Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008] See more...

Aliases for SLC35B4 Gene

Aliases for SLC35B4 Gene

  • Solute Carrier Family 35 Member B4 2 3 4 5
  • Solute Carrier Family 35 (UDP-Xylose/UDP-N-Acetylglucosamine Transporter), Member B4 2 3
  • UDP-Xylose And UDP-N-Acetylglucosamine Transporter 3 4
  • YEA4 Homolog 3 4
  • YEA4 3 4
  • UDP-Xylose/N-Acetylglucosamine Transporter 3
  • Solute Carrier Family 35, Member B4 2
  • YEA 3

External Ids for SLC35B4 Gene

Previous GeneCards Identifiers for SLC35B4 Gene

  • GC07M133377
  • GC07M133394
  • GC07M133435
  • GC07M133624
  • GC07M133974
  • GC07M128275

Summaries for SLC35B4 Gene

Entrez Gene Summary for SLC35B4 Gene

  • Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35B4 Gene

SLC35B4 (Solute Carrier Family 35 Member B4) is a Protein Coding gene. Diseases associated with SLC35B4 include Exhibitionism. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include UDP-N-acetylglucosamine transmembrane transporter activity and UDP-xylose transmembrane transporter activity. An important paralog of this gene is SLC35B3.

UniProtKB/Swiss-Prot Summary for SLC35B4 Gene

  • Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Gene Wiki entry for SLC35B4 Gene

Additional gene information for SLC35B4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35B4 Gene

Genomics for SLC35B4 Gene

GeneHancer (GH) Regulatory Elements for SLC35B4 Gene

Promoters and enhancers for SLC35B4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J134315 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 531.3 +3.6 3595 2.2 ZBTB40 ZNF217 EP300 CTCF TCF12 NRF1 USF1 POLR2G SP1 PHF8 SLC35B4 WDR91 RF01045-140 lnc-AKR1B1-2
GH07J134320 Promoter/Enhancer 0.5 EPDnew Ensembl 500.7 -0.1 -87 0.4 RF01045-140 SLC35B4 piR-56037-068
GH07J134292 Enhancer 1.1 Ensembl ENCODE 31.2 +27.1 27113 2 RXRA FOXK2 ZBTB40 SP1 NCOR1 EP300 KDM6A TCF7 FOXA1 RCOR1 lnc-AKR1B1-2 piR-45209 SLC35B4 ENSG00000231098
GH07J134288 Enhancer 0.7 Ensembl ENCODE 31.2 +30.8 30830 3.4 FOS CEBPG ATF4 CEBPB KLF1 ATF3 SP1 SLC35B4 ENSG00000231098 piR-45209
GH07J134298 Enhancer 0.6 Ensembl ENCODE 31.6 +20.9 20913 1.2 ZNF316 RFX5 NFE2 ZFP91 MAFG EMSY SLC35B4 lnc-AKR1B1-2 RF01045-140
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35B4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35B4

Top Transcription factor binding sites by QIAGEN in the SLC35B4 gene promoter:
  • AML1a
  • Cart-1
  • CUTL1
  • FOXD3
  • GATA-1
  • GATA-2
  • POU2F1
  • POU2F1a
  • PPAR-alpha

Genomic Locations for SLC35B4 Gene

Genomic Locations for SLC35B4 Gene
chr7:134,289,332-134,320,314
(GRCh38/hg38)
Size:
30,983 bases
Orientation:
Minus strand
chr7:133,974,084-134,001,827
(GRCh37/hg19)
Size:
27,744 bases
Orientation:
Minus strand

Genomic View for SLC35B4 Gene

Genes around SLC35B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B4 Gene

Proteins for SLC35B4 Gene

  • Protein details for SLC35B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969S0-S35B4_HUMAN
    Recommended name:
    UDP-xylose and UDP-N-acetylglucosamine transporter
    Protein Accession:
    Q969S0
    Secondary Accessions:
    • A4D1P3
    • A6NNS4
    • Q53GQ7
    • Q8TCU7
    • Q96K33

    Protein attributes for SLC35B4 Gene

    Size:
    331 amino acids
    Molecular mass:
    37424 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B4 Gene

Post-translational modifications for SLC35B4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35B4 Gene

No data available for DME Specific Peptides for SLC35B4 Gene

Domains & Families for SLC35B4 Gene

Gene Families for SLC35B4 Gene

Protein Domains for SLC35B4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35B4 Gene

GenScript: Design optimal peptide antigens:
  • YEA4 homolog (S35B4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969S0

UniProtKB/Swiss-Prot:

S35B4_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B4: view

Function for SLC35B4 Gene

Molecular function for SLC35B4 Gene

UniProtKB/Swiss-Prot Function:
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.

