Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, J... See more...
Aliases for SLC2A9 Gene
Aliases for SLC2A9 Gene
External Ids for SLC2A9 Gene
- HGNC: 13446
- Entrez Gene: 56606
- Ensembl: ENSG00000109667
- OMIM: 606142
- UniProtKB: Q9NRM0
Previous GeneCards Identifiers for SLC2A9 Gene
- GC04M009497
- GC04M009778
- GC04M009578
- GC04M009504
- GC04M009827
- GC04M009162
Summaries for SLC2A9 Gene
-
This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC2A9 Gene
SLC2A9 (Solute Carrier Family 2 Member 9) is a Protein Coding gene. Diseases associated with SLC2A9 include Hypouricemia, Renal, 2 and Hypouricemia, Renal, 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A5.
UniProtKB/Swiss-Prot Summary for SLC2A9 Gene
-
Urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:28083649). Does not transport glucose, fructose or galactose (PubMed:28083649).
Additional gene information for SLC2A9 Gene
- HGNC(13446)
- Entrez Gene(56606)
- Ensembl(ENSG00000109667)
- OMIM(606142)
- UniProtKB(Q9NRM0)
- Open Targets Platform(ENSG00000109667)
- Monarch Initiative
- Search for SLC2A9 at DataMed
- Search for SLC2A9 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A9 Gene
Genomics for SLC2A9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC2A9 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J010018 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 624.2 | +34.0 | 34037 | 5 | HNRNPL GATAD2A CTCF ZBTB33 REST TFE3 KDM1A RCOR2 POLR2A BACH1 | SLC2A9 MN298094 lnc-WDR1-8 lnc-WDR1-5 DRD5 | |
| GH04J010053 | Enhancer | 0.5 | Ensembl | 617.9 | +0.1 | 136 | 2 | CEBPA TFDP1 CEBPB SOX5 CEBPG | SLC2A9 ENSG00000250413 lnc-WDR1-3 DRD5 | |
| GH04J010040 | Promoter | 0.3 | EPDnew | 600.4 | +14.6 | 14646 | 0.1 | lnc-WDR1-3 SLC2A9 lnc-WDR1-5 DRD5 | ||
| GH04J010056 | Enhancer | 0.3 | Ensembl | 600.7 | -1.4 | -1365 | 0.2 | NR2F6 | SLC2A9 lnc-DRD5-3 WDR1 | |
| GH04J010114 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 21 | -64.6 | -64643 | 10.6 | HNRNPL CREB1 GATAD2A ZNF629 REST RFX1 LEF1 IKZF1 POLR2A RCOR2 | WDR1 piR-36726 piR-36807 piR-37257 piR-37951 piR-34673 piR-32075 piR-38341 piR-40003 piR-42319 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC2A9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC2A9
- Top Transcription factor binding sites by QIAGEN in the SLC2A9 gene promoter:
-
- Ik-3
- LUN-1
- Pax-2
- Pax-2a
- Pax-5
- Pax-6
- POU2F1
- POU2F1a
Genomic Locations for SLC2A9 Gene
Genomic Locations for SLC2A9 Gene
- chr4:9,771,125-10,054,936
- (GRCh38/hg38)
- Size:
- 283,812 bases
- Orientation:
- Minus strand
- chr4:9,772,777-10,056,560
- (GRCh37/hg19)
- Size:
- 283,784 bases
- Orientation:
- Minus strand
Genomic View for SLC2A9 Gene
Genes around SLC2A9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.1 by HGNC
- 4p16.1 by Entrez Gene
- 4p16.1 by Ensembl
SLC2A9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC2A9 Gene
Proteins for SLC2A9 Gene
-
Protein details for SLC2A9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRM0-GTR9_HUMAN
- Recommended name:
- Solute carrier family 2, facilitated glucose transporter member 9
- Protein Accession:
- Q9NRM0
- Q0VGC4
- Q4W5D1
- Q8WV30
- Q96P00
Protein attributes for SLC2A9 Gene
- Size:
- 540 amino acids
- Molecular mass:
- 58702 Da
- Quaternary structure:
- No Data Available
Protein Expression for SLC2A9 Gene
Post-translational modifications for SLC2A9 Gene
Other Protein References for SLC2A9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_006714031.1
- XP_006714032.1
- XP_011512158.1
- XP_011512159.1
- XP_011512160.1
- XP_011512161.1
- XP_011512162.1
- XP_011512163.1
- XP_011512164.1
- XP_011512166.1
