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This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells.... See more...
Aliases for SLC30A5 Gene
Aliases for SLC30A5 Gene
External Ids for SLC30A5 Gene
- HGNC: 19089
- NCBI Entrez Gene: 64924
- Ensembl: ENSG00000145740
- OMIM®: 607819
- UniProtKB/Swiss-Prot: Q8TAD4
Previous GeneCards Identifiers for SLC30A5 Gene
- GC05P068541
- GC05P069955
- GC05P068360
- GC05P068405
- GC05P068369
- GC05P068425
- GC05P068389
- GC05P065345
Summaries for SLC30A5 Gene
-
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]
GeneCards Summary for SLC30A5 Gene
SLC30A5 (Solute Carrier Family 30 Member 5) is a Protein Coding gene. Diseases associated with SLC30A5 include Hypertrophic Cardiomyopathy and Left Ventricular Noncompaction. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A7.
UniProtKB/Swiss-Prot Summary for SLC30A5 Gene
-
Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
Additional gene information for SLC30A5 Gene
- HGNC (19089)
- NCBI Entrez Gene (64924)
- Ensembl (ENSG00000145740)
- OMIM® (607819)
- UniProtKB/Swiss-Prot (Q8TAD4)
- Open Targets Platform(ENSG00000145740)
- Alliance of Genome Resources
- Search for SLC30A5 at DataMed
- Search for SLC30A5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC30A5 Gene
Genomics for SLC30A5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC30A5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC30A5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC30A5
- Top Transcription factor binding sites by QIAGEN in the SLC30A5 gene promoter:
-
- FOXJ2
- FOXJ2 (long isoform)
- HTF
- ITF-2
- Tal-1beta
Genomic Locations for SLC30A5 Gene
Latest Assembly
- chr5:69,093,949-69,131,069
- (GRCh38/hg38)
- Size:
- 37,121 bases
- Orientation:
- Plus strand
Previous Assembly
- chr5:68,389,841-68,426,896
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 37,056 bases
- Orientation:
- Plus strand
Genomic View for SLC30A5 Gene
Genes around SLC30A5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q13.1-q13.2 by HGNC
- 5q13.1-q13.2 by Entrez Gene
- 5q13.1 by Ensembl
SLC30A5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC30A5 Gene
Proteins for SLC30A5 Gene
-
Protein details for SLC30A5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TAD4-ZNT5_HUMAN
- Recommended name:
- Zinc transporter 5
- Protein Accession:
- Q8TAD4
- B7ZM89
- Q6UX54
- Q7L4M4
- Q8TDG3
- Q9BVY8
- Q9H9H1
Protein attributes for SLC30A5 Gene
- Size:
- 765 amino acids
- Molecular mass:
- 84047 Da
- Quaternary structure:
-
- Heterooligomer. Interacts with ZNT6.
- SequenceCaution:
-
- Sequence=BAB14258.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP.
Protein Expression for SLC30A5 Gene
Post-translational modifications for SLC30A5 Gene
Other Protein References for SLC30A5 Gene
Antibodies for research
- Novus Biologicals Antibodies for SLC30A5
- Invitrogen Antibodies for SLC30A5 (AFLGC-SLC30A5)
-
Biorbyt antibodies for SLC30A5
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC30A5
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC30A5
- Origene Custom Protein Services for SLC30A5
- Novus Biologicals proteins for SLC30A5
-
Abcam proteins for SLC30A5
Assay products for research
- antibodies-online: Show 6 available SLC30A5 Elisa Kits ranked by validation data
- Compare Top SLC30A5 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SLC30A5 Gene
Domains & Families for SLC30A5 Gene
Gene Families for SLC30A5 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for SLC30A5 Gene
- InterPro:
- Blocks:
-
- Cation efflux protein
Suggested Antigen Peptide Sequences for SLC30A5 Gene
- GenScript: Design optimal peptide antigens:
-
- ZnT-like transporter 1 (ZNT5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TAD4UniProtKB/Swiss-Prot:
ZNT5_HUMAN :- Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
- Family:
-
- Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Function for SLC30A5 Gene
Molecular function for SLC30A5 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by ZNF658 in response to zinc.
