-520a-3p (MIRT625857)
- hsa-miR-373-3p (MIRT625858)
- hsa-miR-372-3p (MIRT625859)
- hsa-miR-302e (MIRT625860)
- hsa-miR-302d-3p (MIRT625861)
- hsa-miR-302c-3p (MIRT625862)
- hsa-miR-302b-3p (MIRT625863)
- hsa-miR-302a-3p (MIRT625864)
- hsa-miR-519c-3p (MIRT625865)
- hsa-miR-519b-3p (MIRT625866)
- hsa-miR-519a-3p (MIRT625867)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC35C2
- Browse OriGene Inhibitory RNA Products For SLC35C2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35C2
Clone Products
- Applied Biological Materials (abm): Clones for SLC35C2 - Select products 50% OFF >
- * SLC35C2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205597
- MR205597
- MR205597L3
- MR205597L4
- MR228788
- MR229503
- MR229504
- RC204316
- RC204316L3
- RC204316L4
- RC206843
- RC206843L3
- RC206843L4
- RC223417
- RC223417L1
- RC223417L2
- RC223417L3
- RC223417L4
- RC236741
- RC236937
- RC237742
- RC237944
- RG204316
- RG206843
- RG223417
- RR204997
- RR204997L3
- RR204997L4
- MR205597L3V
- MR205597L4V
- RC204316L3V
- RC204316L4V
- RC206843L3V
- RC206843L4V
- RC223417L1V
- RC223417L2V
- RC223417L3V
- RC223417L4V
- RR204997L3V
- RR204997L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC35C2
- Addgene plasmids for SLC35C2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC35C2
Cell Line Products
-
Horizon Cell Lines for SLC35C2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC35C2 Gene
Localization for SLC35C2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC35C2 Gene
- Membrane. Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| nucleus | 4 |
| plasma membrane | 2 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | IDA | 20837470 |
| GO:0005794 | Golgi apparatus | IBA,IDA | -- |
| GO:0005801 | cis-Golgi network | IEA,IDA | 20837470 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SLC35C2 Gene
Interacting Proteins for SLC35C2 Gene
Selected Interacting proteins:
Q9NQQ7-S35C2_HUMAN
ENSP00000318960
for SLC35C2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SLC35C2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010629 | negative regulation of gene expression | IEA | -- |
| GO:0015786 | UDP-glucose transmembrane transport | IBA | 21873635 |
| GO:0036065 | fucosylation | IEA | -- |
| GO:0036066 | protein O-linked fucosylation | IEA | -- |
| GO:0045747 | positive regulation of Notch signaling pathway | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SLC35C2 Gene
Transcripts for SLC35C2 Gene
mRNA/cDNA for SLC35C2 Gene
- 7 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000243896 2447 nts (view in UCSC)
- ENST00000317734 2175 nts (view in UCSC)
- ENST00000372227 2505 nts (view in UCSC)
- ENST00000372230 5820 nts (view in UCSC)
- ENST00000420518 588 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC35C2 - Select products 50% OFF >
- * SLC35C2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC35C2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC35C2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC35C2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC35C2
- Browse OriGene Inhibitory RNA Products For SLC35C2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35C2
Clone Products
- Applied Biological Materials (abm): Clones for SLC35C2 - Select products 50% OFF >
- * SLC35C2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG205597
- MR205597
- MR205597L3
- MR205597L4
- MR228788
- MR229503
- MR229504
- RC204316
- RC204316L3
- RC204316L4
- RC206843
- RC206843L3
- RC206843L4
- RC223417
- RC223417L1
- RC223417L2
- RC223417L3
- RC223417L4
- RC236741
- RC236937
- RC237742
- RC237944
- RG204316
- RG206843
- RG223417
- RR204997
- RR204997L3
- RR204997L4
- MR205597L3V
- MR205597L4V
- RC204316L3V
- RC204316L4V
- RC206843L3V
- RC206843L4V
- RC223417L1V
- RC223417L2V
- RC223417L3V
- RC223417L4V
- RR204997L3V
- RR204997L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC35C2
- Addgene plasmids for SLC35C2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC35C2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP25: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP26: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP27: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP28: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP29: | - | - |
| ExUns: | 9d | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP12: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP13: | - | ||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||
| SP17: | - | ||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | |||||||||||||||||||||||||||||||||
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Relevant External Links for SLC35C2 Gene
- GeneLoc Exon Structure for
- SLC35C2
Expression for SLC35C2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
This gene is overexpressed in Cervix (32.6) and Spleen (31.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35C2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35C2
SOURCE GeneReport for Unigene cluster for SLC35C2 Gene:
Hs.593344mRNA Expression by UniProt/SwissProt for SLC35C2 Gene:
Q9NQQ7-S35C2_HUMAN
Tissue specificity:
Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.
Evidence on tissue expression from TISSUES for SLC35C2 Gene
- Nervous system(4.9)
- Skin(4.5)
- Intestine(4.5)
- Kidney(4.3)
- Spleen(4.3)
Primer Products
-
OriGene qPCR primer pairs for SLC35C2
-
OriGene qPCR primer pairs and template standards for SLC35C2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35C2 Gene
Orthologs for SLC35C2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC35C2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC35C2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC35C2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc35c2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc35c2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC35C2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC35C2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC35C2 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6085 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | slc35c2 30 |
|
||
| Dr.7973 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG14971 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005537 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y47G6A.7 30 |
|
||
| Y47G6A.7 31 |
|
OneToOne | |||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR462C 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YMD8 30 31 33 33 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F10131g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G06470 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0749900 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4074 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC22E12.01 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.8485 30 |
|
- Species where no ortholog for SLC35C2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for SLC35C2 Gene
- ENSEMBL:
- Gene Tree for SLC35C2 (if available)
- TreeFam:
- Gene Tree for SLC35C2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC35C2: view image
Paralogs for SLC35C2 Gene
Variants for SLC35C2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2722457 | CNV | deletion | 23290073 |
| nsv1057686 | CNV | loss | 25217958 |
| nsv586155 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.13;
22.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC35C2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC35C2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35C2 Gene
Disorders for SLC35C2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dicarboxylic aminoaciduria |
|
|
| hydranencephaly |
|
|
| spastic paraplegia 42, autosomal dominant |
|
|
| benign chronic pemphigus |
|
|
| ovarian cancer |
|
|
Search SLC35C2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC35C2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35C2 Gene
Publications for SLC35C2 Gene
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
- Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. (PMID: 20837470) Lu L … Stanley P (The Journal of biological chemistry 2010) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Identification, molecular characterization, and tissue expression of OVCOV1. (PMID: 12461647) Leach RE … Krawetz SA (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 3 4
ExternalLinks
Products for SLC35C2 Gene
- Custom Antibody ServicesOriGene Antibodies for SLC35C2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC35C2
- Origene Custom Protein Services for SLC35C2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC35C2
- Browse OriGene Inhibitory RNA Products For SLC35C2
- OriGene qPCR primer pairs for SLC35C2
- OriGene qPCR primer pairs and template standards for SLC35C2
- OriGene CRISPR knockouts for SLC35C2