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Aliases for SLC35C1 Gene

Aliases for SLC35C1 Gene

  • Solute Carrier Family 35 Member C1 2 3 4 5
  • Solute Carrier Family 35 (GDP-Fucose Transporter), Member C1 2 3
  • FUCT1 3 4
  • Solute Carrier Family 35, Member C1 2
  • GDP-Fucose Transporter 1 3
  • CDG2C 3

External Ids for SLC35C1 Gene

Previous GeneCards Identifiers for SLC35C1 Gene

  • GC00U913330
  • GC11P045791
  • GC11P045792
  • GC11P045783
  • GC11P045532
  • GC11P045826
  • GC11P045806
  • GC11P045814
  • GC11P045827
  • GC11P045843
  • GC11P045853

Summaries for SLC35C1 Gene

Entrez Gene Summary for SLC35C1 Gene

  • This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for SLC35C1 Gene

SLC35C1 (Solute Carrier Family 35 Member C1) is a Protein Coding gene. Diseases associated with SLC35C1 include Congenital Disorder Of Glycosylation, Type Iic and Leukocyte Adhesion Deficiency, Type I. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for SLC35C1 Gene

  • Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.

Gene Wiki entry for SLC35C1 Gene

Additional gene information for SLC35C1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35C1 Gene

Genomics for SLC35C1 Gene

GeneHancer (GH) Regulatory Elements for SLC35C1 Gene

Promoters and enhancers for SLC35C1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I045803 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 562.8 +1.1 1138 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZBTB7B YY1 POLR2B SLC35C1 DKFZp779M0652 ENSG00000255447
GH11I045801 Enhancer 0.7 ENCODE 550.8 -1.7 -1708 1.7 FOXA2 USF1 SUZ12 MAX RAD21 YY1 ZNF143 NFE2 THAP11 AFF1 SLC35C1 DKFZp779M0652
GH11I045846 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.9 +43.7 43689 3.2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 CRY2 MAPK8IP1 SLC35C1
GH11I045771 Promoter/Enhancer 1.4 Ensembl ENCODE 7.7 -32.2 -32187 1.6 HDGF PKNOX1 CLOCK SIN3A ZNF2 IRF4 BRCA1 ZNF48 YY1 ZNF121 DKFZp779M0652 SLC35C1 CHST1 GC11P045681
GH11I046236 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +434.3 434264 4.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 POLR2B CBX5 ZNF213 ENSG00000254639 ENSG00000270060 RPS10P19 DDB2 LINC02489 CREB3L1 ZNF408 LARGE2 DGKZ SLC35C1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35C1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35C1 gene promoter:

Genomic Locations for SLC35C1 Gene

Genomic Locations for SLC35C1 Gene
8,945 bases
Plus strand

Genomic View for SLC35C1 Gene

Genes around SLC35C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35C1 Gene

Proteins for SLC35C1 Gene

  • Protein details for SLC35C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GDP-fucose transporter 1
    Protein Accession:
    Secondary Accessions:
    • B2RDB2
    • Q9BV76
    • Q9NUJ8

    Protein attributes for SLC35C1 Gene

    364 amino acids
    Molecular mass:
    39809 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92126.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35C1 Gene


neXtProt entry for SLC35C1 Gene

Post-translational modifications for SLC35C1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35C1 Gene

No data available for DME Specific Peptides for SLC35C1 Gene

Domains & Families for SLC35C1 Gene

Gene Families for SLC35C1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35C1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPT transporter family. SLC35C subfamily.
  • Belongs to the TPT transporter family. SLC35C subfamily.
genes like me logo Genes that share domains with SLC35C1: view

Function for SLC35C1 Gene

Molecular function for SLC35C1 Gene

UniProtKB/Swiss-Prot Function:
Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.

