Aliases for SLC31A2 Gene
Aliases for SLC31A2 Gene
External Ids for SLC31A2 Gene
- HGNC: 11017
- Entrez Gene: 1318
- Ensembl: ENSG00000136867
- OMIM: 603088
- UniProtKB: O15432
Previous HGNC Symbols for SLC31A2 Gene
- COPT2
Previous GeneCards Identifiers for SLC31A2 Gene
- GC09P106711
- GC09P107645
- GC09P109366
- GC09P111289
- GC09P112992
- GC09P114953
- GC09P115913
- GC09P085521
Summaries for SLC31A2 Gene
GeneCards Summary for SLC31A2 Gene
SLC31A2 (Solute Carrier Family 31 Member 2) is a Protein Coding gene. Among its related pathways are Copper homeostasis. Gene Ontology (GO) annotations related to this gene include copper ion transmembrane transporter activity. An important paralog of this gene is SLC31A1.
UniProtKB/Swiss-Prot for SLC31A2 Gene
-
Involved in low-affinity copper uptake.
Additional gene information for SLC31A2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC31A2 Gene
Genomics for SLC31A2 Gene
GeneHancer (GH) Regulatory Elements for SLC31A2 Gene
Promoters and enhancers for SLC31A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SLC31A2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SLC31A2 gene promoter:
Regulatory Element Products
Genomic Locations for SLC31A2 Gene
Genomic Locations for SLC31A2 Gene
- chr9:113,150,942-113,164,142
- (GRCh38/hg38)
- Size:
- 13,201 bases
- Orientation:
- Plus strand
- chr9:115,913,222-115,926,422
- (GRCh37/hg19)
Genomic View for SLC31A2 Gene
Genes around SLC31A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q32 by Ensembl
- 9q32 by Entrez Gene
- 9q32 by HGNC
SLC31A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC31A2 Gene
Proteins for SLC31A2 Gene
-
Protein details for SLC31A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15432-COPT2_HUMAN
- Recommended name:
- Probable low affinity copper uptake protein 2
- Protein Accession:
- O15432
Protein attributes for SLC31A2 Gene
- Size:
- 143 amino acids
- Molecular mass:
- 15681 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for SLC31A2 Gene
No Post-translational modifications
Other Protein References for SLC31A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SLC31A2
- Novus Biologicals Antibodies for SLC31A2
-
Abcam antibodies for SLC31A2
- Invitrogen Antibodies for SLC31A2
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Protein Products
-
OriGene Purified Proteins for SLC31A2
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Assay Products
No data available for DME Specific Peptides for SLC31A2 Gene
Domains & Families for SLC31A2 Gene
Gene Families for SLC31A2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC31A2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC31A2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15432UniProtKB/Swiss-Prot:
COPT2_HUMAN :- Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
- Family:
-
- Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
Function for SLC31A2 Gene
Molecular function for SLC31A2 Gene
- GENATLAS Biochemistry:
- solute carrier family 31,copper uptake transport,low affinity,homolog to yeast ctr2,with an alternatively spliced form CTR2X,ubiquitously expressed
- UniProtKB/Swiss-Prot Function:
- Involved in low-affinity copper uptake.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005375 | copper ion transmembrane transporter activity | IEA | -- |
Phenotypes for SLC31A2 Gene
Animal Model Products
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-
-
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-
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-
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- genomics-online: gRNA clones - Search results for 107 available SLC31A2 gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for SLC31A2 Gene
- miRTarBase miRNAs that target SLC31A2
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Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC31A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
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-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC31A2 Gene
Localization for SLC31A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC31A2 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 3 |
| endosome | 3 |
| cytoskeleton | 2 |
| nucleus | 2 |
| lysosome | 2 |
| extracellular | 1 |
- Intermediate filaments (2)
- Nuclear speckles (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005770 | late endosome | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9207117 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0055037 | recycling endosome | IEA | -- |
Pathways & Interactions for SLC31A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Copper homeostasis | ||
Pathways by source for SLC31A2 Gene
1 BioSystems pathway for SLC31A2 Gene
Interacting Proteins for SLC31A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006825 | copper ion transport | TAS | 9207117 |
| GO:0006878 | cellular copper ion homeostasis | IEA | -- |
| GO:0035434 | copper ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC31A2 Gene
Drugs & Compounds for SLC31A2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Transporter | 202 | ||
| Carboplatin | Approved | Pharma | Transporter, substrate | Antitumor agent that forms platinum-DNA adducts., Platinum | 2141 | |