Phenotypes From GWAS Catalog for SLC30A5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005385 | zinc ion transmembrane transporter activity | TAS | -- |
| GO:0008270 | zinc ion binding | NAS | 11937503 |
| GO:0008324 | cation transmembrane transporter activity | IEA | -- |
Phenotypes for SLC30A5 Gene
- MGI mutant phenotypes for SLC30A5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC30A5:
Animal Models for SLC30A5 Gene
- MGI Knock Outs for SLC30A5:
-
- Slc30a5 Slc30a5<tm1Ynak>
Animal Models for research
-
Taconic Biosciences Mouse Models for SLC30A5
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC30A5 - Starting at $85 >
- * SLC30A5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC30A5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC30A5
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC30A5
miRNA for SLC30A5 Gene
- miRTarBase miRNAs that target SLC30A5
-
- mmu-miR-190a-5p (MIRT013578)
- hsa-miR-361-5p (MIRT044053)
- hsa-miR-218-5p (MIRT439610)
- hsa-miR-6807-5p (MIRT521021)
- hsa-miR-1273e (MIRT521022)
- hsa-miR-582-5p (MIRT521023)
- hsa-miR-101-3p (MIRT521024)
- hsa-miR-7847-3p (MIRT521025)
- hsa-miR-6880-5p (MIRT521026)
- hsa-miR-6851-5p (MIRT521027)
- hsa-miR-3689d (MIRT521028)
- hsa-miR-655-5p (MIRT521029)
- hsa-miR-6134 (MIRT521030)
- hsa-miR-6840-3p (MIRT521031)
- hsa-miR-4459 (MIRT521032)
- hsa-miR-665 (MIRT521033)
- hsa-miR-3674 (MIRT539945)
- hsa-miR-1178-3p (MIRT539946)
- hsa-miR-6832-5p (MIRT539947)
- hsa-miR-4732-5p (MIRT539948)
- hsa-miR-3934-3p (MIRT539949)
- hsa-miR-31-3p (MIRT539950)
- hsa-miR-1273f (MIRT539951)
- hsa-miR-4781-3p (MIRT539952)
- hsa-miR-4279 (MIRT632407)
- hsa-miR-377-3p (MIRT632408)
- hsa-miR-6778-3p (MIRT632409)
- hsa-miR-4772-3p (MIRT632410)
- hsa-miR-1976 (MIRT632411)
- hsa-miR-3653-5p (MIRT632412)
- hsa-miR-1281 (MIRT632413)
- hsa-miR-6747-3p (MIRT632414)
- hsa-miR-6727-3p (MIRT632415)
- hsa-miR-4722-3p (MIRT632416)
- hsa-miR-4485-5p (MIRT632417)
- hsa-miR-4532 (MIRT632418)
- hsa-miR-1247-3p (MIRT632419)
- hsa-miR-1228-3p (MIRT632420)
- hsa-miR-6890-3p (MIRT666284)
- hsa-miR-4735-3p (MIRT699386)
- hsa-miR-3907 (MIRT699387)
- hsa-miR-503-3p (MIRT699388)
- hsa-miR-7158-5p (MIRT699389)
- hsa-miR-7853-5p (MIRT699390)
- hsa-miR-105-5p (MIRT699391)
- hsa-miR-135a-3p (MIRT699392)
- hsa-miR-6755-5p (MIRT699393)
- hsa-miR-6841-5p (MIRT699394)
- hsa-miR-33a-3p (MIRT699395)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC30A5
- Browse OriGene Inhibitory RNA Products For SLC30A5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC30A5
Clone products for research
- Applied Biological Materials (abm): Clones for SLC30A5 - Starting at $45 >
- * SLC30A5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210522
- MR210522
- MR210522L3
- MR210522L4
- RC214171
- RC214171L3
- RC214171L4
- RC224857
- RC224857L1
- RC224857L2
- RC224857L3
- RC224857L4
- RC233239
- RG214171
- RG224857
- RG233239
- RR202819
- RR202819L3
- RR202819L4
- MR210522L3V
- MR210522L4V
- RC214171L3V
- RC214171L4V
- RC224857L1V
- RC224857L2V
- RC224857L3V
- RC224857L4V
- RR202819L3V
- RR202819L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC30A5
- Addgene plasmids for SLC30A5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC30A5
Cell Lines for research
-
Horizon Cell Lines for SLC30A5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC30A5 Gene
Localization for SLC30A5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC30A5 Gene
