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Aliases for SLC35C2 Gene

Aliases for SLC35C2 Gene

  • Solute Carrier Family 35 Member C2 2 3 5
  • Solute Carrier Family 35 (GDP-Fucose Transporter), Member C2 2 3
  • Ovarian Cancer-Overexpressed Gene 1 Protein 3 4
  • C20orf5 3 4
  • OVCOV1 3 4
  • Solute Carrier Family 35, Member C2 2
  • Ovarian Cancer Overexpressed 1 2
  • BA394O2.1 3
  • CGI-15 3

External Ids for SLC35C2 Gene

Previous HGNC Symbols for SLC35C2 Gene

  • C20orf5
  • OVCOV1

Previous GeneCards Identifiers for SLC35C2 Gene

  • GC20M045616
  • GC20M045663
  • GC20M044411
  • GC20M044978
  • GC20M041719

Summaries for SLC35C2 Gene

Entrez Gene Summary for SLC35C2 Gene

  • This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC35C2 Gene

SLC35C2 (Solute Carrier Family 35 Member C2) is a Protein Coding gene. Diseases associated with SLC35C2 include Ovarian Cancer.

UniProtKB/Swiss-Prot for SLC35C2 Gene

  • May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.

Gene Wiki entry for SLC35C2 Gene

Additional gene information for SLC35C2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35C2 Gene

Genomics for SLC35C2 Gene

GeneHancer (GH) Regulatory Elements for SLC35C2 Gene

Promoters and enhancers for SLC35C2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I046361 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.2 +0.3 307 6 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 SLC35C2 ENSG00000273828 CD40 PCIF1 NCOA5 SLC12A5 SLC12A5-AS1 ELMO2 GC20M046352 PIR48117
GH20I045967 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 62.8 +393.6 393584 5.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF335 NCOA5 SLC35C2 TP53RK ZNF334 PCIF1 ZNF663P CD40 ENSG00000271984 SPATA25
GH20I047342 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.7 -988.7 -988701 21 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF263 ZMYND8 LOC101927377 SLC35C2 TP53RK RPL35AP RNU6-497P NCOA3 SULF2 ENSG00000273451 GC20M047326
GH20I045933 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.5 +428.1 428128 6.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCIF1 SNX21 NCOA5 TP53RK SPATA25 ZNF335 PLTP SLC35C2 WFDC3 ENSG00000271984
GH20I045880 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.3 +483.2 483186 1.5 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZSWIM1 NCOA5 TP53RK PCIF1 CD40 ZNF335 WFDC3 SLC35C2 SPATA25 RPS2P7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35C2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35C2 gene promoter:

Genomic Locations for SLC35C2 Gene

Genomic Locations for SLC35C2 Gene
chr20:46,345,980-46,364,458
(GRCh38/hg38)
Size:
18,479 bases
Orientation:
Minus strand
chr20:44,978,167-44,993,064
(GRCh37/hg19)

Genomic View for SLC35C2 Gene

Genes around SLC35C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35C2 Gene

Proteins for SLC35C2 Gene

  • Protein details for SLC35C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQQ7-S35C2_HUMAN
    Recommended name:
    Solute carrier family 35 member C2
    Protein Accession:
    Q9NQQ7
    Secondary Accessions:
    • B7Z6V6
    • E1P5T0
    • Q53GK3
    • Q5JW05
    • Q96CJ8
    • Q9Y304

    Protein attributes for SLC35C2 Gene

    Size:
    365 amino acids
    Molecular mass:
    40432 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27724.1; Type=Frameshift; Positions=168, 211, 305; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35C2 Gene

Post-translational modifications for SLC35C2 Gene

  • Glycosylation at posLast=102102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC35C2 Gene

Domains & Families for SLC35C2 Gene

Gene Families for SLC35C2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35C2 Gene

Suggested Antigen Peptide Sequences for SLC35C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQQ7

UniProtKB/Swiss-Prot:

S35C2_HUMAN :
  • Belongs to the TPT transporter family. SLC35C subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35C subfamily.
genes like me logo Genes that share domains with SLC35C2: view

Function for SLC35C2 Gene

Molecular function for SLC35C2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
UniProtKB/Swiss-Prot Induction:
In hypoxic trophoblast cells.

