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Aliases for SLC35B1 Gene

Aliases for SLC35B1 Gene

  • Solute Carrier Family 35 Member B1 2 3 5
  • UDP-Galactose Transporter-Related Protein 1 3 4
  • UGTREL1 3 4
  • Solute Carrier Family 35, Member B1 2
  • UDP-Galactose Transporter Related 3
  • HUGTrel1 4

External Ids for SLC35B1 Gene

Previous GeneCards Identifiers for SLC35B1 Gene

  • GC17M048120
  • GC17M048253
  • GC17M045133
  • GC17M047779
  • GC17M043143

Summaries for SLC35B1 Gene

Entrez Gene Summary for SLC35B1 Gene

  • This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC35B1 Gene

SLC35B1 (Solute Carrier Family 35 Member B1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include UDP-galactose transmembrane transporter activity. An important paralog of this gene is SLC35B2.

UniProtKB/Swiss-Prot for SLC35B1 Gene

  • Probable sugar transporter.

Additional gene information for SLC35B1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B1 Gene

Genomics for SLC35B1 Gene

GeneHancer (GH) Regulatory Elements for SLC35B1 Gene

Promoters and enhancers for SLC35B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I049706 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.8 796 2.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ENSG00000250751 PIR42611 SLC35B1 KAT7 CALCOCO2 CACNA1G-AS1 ENSG00000230532 PICART1 NXPH3 UBE2Z
GH17I049758 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE dbSUPER 12.3 -52.9 -52935 6.4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B FAM117A ENSG00000262837 UBE2Z LUC7L3 FLJ45513 SPOP COL1A1 TAC4 SLC35B1 ITGA3
GH17I049674 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.9 +32.3 32327 4.1 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SPOP ENSG00000262837 SLC35B1 ENSG00000250751 UBE2Z ENSG00000250310 EME1 CACNA1G-AS1 SPATA20 PHB
GH17I049735 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.7 -34.2 -34203 15.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT SIN3A FEZF1 IRF4 YY1 ZNF766 LUC7L3 ENSG00000262837 FAM117A UBE2Z FLJ45513 NXPH3 ZNF652 KAT7 ENSG00000230532 SLC35B1
GH17I049850 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 -142.5 -142520 1.9 HDGF ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 GTF3C2 ZNF121 ENSG00000248172 DLX3 SLC35B1 ENSG00000250310 LOC100288866 NXPH3 SPOP FAM117A TAC4 ENSG00000248954
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35B1 gene promoter:

Genomic Locations for SLC35B1 Gene

Genomic Locations for SLC35B1 Gene
chr17:49,700,934-49,709,014
(GRCh38/hg38)
Size:
8,081 bases
Orientation:
Minus strand
chr17:47,778,305-47,786,376
(GRCh37/hg19)

Genomic View for SLC35B1 Gene

Genes around SLC35B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B1 Gene

Proteins for SLC35B1 Gene

  • Protein details for SLC35B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78383-S35B1_HUMAN
    Recommended name:
    Solute carrier family 35 member B1
    Protein Accession:
    P78383
    Secondary Accessions:
    • B4DEC4
    • J3KQV4
    • Q96EW7

    Protein attributes for SLC35B1 Gene

    Size:
    322 amino acids
    Molecular mass:
    35760 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B1 Gene

Post-translational modifications for SLC35B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC35B1 Gene

Domains & Families for SLC35B1 Gene

Gene Families for SLC35B1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35B1 Gene

Graphical View of Domain Structure for InterPro Entry

P78383

UniProtKB/Swiss-Prot:

S35B1_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B1: view

Function for SLC35B1 Gene

Molecular function for SLC35B1 Gene

UniProtKB/Swiss-Prot Function:
Probable sugar transporter.

