Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesiz... See more...

Aliases for SLC35B2 Gene

Aliases for SLC35B2 Gene

  • Solute Carrier Family 35 Member B2 2 3 4 5
  • Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate Transporter), Member B2 2 3
  • Adenosine 3'-Phospho 5'-Phosphosulfate Transporter 1 3 4
  • Putative NF-Kappa-B-Activating Protein 48 3 4
  • Putative MAPK-Activating Protein PM15 3 4
  • PAPS Transporter 1 3 4
  • UGTrel4 2 3
  • PAPST1 3 4
  • 3'-Phosphoadenosine 5'-Phosphosulfate Transporter 3
  • Solute Carrier Family 35 Member B2 Variant 2 3
  • Solute Carrier Family 35, Member B2 2
  • SLC35B2 5
  • SLL 3

External Ids for SLC35B2 Gene

Previous GeneCards Identifiers for SLC35B2 Gene

  • GC06M044225
  • GC06M044270
  • GC06M044271
  • GC06M044329
  • GC06M044221
  • GC06M043943

Summaries for SLC35B2 Gene

Entrez Gene Summary for SLC35B2 Gene

  • Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35B2 Gene

SLC35B2 (Solute Carrier Family 35 Member B2) is a Protein Coding gene. Diseases associated with SLC35B2 include Primary Bone Dysplasia With Multiple Joint Dislocations and Primary Bone Dysplasia. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. An important paralog of this gene is SLC35B1.

UniProtKB/Swiss-Prot Summary for SLC35B2 Gene

  • Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.

Gene Wiki entry for SLC35B2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35B2 Gene

Genomics for SLC35B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC35B2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35B2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35B2

Top Transcription factor binding sites by QIAGEN in the SLC35B2 gene promoter:
  • Egr-2
  • Egr-4
  • Elk-1
  • GATA-3
  • ISGF-3
  • MZF-1
  • p300
  • RORalpha1

Genomic Locations for SLC35B2 Gene

Latest Assembly
chr6:44,254,096-44,257,890
(GRCh38/hg38)
Size:
3,795 bases
Orientation:
Minus strand

Previous Assembly
chr6:44,221,838-44,225,627
(GRCh37/hg19 by Entrez Gene)
Size:
3,790 bases
Orientation:
Minus strand

chr6:44,221,833-44,225,291
(GRCh37/hg19 by Ensembl)
Size:
3,459 bases
Orientation:
Minus strand

Genomic View for SLC35B2 Gene

Genes around SLC35B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B2 Gene

Proteins for SLC35B2 Gene

  • Protein details for SLC35B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB61-S35B2_HUMAN
    Recommended name:
    Adenosine 3'-phospho 5'-phosphosulfate transporter 1
    Protein Accession:
    Q8TB61
    Secondary Accessions:
    • B4DDM2
    • B4DDU9
    • F5H7Y9
    • Q2VY06
    • Q53GA3
    • Q5T9W1
    • Q5T9W2
    • Q7Z2G3
    • Q8NBK6
    • Q96AR6

    Protein attributes for SLC35B2 Gene

    Size:
    432 amino acids
    Molecular mass:
    47515 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35B2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B2 Gene

Post-translational modifications for SLC35B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for SLC35B2
  • Boster Bio Antibodies for SLC35B2
  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC35B2

No data available for DME Specific Peptides for SLC35B2 Gene

Domains & Families for SLC35B2 Gene

Gene Families for SLC35B2 Gene

Protein Domains for SLC35B2 Gene

InterPro:
Blocks:
  • UAA transporter

Suggested Antigen Peptide Sequences for SLC35B2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59462, highly similar to Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (B4DDM2_HUMAN)
  • Solute carrier family 35 member B2 (S35B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TB61

UniProtKB/Swiss-Prot:

S35B2_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B2: view

Function for SLC35B2 Gene

Molecular function for SLC35B2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 uM for PAPS {ECO:0000269|PubMed:12716889};

Phenotypes From GWAS Catalog for SLC35B2 Gene

Gene Ontology (GO) - Molecular Function for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0022857 transmembrane transporter activity IBA 21873635
GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA,IDA 12716889
genes like me logo Genes that share ontologies with SLC35B2: view
genes like me logo Genes that share phenotypes with SLC35B2: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC35B2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35B2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B2 Gene

Localization for SLC35B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B2 Gene

Golgi apparatus membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA,IDA 12716889
GO:0016020 membrane IEA,IDA 12716889
GO:0016021 integral component of membrane NAS 12716889
GO:0030173 integral component of Golgi membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC35B2: view

Pathways & Interactions for SLC35B2 Gene

genes like me logo Genes that share pathways with SLC35B2: view

Gene Ontology (GO) - Biological Process for SLC35B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP 12761501
GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport IDA 12716889
GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process TAS --
GO:0055085 transmembrane transport IEA --
GO:1902559 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35B2: view

No data available for SIGNOR curated interactions for SLC35B2 Gene

Drugs & Compounds for SLC35B2 Gene

(3) Drugs for SLC35B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma 664
3'-phospho-5'-adenylyl sulfate Experimental Pharma 0
Adenosine phosphosulfate Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with SLC35B2: view

Transcripts for SLC35B2 Gene

mRNA/cDNA for SLC35B2 Gene

9 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35B2

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP2: -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for SLC35B2 Gene

GeneLoc Exon Structure for
SLC35B2

Expression for SLC35B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35B2 Gene

Protein differential expression in normal tissues from HIPED for SLC35B2 Gene

This gene is overexpressed in Nasal epithelium (59.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35B2 Gene



Protein tissue co-expression partners for SLC35B2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35B2

SOURCE GeneReport for Unigene cluster for SLC35B2 Gene:

Hs.182885

mRNA Expression by UniProt/SwissProt for SLC35B2 Gene:

Q8TB61-S35B2_HUMAN
Tissue specificity: Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not expressed in colon, heart and prostate.

Evidence on tissue expression from TISSUES for SLC35B2 Gene

  • Intestine(4.6)
  • Lung(4.4)
  • Nervous system(4.3)
  • Thyroid gland(4.3)
  • Heart(3.5)
  • Skin(3.4)
  • Muscle(3.2)
  • Stomach(3)
  • Kidney(3)
  • Liver(3)
genes like me logo Genes that share expression patterns with SLC35B2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B2 Gene

Orthologs for SLC35B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B2 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia PAPST1 30
  • 92 (a)
OneToOne
SLC35B2 29
  • 91.28 (n)
Cow
(Bos Taurus)
Mammalia SLC35B2 29 30
  • 89.74 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc35b2 29 16 30
  • 88.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc35b2 29
  • 88.01 (n)
Oppossum
(Monodelphis domestica)
Mammalia SLC35B2 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC35B2 29 30
  • 72.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC35B2 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc35b2 29
  • 71.59 (n)
LOC394918 29
African clawed frog
(Xenopus laevis)
Amphibia slc35b1-prov 29
Zebrafish
(Danio rerio)
Actinopterygii slc35b2 29 30
  • 68.16 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6248 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002571 29
  • 56.62 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta sll 29 30
  • 55.7 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea pst-1 29 30
  • 48.13 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 30
  • 23 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G59740 29
  • 47.56 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0115700 29
  • 47.51 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 51 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.13223 29
Species where no ortholog for SLC35B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC35B2 Gene

ENSEMBL:
Gene Tree for SLC35B2 (if available)
TreeFam:
Gene Tree for SLC35B2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35B2: view image
Alliance of Genome Resources:
Additional Orthologs for SLC35B2

Paralogs for SLC35B2 Gene

Paralogs for SLC35B2 Gene

(1) SIMAP similar genes for SLC35B2 Gene using alignment to 3 proteins:

  • S35B2_HUMAN
  • B4DDM2_HUMAN
  • F5H7Y9_HUMAN
genes like me logo Genes that share paralogs with SLC35B2: view

Variants for SLC35B2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35B2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs35112470 Benign: not provided 44,255,555(-) C/T
NM_178148.4(SLC35B2):c.450G>A (p.Thr150=)
SYNONYMOUS
rs3734707 Benign: not provided 44,254,981(-) G/Cp.Leu342Val
NM_178148.4(SLC35B2):c.1024C>G (p.Leu342Val)
MISSENSE
rs760851221 Pathogenic: Primary bone dysplasia with multiple joint dislocations 44,254,784(-) GAGC/G
NM_178148.4(SLC35B2):c.1218_1220del (p.Leu407del)
INFRAME_DELETION

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC35B2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC35B2 Gene

Variant ID Type Subtype PubMed ID
dgv10641n54 CNV loss 21841781
nsv462936 CNV loss 19166990
nsv524398 CNV loss 19592680
nsv5282 CNV insertion 18451855
nsv603003 CNV gain 21841781

Variation tolerance for SLC35B2 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35B2 Gene

Human Gene Mutation Database (HGMD)
SLC35B2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35B2
Leiden Open Variation Database (LOVD)
SLC35B2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B2 Gene

Disorders for SLC35B2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SLC35B2 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
primary bone dysplasia with multiple joint dislocations
  • primary osteodysplasia with multiple joint dislocations
primary bone dysplasia
  • primary osteodysplasia
animal phobia
  • fear of animals
retinitis pigmentosa 55
  • rp55
sjogren-larsson syndrome
  • sls
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC35B2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC35B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35B2 Gene

Publications for SLC35B2 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 40
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter. (PMID: 12716889) Kamiyama S … Nishihara S (The Journal of biological chemistry 2003) 3 4
  5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4

Products for SLC35B2 Gene

Sources for SLC35B2 Gene