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This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and ca... See more...
Aliases for SLC2A8 Gene
Aliases for SLC2A8 Gene
External Ids for SLC2A8 Gene
- HGNC: 13812
- NCBI Entrez Gene: 29988
- Ensembl: ENSG00000136856
- OMIM®: 605245
- UniProtKB/Swiss-Prot: Q9NY64
Previous GeneCards Identifiers for SLC2A8 Gene
- GC09P121274
- GC09P121806
- GC09P123613
- GC09P125535
- GC09P127239
- GC09P129199
- GC09P130159
- GC09P099775
Summaries for SLC2A8 Gene
-
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for SLC2A8 Gene
SLC2A8 (Solute Carrier Family 2 Member 8) is a Protein Coding gene. Diseases associated with SLC2A8 include Endometrial Clear Cell Adenocarcinoma. Among its related pathways are Vesicle-mediated transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A6.
UniProtKB/Swiss-Prot Summary for SLC2A8 Gene
-
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
Additional gene information for SLC2A8 Gene
- HGNC (13812)
- NCBI Entrez Gene (29988)
- Ensembl (ENSG00000136856)
- OMIM® (605245)
- UniProtKB/Swiss-Prot (Q9NY64)
- Open Targets Platform(ENSG00000136856)
- Search for SLC2A8 at DataMed
- Search for SLC2A8 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A8 Gene
Genomics for SLC2A8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC2A8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC2A8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC2A8
- Top Transcription factor binding sites by QIAGEN in the SLC2A8 gene promoter:
-
- AP-1
- AREB6
- FOXD1
- HOXA5
- HTF
- MyoD
- NRSF form 1
- NRSF form 2
- RORalpha1
- RP58
Genomic Locations for SLC2A8 Gene
Latest Assembly
- chr9:127,397,138-127,408,424
- (GRCh38/hg38)
- Size:
- 11,287 bases
- Orientation:
- Plus strand
Previous Assembly
- chr9:130,159,448-130,170,177
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 10,730 bases
- Orientation:
- Plus strand
- chr9:130,159,421-130,170,703
- (GRCh37/hg19 by Ensembl)
- Size:
- 11,283 bases
- Orientation:
- Plus strand
Genomic View for SLC2A8 Gene
Genes around SLC2A8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q33.3 by HGNC
- 9q33.3 by Entrez Gene
- 9q33.3 by Ensembl
SLC2A8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC2A8 Gene
Proteins for SLC2A8 Gene
-
Protein details for SLC2A8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NY64-GTR8_HUMAN
- Recommended name:
- Solute carrier family 2, facilitated glucose transporter member 8
- Protein Accession:
- Q9NY64
- Q8WUZ9
- Q9NSC4
Protein attributes for SLC2A8 Gene
- Size:
- 477 amino acids
- Molecular mass:
- 50819 Da
- Quaternary structure:
-
- Interacts with AP2B1.
