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Aliases for SLC35A5 Gene

Aliases for SLC35A5 Gene

  • Solute Carrier Family 35 Member A5 2 3 4 5
  • Solute Carrier Family 35, Member A5 2

External Ids for SLC35A5 Gene

Previous GeneCards Identifiers for SLC35A5 Gene

  • GC03P111851
  • GC03P113562
  • GC03P113601
  • GC03P113763
  • GC03P112281
  • GC03P109664

Summaries for SLC35A5 Gene

Entrez Gene Summary for SLC35A5 Gene

  • This gene encodes a transmembrane protein which belongs to subfamily 35A of the solute carrier superfamily. The encoded protein is a nucleoside-sugar transporter. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for SLC35A5 Gene

SLC35A5 (Solute Carrier Family 35 Member A5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sugar:proton symporter activity and nucleotide-sugar transmembrane transporter activity. An important paralog of this gene is SLC35A2.

Additional gene information for SLC35A5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35A5 Gene

Genomics for SLC35A5 Gene

GeneHancer (GH) Regulatory Elements for SLC35A5 Gene

Promoters and enhancers for SLC35A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I112559 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 569.4 -0.1 -105 4.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC35A5 ATG3 SPICE1 NEPRO LOC101180897 CFAP44 BOC CCDC80 MIR567 C3orf52
GH03I112494 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.3 -63.6 -63576 6.3 PKNOX1 RB1 JUN IRF4 RELA POLR2A ETV6 BCLAF1 IKZF2 RUNX3 BTLA SLC35A5 CD200 MIR567 C3orf52 LOC105374041
GH03I112539 Enhancer 1 FANTOM5 ENCODE dbSUPER 25.9 -21.4 -21391 0.9 JUNB BATF ATF2 IKZF1 ETV6 ATF7 RUNX3 SPI1 SLC35A5 CD200 C3orf52 MIR567 ATG3 ENSG00000279349
GH03I112531 Enhancer 0.6 dbSUPER 25.8 -27.8 -27791 5.5 CTCF MAFG RAD21 ZNF316 MAFF SMC3 EMSY MAFK SLC35A5 CD200 SLC9C1 MIR567 C3orf52 ENSG00000279349 ATG3
GH03I112634 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5 +77.9 77885 10.2 PKNOX1 ZNF133 SIN3A ZNF2 POLR2B ARID2 ZNF143 FOS RUNX3 DEK CCDC80 CD200R1 ENSG00000242770 SPICE1 C3orf52 MIR567 SLC35A5 LINC01279
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35A5 gene promoter:

Genomic Locations for SLC35A5 Gene

Genomic Locations for SLC35A5 Gene
chr3:112,561,709-112,585,577
(GRCh38/hg38)
Size:
23,869 bases
Orientation:
Plus strand
chr3:112,280,556-112,304,424
(GRCh37/hg19)

Genomic View for SLC35A5 Gene

Genes around SLC35A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A5 Gene

Proteins for SLC35A5 Gene

  • Protein details for SLC35A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS91-S35A5_HUMAN
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A5
    Protein Accession:
    Q9BS91
    Secondary Accessions:
    • D3DN66
    • Q69YY6
    • Q6ZMD6
    • Q9NWM9

    Protein attributes for SLC35A5 Gene

    Size:
    424 amino acids
    Molecular mass:
    48500 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18792.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC35A5 Gene

Post-translational modifications for SLC35A5 Gene

  • Glycosylation at isoforms=204
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC35A5 Gene

Domains & Families for SLC35A5 Gene

Gene Families for SLC35A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35A5 Gene

Suggested Antigen Peptide Sequences for SLC35A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BS91

UniProtKB/Swiss-Prot:

S35A5_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A5: view

Function for SLC35A5 Gene

Phenotypes From GWAS Catalog for SLC35A5 Gene

Gene Ontology (GO) - Molecular Function for SLC35A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IEA --
genes like me logo Genes that share ontologies with SLC35A5: view

Phenotypes for SLC35A5 Gene

GenomeRNAi human phenotypes for SLC35A5:
genes like me logo Genes that share phenotypes with SLC35A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35A5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A5 Gene

Localization for SLC35A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35A5 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35A5: view

Pathways & Interactions for SLC35A5 Gene

SuperPathways for SLC35A5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015992 proton transport IEA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35A5 Gene

Drugs & Compounds for SLC35A5 Gene

No Compound Related Data Available

Transcripts for SLC35A5 Gene

Unigene Clusters for SLC35A5 Gene

Solute carrier family 35, member A5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6:

Relevant External Links for SLC35A5 Gene

GeneLoc Exon Structure for
SLC35A5
ECgene alternative splicing isoforms for
SLC35A5

Expression for SLC35A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35A5 Gene

This gene is overexpressed in Monocytes (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35A5 Gene



Protein tissue co-expression partners for SLC35A5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35A5 Gene:

SLC35A5

SOURCE GeneReport for Unigene cluster for SLC35A5 Gene:

Hs.237480

Evidence on tissue expression from TISSUES for SLC35A5 Gene

  • Nervous system(4.4)
  • Kidney(4.3)
  • Liver(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with SLC35A5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35A5 Gene

Orthologs for SLC35A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35A5 33 34
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia SLC35A5 33 34
  • 90.53 (n)
dog
(Canis familiaris)
Mammalia SLC35A5 33 34
  • 89.47 (n)
mouse
(Mus musculus)
Mammalia Slc35a5 33 16 34
  • 86.49 (n)
rat
(Rattus norvegicus)
Mammalia Slc35a5 33
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35A5 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35A5 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35A5 33 34
  • 70.96 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35A5 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35a5 33
  • 62.61 (n)
zebrafish
(Danio rerio)
Actinopterygii slc35a5 33 34
  • 62.17 (n)
zgc66231 33
fruit fly
(Drosophila melanogaster)
Insecta CG14040 34
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35335 33
  • 27.82 (n)
rice
(Oryza sativa)
Liliopsida Os07g0573700 33
  • 47.83 (n)
Species where no ortholog for SLC35A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35A5 Gene

ENSEMBL:
Gene Tree for SLC35A5 (if available)
TreeFam:
Gene Tree for SLC35A5 (if available)

Paralogs for SLC35A5 Gene

Paralogs for SLC35A5 Gene

genes like me logo Genes that share paralogs with SLC35A5: view

Variants for SLC35A5 Gene

Sequence variations from dbSNP and Humsavar for SLC35A5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs869025247 uncertain-significance, Monoclonal B-Cell Lymphocytosis 112,570,663(+) T/G coding_sequence_variant, missense_variant
rs1000096201 -- 112,575,513(+) T/G intron_variant
rs1000101588 -- 112,569,400(+) G/T intron_variant
rs1000164128 -- 112,580,079(+) G/A intron_variant
rs1000365234 -- 112,570,430(+) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35A5 Gene

Variant ID Type Subtype PubMed ID
esv2491896 CNV deletion 19546169
nsv1151003 CNV deletion 26484159
nsv591293 CNV loss 21841781
nsv591301 CNV loss 21841781

Variation tolerance for SLC35A5 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35A5 Gene

Disorders for SLC35A5 Gene

Additional Disease Information for SLC35A5

No disorders were found for SLC35A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35A5 Gene

Publications for SLC35A5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for SLC35A5 Gene

Sources for SLC35A5 Gene

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