Phenotypes From GWAS Catalog for SLC35B4 Gene

Gene Ontology (GO) - Molecular Function for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity TAS --
GO:0005464 UDP-xylose transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0022857 transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC35B4: view
genes like me logo Genes that share phenotypes with SLC35B4: view

Animal Models for SLC35B4 Gene

MGI Knock Outs for SLC35B4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B4

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC35B4 Gene

Localization for SLC35B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B4 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B4 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IDA 21918738
GO:0005794 Golgi apparatus IEA,IDA 15911612
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35B4 Gene

Pathways & Interactions for SLC35B4 Gene

genes like me logo Genes that share pathways with SLC35B4: view

Interacting Proteins for SLC35B4 Gene

;

Gene Ontology (GO) - Biological Process for SLC35B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006111 regulation of gluconeogenesis IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015790 UDP-xylose transmembrane transport IDA 15911612
GO:0055085 transmembrane transport IEA --
GO:1990569 UDP-N-acetylglucosamine transmembrane transport IDA 15911612
genes like me logo Genes that share ontologies with SLC35B4: view

No data available for SIGNOR curated interactions for SLC35B4 Gene

Drugs & Compounds for SLC35B4 Gene

No Compound Related Data Available

Transcripts for SLC35B4 Gene

mRNA/cDNA for SLC35B4 Gene

1 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B4 Gene

No ASD Table

Relevant External Links for SLC35B4 Gene

GeneLoc Exon Structure for
SLC35B4

Expression for SLC35B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35B4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35B4 Gene

This gene is overexpressed in Fetal Brain (21.3), Retina (21.1), Testis (14.0), and Ovary (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35B4 Gene



Protein tissue co-expression partners for SLC35B4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35B4

SOURCE GeneReport for Unigene cluster for SLC35B4 Gene:

Hs.490181

Evidence on tissue expression from TISSUES for SLC35B4 Gene

  • Liver(4.2)
  • Skin(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC35B4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B4 Gene

Orthologs for SLC35B4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC35B4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35B4 31 30
  • 99.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC35B4 31 30
  • 92.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35B4 31 30
  • 90.61 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35b4 30
  • 89.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35B4 31
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35B4 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b4 17 31 30
  • 88.92 (n)
chicken
(Gallus gallus)
Aves SLC35B4 31 30
  • 76.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35B4 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b4 30
  • 73.01 (n)
zebrafish
(Danio rerio)
Actinopterygii slc35b4 31 30
  • 68.29 (n)
OneToOne
Dr.2187 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011493 30
  • 60.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Efr 31 30
  • 57.62 (n)
OneToMany
CG14511 31
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nstp-2 31 30
  • 51.12 (n)
OneToMany
nstp-1 31
  • 36 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03157g 30
  • 45.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YEA4 33 31 30
  • 43.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02980 30
  • 46.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1734.09 30
  • 46.32 (n)
Species where no ortholog for SLC35B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B4 Gene

ENSEMBL:
Gene Tree for SLC35B4 (if available)
TreeFam:
Gene Tree for SLC35B4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35B4: view image

Paralogs for SLC35B4 Gene

Paralogs for SLC35B4 Gene

genes like me logo Genes that share paralogs with SLC35B4: view

Variants for SLC35B4 Gene

Additional dbSNP identifiers (rs#s) for SLC35B4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC35B4 Gene

Variant ID Type Subtype PubMed ID
esv3615084 CNV gain 21293372
esv3615093 CNV gain 21293372
nsv1020759 CNV gain 25217958
nsv608444 CNV gain 21841781
nsv831145 CNV gain 17160897

Variation tolerance for SLC35B4 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35B4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35B4 Gene

Disorders for SLC35B4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC35B4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
exhibitionism
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC35B4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC35B4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35B4 Gene

Publications for SLC35B4 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
  2. The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. (PMID: 15911612) Ashikov A … Bakker H (The Journal of biological chemistry 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54

Products for SLC35B4 Gene

Sources for SLC35B4 Gene