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Aliases for SLC35A4 Gene

Aliases for SLC35A4 Gene

  • Solute Carrier Family 35 Member A4 2 3 4 5
  • Solute Carrier Family 35, Member A4 2

External Ids for SLC35A4 Gene

Previous GeneCards Identifiers for SLC35A4 Gene

  • GC05P140528
  • GC05P139927
  • GC05P139972
  • GC05P139924
  • GC05P139944
  • GC05P135089
  • GC05P140697
  • GC05P141463
  • GC05P141525
  • GC05P141679
  • GC05P141781
  • GC05P141851
  • GC05P141943

Summaries for SLC35A4 Gene

GeneCards Summary for SLC35A4 Gene

SLC35A4 (Solute Carrier Family 35 Member A4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sugar:proton symporter activity. An important paralog of this gene is SLC35A2.

Additional gene information for SLC35A4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35A4 Gene

Genomics for SLC35A4 Gene

GeneHancer (GH) Regulatory Elements for SLC35A4 Gene

Promoters and enhancers for SLC35A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I140563 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 470 3.1 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YBX1 ZNF2 YY1 POLR2B SLC35A4 APBB3 MIR6831 CD14 WDR55 DND1 ENSG00000200051 ANKHD1-EIF4EBP3 ANKHD1 ENSG00000253965
GH05I140301 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.5 -261.6 -261633 2.2 PKNOX1 SMAD1 ATF1 ARNT ARID4B SIN3A YBX1 ZNF2 ZNF48 YY1 PFDN1 CYSTM1 HBEGF ENSG00000253965 SLC4A9 EIF4EBP3 SLC35A4 GC05M140174
GH05I140399 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -162.4 -162427 4.7 CLOCK ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 ANKHD1 ENSG00000249637 ANKHD1-EIF4EBP3 PURA HARS2 PCDHB18P PCDHGA6 IK APBB3 PCDHGA7
GH05I140699 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 +136.2 136231 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZMAT2 SRA1 WDR55 DND1 EIF4EBP3 SLC35A4 VTRNA1-1 GC05P142198 GC05P142218
GH05I140609 Enhancer 1.5 FANTOM5 Ensembl ENCODE 12.8 +46.4 46444 3.8 PKNOX1 ATF1 FOXA2 ARNT ZNF280A TCF12 ZNF766 CBX5 GATA2 E2F8 RPL36P11 CD14 APBB3 TMCO6 SLC35A4 IK EIF4EBP3 ANKHD1 NDUFA2 SRA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35A4 gene promoter:

Genomic Locations for SLC35A4 Gene

Genomic Locations for SLC35A4 Gene
chr5:140,564,456-140,569,104
(GRCh38/hg38)
Size:
4,649 bases
Orientation:
Plus strand
chr5:139,944,041-139,948,688
(GRCh37/hg19)

Genomic View for SLC35A4 Gene

Genes around SLC35A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A4 Gene

Proteins for SLC35A4 Gene

  • Protein details for SLC35A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    L0R6Q1-S35U4_HUMAN
    Recommended name:
    SLC35A4 upstream open reading frame protein
    Protein Accession:
    L0R6Q1

    Protein attributes for SLC35A4 Gene

    Size:
    103 amino acids
    Molecular mass:
    11133 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35A4 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for SLC35A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G79-S35A4_HUMAN
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A4
    Protein Accession:
    Q96G79
    Secondary Accessions:
    • A8K013

    Protein attributes for SLC35A4 Gene

    Size:
    324 amino acids
    Molecular mass:
    34593 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35A4 Gene

Post-translational modifications for SLC35A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35A4 Gene

No data available for DME Specific Peptides for SLC35A4 Gene

Domains & Families for SLC35A4 Gene

Gene Families for SLC35A4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G79

UniProtKB/Swiss-Prot:

S35A4_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A4: view

Function for SLC35A4 Gene

Gene Ontology (GO) - Molecular Function for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IEA --
genes like me logo Genes that share ontologies with SLC35A4: view
genes like me logo Genes that share phenotypes with SLC35A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35A4

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A4 Gene

Localization for SLC35A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A4 Gene

Membrane; Single-pass membrane protein.
Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35A4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35A4: view

Pathways & Interactions for SLC35A4 Gene

SuperPathways for SLC35A4 Gene

No Data Available

Interacting Proteins for SLC35A4 Gene

Gene Ontology (GO) - Biological Process for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015992 proton transport IEA --
GO:0032056 positive regulation of translation in response to stress IDA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35A4 Gene

Drugs & Compounds for SLC35A4 Gene

No Compound Related Data Available

Transcripts for SLC35A4 Gene

Unigene Clusters for SLC35A4 Gene

Solute carrier family 35, member A4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3:

Relevant External Links for SLC35A4 Gene

GeneLoc Exon Structure for
SLC35A4
ECgene alternative splicing isoforms for
SLC35A4

Expression for SLC35A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35A4 Gene:

SLC35A4

SOURCE GeneReport for Unigene cluster for SLC35A4 Gene:

Hs.406840

Evidence on tissue expression from TISSUES for SLC35A4 Gene

  • Muscle(4.5)
  • Adrenal gland(4.3)
  • Nervous system(3.8)
  • Lung(2.8)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with SLC35A4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35A4 Gene

Orthologs for SLC35A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35A4 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia SLC35A4 33 34
  • 89.51 (n)
cow
(Bos Taurus)
Mammalia SLC35A4 33 34
  • 89.09 (n)
rat
(Rattus norvegicus)
Mammalia Slc35a4 33
  • 87.1 (n)
mouse
(Mus musculus)
Mammalia Slc35a4 33 16 34
  • 85.96 (n)
Gm5866 34
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC35A4 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC35A4 33
  • 64.29 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35A4 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35a4 33
  • 57.28 (n)
Str.15202 33
zebrafish
(Danio rerio)
Actinopterygii slc35a4 33 34
  • 55.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14040 34
  • 19 (a)
OneToMany
Species where no ortholog for SLC35A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35A4 Gene

ENSEMBL:
Gene Tree for SLC35A4 (if available)
TreeFam:
Gene Tree for SLC35A4 (if available)

Paralogs for SLC35A4 Gene

Paralogs for SLC35A4 Gene

Pseudogenes.org Pseudogenes for SLC35A4 Gene

genes like me logo Genes that share paralogs with SLC35A4: view

Variants for SLC35A4 Gene

Sequence variations from dbSNP and Humsavar for SLC35A4 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000116414 -- 140,568,890(+) A/T 3_prime_UTR_variant
rs1000183069 -- 140,565,698(+) T/C intron_variant
rs1000786513 -- 140,564,451(+) T/C upstream_transcript_variant
rs1001071782 -- 140,564,687(+) C/T 5_prime_UTR_variant
rs1001139894 -- 140,569,531(+) AAAAAAAA/AAAA downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35A4 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV loss 19166990
nsv599825 CNV loss 21841781

Variation tolerance for SLC35A4 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35A4 Gene

Disorders for SLC35A4 Gene

Additional Disease Information for SLC35A4

No disorders were found for SLC35A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35A4 Gene

Publications for SLC35A4 Gene

  1. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev DE … Baranov PV (eLife 2015) 3 4 58
  2. An insight into the orphan nucleotide sugar transporter SLC35A4. (PMID: 28167211) Sosicka P … Olczak M (Biochimica et biophysica acta 2017) 3 58
  3. Direct detection of alternative open reading frames translation products in human significantly expands the proteome. (PMID: 23950983) Vanderperre B … Roucou X (PloS one 2013) 4 58
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for SLC35A4 Gene

Sources for SLC35A4 Gene

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