- Golgi apparatus, trans-Golgi network membrane. Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 5 |
| nucleus | 4 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005794 | Golgi apparatus | IBA,IDA | 17349999 |
| GO:0005887 | integral component of plasma membrane | TAS | 11937503 |
| GO:0016020 | membrane | IEA,IDA | 11904301 |
Pathways & Interactions for SLC30A5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metal ion SLC transporters |
.38
|
|
| 2 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 3 | Peptide hormone metabolism | ||
| 4 | Metabolism of proteins | ||
Pathways by source for SLC30A5 Gene
1 BioSystems pathway for SLC30A5 Gene
9 Reactome pathways for SLC30A5 Gene
Interacting Proteins for SLC30A5 Gene
GPS-Prot Interaction Network for SLC30A5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006812 | cation transport | IEA | -- |
| GO:0006824 | cobalt ion transport | IDA | 11937503 |
| GO:0006829 | zinc ion transport | IEA,IDA | 11937503 |
| GO:0006882 | cellular zinc ion homeostasis | IDA | 11937503 |
No data available for SIGNOR curated interactions for SLC30A5 Gene
Drugs & Compounds for SLC30A5 Gene
Transcripts for SLC30A5 Gene
mRNA/cDNA for SLC30A5 Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380860 1317 nts (view in UCSC)
- ENST00000396591 3992 nts (view in UCSC)
- ENST00000502979 681 nts (view in UCSC)
- ENST00000504103 382 nts (view in UCSC)
- ENST00000507354 2310 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC30A5 - Starting at $85 >
- * SLC30A5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC30A5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC30A5
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC30A5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC30A5
- Browse OriGene Inhibitory RNA Products For SLC30A5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC30A5
Clone products for research
- Applied Biological Materials (abm): Clones for SLC30A5 - Starting at $45 >
- * SLC30A5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210522
- MR210522
- MR210522L3
- MR210522L4
- RC214171
- RC214171L3
- RC214171L4
- RC224857
- RC224857L1
- RC224857L2
- RC224857L3
- RC224857L4
- RC233239
- RG214171
- RG224857
- RG233239
- RR202819
- RR202819L3
- RR202819L4
- MR210522L3V
- MR210522L4V
- RC214171L3V
- RC214171L4V
- RC224857L1V
- RC224857L2V
- RC224857L3V
- RC224857L4V
- RR202819L3V
- RR202819L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC30A5
- Addgene plasmids for SLC30A5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC30A5
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c | · | 18d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | |||||||||||||||
| SP3: | - | - | |||||||||||||
| SP4: | |||||||||||||||
| SP5: | - | - | - | ||||||||||||
| SP6: | |||||||||||||||
| SP7: | |||||||||||||||
| SP8: | |||||||||||||||
| SP9: | |||||||||||||||
| SP10: | - | - | |||||||||||||
| SP11: | |||||||||||||||
| SP12: | - |
Relevant External Links for SLC30A5 Gene
- GeneLoc Exon Structure for
- SLC30A5
Expression for SLC30A5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Heart (Cardiovascular System)
This gene is overexpressed in Nasal epithelium (56.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC30A5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC30A5
SOURCE GeneReport for Unigene cluster for SLC30A5 Gene:
Hs.631975mRNA Expression by UniProt/SwissProt for SLC30A5 Gene:
Q8TAD4-ZNT5_HUMAN
Tissue specificity:
Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.