Protein Expression for SLC2A8 Gene
Post-translational modifications for SLC2A8 Gene
Other Protein References for SLC2A8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for SLC2A8
- Novus Biologicals Antibodies for SLC2A8
-
Abcam antibodies for SLC2A8
- Invitrogen Antibodies for SLC2A8 (AFLGC-SLC2A8)
-
Boster Bio Antibodies for SLC2A8
Protein products for research
-
OriGene Purified Proteins for SLC2A8
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC2A8
- Origene Custom Protein Services for SLC2A8
- Novus Biologicals proteins for SLC2A8
- antibodies-online: Show 4 available SLC2A8 Proteins ranked by validation data
- Compare Top SLC2A8 Proteins
-
Quality Products:
-
Abcam proteins for SLC2A8
Assay products for research
- antibodies-online: Show 7 available SLC2A8 Elisa Kits ranked by validation data
- Compare Top SLC2A8 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SLC2A8 Gene
Domains & Families for SLC2A8 Gene
Gene Families for SLC2A8 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC2A8 Gene
- InterPro:
- Blocks:
-
- Mammalian facilitated glucose transporter family signature
- Sugar transporter signature
- Sugar transporter superfamily
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC2A8 Gene
- GenScript: Design optimal peptide antigens:
-
- Glucose transporter type X1 (GTR8_HUMAN)
- Solute carrier family 2 (Facilitated glucose transporter), member 8 (Q5VVV4_HUMAN)
- Solute carrier family 2 (Facilitated glucose transporter), member 8 (Q5VVV7_HUMAN)
- Solute carrier family 2, (Facilitated glucose transporter) member 8, isoform CRA_d (Q8WZ05_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NY64UniProtKB/Swiss-Prot:
GTR8_HUMAN :- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
- Family:
-
- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Function for SLC2A8 Gene
Molecular function for SLC2A8 Gene
- UniProtKB/Swiss-Prot Function:
- Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence={ECO:0000250|UniProtKB:Q9JIF3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=D-fructose(out) = D-fructose(in); Xref=Rhea:RHEA:60372, ChEBI:CHEBI:37721; Evidence={ECO:0000250|UniProtKB:Q9JIF3};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-dehydroascorbate(out) = L-dehydroascorbate(in); Xref=Rhea:RHEA:60380, ChEBI:CHEBI:58539; Evidence={ECO:0000250|UniProtKB:Q9JIF3};.
- UniProtKB/Swiss-Prot Induction:
- In testis, down-regulated by estrogen.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by cytochalasin B.
Phenotypes From GWAS Catalog for SLC2A8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005353 | fructose transmembrane transporter activity | ISS | -- |
| GO:0005355 | glucose transmembrane transporter activity | ISS | -- |
| GO:0005536 | glucose binding | IEA | -- |
| GO:0022857 | transmembrane transporter activity | IEA | -- |
| GO:0033300 | dehydroascorbic acid transmembrane transporter activity | ISS | -- |
Phenotypes for SLC2A8 Gene
- MGI mutant phenotypes for SLC2A8:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for SLC2A8:
Animal Models for SLC2A8 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for SLC2A8
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC2A8 - Starting at $85 >
- * SLC2A8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC2A8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A8
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A8
miRNA for SLC2A8 Gene
- miRTarBase miRNAs that target SLC2A8
-
- hsa-miR-5089-5p (MIRT509081)
- hsa-miR-6506-5p (MIRT509082)
- hsa-miR-6807-5p (MIRT509083)
- hsa-miR-619-5p (MIRT509084)
- hsa-miR-6835-3p (MIRT509085)
- hsa-miR-548m (MIRT509086)
- hsa-miR-1587 (MIRT713562)
- hsa-miR-3620-5p (MIRT713563)
- hsa-miR-6515-5p (MIRT713564)
- hsa-miR-4741 (MIRT713565)
- hsa-miR-4675 (MIRT713566)
- hsa-miR-762 (MIRT713567)
- hsa-miR-5001-5p (MIRT713568)
- hsa-miR-4498 (MIRT713569)
- hsa-miR-4492 (MIRT713570)
- hsa-miR-6829-5p (MIRT713571)
- hsa-miR-4656 (MIRT713572)
- hsa-miR-4430 (MIRT713573)
- hsa-miR-6797-5p (MIRT713574)
- hsa-miR-3652 (MIRT713575)
