This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and ca... See more...

Aliases for SLC2A8 Gene

Aliases for SLC2A8 Gene

  • Solute Carrier Family 2 Member 8 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 8 2 3
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 8 3 4
  • Glucose Transporter Type X1 3 4
  • Glucose Transporter Type 8 3 4
  • GLUTX1 3 4
  • GLUT8 3 4
  • Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 8 2
  • GLUT-8 4

External Ids for SLC2A8 Gene

Previous GeneCards Identifiers for SLC2A8 Gene

  • GC09P121274
  • GC09P121806
  • GC09P123613
  • GC09P125535
  • GC09P127239
  • GC09P129199
  • GC09P130159
  • GC09P099775

Summaries for SLC2A8 Gene

Entrez Gene Summary for SLC2A8 Gene

  • This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC2A8 Gene

SLC2A8 (Solute Carrier Family 2 Member 8) is a Protein Coding gene. Among its related pathways are NRF2 pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A6.

UniProtKB/Swiss-Prot Summary for SLC2A8 Gene

  • Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.

Additional gene information for SLC2A8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A8 Gene

Genomics for SLC2A8 Gene

GeneHancer (GH) Regulatory Elements for SLC2A8 Gene

Promoters and enhancers for SLC2A8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC2A8

Top Transcription factor binding sites by QIAGEN in the SLC2A8 gene promoter:
  • AP-1
  • AREB6
  • FOXD1
  • HOXA5
  • HTF
  • MyoD
  • NRSF form 1
  • NRSF form 2
  • RORalpha1
  • RP58

Genomic Locations for SLC2A8 Gene

Genomic Locations for SLC2A8 Gene
chr9:127,397,138-127,408,424
(GRCh38/hg38)
Size:
11,287 bases
Orientation:
Plus strand
chr9:130,159,421-130,170,703
(GRCh37/hg19)
Size:
11,283 bases
Orientation:
Plus strand

Genomic View for SLC2A8 Gene

Genes around SLC2A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A8 Gene

Proteins for SLC2A8 Gene

  • Protein details for SLC2A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY64-GTR8_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 8
    Protein Accession:
    Q9NY64
    Secondary Accessions:
    • Q8WUZ9
    • Q9NSC4

    Protein attributes for SLC2A8 Gene

    Size:
    477 amino acids
    Molecular mass:
    50819 Da
    Quaternary structure:
    • Interacts with AP2B1.

neXtProt entry for SLC2A8 Gene

Post-translational modifications for SLC2A8 Gene

  • Glycosylation at Asn349
  • Ubiquitination at Lys465
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A8 Gene

Domains & Families for SLC2A8 Gene

Gene Families for SLC2A8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC2A8 Gene

Blocks:
  • Sugar transporter superfamily
  • Mammalian facilitated glucose transporter family signature
  • Sugar transporter signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC2A8 Gene

GenScript: Design optimal peptide antigens:
  • Glucose transporter type X1 (GTR8_HUMAN)
  • Solute carrier family 2 (Facilitated glucose transporter), member 8 (Q5VVV4_HUMAN)
  • Solute carrier family 2 (Facilitated glucose transporter), member 8 (Q5VVV7_HUMAN)
  • Solute carrier family 2, (Facilitated glucose transporter) member 8, isoform CRA_d (Q8WZ05_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NY64

UniProtKB/Swiss-Prot:

GTR8_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A8: view

Function for SLC2A8 Gene

Molecular function for SLC2A8 Gene

UniProtKB/Swiss-Prot Function:
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-fructose(out) = D-fructose(in); Xref=Rhea:RHEA:60372, ChEBI:CHEBI:37721; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-dehydroascorbate(out) = L-dehydroascorbate(in); Xref=Rhea:RHEA:60380, ChEBI:CHEBI:58539; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by cytochalasin B.
UniProtKB/Swiss-Prot Induction:
In testis, down-regulated by estrogen.

Phenotypes From GWAS Catalog for SLC2A8 Gene

Gene Ontology (GO) - Molecular Function for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005351 carbohydrate:proton symporter activity IBA 21873635
GO:0005353 fructose transmembrane transporter activity ISS --
GO:0005355 glucose transmembrane transporter activity ISS --
GO:0005536 glucose binding IEA --
genes like me logo Genes that share ontologies with SLC2A8: view
genes like me logo Genes that share phenotypes with SLC2A8: view

Animal Models for SLC2A8 Gene

MGI Knock Outs for SLC2A8:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A8

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A8 Gene

Localization for SLC2A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A8 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250 UniProtKB:Q9JJZ1}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A8 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
lysosome 2
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,TAS 21873635
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A8: view

Pathways & Interactions for SLC2A8 Gene

genes like me logo Genes that share pathways with SLC2A8: view

Gene Ontology (GO) - Biological Process for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0005975 carbohydrate metabolic process TAS 10671487
GO:0007141 male meiosis I IEA --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0008643 carbohydrate transport IEA --
genes like me logo Genes that share ontologies with SLC2A8: view

No data available for SIGNOR curated interactions for SLC2A8 Gene

Drugs & Compounds for SLC2A8 Gene

(3) Drugs for SLC2A8 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dextrose, unspecified form Approved, Vet_approved Pharma Transporter, substrate 0
D-glucose Approved, Investigational, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose (18F) Approved, Investigational Pharma Transporter, substrate 0

(1) Additional Compounds for SLC2A8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A8: view

Transcripts for SLC2A8 Gene

mRNA/cDNA for SLC2A8 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A8

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP8: - - - -
SP9:
SP10:

Relevant External Links for SLC2A8 Gene

GeneLoc Exon Structure for
SLC2A8

Expression for SLC2A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC2A8 Gene

Protein differential expression in normal tissues from HIPED for SLC2A8 Gene

This gene is overexpressed in Nasal epithelium (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A8 Gene



Protein tissue co-expression partners for SLC2A8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC2A8

SOURCE GeneReport for Unigene cluster for SLC2A8 Gene:

Hs.179522

mRNA Expression by UniProt/SwissProt for SLC2A8 Gene:

Q9NY64-GTR8_HUMAN
Tissue specificity: Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.