- XP_011512167.1
- XP_011512168.1
- XP_011512169.1
- XP_011512170.1
- XP_016863946.1
- XP_016863947.1
- XP_016863948.1
- XP_016863949.1
- XP_024309918.1
- XP_024309919.1
- XP_024309920.1
- XP_024309921.1
- NP_001001290.1
- NP_064425.2
Antibody Products
- Novus Biologicals Antibodies for SLC2A9
-
Abcam antibodies for SLC2A9
- Invitrogen Antibodies for SLC2A9 (AFLGC-SLC2A9)
-
Boster Bio Antibodies for SLC2A9
Protein Products
-
OriGene Purified Proteins for SLC2A9
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC2A9
- Origene Custom Protein Services for SLC2A9
-
Abcam proteins for SLC2A9
No data available for DME Specific Peptides for SLC2A9 Gene
Domains & Families for SLC2A9 Gene
Gene Families for SLC2A9 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Potential drug targets
- Predicted membrane proteins
- Transporters
Protein Domains for SLC2A9 Gene
- InterPro:
- Blocks:
-
- Sugar transporter signature
- Sugar transporter superfamily
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC2A9 Gene
- GenScript: Design optimal peptide antigens:
-
- Glucose transporter type 9 (GTR9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NRM0UniProtKB/Swiss-Prot:
GTR9_HUMAN :- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
- Family:
-
- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Function for SLC2A9 Gene
Molecular function for SLC2A9 Gene
- UniProtKB/Swiss-Prot Function:
- Urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:28083649). Does not transport glucose, fructose or galactose (PubMed:28083649).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=urate(out) = urate(in); Xref=Rhea:RHEA:60368, ChEBI:CHEBI:17775; Evidence={ECO:0000269|PubMed:28083649};.
Phenotypes From GWAS Catalog for SLC2A9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005351 | carbohydrate:proton symporter activity | NAS | 10860667 |
| GO:0005355 | glucose transmembrane transporter activity | IEA | -- |
| GO:0015143 | urate transmembrane transporter activity | IDA | 18327257 |
| GO:0022857 | transmembrane transporter activity | TAS | -- |
Phenotypes for SLC2A9 Gene
- MGI mutant phenotypes for SLC2A9:
-
inferred from 3 alleles
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- digestive/alimentary phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for SLC2A9:
Animal Models for SLC2A9 Gene
- MGI Knock Outs for SLC2A9:
-
- Slc2a9 Slc2a9<tm1.2Thor>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC2A9 - Select products 50% OFF >
- * SLC2A9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC2A9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A9
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A9
miRNA for SLC2A9 Gene
- miRTarBase miRNAs that target SLC2A9
-
- hsa-miR-5691 (MIRT531729)
- hsa-miR-6805-3p (MIRT531730)
- hsa-miR-466 (MIRT531731)
- hsa-miR-6740-3p (MIRT531732)
- hsa-miR-4778-3p (MIRT531733)
- hsa-miR-4643 (MIRT531734)
- hsa-miR-4789-3p (MIRT531735)
- hsa-miR-1264 (MIRT531736)
- hsa-miR-4446-5p (MIRT637842)
- hsa-miR-3156-3p (MIRT637843)
- hsa-miR-1260b (MIRT637844)
- hsa-miR-1260a (MIRT637845)
- hsa-miR-188-3p (MIRT637846)
- hsa-miR-1224-3p (MIRT637847)
- hsa-miR-4307 (MIRT637848)
- hsa-miR-33a-3p (MIRT637849)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A9
- Browse OriGene Inhibitory RNA Products For SLC2A9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A9
Clone Products
- Applied Biological Materials (abm): Clones for SLC2A9 - Select products 50% OFF >
- * SLC2A9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206578
- MG222806
- MG222809
- MG222811
- MR206578
- MR206578L3
- MR206578L4
- MR222806
- MR222806L3
- MR222806L4
- MR222809