- hsa-miR-1249-5p (MIRT713576)
- hsa-miR-3135b (MIRT713577)
- hsa-miR-6133 (MIRT713578)
- hsa-miR-6130 (MIRT713579)
- hsa-miR-6129 (MIRT713580)
- hsa-miR-6127 (MIRT713581)
- hsa-miR-4510 (MIRT713582)
- hsa-miR-4419a (MIRT713583)
- hsa-miR-5587-3p (MIRT713584)
- hsa-miR-6769a-3p (MIRT722146)
- hsa-miR-3943 (MIRT722147)
- hsa-miR-4323 (MIRT722148)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A8
- Browse OriGene Inhibitory RNA Products For SLC2A8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A8
Clone products for research
- Applied Biological Materials (abm): Clones for SLC2A8 - Starting at $45 >
- * SLC2A8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SLC2A8
- Addgene plasmids for SLC2A8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A8
Cell Lines for research
-
Horizon Cell Lines for SLC2A8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A8 Gene
Localization for SLC2A8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC2A8 Gene
- Cell membrane. Multi-pass membrane protein. Cytoplasmic vesicle membrane. Multi-pass membrane protein. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250 UniProtKB:Q9JJZ1}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 4 |
| extracellular | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005765 | lysosomal membrane | HDA | 17897319 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IEA | -- |
| GO:0008021 | synaptic vesicle | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SLC2A8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
.37
|
|
| 2 | Clathrin-mediated endocytosis | ||
| 3 | Vesicle-mediated transport | ||
| 4 | NRF2 pathway | ||
Pathways by source for SLC2A8 Gene
1 BioSystems pathway for SLC2A8 Gene
Interacting Proteins for SLC2A8 Gene
GPS-Prot Interaction Network for SLC2A8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0005975 | carbohydrate metabolic process | TAS | 10671487 |
| GO:0007141 | male meiosis I | IEA | -- |
| GO:0008286 | insulin receptor signaling pathway | IEA | -- |
| GO:0008643 | carbohydrate transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC2A8 Gene
Drugs & Compounds for SLC2A8 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dextrose, unspecified form | Approved, Vet_approved | Pharma | Transporter, substrate | 0 | ||
| D-glucose | Approved, Experimental, Investigational, Vet_approved | Pharma | Transporter, substrate | 0 | ||
| Fludeoxyglucose (18F) | Approved, Investigational | Pharma | Transporter, substrate | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for SLC2A8 Gene
mRNA/cDNA for SLC2A8 Gene
- 3 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000373352 914 nts (view in UCSC)
- ENST00000373360 1937 nts (view in UCSC)
- ENST00000373371 2145 nts (view in UCSC)
- ENST00000419132 506 nts (view in UCSC)
- ENST00000419917 793 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SLC2A8 - Starting at $85 >
- * SLC2A8 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SLC2A8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A8
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A8
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A8
- Browse OriGene Inhibitory RNA Products For SLC2A8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A8
Clone products for research
- Applied Biological Materials (abm): Clones for SLC2A8 - Starting at $45 >
- * SLC2A8 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SLC2A8
- Addgene plasmids for SLC2A8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A8
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for SLC2A8 Gene
- GeneLoc Exon Structure for
- SLC2A8
Expression for SLC2A8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Nasal epithelium (67.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A8 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC2A8
SOURCE GeneReport for Unigene cluster for SLC2A8 Gene:
Hs.179522mRNA Expression by UniProt/SwissProt for SLC2A8 Gene:
Q9NY64-GTR8_HUMAN
Tissue specificity:
Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.