Evidence on tissue expression from TISSUES for SLC2A8 Gene

  • Skin(4.2)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with SLC2A8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A8 Gene

Orthologs for SLC2A8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A8 31 30
  • 99.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A8 31 30
  • 88.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A8 31 30
  • 88.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a8 17 31 30
  • 85.5 (n)
rat
(Rattus norvegicus)
Mammalia Slc2a8 30
  • 85.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A8 31
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A8 31
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A8 31 30
  • 60.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A8 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486943 30
  • 65.5 (n)
zebrafish
(Danio rerio)
Actinopterygii slc2a8 31 30
  • 61.35 (n)
OneToOne
Dr.17429 30
fruit fly
(Drosophila melanogaster)
Insecta Tret1-2 31 30
  • 49.09 (n)
ManyToMany
CG8234 32
  • 38 (a)
CG6484 31 32
  • 34 (a)
ManyToMany
CG10960 31 32
  • 32 (a)
ManyToMany
sut4 31 32
  • 32 (a)
ManyToMany
CG1208 31
  • 31 (a)
ManyToMany
CG1213 31 32
  • 30 (a)
ManyToMany
CG33281 31
  • 27 (a)
ManyToMany
CG15406 31
  • 26 (a)
ManyToMany
CG3285 31
  • 25 (a)
ManyToMany
CG8249 31 32
  • 24 (a)
ManyToMany
CG33282 31
  • 24 (a)
ManyToMany
CG14606 31
  • 24 (a)
ManyToMany
CG14605 31
  • 23 (a)
ManyToMany
CG15408 31 32
  • 23 (a)
ManyToMany
CG4797 31 32
  • 22 (a)
ManyToMany
CG4607 31
  • 22 (a)
ManyToMany
Glut3 31
  • 20 (a)
ManyToMany
CG8837 31
  • 19 (a)
ManyToMany
Tret1-1 31
  • 19 (a)
ManyToMany
CG31100 31
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HXT10 31
  • 24 (a)
ManyToMany
HXT2 31
  • 24 (a)
ManyToMany
HXT5 31
  • 22 (a)
ManyToMany
HXT3 31
  • 22 (a)
ManyToMany
HXT6 31
  • 22 (a)
ManyToMany
HXT4 31
  • 22 (a)
ManyToMany
HXT1 31
  • 22 (a)
ManyToMany
HXT7 31
  • 22 (a)
ManyToMany
GAL2 31
  • 21 (a)
ManyToMany
HXT17 31
  • 21 (a)
ManyToMany
HXT9 31
  • 21 (a)
ManyToMany
HXT16 31
  • 21 (a)
ManyToMany
HXT13 31
  • 21 (a)
ManyToMany
HXT15 31
  • 21 (a)
ManyToMany
HXT8 31
  • 21 (a)
ManyToMany
HXT11 31
  • 21 (a)
ManyToMany
STL1 31
  • 20 (a)
ManyToMany
HXT14 31
  • 18 (a)
ManyToMany
RGT2 31
  • 15 (a)
ManyToMany
SNF3 31
  • 13 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75220 30
  • 45.29 (n)
rice
(Oryza sativa)
Liliopsida Os05g0579000 30
  • 49.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
ManyToMany
CSA.10291 31
  • 36 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
Species where no ortholog for SLC2A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A8 Gene

ENSEMBL:
Gene Tree for SLC2A8 (if available)
TreeFam:
Gene Tree for SLC2A8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC2A8: view image

Paralogs for SLC2A8 Gene

(4) SIMAP similar genes for SLC2A8 Gene using alignment to 10 proteins:

  • GTR8_HUMAN
  • H0Y7M6_HUMAN
  • Q5VVV3_HUMAN
  • Q5VVV4_HUMAN
  • Q5VVV5_HUMAN
  • Q5VVV6_HUMAN
  • Q5VVV9_HUMAN
  • Q5VVW0_HUMAN
  • Q5VVW5_HUMAN
  • Q8WZ05_HUMAN
genes like me logo Genes that share paralogs with SLC2A8: view

Variants for SLC2A8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC2A8 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs34064803 - p.Ile253Thr

Additional dbSNP identifiers (rs#s) for SLC2A8 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC2A8 Gene

Variant ID Type Subtype PubMed ID
nsv615343 CNV loss 21841781

Variation tolerance for SLC2A8 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A8 Gene

Disorders for SLC2A8 Gene

Additional Disease Information for SLC2A8

No disorders were found for SLC2A8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A8 Gene

Publications for SLC2A8 Gene

  1. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. (PMID: 10821868) Doege H … Joost HG (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. (PMID: 10671487) Ibberson M … Thorens B (The Journal of biological chemistry 2000) 2 3 4 54
  3. The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. (PMID: 11845330) Schürmann A … Joost HG (Cell and tissue research 2002) 3 23 54
  4. Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction. (PMID: 29590129) Janzen C … Devaskar SU (PloS one 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for SLC2A8 Gene

Sources for SLC2A8 Gene