- MR222809L3
- MR222809L4
- MR222811
- MR222811L3
- MR222811L4
- RC202647
- RC202647L1
- RC202647L2
- RC202647L3
- RC202647L4
- RC210624
- RC210624L1
- RC210624L2
- RC210624L3
- RC210624L4
- RG202647
- RG210624
- RR216885
- MR206578L3V
- MR206578L4V
- MR222806L3V
- MR222806L4V
- MR222809L3V
- MR222809L4V
- MR222811L3V
- MR222811L4V
- RC202647L1V
- RC202647L2V
- RC202647L3V
- RC202647L4V
- RC210624L1V
- RC210624L2V
- RC210624L3V
- RC210624L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC2A9
- Addgene plasmids for SLC2A9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A9
Cell Line Products
-
Horizon Cell Lines for SLC2A9
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC2A9 Gene
Localization for SLC2A9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC2A9 Gene
- [Isoform 1]: Basolateral cell membrane. Multi-pass membrane protein.
- [Isoform 2]: Apical cell membrane. Multi-pass membrane protein. Basolateral cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 10860667 |
| GO:0016323 | basolateral plasma membrane | IEA | -- |
| GO:0016324 | apical plasma membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A9 Gene
Pathways & Interactions for SLC2A9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
.01
|
|
| 2 | Uricosurics Pathway, Pharmacodynamics | ||
| 3 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
|
| 4 | NRF2 pathway | ||
Pathways by source for SLC2A9 Gene
1 BioSystems pathway for SLC2A9 Gene
1 PharmGKB pathway for SLC2A9 Gene
1 Qiagen pathway for SLC2A9 Gene
- Antioxidant Action of Vitamin-C
Interacting Proteins for SLC2A9 Gene
GPS-Prot Interaction Network for SLC2A9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008645 | hexose transmembrane transport | TAS | -- |
| GO:0015747 | urate transport | IEA | -- |
| GO:0046415 | urate metabolic process | IMP | 18834626 |
| GO:0055085 | transmembrane transport | IEA | -- |
| GO:1902600 | proton transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC2A9 Gene
Drugs & Compounds for SLC2A9 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dextrose, unspecified form | Approved, Vet_approved | Pharma | Transporter, substrate | 0 | ||
| D-glucose | Approved, Investigational, Vet_approved | Pharma | Transporter, substrate | 0 | ||
| Fludeoxyglucose (18F) | Approved, Investigational | Pharma | Transporter, substrate | 0 | ||
| Losartan | Approved | Pharma | Antagonist, Transporter, inhibitor | 345 | ||
| Probenecid | Approved, Investigational | Pharma | Inhibitor, Inhibition, Activator, Transporter, inhibitor | 40 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for SLC2A9 Gene
mRNA/cDNA for SLC2A9 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264784 1864 nts (view in UCSC)
- ENST00000309065 1866 nts (view in UCSC)
- ENST00000481042 2175 nts (view in UCSC)
- ENST00000503280 584 nts (view in UCSC)
- ENST00000503803 644 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC2A9 - Select products 50% OFF >
- * SLC2A9 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC2A9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A9
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A9
- Browse OriGene Inhibitory RNA Products For SLC2A9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A9
Clone Products
- Applied Biological Materials (abm): Clones for SLC2A9 - Select products 50% OFF >
- * SLC2A9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206578
- MG222806
- MG222809
- MG222811
- MR206578
- MR206578L3
- MR206578L4
- MR222806
- MR222806L3
- MR222806L4
- MR222809
- MR222809L3
- MR222809L4
- MR222811
- MR222811L3
- MR222811L4
- RC202647
- RC202647L1
- RC202647L2
- RC202647L3
- RC202647L4