Phenotypes From GWAS Catalog for SLC35C1 Gene

Gene Ontology (GO) - Molecular Function for SLC35C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005457 GDP-fucose transmembrane transporter activity TAS,IEA --
genes like me logo Genes that share ontologies with SLC35C1: view
genes like me logo Genes that share phenotypes with SLC35C1: view

Human Phenotype Ontology for SLC35C1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC35C1 Gene

MGI Knock Outs for SLC35C1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC35C1 Gene

Localization for SLC35C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35C1 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35C1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35C1: view

Pathways & Interactions for SLC35C1 Gene

genes like me logo Genes that share pathways with SLC35C1: view

Interacting Proteins for SLC35C1 Gene

Gene Ontology (GO) - Biological Process for SLC35C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0030259 lipid glycosylation IEA --
GO:0036085 GDP-fucose import into Golgi lumen IEA --
GO:0045746 negative regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with SLC35C1: view

No data available for SIGNOR curated interactions for SLC35C1 Gene

Drugs & Compounds for SLC35C1 Gene

No Compound Related Data Available

Transcripts for SLC35C1 Gene

Unigene Clusters for SLC35C1 Gene

Solute carrier family 35, member C1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35C1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -
SP4: - - - -

Relevant External Links for SLC35C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC35C1 Gene

This gene is overexpressed in Liver (x9.6).

Protein differential expression in normal tissues from HIPED for SLC35C1 Gene

This gene is overexpressed in Nasal epithelium (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35C1 Gene:


SOURCE GeneReport for Unigene cluster for SLC35C1 Gene:


Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35C1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • ear
  • head
  • jaw
  • mandible
  • maxilla
  • middle ear
  • mouth
  • skull
  • tooth
  • lung
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with SLC35C1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for SLC35C1 Gene

Orthologs for SLC35C1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35C1 33 34
  • 99.15 (n)
(Canis familiaris)
Mammalia SLC35C1 33 34
  • 91.12 (n)
(Bos Taurus)
Mammalia SLC35C1 33 34
  • 89.56 (n)
(Ornithorhynchus anatinus)
Mammalia SLC35C1 34
  • 86 (a)
(Mus musculus)
Mammalia Slc35c1 33 16 34
  • 85.4 (n)
(Rattus norvegicus)
Mammalia Slc35c1 33
  • 85.31 (n)
(Monodelphis domestica)
Mammalia SLC35C1 34
  • 84 (a)
(Gallus gallus)
Aves SLC35C1 33 34
  • 77.41 (n)
(Anolis carolinensis)
Reptilia SLC35C1 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35c1 33
  • 72.39 (n)
(Danio rerio)
Actinopterygii slc35c1 33 34
  • 67.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002393 33
  • 59.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gfr 33 34
  • 57.25 (n)
(Caenorhabditis elegans)
Secernentea nstp-10 33 34
  • 54.3 (n)
nstp-9 34
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1609 34
  • 46 (a)
Species where no ortholog for SLC35C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35C1 Gene

Gene Tree for SLC35C1 (if available)
Gene Tree for SLC35C1 (if available)

Paralogs for SLC35C1 Gene

No data available for Paralogs for SLC35C1 Gene

Variants for SLC35C1 Gene

Sequence variations from dbSNP and Humsavar for SLC35C1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1018321380 uncertain-significance, Congenital disorder of glycosylation 45,811,863(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs10838518 likely-benign, Congenital disorder of glycosylation 45,812,915(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1139266 benign, not specified, Congenital disorder of glycosylation 45,811,384(+) G/A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1139267 likely-benign, Congenital disorder of glycosylation 45,811,749(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs115509471 uncertain-significance, Congenital disorder of glycosylation 45,812,543(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Variation tolerance for SLC35C1 Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35C1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35C1 Gene

Disorders for SLC35C1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC35C1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards


  • Congenital disorder of glycosylation 2C (CDG2C) [MIM:266265]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The clinical features of CDG2C include mental retardation, short stature, facial stigmata, and recurrent bacterial peripheral infections with persistently elevated peripheral leukocytes. Biochemically, CDG2C is characterized by a lack of fucosylated glycoconjugates, including selectin ligands. {ECO:0000269 PubMed:11326279, ECO:0000269 PubMed:11326280}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLC35C1

genes like me logo Genes that share disorders with SLC35C1: view

No data available for Genatlas for SLC35C1 Gene

Publications for SLC35C1 Gene

  1. The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter. (PMID: 11326279) Lühn K … Vestweber D (Nature genetics 2001) 2 3 4 58
  2. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. (PMID: 11326280) Lübke T … Körner C (Nature genetics 2001) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SLC35C1 Gene

Sources for SLC35C1 Gene

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