The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016] See more...

Aliases for SLC2A5 Gene

Aliases for SLC2A5 Gene

  • Solute Carrier Family 2 Member 5 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter), Member 5 2 3
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 5 3 4
  • Glucose Transporter Type 5, Small Intestine 3 4
  • GLUT-5 3 4
  • GLUT5 3 4
  • Glucose Transporter-Like Protein 5 3
  • Testicular Tissue Protein Li 81 3
  • Fructose Transporter 4
  • SLC2A5 5

External Ids for SLC2A5 Gene

Previous HGNC Symbols for SLC2A5 Gene

  • GLUT5

Previous GeneCards Identifiers for SLC2A5 Gene

  • GC01M008717
  • GC01M008908
  • GC01M008772
  • GC01M009031
  • GC01M009019
  • GC01M009095
  • GC01M008246

Summaries for SLC2A5 Gene

Entrez Gene Summary for SLC2A5 Gene

  • The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]

GeneCards Summary for SLC2A5 Gene

SLC2A5 (Solute Carrier Family 2 Member 5) is a Protein Coding gene. Diseases associated with SLC2A5 include Fructose Utilization and Fructosuria, Essential. Among its related pathways are HIF1Alpha Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A7.

UniProtKB/Swiss-Prot Summary for SLC2A5 Gene

  • Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A5 Gene

Genomics for SLC2A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC2A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J009066 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 279.5 +20.0 20021 4.4 BCLAF1 SP1 POLR2A CEBPA ZIC2 MXD4 BCL11A CEBPB KLF11 SIN3A SLC2A5 HSALNG0000675 SLC2A7 RNU6-304P ENSG00000252404
GH01J009232 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.3 -146.2 -146229 3.8 NCOR1 MYC IKZF1 ZNF580 ZNF592 ZMYM3 POLR2A CEBPA ATF3 NFIC H6PD HSALNG0000687 lnc-GPR157-5 GPR157 SLC2A5 HSALNG0000677
GH01J009074 Promoter/Enhancer 1.2 Ensembl ENCODE 13.2 +10.6 10586 7.3 BCLAF1 SP1 ZIC2 BCL11A ZNF592 TARDBP TRIM22 BHLHE40 FEZF1 NR2C1 SLC2A5 RERE SLC2A7 RNU6-304P GPR157 ENSG00000252404 HSALNG0000675
GH01J009051 Enhancer 0.7 FANTOM5 Ensembl 24.5 +37.3 37277 1.6 POLR2A ZNF366 ZNF512 RNF2 USF1 SCRT2 HSALNG0000674 piR-45035-003 SLC2A5 SLC2A7 GPR157 MIR34A RNU6-304P RERE lnc-SLC2A7-2
GH01J009036 Enhancer 0.9 Ensembl ENCODE 16.6 +51.0 51023 2.3 BCLAF1 POLR2A CTBP1 CUX1 IRF4 SMARCA5 BHLHE40 SMARCE1 BATF ELF1 piR-57807 SLC2A5 hsa-miR-1273e-001 SLC2A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC2A5

Top Transcription factor binding sites by QIAGEN in the SLC2A5 gene promoter:
  • AREB6
  • E47
  • GR
  • GR-alpha
  • GR-beta
  • Pbx1a
  • Tal-1

Genomic Locations for SLC2A5 Gene

Latest Assembly
chr1:9,035,106-9,088,478
(GRCh38/hg38)
Size:
53,373 bases
Orientation:
Minus strand

Previous Assembly
chr1:9,095,165-9,132,318
(GRCh37/hg19 by Entrez Gene)
Size:
37,154 bases
Orientation:
Minus strand

chr1:9,095,166-9,148,537
(GRCh37/hg19 by Ensembl)
Size:
53,372 bases
Orientation:
Minus strand

Genomic View for SLC2A5 Gene

Genes around SLC2A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A5 Gene

Proteins for SLC2A5 Gene

  • Protein details for SLC2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22732-GTR5_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 5
    Protein Accession:
    P22732
    Secondary Accessions:
    • Q14770
    • Q5T977
    • Q8IVB3

    Protein attributes for SLC2A5 Gene

    Size:
    501 amino acids
    Molecular mass:
    54974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60641.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC2A5 Gene

    Alternative splice isoforms for SLC2A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A5 Gene

Post-translational modifications for SLC2A5 Gene

  • Glycosylation at Asn51
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A5 Gene

Domains & Families for SLC2A5 Gene

Gene Families for SLC2A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SLC2A5 Gene