- RC210624
- RC210624L1
- RC210624L2
- RC210624L3
- RC210624L4
- RG202647
- RG210624
- RR216885
- MR206578L3V
- MR206578L4V
- MR222806L3V
- MR222806L4V
- MR222809L3V
- MR222809L4V
- MR222811L3V
- MR222811L4V
- RC202647L1V
- RC202647L2V
- RC202647L3V
- RC202647L4V
- RC210624L1V
- RC210624L2V
- RC210624L3V
- RC210624L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC2A9
- Addgene plasmids for SLC2A9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A9
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for SLC2A9 Gene
- GeneLoc Exon Structure for
- SLC2A9
Expression for SLC2A9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Distal Cells S-shaped Body Distal Segment
- Distal Tubule Cells Distal Tubule
- Distal Tubule
- S-shaped Body Distal Segment
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Epithelial Cells
- Distal Tubule Cells Distal Tubule
mRNA differential expression in normal tissues according to GTEx for SLC2A9 Gene
This gene is overexpressed in Kidney - Cortex (x9.4).
This gene is overexpressed in Peripheral blood mononuclear cells (20.7), Urine (18.9), Fetal Liver (13.4), and Kidney (12.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A9 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC2A9
SOURCE GeneReport for Unigene cluster for SLC2A9 Gene:
Hs.656895mRNA Expression by UniProt/SwissProt for SLC2A9 Gene:
Q9NRM0-GTR9_HUMAN
Tissue specificity:
Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level).
Evidence on tissue expression from TISSUES for SLC2A9 Gene
- Kidney(4.7)
- Liver(4.5)
- Lung(4.2)
- Urine(2.2)
- Blood(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A9 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- nervous
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- head
Thorax:
- heart
Abdomen:
- duodenum
- intestine
- kidney
- large intestine
- pancreas
- small intestine
- stomach
Pelvis:
- rectum
Primer Products
-
OriGene qPCR primer pairs for SLC2A9
-
OriGene qPCR primer pairs and template standards for SLC2A9
Gene Expression Assay Products
Orthologs for SLC2A9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC2A9 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC2A9 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC2A9 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc2a9 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc2a9 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC2A9 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC2A9 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC2A9 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC2A9 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc2a9 30 |
|
||
| Str.17199 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | slc2a15a 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | sut2 32 |
|
|
|
| sut3 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | K08F9.1 32 |
|
|
|
| Y61A9LA.1 32 |
|
|
|||
| Y37A1A.3 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for SLC2A9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLC2A9 Gene
- ENSEMBL:
- Gene Tree for SLC2A9 (if available)
- TreeFam:
- Gene Tree for SLC2A9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC2A9: view image
Paralogs for SLC2A9 Gene
Paralogs for SLC2A9 Gene
(11) SIMAP similar genes for SLC2A9 Gene using alignment to 2 proteins:
- GTR9_HUMAN
- D6REK5_HUMAN
Variants for SLC2A9 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A9 Gene
- GTR9_HUMAN-Q9NRM0
- Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 2 (UAQTL2) [MIM:612076] (PubMed:18327257). Excess serum accumulation of uric acid can lead to the development of gout (PubMed:18327257).