Phenotypes From GWAS Catalog for SLC35C2 Gene

genes like me logo Genes that share phenotypes with SLC35C2: view

Animal Model Products

CRISPR Products

miRNA for SLC35C2 Gene

miRTarBase miRNAs that target SLC35C2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35C2 Gene

Localization for SLC35C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35C2 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35C2 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
plasma membrane 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA,IDA 20837470
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005801 cis-Golgi network IEA,IDA 20837470
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC35C2: view

Pathways & Interactions for SLC35C2 Gene

SuperPathways for SLC35C2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0015786 UDP-glucose transmembrane transport IBA --
GO:0036065 fucosylation IEA --
GO:0036066 protein O-linked fucosylation IEA --
genes like me logo Genes that share ontologies with SLC35C2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35C2 Gene

Drugs & Compounds for SLC35C2 Gene

No Compound Related Data Available

Transcripts for SLC35C2 Gene

Unigene Clusters for SLC35C2 Gene

Solute carrier family 35, member C2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35C2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - - - - - -
SP2: - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - - - - - - - -
SP15: - - - - - -
SP16: - - -
SP17: - -
SP18: - -
SP19: - - - - - -
SP20: - - - - - -
SP21: - - - -
SP22: - - - - - -
SP23: - - -
SP24: -
SP25: - - -
SP26: -
SP27:
SP28: - - - -
SP29: - -

ExUns: 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15a · 15b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17: -
SP18: - - - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

Relevant External Links for SLC35C2 Gene

GeneLoc Exon Structure for
SLC35C2
ECgene alternative splicing isoforms for
SLC35C2

Expression for SLC35C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35C2 Gene

This gene is overexpressed in Cervix (32.6) and Spleen (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35C2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC35C2 Gene:

SLC35C2

SOURCE GeneReport for Unigene cluster for SLC35C2 Gene:

Hs.593344

mRNA Expression by UniProt/SwissProt for SLC35C2 Gene:

Q9NQQ7-S35C2_HUMAN
Tissue specificity: Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.

Evidence on tissue expression from TISSUES for SLC35C2 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Intestine(4.4)
  • Kidney(4.3)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with SLC35C2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35C2 Gene

Orthologs for SLC35C2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35C2 33 34
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia SLC35C2 33 34
  • 92.28 (n)
dog
(Canis familiaris)
Mammalia SLC35C2 33 34
  • 91.6 (n)
rat
(Rattus norvegicus)
Mammalia Slc35c2 33
  • 88.92 (n)
mouse
(Mus musculus)
Mammalia Slc35c2 33 16 34
  • 88.37 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35C2 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35C2 33 34
  • 72.35 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35C2 34
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6085 33
zebrafish
(Danio rerio)
Actinopterygii slc35c2 33
  • 66.28 (n)
Dr.7973 33
fruit fly
(Drosophila melanogaster)
Insecta CG14971 33 34
  • 55.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005537 33
  • 54.88 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y47G6A.7 33
  • 47.67 (n)
Y47G6A.7 34
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR462C 33
  • 46.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMD8 33 34 36 36
  • 44.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10131g 33
  • 43.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06470 33
  • 45.86 (n)
rice
(Oryza sativa)
Liliopsida Os01g0749900 33
  • 46.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4074 34
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC22E12.01 33
  • 42.32 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8485 33
Species where no ortholog for SLC35C2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC35C2 Gene

ENSEMBL:
Gene Tree for SLC35C2 (if available)
TreeFam:
Gene Tree for SLC35C2 (if available)

Paralogs for SLC35C2 Gene

Pseudogenes.org Pseudogenes for SLC35C2 Gene

genes like me logo Genes that share paralogs with SLC35C2: view

No data available for Paralogs for SLC35C2 Gene

Variants for SLC35C2 Gene

Sequence variations from dbSNP and Humsavar for SLC35C2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000016520 -- 46,353,193(-) A/G intron_variant
rs1000065648 -- 46,365,310(-) C/A upstream_transcript_variant
rs1000215883 -- 46,356,131(-) C/T intron_variant
rs1000326702 -- 46,363,665(-) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000705363 -- 46,362,547(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35C2 Gene

Variant ID Type Subtype PubMed ID
esv2722457 CNV deletion 23290073
nsv1057686 CNV loss 25217958
nsv586155 CNV loss 21841781

Variation tolerance for SLC35C2 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35C2 Gene

Disorders for SLC35C2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC35C2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC35C2

genes like me logo Genes that share disorders with SLC35C2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35C2 Gene

Publications for SLC35C2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. (PMID: 20837470) Lu L … Stanley P (The Journal of biological chemistry 2010) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification, molecular characterization, and tissue expression of OVCOV1. (PMID: 12461647) Leach RE … Krawetz SA (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 3 4 58

Products for SLC35C2 Gene

Sources for SLC35C2 Gene