Phenotypes From GWAS Catalog for SLC35B1 Gene

Gene Ontology (GO) - Molecular Function for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005459 UDP-galactose transmembrane transporter activity TAS 9010752
genes like me logo Genes that share ontologies with SLC35B1: view
genes like me logo Genes that share phenotypes with SLC35B1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B1 Gene

Localization for SLC35B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with SLC35B1: view

Pathways & Interactions for SLC35B1 Gene

SuperPathways for SLC35B1 Gene

No Data Available

Interacting Proteins for SLC35B1 Gene

Selected Interacting proteins: P78383-S35B1_HUMAN for SLC35B1 Gene via IID

Gene Ontology (GO) - Biological Process for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS,IEA 9010752
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport IEA --
GO:0072334 UDP-galactose transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35B1: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35B1 Gene

Drugs & Compounds for SLC35B1 Gene

No Compound Related Data Available

Transcripts for SLC35B1 Gene

Unigene Clusters for SLC35B1 Gene

Solute carrier family 35, member B1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8:
SP9: - - -
SP10: -
SP11:
SP12:

Relevant External Links for SLC35B1 Gene

GeneLoc Exon Structure for
SLC35B1
ECgene alternative splicing isoforms for
SLC35B1

Expression for SLC35B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35B1 Gene

This gene is overexpressed in Liver, secretome (37.4), Liver (10.5), Islet of Langerhans (10.3), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35B1 Gene



Protein tissue co-expression partners for SLC35B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35B1 Gene:

SLC35B1

SOURCE GeneReport for Unigene cluster for SLC35B1 Gene:

Hs.154073

Evidence on tissue expression from TISSUES for SLC35B1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with SLC35B1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B1 Gene

Orthologs for SLC35B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35B1 33 34
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia SLC35B1 33 34
  • 93.5 (n)
cow
(Bos Taurus)
Mammalia SLC35B1 33 34
  • 93.33 (n)
rat
(Rattus norvegicus)
Mammalia Slc35b1 33
  • 90.17 (n)
mouse
(Mus musculus)
Mammalia Slc35b1 33 16 34
  • 89.75 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35B1 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35B1 33 34
  • 77.67 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35B1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b1 33
  • 74.03 (n)
ernst1 33
zebrafish
(Danio rerio)
Actinopterygii slc35b1 33 34 34
  • 68.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001447 33
  • 56.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5802 33 34
  • 54.48 (n)
worm
(Caenorhabditis elegans)
Secernentea hut-1 33 34
  • 50.78 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL154C 33
  • 42.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 33 34
  • 42.38 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12848g 33
  • 41.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons UTR3 33
  • 48.18 (n)
rice
(Oryza sativa)
Liliopsida Os06g0593100 33
  • 48.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9903 34
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hut1 33
  • 46.97 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10721 33
  • 46.79 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7081 33
Species where no ortholog for SLC35B1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B1 Gene

ENSEMBL:
Gene Tree for SLC35B1 (if available)
TreeFam:
Gene Tree for SLC35B1 (if available)

Paralogs for SLC35B1 Gene

Paralogs for SLC35B1 Gene

genes like me logo Genes that share paralogs with SLC35B1: view

Variants for SLC35B1 Gene

Sequence variations from dbSNP and Humsavar for SLC35B1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000276040 -- 49,705,559(-) A/C intron_variant
rs1000571047 -- 49,701,866(-) G/A intron_variant
rs1000918106 -- 49,702,116(-) C/T intron_variant
rs1001098651 -- 49,705,933(-) G/A intron_variant
rs1001950978 -- 49,707,665(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35B1 Gene

Variant ID Type Subtype PubMed ID
nsv525469 CNV gain 19592680

Variation tolerance for SLC35B1 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B1 Gene

Disorders for SLC35B1 Gene

Additional Disease Information for SLC35B1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC35B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35B1 Gene

Publications for SLC35B1 Gene

  1. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. (PMID: 9010752) Ishida N … Kawakita M (Journal of biochemistry 1996) 2 3 4 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. (PMID: 19270184) Dejima K … Nomura K (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLC35B1 Gene

Sources for SLC35B1 Gene

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