Evidence on tissue expression from TISSUES for SLC30A5 Gene
- Nervous system(4.5)
- Intestine(4.5)
- Heart(4.4)
- Pancreas(2.2)
- Kidney(2.1)
- Skin(2.1)
- Liver(2)
Primer products for research
-
OriGene qPCR primer pairs for SLC30A5
-
OriGene qPCR primer pairs and template standards for SLC30A5
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC30A5 Gene
Orthologs for SLC30A5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC30A5 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC30A5 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC30A5 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Slc30a5 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc30a5 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC30A5 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC30A5 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC30A5 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc30a5 29 |
|
||
| Str.15099 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33119 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | slc30a5 29 30 |
|
OneToOne | |
| wufi03d07 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13931 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y105E8A.3 29 |
|
||
| Y105E8A.3 30 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MSC2 30 |
|
OneToMany |
- Species where no ortholog for SLC30A5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLC30A5 Gene
- ENSEMBL:
- Gene Tree for SLC30A5 (if available)
- TreeFam:
- Gene Tree for SLC30A5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC30A5: view image
- Alliance of Genome Resources:
- Additional Orthologs for SLC30A5
Paralogs for SLC30A5 Gene
Paralogs for SLC30A5 Gene
(1) SIMAP similar genes for SLC30A5 Gene using alignment to 4 proteins:
- ZNT5_HUMAN
- D6REM2_HUMAN
- H0Y957_HUMAN
- H0YAH4_HUMAN
Pseudogenes.org Pseudogenes for SLC30A5 Gene
Variants for SLC30A5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC30A5 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 976212 | Uncertain Significance: Cardiomyopathy; Hypertrophic cardiomyopathy; Concentric hypertrophic cardiomyopathy; Hydrops fetalis; Severe hydrops fetalis; Noncompaction cardiomyopathy | 69,115,971(+) |
GTTATC/G NM_022902.5(SLC30A5):c.832_836del (p.Ile278fs) |
FRAMESHIFT | |
| 988899 | Likely Pathogenic: Hypertrophic cardiomyopathy; Concentric hypertrophic cardiomyopathy; Hydrops fetalis; Severe hydrops fetalis; Noncompaction cardiomyopathy | 69,123,406(+) |
TAC/T NM_022902.5(SLC30A5):c.1981_1982del (p.His661fs) |
FRAMESHIFT | |
| rs28450427 | Benign: not provided | 69,103,062(+) |
G/T NM_022902.5(SLC30A5):c.207G>T (p.Gly69=) |
SYNONYMOUS | |
| rs28451541 | Benign: not provided | 69,100,936(+) |
G/A NM_022902.5(SLC30A5):c.206+7G>A |
INTRON | |
| rs397840868 | Benign: not provided | 69,100,937(+) |
T/TG NM_022902.5(SLC30A5):c.206+17dup |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5694n100 | CNV | gain | 25217958 |
| nsv1137005 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.60;
45.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC30A5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A5 Gene
Disorders for SLC30A5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypertrophic cardiomyopathy |
|
|
| left ventricular noncompaction |
|
|
| acrodermatitis enteropathica, zinc-deficiency type |
|
|
| autoimmune lymphoproliferative syndrome |
|
|
Search SLC30A5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC30A5
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC30A5 Gene
Publications for SLC30A5 Gene
- Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. (PMID: 11904301) Kambe T … Nagao M (The Journal of biological chemistry 2002) 2 3 4 22
- A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. (PMID: 11937503) Cragg RA … Ford D (The Journal of biological chemistry 2002) 2 3 4
- Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X … Bell DA (PloS one 2010) 3 40
- Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 40
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for SLC30A5 Gene
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- Taconic Biosciences Mouse Models for SLC30A5
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- Humanized Mice
- Invitrogen Antibodies for SLC30A5 (AFLGC-SLC30A5)
- VectorBuilder Custom and pre-made DNA vectors for SLC30A5 (ie. gene expression, shRNA knockdown, CRISPR)
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- Addgene plasmids for SLC30A5
- antibodies-online: Show 13 available SLC30A5 Antibodies ranked by validation data
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- antibodies-online: Show 5 available SLC30A5 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for SLC30A5
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- Horizon Cell Lines for SLC30A5
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- Biorbyt antibodies for SLC30A5
Sources for SLC30A5 Gene
- (1) GeneCards
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