Aliases for SLC35B2 Gene
- Solute Carrier Family 35 Member B2 2 3 4 5
- Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate Transporter), Member B2 2 3
- Adenosine 3'-Phospho 5'-Phosphosulfate Transporter 1 3 4
- Putative NF-Kappa-B-Activating Protein 48 3 4
- Putative MAPK-Activating Protein PM15 3 4
- PAPS Transporter 1 3 4
External Ids for SLC35B2 Gene
Previous GeneCards Identifiers for SLC35B2 Gene
Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC35B2 Gene
SLC35B2 (Solute Carrier Family 35 Member B2) is a Protein Coding gene. Diseases associated with SLC35B2 include Primary Bone Dysplasia With Multiple Joint Dislocations and Primary Bone Dysplasia. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. An important paralog of this gene is SLC35B1.
UniProtKB/Swiss-Prot Summary for SLC35B2 Gene
Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.