| Cisplatin | Approved | Pharma | Transporter, substrate | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 2906 |
Transcripts for SLC31A2 Gene
mRNA/cDNA for SLC31A2 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (202) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC31A2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC31A2
- genomics-online: gRNA clones - Search results for 107 available SLC31A2 gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC31A2
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- genomics-online: shRNA clones - Search results for 107 available SLC31A2 gene related products
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-
ViGene Biosciences ready-to-package AAV shRNAs for SLC31A2 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC31A2
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- VectorBuilder custom plasmid, inducible vectors for SLC31A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC31A2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC31A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||
| SP8: | - | - | - |
Expression for SLC31A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
- Kidney (Urinary System)
- Epidermis (Integumentary System)
- Hair
mRNA differential expression in normal tissues according to GTEx for SLC31A2 Gene
This gene is overexpressed in Whole Blood (x9.5) and Brain - Spinal cord (cervical c-1) (x4.3).
NURSA nuclear receptor signaling pathways regulating expression of SLC31A2 Gene:
SLC31A2SOURCE GeneReport for Unigene cluster for SLC31A2 Gene:
Hs.24030mRNA Expression by UniProt/SwissProt for SLC31A2 Gene:
O15432-COPT2_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for SLC31A2 Gene
- Nervous system(4)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for SLC31A2
-
OriGene qPCR primer pairs for SLC31A2
- genomics-online: primer clones - Search results for 107 available SLC31A2 gene related products
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No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC31A2 Gene
Orthologs for SLC31A2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC31A2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC31A2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC31A2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc31a2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc31a2 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC31A2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SLC31A2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC31A2 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc31a2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | slc31a2 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ctr1B 34 |
|
ManyToMany | |
| Ctr1A 34 |
|
ManyToMany | |||
| Ctr1C 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for SLC31A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SLC31A2 Gene
Variants for SLC31A2 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000118432 | -- | 113,162,019(+) | G/C | intron_variant | |
| rs1000317304 | -- | 113,160,294(+) | T/C | intron_variant | |
| rs1000372828 | -- | 113,153,740(+) | T/C | 5_prime_UTR_variant, intron_variant | |
| rs1000462913 | -- | 113,149,277(+) | G/A | upstream_transcript_variant | |
| rs1000974677 | -- | 113,155,067(+) | T/G | 5_prime_UTR_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759710 | CNV | gain | 17122850 |
| esv3621538 | CNV | loss | 21293372 |
| esv3891716 | CNV | loss | 25118596 |
| esv3891717 | CNV | loss | 25118596 |
| nsv1051654 | CNV | gain | 25217958 |
| nsv466507 | CNV | loss | 19166990 |
| nsv615212 | CNV | gain | 21841781 |
| nsv615213 | CNV | loss | 21841781 |
| nsv831691 | CNV | loss | 17160897 |
| nsv8563 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.30;
6.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC31A2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC31A2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC31A2 Gene
Disorders for SLC31A2 Gene
Additional Disease Information for SLC31A2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SLC31A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC31A2 Gene
Publications for SLC31A2 Gene
- hCTR1: a human gene for copper uptake identified by complementation in yeast. (PMID: 9207117) Zhou B … Gitschier J (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
- Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin. (PMID: 19509135) Blair BG … Howell SB (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 22 25 58
- Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. (PMID: 17944601) Bertinato J … L'abbé MR (The Biochemical journal 2008) 3 22 58
- Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake. (PMID: 17617060) van den Berghe PV … Klomp LW (The Biochemical journal 2007) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for SLC31A2 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 23 available SLC31A2 Antibodies ranked by validation data
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Sources for SLC31A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
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