Aliases for SLC30A1 Gene

Aliases for SLC30A1 Gene

  • Solute Carrier Family 30 Member 1 2 3 4 5
  • Solute Carrier Family 30 (Zinc Transporter), Member 1 2 3
  • Zinc Transporter 1 3 4
  • ZnT-1 3 4
  • ZNT1 3 4
  • ZRC1 3

External Ids for SLC30A1 Gene

Previous HGNC Symbols for SLC30A1 Gene

  • ZNT1

Previous GeneCards Identifiers for SLC30A1 Gene

  • GC01M210481
  • GC01M207611
  • GC01M208387
  • GC01M208828
  • GC01M208137
  • GC01M209811
  • GC01M211744
  • GC01M182425

Summaries for SLC30A1 Gene

GeneCards Summary for SLC30A1 Gene

SLC30A1 (Solute Carrier Family 30 Member 1) is a Protein Coding gene. Diseases associated with SLC30A1 include Epidermodysplasia Verruciformis 1 and Acrodermatitis Enteropathica, Zinc-Deficiency Type. Among its related pathways are Mineral absorption and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include cation transmembrane transporter activity and calcium channel inhibitor activity. An important paralog of this gene is SLC30A10.

UniProtKB/Swiss-Prot Summary for SLC30A1 Gene

Gene Wiki entry for SLC30A1 Gene

Additional gene information for SLC30A1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC30A1 Gene

Genomics for SLC30A1 Gene

GeneHancer (GH) Regulatory Elements for SLC30A1 Gene

Promoters and enhancers for SLC30A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC30A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC30A1

Top Transcription factor binding sites by QIAGEN in the SLC30A1 gene promoter:
  • AREB6
  • CUTL1
  • Egr-3
  • FOXD3
  • FOXL1
  • Pax-3
  • Pax-5
  • Sox5
  • Sox9

Genomic Locations for SLC30A1 Gene

Genomic Locations for SLC30A1 Gene
chr1:211,571,568-211,579,161
(GRCh38/hg38)
Size:
7,594 bases
Orientation:
Minus strand
chr1:211,744,910-211,752,099
(GRCh37/hg19)
Size:
7,190 bases
Orientation:
Minus strand

Genomic View for SLC30A1 Gene

Genes around SLC30A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A1 Gene

Proteins for SLC30A1 Gene

  • Protein details for SLC30A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M5-ZNT1_HUMAN
    Recommended name:
    Zinc transporter 1
    Protein Accession:
    Q9Y6M5
    Secondary Accessions:
    • Q0VAK9
    • Q9BZF6

    Protein attributes for SLC30A1 Gene

    Size:
    507 amino acids
    Molecular mass:
    55300 Da
    Quaternary structure:
    • Multimer.

neXtProt entry for SLC30A1 Gene

Post-translational modifications for SLC30A1 Gene

  • Glycosylation at Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC30A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC30A1 Gene

Domains & Families for SLC30A1 Gene

Gene Families for SLC30A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC30A1 Gene

Blocks:
  • Cation efflux protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC30A1 Gene

GenScript: Design optimal peptide antigens:
  • Putative zinc transporter 1 (Q96KD7_HUMAN)
  • Solute carrier family 30 member 1 (ZNT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6M5

UniProtKB/Swiss-Prot:

ZNT1_HUMAN :
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A1: view

Function for SLC30A1 Gene

Molecular function for SLC30A1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in zinc transport out of the cell.

Phenotypes From GWAS Catalog for SLC30A1 Gene

Gene Ontology (GO) - Molecular Function for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IEA,TAS --
GO:0005515 protein binding IPI 18158319
GO:0008324 cation transmembrane transporter activity IEA --
GO:0019855 calcium channel inhibitor activity ISS,IEA --
genes like me logo Genes that share ontologies with SLC30A1: view
genes like me logo Genes that share phenotypes with SLC30A1: view

Animal Models for SLC30A1 Gene

MGI Knock Outs for SLC30A1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC30A1 Gene

Localization for SLC30A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC30A1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
extracellular 2
mitochondrion 2
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA 18158319
GO:0005783 endoplasmic reticulum IDA,IBA 18158319
GO:0005794 Golgi apparatus IDA,IBA 18158319
GO:0005886 plasma membrane TAS,IDA --
genes like me logo Genes that share ontologies with SLC30A1: view

