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SLC31A2 (Solute Carrier Family 31 Member 2) is a Protein Coding gene. Diseases associated with SLC31A2 include Cone-Rod Dystrophy 2 and Noonan Syndrome 3. Among its related pathways are Copper homeostasis. Gene Ontology (GO) annotations related to this gene include copper ion transmembrane transporter activity. An important paralog of this gene is SLC31A1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005375 | copper ion transmembrane transporter activity | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005770 | late endosome | IEA | -- |
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0005887 | integral component of plasma membrane | TAS | 9207117 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Copper homeostasis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006825 | copper ion transport | TAS | 9207117 |
GO:0006878 | cellular copper ion homeostasis | IEA,IBA | 21873635 |
GO:0035434 | copper ion transmembrane transport | IEA | -- |
GO:1902311 | regulation of copper ion transmembrane transport | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Transporter | 249 | ||
Carboplatin | Approved | Pharma | Transporter, substrate | Antitumor agent that forms platinum-DNA adducts., Platinum | 2588 | |
Cisplatin | Approved | Pharma | Transporter, substrate | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||
SP8: | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC31A2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC31A2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC31A2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc31a2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Slc31a2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC31A2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC31A2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SLC31A2 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc31a2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | slc31a2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Ctr1B 31 |
|
ManyToMany | |
Ctr1C 31 |
|
ManyToMany | |||
Ctr1A 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759710 | CNV | gain | 17122850 |
esv3621538 | CNV | loss | 21293372 |
esv3891716 | CNV | loss | 25118596 |
esv3891717 | CNV | loss | 25118596 |
nsv1051654 | CNV | gain | 25217958 |
nsv466507 | CNV | loss | 19166990 |
nsv615212 | CNV | gain | 21841781 |
nsv615213 | CNV | loss | 21841781 |
nsv831691 | CNV | loss | 17160897 |
nsv8563 | CNV | gain | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cone-rod dystrophy 2 |
|
|
noonan syndrome 3 |
|
|