Evidence on tissue expression from TISSUES for SLC2A8 Gene
- Skin(4.3)
- Nervous system(3.5)
- Muscle(2.2)
- Liver(2.1)
- Kidney(2.1)
- Blood(2)
Primer products for research
-
OriGene qPCR primer pairs for SLC2A8
-
OriGene qPCR primer pairs and template standards for SLC2A8
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A8 Gene
Orthologs for SLC2A8 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC2A8 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC2A8 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC2A8 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Slc2a8 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc2a8 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC2A8 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC2A8 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC2A8 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC2A8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486943 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | slc2a8 30 31 |
|
OneToOne | |
| Dr.17429 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Tret1-2 30 31 |
|
ManyToMany | |
| CG8234 32 |
|
|
|||
| CG6484 31 32 |
|
ManyToMany | |||
| CG10960 31 32 |
|
ManyToMany | |||
| sut4 31 32 |
|
ManyToMany | |||
| CG1208 31 |
|
ManyToMany | |||
| CG1213 31 32 |
|
ManyToMany | |||
| CG33281 31 |
|
ManyToMany | |||
| CG15406 31 |
|
ManyToMany | |||
| CG3285 31 |
|
ManyToMany | |||
| CG8249 31 32 |
|
ManyToMany | |||
| CG33282 31 |
|
ManyToMany | |||
| CG14606 31 |
|
ManyToMany | |||
| CG14605 31 |
|
ManyToMany | |||
| CG15408 31 32 |
|
ManyToMany | |||
| CG4797 31 32 |
|
ManyToMany | |||
| CG4607 31 |
|
ManyToMany | |||
| Glut3 31 |
|
ManyToMany | |||
| CG8837 31 |
|
ManyToMany | |||
| Tret1-1 31 |
|
ManyToMany | |||
| CG31100 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HXT10 31 |
|
ManyToMany | |
| HXT2 31 |
|
ManyToMany | |||
| HXT5 31 |
|
ManyToMany | |||
| HXT3 31 |
|
ManyToMany | |||
| HXT6 31 |
|
ManyToMany | |||
| HXT4 31 |
|
ManyToMany | |||
| HXT1 31 |
|
ManyToMany | |||
| HXT7 31 |
|
ManyToMany | |||
| GAL2 31 |
|
ManyToMany | |||
| HXT17 31 |
|
ManyToMany | |||
| HXT9 31 |
|
ManyToMany | |||
| HXT16 31 |
|
ManyToMany | |||
| HXT13 31 |
|
ManyToMany | |||
| HXT15 31 |
|
ManyToMany | |||
| HXT8 31 |
|
ManyToMany | |||
| HXT11 31 |
|
ManyToMany | |||
| STL1 31 |
|
ManyToMany | |||
| HXT14 31 |
|
ManyToMany | |||
| RGT2 31 |
|
ManyToMany | |||
| SNF3 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G75220 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os05g0579000 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.10291 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany |
- Species where no ortholog for SLC2A8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SLC2A8 Gene
- ENSEMBL:
- Gene Tree for SLC2A8 (if available)
- TreeFam:
- Gene Tree for SLC2A8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC2A8: view image
Paralogs for SLC2A8 Gene
Paralogs for SLC2A8 Gene
(4) SIMAP similar genes for SLC2A8 Gene using alignment to 10 proteins:
- GTR8_HUMAN
- H0Y7M6_HUMAN
- Q5VVV3_HUMAN
- Q5VVV4_HUMAN
- Q5VVV5_HUMAN
- Q5VVV6_HUMAN
- Q5VVV9_HUMAN
- Q5VVW0_HUMAN
- Q5VVW5_HUMAN
- Q8WZ05_HUMAN
Variants for SLC2A8 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC2A8 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs199808560 | Benign: not provided | 127,402,731(+) |
A/AC NM_014580.5(SLC2A8):c.708dup (p.Ile237fs) |
FRAMESHIFT | |
| rs34064803 | - |
p.Ile253Thr |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.72;
66.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC2A8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC2A8
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A8 Gene
Disorders for SLC2A8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| endometrial clear cell adenocarcinoma |
|
|
Search SLC2A8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC2A8
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A8 Gene
Publications for SLC2A8 Gene
- GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. (PMID: 10821868) Doege H … Joost HG (The Journal of biological chemistry 2000) 2 3 4 23
- GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. (PMID: 10671487) Ibberson M … Thorens B (The Journal of biological chemistry 2000) 2 3 4
- The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. (PMID: 11845330) Schürmann A … Joost HG (Cell and tissue research 2002) 3 23
- Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. (PMID: 29590129) Janzen C … Devaskar SU (PloS one 2018) 3
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
ExternalLinks
Products for SLC2A8 Gene
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Sources for SLC2A8 Gene
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