SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008] See more...

Aliases for SLC2A7 Gene

Aliases for SLC2A7 Gene

  • Solute Carrier Family 2 Member 7 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 7 2 3
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 7 3 4
  • Intestinal Facilitative Glucose Transporter 7 2 3
  • Glucose Transporter Type 7 3 4
  • GLUT-7 3 4
  • HGLUT7 3 4
  • GLUT7 3 4

External Ids for SLC2A7 Gene

Previous GeneCards Identifiers for SLC2A7 Gene

  • GC01U990466
  • GC01M008998
  • GC01M008985
  • GC01M009063
  • GC01M008213

Summaries for SLC2A7 Gene

Entrez Gene Summary for SLC2A7 Gene

  • SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC2A7 Gene

SLC2A7 (Solute Carrier Family 2 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and NRF2 pathway. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A5.

UniProtKB/Swiss-Prot Summary for SLC2A7 Gene

  • Probable sugar transporter (PubMed:28083649). Its physiological substrate is subject to discussion (PubMed:16186102, PubMed:28083649). Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637).

Gene Wiki entry for SLC2A7 Gene

Additional gene information for SLC2A7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A7 Gene

Genomics for SLC2A7 Gene

GeneHancer (GH) Regulatory Elements for SLC2A7 Gene

Promoters and enhancers for SLC2A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009021 Enhancer 0.5 ENCODE 508 +1.8 1840 6.3 GABPB1 BHLHE40 CTCF ELF3 ZNF362 YY1 ETV5 GABPA CEBPA SLC2A7 SLC2A5 piR-52079-002
GH01J009066 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 11.9 -42.1 -42073 4.4 SIN3A SP1 FOS EP300 ZIC2 RELA MEF2C MYC TRIM22 POLR2A SLC2A5 SLC2A7 RNU6-304P ENSG00000252404 lnc-SLC2A7-2
GH01J009074 Promoter/Enhancer 1.3 Ensembl ENCODE 11.9 -51.5 -51508 7.3 TCF12 SP1 EP300 ZIC2 TRIM28 RFX1 CUX1 RELA MEF2C CTBP1 SLC2A5 SLC2A7 RNU6-304P GPR157 ENSG00000252404 lnc-SLC2A7-2
GH01J008980 Enhancer 1 Ensembl ENCODE 12.9 +41.6 41583 11.2 CTCF ZNF623 REST RAD21 TRIM22 SMC3 MCM3 RBM25 ESRRA FOS CA6 SLC2A7 RNU6-304P MIR34A GPR157 MIR34AHG RF00017-037 RN7SL451P lnc-SLC2A7-1 piR-59425-001
GH01J009005 Enhancer 0.8 ENCODE 13.4 +21.1 21087 0.2 CTCF NRF1 TARDBP REST RAD21 TRIM22 SMC3 CREB3L1 SAP130 MAX piR-59425-001 SLC2A7 SLC2A5 piR-52079-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC2A7

Top Transcription factor binding sites by QIAGEN in the SLC2A7 gene promoter:
  • AP-4
  • ATF
  • E47
  • GATA-6
  • NF-1
  • NF-1/L
  • p53
  • Pax-4a
  • RP58
  • YY1

Genomic Locations for SLC2A7 Gene

Genomic Locations for SLC2A7 Gene
chr1:8,960,853-9,026,384
(GRCh38/hg38)
Size:
65,532 bases
Orientation:
Minus strand
chr1:9,063,359-9,086,404
(GRCh37/hg19)
Size:
23,046 bases
Orientation:
Minus strand

Genomic View for SLC2A7 Gene

Genes around SLC2A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A7 Gene

Proteins for SLC2A7 Gene

  • Protein details for SLC2A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PXP3-GTR7_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 7
    Protein Accession:
    Q6PXP3
    Secondary Accessions:
    • A2A333

    Protein attributes for SLC2A7 Gene

    Size:
    512 amino acids
    Molecular mass:
    55728 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SLC2A7 Gene

neXtProt entry for SLC2A7 Gene

Post-translational modifications for SLC2A7 Gene

  • Glycosylation at Asn57

Other Protein References for SLC2A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A7 Gene

Domains & Families for SLC2A7 Gene

Gene Families for SLC2A7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC2A7 Gene

Blocks:
  • Sugar transporter superfamily
  • Mammalian facilitated glucose transporter family signature
  • Sugar transporter signature
  • Fructose transporter (GLUT5) signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC2A7 Gene

GenScript: Design optimal peptide antigens:
  • Glucose transporter type 7 (GTR7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PXP3

UniProtKB/Swiss-Prot:

GTR7_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A7: view

Function for SLC2A7 Gene

Molecular function for SLC2A7 Gene

UniProtKB/Swiss-Prot Function:
Probable sugar transporter (PubMed:28083649). Its physiological substrate is subject to discussion (PubMed:16186102, PubMed:28083649). Does not transport galactose, 2-deoxy-d-glucose and xylose (PubMed:15033637).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for glucose {ECO:0000269 PubMed:15033637};