Pathways & Interactions for SLC30A1 Gene

genes like me logo Genes that share pathways with SLC30A1: view

Gene Ontology (GO) - Biological Process for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006829 zinc ion transport ISS --
GO:0006874 cellular calcium ion homeostasis ISS,IEA --
genes like me logo Genes that share ontologies with SLC30A1: view

No data available for SIGNOR curated interactions for SLC30A1 Gene

Drugs & Compounds for SLC30A1 Gene

(3) Drugs for SLC30A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC30A1: view

Transcripts for SLC30A1 Gene

mRNA/cDNA for SLC30A1 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A1 Gene

No ASD Table

Relevant External Links for SLC30A1 Gene

GeneLoc Exon Structure for
SLC30A1

Expression for SLC30A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC30A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A1 Gene

This gene is overexpressed in Liver (x6.0).

Protein differential expression in normal tissues from HIPED for SLC30A1 Gene

This gene is overexpressed in Liver (15.7), Placenta (9.9), Adrenal (7.2), Fetal Liver (6.5), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC30A1 Gene



Protein tissue co-expression partners for SLC30A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC30A1

SOURCE GeneReport for Unigene cluster for SLC30A1 Gene:

Hs.519469

Evidence on tissue expression from TISSUES for SLC30A1 Gene

  • Liver(2.8)
  • Intestine(2.3)
  • Nervous system(2.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with SLC30A1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC30A1 Gene

Orthologs for SLC30A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A1 31 30
  • 99.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A1 31 30
  • 93.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC30A1 31 30
  • 92.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a1 30
  • 83.9 (n)
mouse
(Mus musculus)
Mammalia Slc30a1 17 31 30
  • 83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A1 31
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC30A1 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A1 31 30
  • 68.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A1 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a1 30
  • 64.1 (n)
Str.18707 30
African clawed frog
(Xenopus laevis)
Amphibia slc30a1-prov 30
zebrafish
(Danio rerio)
Actinopterygii slc30a1a 31 30
  • 62.72 (n)
OneToMany
slc30a1b 31
  • 54 (a)
OneToMany
zgc77589 30
fruit fly
(Drosophila melanogaster)
Insecta ZnT63C 31 30
  • 52.79 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005918 30
  • 52.23 (n)
worm
(Caenorhabditis elegans)
Secernentea cdf-1 31
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR129C 30
  • 50.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZRC1 31 30
  • 48.35 (n)
ManyToMany
COT1 31
  • 30 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08723g 30
  • 47.28 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03145 30
  • 49.08 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes zhf1 30
  • 48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10885 31
  • 38 (a)
OneToOne
Species where no ortholog for SLC30A1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A1 Gene

ENSEMBL:
Gene Tree for SLC30A1 (if available)
TreeFam:
Gene Tree for SLC30A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC30A1: view image

Paralogs for SLC30A1 Gene

(1) SIMAP similar genes for SLC30A1 Gene using alignment to 2 proteins:

  • ZNT1_HUMAN
  • Q96KD7_HUMAN
genes like me logo Genes that share paralogs with SLC30A1: view

Variants for SLC30A1 Gene

Additional dbSNP identifiers (rs#s) for SLC30A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC30A1 Gene

Variant ID Type Subtype PubMed ID
dgv801n54 CNV loss 21841781
dgv802n54 CNV loss 21841781
dgv803n54 CNV loss 21841781
esv27192 CNV loss 19812545
nsv549125 CNV gain 21841781
nsv549129 CNV gain 21841781
nsv549137 CNV loss 21841781
nsv826542 CNV gain 20364138
nsv832514 CNV loss 17160897

Variation tolerance for SLC30A1 Gene

Residual Variation Intolerance Score: 8.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC30A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC30A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC30A1 Gene

Disorders for SLC30A1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC30A1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epidermodysplasia verruciformis 1
  • epidermodysplasia verruciformis, susceptibility to, 1
acrodermatitis enteropathica, zinc-deficiency type
  • aez
myasthenic syndrome, congenital, 5
  • cms5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC30A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC30A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC30A1 Gene

Publications for SLC30A1 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41 54
  2. The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected]. (PMID: 20201890) Beharier O … Moran A (Annals of the New York Academy of Sciences 2010) 3 23 54
  3. Regulation of metallothioneins and ZnT-1 transporter expression in human hepatoma cells HepG2 exposed to zinc and cadmium. (PMID: 19900532) Urani C … Gribaldo L (Toxicology in vitro : an international journal published in association with BIBRA 2010) 3 23 54
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 41 54
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41 54

Products for SLC30A1 Gene

Sources for SLC30A1 Gene