Aliases for SLC2A4 Gene
- Solute Carrier Family 2 Member 4 2 3 5
- Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 2 3
- Solute Carrier Family 2, Facilitated Glucose Transporter Member 4 3 4
- Glucose Transporter Type 4, Insulin-Responsive 3 4
- GLUT-4 3 4
- GLUT4 3 4
- Insulin-Responsive Glucose Transporter Type 4 3
External Ids for SLC2A4 Gene
Previous HGNC Symbols for SLC2A4 Gene
Previous GeneCards Identifiers for SLC2A4 Gene
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC2A4 Gene
SLC2A4 (Solute Carrier Family 2 Member 4) is a Protein Coding gene. Diseases associated with SLC2A4 include Diabetes Mellitus, Noninsulin-Dependent and Diabetes Mellitus. Among its related pathways are Cori Cycle and Translocation of GLUT4 to the plasma membrane. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A1.
UniProtKB/Swiss-Prot Summary for SLC2A4 Gene
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.