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC2A9 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 725274 | Benign: Renal hypouricemia 2; not provided | 10,021,307(-) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 736857 | Benign: not provided | 9,835,014(-) | G/A | INTRON_VARIANT | |
| 751878 | Likely Benign: not provided | 10,019,056(-) | G/C | SYNONYMOUS_VARIANT | |
| 829962 | Uncertain Significance: Renal hypouricemia 2 | 9,941,968(-) | C/T | SYNONYMOUS_VARIANT | |
| 830032 | Likely Pathogenic: Renal hypouricemia 2 | 9,834,957(-) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.85;
96.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC2A9 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for SLC2A9 Gene
(13) MalaCards diseases for SLC2A9 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypouricemia, renal, 2 |
|
|
| hypouricemia, renal, 1 |
|
|
| gout |
|
|
| nephrolithiasis, uric acid |
|
|
| renal artery atheroma |
|
|
Search SLC2A9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GTR9_HUMAN- Hypouricemia renal 2 (RHUC2) [MIM:612076]: A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. {ECO:0000269 PubMed:19026395, ECO:0000269 PubMed:19926891, ECO:0000269 PubMed:21810765}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SLC2A9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for SLC2A9 Gene
Publications for SLC2A9 Gene
- Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). (PMID: 10860667) Phay JE … Moley JF (Genomics 2000) 2 3 4 23
- Homozygous SLC2A9 mutations cause severe renal hypouricemia. (PMID: 19926891) Dinour D … Holtzman EJ (Journal of the American Society of Nephrology : JASN 2010) 3 4 23
- Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. (PMID: 20162745) Polasek O … Lauc G (Croatian medical journal 2010) 3 23 41
- SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. (PMID: 18327256) Döring A … Meisinger C (Nature genetics 2008) 3 4 41
- SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (PMID: 18327257) Vitart V … Wright AF (Nature genetics 2008) 3 4 41
ExternalLinks
Products for SLC2A9 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SLC2A9
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC2A9
- Origene Custom Protein Services for SLC2A9
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A9
- Browse OriGene Inhibitory RNA Products For SLC2A9
- OriGene qPCR primer pairs for SLC2A9
- OriGene qPCR primer pairs and template standards for SLC2A9
- OriGene CRISPR knockouts for SLC2A9
- MG206578
- MG222806
- MG222809
- MG222811
- MR206578
- MR206578L3
- MR206578L4
- MR222806
- MR222806L3
- MR222806L4
- MR222809
- MR222809L3
- MR222809L4
- MR222811
- MR222811L3
- MR222811L4
- RC202647
- RC202647L1
- RC202647L2
- RC202647L3
- RC202647L4
- RC210624
- RC210624L1
- RC210624L2
- RC210624L3
- RC210624L4
- RG202647
- RG210624
- RR216885
- MR206578L3V
- MR206578L4V
- MR222806L3V
- MR222806L4V
- MR222809L3V
- MR222809L4V
- MR222811L3V
- MR222811L4V
- RC202647L1V
- RC202647L2V
- RC202647L3V
- RC202647L4V
- RC210624L1V
- RC210624L2V
- RC210624L3V
- RC210624L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SLC2A9
- Sino Biological Human cDNA Clone for SLC2A9
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SLC2A9
- Novus Biologicals proteins and lysates for SLC2A9
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SLC2A9
- Abcam proteins for SLC2A9
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SLC2A9 (AFLGC-SLC2A9)
- VectorBuilder Custom and pre-made DNA vectors for SLC2A9 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SLC2A9 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SLC2A9 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SLC2A9 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SLC2A9
- Addgene plasmids for SLC2A9
- antibodies-online: Show 13 available SLC2A9 Antibodies ranked by validation data
- Compare Top SLC2A9 Antibodies
- antibodies-online: Search results for available SLC2A9 related products ranked by validation data
- antibodies-online: Search results for available SLC2A9 related products ranked by validation data
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for SLC2A9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A9
- Horizon Cell Lines for SLC2A9
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A9
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SLC2A9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A9
- Boster Bio Antibodies for SLC2A9
- Browse Boster Bio ELISA Kits
Sources for SLC2A9 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB