This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] See more...

Aliases for SLC35B1 Gene

Aliases for SLC35B1 Gene

  • Solute Carrier Family 35 Member B1 2 3 4 5
  • UDP-Galactose Transporter-Related Protein 1 3 4
  • UGTREL1 3 4
  • Solute Carrier Family 35, Member B1 2
  • UDP-Galactose Transporter Related 3
  • HUGTrel1 4
  • UGTrel1 4

External Ids for SLC35B1 Gene

Previous GeneCards Identifiers for SLC35B1 Gene

  • GC17M048120
  • GC17M048253
  • GC17M045133
  • GC17M047779
  • GC17M043143

Summaries for SLC35B1 Gene

Entrez Gene Summary for SLC35B1 Gene

  • This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC35B1 Gene

SLC35B1 (Solute Carrier Family 35 Member B1) is a Protein Coding gene. Diseases associated with SLC35B1 include Dicarboxylic Aminoaciduria and Hydranencephaly. Gene Ontology (GO) annotations related to this gene include UDP-galactose transmembrane transporter activity. An important paralog of this gene is SLC35B2.

UniProtKB/Swiss-Prot Summary for SLC35B1 Gene

Additional gene information for SLC35B1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35B1 Gene

Genomics for SLC35B1 Gene

GeneHancer (GH) Regulatory Elements for SLC35B1 Gene

Promoters and enhancers for SLC35B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35B1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35B1

Top Transcription factor binding sites by QIAGEN in the SLC35B1 gene promoter:
  • Bach2
  • c-Myb
  • FOXI1
  • HFH-3
  • HNF-4alpha1
  • HNF-4alpha2
  • MRF-2
  • Nkx6-1
  • Zic3

Genomic Locations for SLC35B1 Gene

Genomic Locations for SLC35B1 Gene
chr17:49,700,934-49,709,014
(GRCh38/hg38)
Size:
8,081 bases
Orientation:
Minus strand
chr17:47,778,305-47,786,376
(GRCh37/hg19)
Size:
8,072 bases
Orientation:
Minus strand

Genomic View for SLC35B1 Gene

Genes around SLC35B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B1 Gene

Proteins for SLC35B1 Gene

  • Protein details for SLC35B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78383-S35B1_HUMAN
    Recommended name:
    Solute carrier family 35 member B1
    Protein Accession:
    P78383
    Secondary Accessions:
    • B4DEC4
    • J3KQV4
    • Q96EW7

    Protein attributes for SLC35B1 Gene

    Size:
    322 amino acids
    Molecular mass:
    35760 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B1 Gene

Post-translational modifications for SLC35B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC35B1 Gene

Domains & Families for SLC35B1 Gene

Gene Families for SLC35B1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35B1 Gene

Blocks:
  • Protein of unknown function DUF6
  • UAA transporter
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35B1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59156, highly similar to Solute carrier family 35 member B1 (B4DJG9_HUMAN)
  • Solute carrier family 35, member B1, isoform CRA_a (D3DTX1_HUMAN)
  • UDP-galactose transporter-related protein 1 (S35B1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78383

UniProtKB/Swiss-Prot:

S35B1_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B1: view

Function for SLC35B1 Gene

Molecular function for SLC35B1 Gene

UniProtKB/Swiss-Prot Function:
Probable sugar transporter.

Phenotypes From GWAS Catalog for SLC35B1 Gene

Gene Ontology (GO) - Molecular Function for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005459 UDP-galactose transmembrane transporter activity IBA 21873635
GO:0005460 UDP-glucose transmembrane transporter activity IBA 21873635
GO:0022857 transmembrane transporter activity IBA 21873635
genes like me logo Genes that share ontologies with SLC35B1: view
genes like me logo Genes that share phenotypes with SLC35B1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B1 Gene

Localization for SLC35B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 3
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC35B1: view

Pathways & Interactions for SLC35B1 Gene

PathCards logo

SuperPathways for SLC35B1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0015786 UDP-glucose transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
GO:0072334 UDP-galactose transmembrane transport IBA 21873635
genes like me logo Genes that share ontologies with SLC35B1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35B1 Gene

Drugs & Compounds for SLC35B1 Gene

No Compound Related Data Available

Transcripts for SLC35B1 Gene

mRNA/cDNA for SLC35B1 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8:
SP9: - - -
SP10: -
SP11:
SP12:

Relevant External Links for SLC35B1 Gene

GeneLoc Exon Structure for
SLC35B1

Expression for SLC35B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35B1 Gene

This gene is overexpressed in Liver, secretome (37.4), Liver (10.5), Islet of Langerhans (10.3), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35B1 Gene



Protein tissue co-expression partners for SLC35B1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35B1

SOURCE GeneReport for Unigene cluster for SLC35B1 Gene:

Hs.154073

Evidence on tissue expression from TISSUES for SLC35B1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with SLC35B1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B1 Gene

Orthologs for SLC35B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35B1 31 30
  • 99.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35B1 31 30
  • 93.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC35B1 31 30
  • 93.33 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35b1 30
  • 90.17 (n)
mouse
(Mus musculus)
Mammalia Slc35b1 17 31 30
  • 89.75 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35B1 31
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35B1 31 30
  • 77.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35B1 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b1 30
  • 74.03 (n)
ernst1 30
zebrafish
(Danio rerio)
Actinopterygii slc35b1 31 31 30
  • 68.81 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001447 30
  • 56.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5802 31 30
  • 54.48 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hut-1 31 30
  • 50.78 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL154C 30
  • 42.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 31 30
  • 42.38 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12848g 30
  • 41.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons UTR3 30
  • 48.18 (n)
rice
(Oryza sativa)
Liliopsida Os06g0593100 30
  • 48.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9903 31
  • 55 (a)
OneToOne
Cin.7081 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hut1 30
  • 46.97 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10721 30
  • 46.79 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7081 30
Species where no ortholog for SLC35B1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B1 Gene

ENSEMBL:
Gene Tree for SLC35B1 (if available)
TreeFam:
Gene Tree for SLC35B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35B1: view image

Paralogs for SLC35B1 Gene

Paralogs for SLC35B1 Gene

(2) SIMAP similar genes for SLC35B1 Gene using alignment to 11 proteins:

  • S35B1_HUMAN
  • D3DTX1_HUMAN
  • D6R981_HUMAN
  • D6R9G9_HUMAN
  • D6RB73_HUMAN
  • D6RDY9_HUMAN
  • D6RE58_HUMAN
  • D6RF81_HUMAN
  • D6RG34_HUMAN
  • D6RHG0_HUMAN
  • J3KQV4_HUMAN
genes like me logo Genes that share paralogs with SLC35B1: view

Variants for SLC35B1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35B1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1135034 - p.Arg81His

Additional dbSNP identifiers (rs#s) for SLC35B1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC35B1 Gene

Variant ID Type Subtype PubMed ID
nsv525469 CNV gain 19592680

Variation tolerance for SLC35B1 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B1 Gene

Disorders for SLC35B1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC35B1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dicarboxylic aminoaciduria
  • dcbxa
hydranencephaly
  • hydroanencephaly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC35B1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC35B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35B1 Gene

Publications for SLC35B1 Gene

  1. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. (PMID: 9010752) Ishida N … Kawakita M (Journal of biochemistry 1996) 2 3 4 54
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41 54
  3. The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. (PMID: 19270184) Dejima K … Nomura K (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for SLC35B1 Gene

  • Biorbyt antibodies for SLC35B1

Sources for SLC35B1 Gene