InterPro:
Blocks:
  • Mammalian facilitated glucose transporter family signature
  • Sugar transporter signature
  • Sugar transporter superfamily
  • Fructose transporter (GLUT5) signature

Suggested Antigen Peptide Sequences for SLC2A5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50662, highly similar to Solute carrier family 2, facilitated glucosetransporter member 5 (B4DT82_HUMAN)
  • cDNA FLJ50679, highly similar to Solute carrier family 2, facilitated glucosetransporter member 5 (B4DU31_HUMAN)
  • cDNA FLJ55285, highly similar to Solute carrier family 2, facilitated glucose transporter member 5 (B4DXN5_HUMAN)
  • Glucose transporter type 5, small intestine (GTR5_HUMAN)
  • cDNA FLJ75217, highly similar to Homo sapiens solute carrier family 2 (facilitated glucose/fructose transporter), member 5, mRNA (Q8IVB3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22732

UniProtKB/Swiss-Prot:

GTR5_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A5: view

Function for SLC2A5 Gene

Molecular function for SLC2A5 Gene

UniProtKB/Swiss-Prot Function:
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-fructose(out) = D-fructose(in); Xref=Rhea:RHEA:60372, ChEBI:CHEBI:37721; Evidence={ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:8333543};.
UniProtKB/Swiss-Prot Induction:
By forskolin in Caco-2 cells.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30.1 mM for fructose {ECO:0000269|PubMed:28083649};
UniProtKB/Swiss-Prot EnzymeRegulation:
The uptake of 2-deoxyglucose is inhibited by cytochalasin B.
GENATLAS Biochemistry:
solute carrier family 2,member A5,facilitated glucose transporter

Phenotypes From GWAS Catalog for SLC2A5 Gene

Gene Ontology (GO) - Molecular Function for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005353 fructose transmembrane transporter activity IEA,TAS --
GO:0005355 glucose transmembrane transporter activity TAS 1695905
GO:0005515 protein binding IPI 32296183
GO:0022857 transmembrane transporter activity IEA --
GO:0070061 fructose binding ISS --
genes like me logo Genes that share ontologies with SLC2A5: view
genes like me logo Genes that share phenotypes with SLC2A5: view

Animal Models for SLC2A5 Gene

MGI Knock Outs for SLC2A5:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC2A5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A5 Gene

Localization for SLC2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A5 Gene

Apical cell membrane. Multi-pass membrane protein. Cell membrane. Multi-pass membrane protein. Cell membrane, sarcolemma. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. {ECO:0000250 UniProtKB:Q9WV38}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A5 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IDA 8333543
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA,ISS --
genes like me logo Genes that share ontologies with SLC2A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A5 Gene

Pathways & Interactions for SLC2A5 Gene

genes like me logo Genes that share pathways with SLC2A5: view

Pathways by source for SLC2A5 Gene

1 KEGG pathway for SLC2A5 Gene
2 Qiagen pathways for SLC2A5 Gene
  • Antioxidant Action of Vitamin-C
  • HIF1Alpha Pathway

Gene Ontology (GO) - Biological Process for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal ISS --
GO:0005975 carbohydrate metabolic process TAS 1634504
GO:0008643 carbohydrate transport IEA --
GO:0009750 response to fructose ISS --
GO:0015755 fructose transmembrane transport IEA,IDA 28083649
genes like me logo Genes that share ontologies with SLC2A5: view

No data available for SIGNOR curated interactions for SLC2A5 Gene

Drugs & Compounds for SLC2A5 Gene

(7) Drugs for SLC2A5 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-glucose Approved, Experimental, Investigational, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose (18F) Approved, Investigational Pharma Transporter, substrate 0
Invert sugar Experimental Pharma Transporter, substrate 0
Glufosfamide Investigational Pharma inhibitor 0

(7) Additional Compounds for SLC2A5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A5: view

Transcripts for SLC2A5 Gene

mRNA/cDNA for SLC2A5 Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A5

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SLC2A5 Gene

GeneLoc Exon Structure for
SLC2A5

Expression for SLC2A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC2A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.1), Brain - Spinal cord (cervical c-1) (x4.3), Testis (x4.2), and Muscle - Skeletal (x4.0).