Phenotypes From GWAS Catalog for SLC2A7 Gene

Gene Ontology (GO) - Molecular Function for SLC2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005353 NOT fructose transmembrane transporter activity IDA 28083649
GO:0005355 NOT glucose transmembrane transporter activity IDA 28083649
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC2A7: view
genes like me logo Genes that share phenotypes with SLC2A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC2A7 Gene

Localization for SLC2A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A7 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for SLC2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC2A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A7 Gene

Pathways & Interactions for SLC2A7 Gene

genes like me logo Genes that share pathways with SLC2A7: view

Interacting Proteins for SLC2A7 Gene

;

Gene Ontology (GO) - Biological Process for SLC2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transmembrane transport TAS --
GO:0015755 NOT fructose transmembrane transport IEA,IDA 28083649
GO:0055085 transmembrane transport IEA --
GO:1904659 NOT glucose transmembrane transport IDA,IEA 28083649
genes like me logo Genes that share ontologies with SLC2A7: view

No data available for SIGNOR curated interactions for SLC2A7 Gene

Drugs & Compounds for SLC2A7 Gene

(3) Drugs for SLC2A7 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dextrose, unspecified form Approved, Vet_approved Pharma Transporter, substrate 0
D-glucose Approved, Investigational, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose (18F) Approved, Investigational Pharma Transporter, substrate 0
genes like me logo Genes that share compounds with SLC2A7: view

Transcripts for SLC2A7 Gene

mRNA/cDNA for SLC2A7 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A7

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A7 Gene

No ASD Table

Relevant External Links for SLC2A7 Gene

GeneLoc Exon Structure for
SLC2A7

Expression for SLC2A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC2A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC2A7 Gene

This gene is overexpressed in Testis (x15.6) and Small Intestine - Terminal Ileum (x9.2).

Protein differential expression in normal tissues from HIPED for SLC2A7 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A7 Gene



Protein tissue co-expression partners for SLC2A7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC2A7

SOURCE GeneReport for Unigene cluster for SLC2A7 Gene:

Hs.531239

mRNA Expression by UniProt/SwissProt for SLC2A7 Gene:

Q6PXP3-GTR7_HUMAN
Tissue specificity: Expressed in small intestine and colon (PubMed:15033637). Weakly expressed in testis and prostate (PubMed:15033637).
genes like me logo Genes that share expression patterns with SLC2A7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A7 Gene

Orthologs for SLC2A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC2A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A7 31 30
  • 99.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362644 30
  • 80.08 (n)
mouse
(Mus musculus)
Mammalia Slc2a7 17 31 30
  • 78.15 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC2A7 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 43 (a)
OneToMany
-- 31
  • 40 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii slc2a11a 31
  • 40 (a)
ManyToMany
slc2a15b 31
  • 39 (a)
ManyToMany
Species where no ortholog for SLC2A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A7 Gene

ENSEMBL:
Gene Tree for SLC2A7 (if available)
TreeFam:
Gene Tree for SLC2A7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC2A7: view image

Paralogs for SLC2A7 Gene

(11) SIMAP similar genes for SLC2A7 Gene using alignment to 1 proteins:

  • GTR7_HUMAN
genes like me logo Genes that share paralogs with SLC2A7: view

Variants for SLC2A7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC2A7 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12402973 - p.Arg261Gln
rs34545462 - p.Val135Ile

Additional dbSNP identifiers (rs#s) for SLC2A7 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC2A7 Gene

Variant ID Type Subtype PubMed ID
dgv15n100 CNV loss 25217958
nsv1004025 CNV gain 25217958
nsv1009004 CNV loss 25217958
nsv462616 CNV gain 19166990
nsv462727 CNV loss 19166990
nsv525092 CNV gain 19592680
nsv545345 CNV gain 21841781
nsv545346 CNV gain 21841781
nsv545347 CNV loss 21841781

Variation tolerance for SLC2A7 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A7 Gene

Disorders for SLC2A7 Gene

Additional Disease Information for SLC2A7

No disorders were found for SLC2A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A7 Gene

Publications for SLC2A7 Gene

  1. Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7). (PMID: 16186102) Manolescu A … Cheeseman CI (The Journal of biological chemistry 2005) 3 4 23 54
  2. Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. (PMID: 15033637) Li Q … Cheeseman CI (American journal of physiology. Gastrointestinal and liver physiology 2004) 3 4 23 54
  3. The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). (PMID: 11780753) Joost HG … Thorens B (Molecular membrane biology 2001) 2 3 23 54
  4. Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters. (PMID: 28083649) Ebert K … Witt H (The Journal of membrane biology 2017) 3 4 54
  5. Insight into the "odd" hexose transporters GLUT3, GLUT5, and GLUT7. (PMID: 18460594) Schürmann A (American journal of physiology. Endocrinology and metabolism 2008) 3 23 54

Products for SLC2A7 Gene

Sources for SLC2A7 Gene