Aliases for SLC35A4 Gene

Aliases for SLC35A4 Gene

  • Solute Carrier Family 35 Member A4 2 3 4 5
  • Probable UDP-Sugar Transporter Protein SLC35A4 3 4
  • Solute Carrier Family 35 (UDP-Galactose Transporter), Member A4 3
  • SLC35A4 Upstream Open Reading Frame Protein 4
  • Solute Carrier Family 35, Member A4 2
  • Tumor Rejection Antigen 3
  • SLC35A4 5

External Ids for SLC35A4 Gene

Previous GeneCards Identifiers for SLC35A4 Gene

  • GC05P140528
  • GC05P139927
  • GC05P139972
  • GC05P139924
  • GC05P139944
  • GC05P135089
  • GC05P140697
  • GC05P141463
  • GC05P142382
  • GC05P142488
  • GC05P142597
  • GC05P142822
  • GC05P141525
  • GC05P141679
  • GC05P141781
  • GC05P141851
  • GC05P141943
  • GC05P142056
  • GC05P142194
  • GC05P142295

Summaries for SLC35A4 Gene

GeneCards Summary for SLC35A4 Gene

SLC35A4 (Solute Carrier Family 35 Member A4) is a Protein Coding gene. Diseases associated with SLC35A4 include Dicarboxylic Aminoaciduria and Hydranencephaly. Gene Ontology (GO) annotations related to this gene include carbohydrate:proton symporter activity. An important paralog of this gene is SLC35A2.

Additional gene information for SLC35A4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC35A4 Gene

Genomics for SLC35A4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC35A4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35A4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC35A4

Top Transcription factor binding sites by QIAGEN in the SLC35A4 gene promoter:
  • NRSF form 1
  • NRSF form 2
  • p53
  • TBP
  • TFIID

Genomic Locations for SLC35A4 Gene

Genomic Locations for SLC35A4 Gene
chr5:140,564,565-140,569,104
(GRCh38/hg38)
Size:
4,540 bases
Orientation:
Plus strand
chr5:139,944,041-139,948,688
(GRCh37/hg19)
Size:
4,648 bases
Orientation:
Plus strand

Genomic View for SLC35A4 Gene

Genes around SLC35A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A4 Gene

Proteins for SLC35A4 Gene

  • Protein details for SLC35A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G79-S35A4_HUMAN
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A4
    Protein Accession:
    Q96G79
    Secondary Accessions:
    • A8K013

    Protein attributes for SLC35A4 Gene

    Size:
    324 amino acids
    Molecular mass:
    34593 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35A4 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for SLC35A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    L0R6Q1-S35U4_HUMAN
    Recommended name:
    SLC35A4 upstream open reading frame protein
    Protein Accession:
    L0R6Q1

    Protein attributes for SLC35A4 Gene

    Size:
    103 amino acids
    Molecular mass:
    11133 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: Product of the upstream open reading frame of this bicistronic gene. This may be the major product of the gene under normal conditions.

    Alternative splice isoforms for SLC35A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35A4 Gene

Post-translational modifications for SLC35A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35A4 Gene

No data available for DME Specific Peptides for SLC35A4 Gene

Domains & Families for SLC35A4 Gene

Gene Families for SLC35A4 Gene

Protein Domains for SLC35A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35A4 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 35 member A4 (S35A4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96G79

UniProtKB/Swiss-Prot:

S35U4_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A4: view

Function for SLC35A4 Gene

Phenotypes From GWAS Catalog for SLC35A4 Gene

Gene Ontology (GO) - Molecular Function for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC35A4: view
genes like me logo Genes that share phenotypes with SLC35A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35A4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35A4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A4 Gene

Localization for SLC35A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A4 Gene

Golgi apparatus membrane. Multi-pass membrane protein.
Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35A4 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IBA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC35A4: view

Pathways & Interactions for SLC35A4 Gene

PathCards logo

SuperPathways for SLC35A4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0032056 positive regulation of translation in response to stress IDA --
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35A4 Gene

Drugs & Compounds for SLC35A4 Gene

No Compound Related Data Available

Transcripts for SLC35A4 Gene

mRNA/cDNA for SLC35A4 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC35A4

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3:

Relevant External Links for SLC35A4 Gene

GeneLoc Exon Structure for
SLC35A4

Expression for SLC35A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35A4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC35A4

SOURCE GeneReport for Unigene cluster for SLC35A4 Gene:

Hs.406840

Evidence on tissue expression from TISSUES for SLC35A4 Gene

  • Muscle(4.5)
  • Adrenal gland(4.3)
  • Nervous system(3.8)
  • Lung(3)
  • Skin(2.7)
  • Kidney(2.4)
  • Liver(2.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with SLC35A4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35A4 Gene

Orthologs for SLC35A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35A4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC35A4 30 31
  • 99.28 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC35A4 30 31
  • 89.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC35A4 30 31
  • 89.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc35a4 30
  • 87.1 (n)
Mouse
(Mus musculus)
Mammalia Slc35a4 30 17 31
  • 85.96 (n)
OneToMany
Gm5866 31
  • 83 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia SLC35A4 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 25 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SLC35A4 30
  • 64.29 (n)
Lizard
(Anolis carolinensis)
Reptilia SLC35A4 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc35a4 30
  • 57.28 (n)
Str.15202 30
Zebrafish
(Danio rerio)
Actinopterygii slc35a4 30 31
  • 55.06 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG14040 31
  • 19 (a)
OneToMany
Species where no ortholog for SLC35A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC35A4 Gene

ENSEMBL:
Gene Tree for SLC35A4 (if available)
TreeFam:
Gene Tree for SLC35A4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC35A4: view image

Paralogs for SLC35A4 Gene

Paralogs for SLC35A4 Gene

Pseudogenes.org Pseudogenes for SLC35A4 Gene

genes like me logo Genes that share paralogs with SLC35A4: view

Variants for SLC35A4 Gene

Additional dbSNP identifiers (rs#s) for SLC35A4 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC35A4 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV loss 19166990
nsv599825 CNV loss 21841781

Variation tolerance for SLC35A4 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC35A4 Gene

Disorders for SLC35A4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC35A4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dicarboxylic aminoaciduria
  • dcbxa
hydranencephaly
  • hydroanencephaly
benign chronic pemphigus
  • bcpm
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SLC35A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35A4 Gene

Publications for SLC35A4 Gene

  1. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev DE … Baranov PV (eLife 2015) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  5. An insight into the orphan nucleotide sugar transporter SLC35A4. (PMID: 28167211) Sosicka P … Olczak M (Biochimica et biophysica acta. Molecular cell research 2017) 3

Products for SLC35A4 Gene

Sources for SLC35A4 Gene