Protein differential expression in normal tissues from HIPED for SLC2A5 Gene

This gene is overexpressed in Urine (59.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC2A5

SOURCE GeneReport for Unigene cluster for SLC2A5 Gene:

Hs.530003

mRNA Expression by UniProt/SwissProt for SLC2A5 Gene:

P22732-GTR5_HUMAN
Tissue specificity: Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Evidence on tissue expression from TISSUES for SLC2A5 Gene

  • Nervous system(4.8)
  • Intestine(4.6)
  • Blood(4.5)
  • Kidney(3.4)
  • Muscle(2.5)
  • Bone marrow(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SLC2A5: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A5 Gene

Orthologs for SLC2A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC2A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC2A5 29 30
  • 99.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC2A5 29 30
  • 83.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC2A5 29 30
  • 80.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc2a5 29
  • 80.27 (n)
Mouse
(Mus musculus)
Mammalia Slc2a5 29 16 30
  • 79.53 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC2A5 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 73 (a)
OneToMany
-- 30
  • 73 (a)
OneToMany
-- 30
  • 67 (a)
OneToMany
Chicken
(Gallus gallus)
Aves SLC2A5 29 30
  • 66.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC2A5 30
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc2a5 29
  • 61.85 (n)
Zebrafish
(Danio rerio)
Actinopterygii slc2a5 30
  • 66 (a)
OneToOne
wufc10e01 29
Fruit Fly
(Drosophila melanogaster)
Insecta sut1 31
  • 34 (a)
sut2 31
  • 30 (a)
CG7882 31
  • 29 (a)
sut3 31
  • 27 (a)
Worm
(Caenorhabditis elegans)
Secernentea H17B01.1a 31
  • 37 (a)
H17B01.1b 31
  • 37 (a)
R09B5.11 31
  • 32 (a)
Y61A9LA.1 31
  • 22 (a)
Species where no ortholog for SLC2A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC2A5 Gene

ENSEMBL:
Gene Tree for SLC2A5 (if available)
TreeFam:
Gene Tree for SLC2A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC2A5: view image
Alliance of Genome Resources:
Additional Orthologs for SLC2A5

Paralogs for SLC2A5 Gene

(11) SIMAP similar genes for SLC2A5 Gene using alignment to 8 proteins:

  • GTR5_HUMAN
  • B4DT82_HUMAN
  • B4DU31_HUMAN
  • K7EIT1_HUMAN
  • K7EJR1_HUMAN
  • K7EJZ0_HUMAN
  • K7EQI3_HUMAN
  • L8E9T0_HUMAN
genes like me logo Genes that share paralogs with SLC2A5: view

Variants for SLC2A5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC2A5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs146964071 Benign: not provided 9,047,700(-) T/C
NM_003039.3(SLC2A5):c.328A>G (p.Ile110Val)
MISSENSE_VARIANT,INTRON
rs77511432 Likely Benign: not provided 9,058,188(-) A/C
NM_003039.3(SLC2A5):c.96T>G (p.Tyr32Ter)
INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT,NONSENSE,INTRON
rs779760381 Association: Long QT syndrome 9,039,877(-) G/A
NM_003039.3(SLC2A5):c.808C>T (p.Arg270Trp)
MISSENSE
rs145150305 -- p.Ile296Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC2A5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC2A5 Gene

Variant ID Type Subtype PubMed ID
dgv15n100 CNV loss 25217958
esv1504235 CNV insertion 17803354
esv1740239 CNV insertion 17803354
esv3542788 CNV deletion 23714750
esv3577721 CNV loss 25503493
esv3585161 CNV gain 21293372
nsv1004025 CNV gain 25217958
nsv462727 CNV loss 19166990
nsv512717 CNV insertion 21212237
nsv545347 CNV loss 21841781
nsv831981 CNV loss 17160897

Variation tolerance for SLC2A5 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A5 Gene

Human Gene Mutation Database (HGMD)
SLC2A5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A5
Leiden Open Variation Database (LOVD)
SLC2A5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A5 Gene

Disorders for SLC2A5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLC2A5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
fructose utilization
fructosuria, essential
  • hepatic fructokinase deficiency
fructose intolerance, hereditary
  • hfi
osmotic diarrhea
lactose intolerance
  • lm - lactose malabsorption
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC2A5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC2A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A5 Gene

Publications for SLC2A5 Gene

  1. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PMID: 9691177) White PS … Brodeur GM (Cytogenetics and cell genetics 1998) 2 3 22
  2. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PMID: 8037665) Mahraoui L … Brot-Laroche E (The Biochemical journal 1994) 3 4 22
  3. Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5. (PMID: 8333543) Rand EB … Burant CF (The American journal of physiology 1993) 3 4 22
  4. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PMID: 1695905) Kayano T … Bell GI (The Journal of biological chemistry 1990) 3 4 22
  5. Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters. (PMID: 28083649) Ebert K … Witt H (The Journal of membrane biology 2017) 3 4

Products for SLC2A5 Gene

Sources for SLC2A5 Gene