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Aliases for SLC2A4 Gene

Aliases for SLC2A4 Gene

  • Solute Carrier Family 2 Member 4 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 2 3
  • Glucose Transporter Type 4, Insulin-Responsive 3 4
  • GLUT-4 3 4
  • GLUT4 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 4 3
  • Insulin-Responsive Glucose Transporter Type 4 3

External Ids for SLC2A4 Gene

Previous HGNC Symbols for SLC2A4 Gene

  • GLUT4

Previous GeneCards Identifiers for SLC2A4 Gene

  • GC17P007543
  • GC17P007914
  • GC17P007127
  • GC17P007385
  • GC17P007125
  • GC17P007186
  • GC17P007076

Summaries for SLC2A4 Gene

Entrez Gene Summary for SLC2A4 Gene

  • This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC2A4 Gene

SLC2A4 (Solute Carrier Family 2 Member 4) is a Protein Coding gene. Diseases associated with SLC2A4 include Diabetes Mellitus, Noninsulin-Dependent and Diabetes Mellitus. Among its related pathways are Akt Signaling and Cori Cycle. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A1.

UniProtKB/Swiss-Prot for SLC2A4 Gene

  • Insulin-regulated facilitative glucose transporter.

Gene Wiki entry for SLC2A4 Gene

Additional gene information for SLC2A4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A4 Gene

Genomics for SLC2A4 Gene

GeneHancer (GH) Regulatory Elements for SLC2A4 Gene

Promoters and enhancers for SLC2A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007279 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 659.8 -0.3 -329 4.3 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 SLC2A4 YBX2 ELP5 PFAS DVL2 CTC1 ENSG00000262089 CNTROB WRAP53 SNORD10
GH17J007312 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13 +32.9 32878 4 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 GPS2 GC17M007314 NEURL4 EIF5A ACAP1 SLC2A4 ENSG00000202251 CLDN7 CTDNEP1 ELP5
GH17J007380 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 10.8 +99.5 99504 1.4 DRAP1 ELF3 KLF1 RB1 SAP130 ARID4B SIN3A KDM3A TEAD3 PHF20 TNK1 CHRNB1 KCTD11 TMEM95 NLGN2 TMEM256 SPEM1 SPEM2 ACAP1 NEURL4
GH17J007328 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 7.3 +48.1 48057 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 ZNF207 ENSG00000224647 NEURL4 SNORD10 EIF5A SNORA48 PLSCR3 EIF4A1 DVL2 TP53 KCTD11
GH17J007256 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 5 -20.9 -20869 8.7 HDGF FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 CLDN7 ENSG00000262302 PIR33341 GC17M007249 CTDNEP1 ELP5 YBX2 WRAP53 POLR2A CNTROB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC2A4 gene promoter:
  • aMEF-2
  • MEF-2A
  • PPAR-gamma2
  • PPAR-gamma1

Genomic Locations for SLC2A4 Gene

Genomic Locations for SLC2A4 Gene
chr17:7,281,667-7,288,257
(GRCh38/hg38)
Size:
6,591 bases
Orientation:
Plus strand
chr17:7,184,986-7,191,576
(GRCh37/hg19)
Size:
6,591 bases
Orientation:
Plus strand

Genomic View for SLC2A4 Gene

Genes around SLC2A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A4 Gene

Proteins for SLC2A4 Gene

  • Protein details for SLC2A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14672-GTR4_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 4
    Protein Accession:
    P14672
    Secondary Accessions:
    • Q05BQ3
    • Q14CX2

    Protein attributes for SLC2A4 Gene

    Size:
    509 amino acids
    Molecular mass:
    54787 Da
    Quaternary structure:
    • Interacts with NDUFA9 (By similarity). Binds to DAXX. Interacts via its N-terminus with SRFBP1.
    Miscellaneous:
    • Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.

    Alternative splice isoforms for SLC2A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A4 Gene

Post-translational modifications for SLC2A4 Gene

Other Protein References for SLC2A4 Gene

No data available for DME Specific Peptides for SLC2A4 Gene

Domains & Families for SLC2A4 Gene

Gene Families for SLC2A4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC2A4 Gene

Graphical View of Domain Structure for InterPro Entry

P14672

UniProtKB/Swiss-Prot:

GTR4_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A4: view

Function for SLC2A4 Gene

Molecular function for SLC2A4 Gene

UniProtKB/Swiss-Prot Function:
Insulin-regulated facilitative glucose transporter.
GENATLAS Biochemistry:
solute carrier family 2,member A4,facilitated glucose transporter,associated to susceptibility to NIDDM with a polymorphic variant

Phenotypes From GWAS Catalog for SLC2A4 Gene

Gene Ontology (GO) - Molecular Function for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005355 glucose transmembrane transporter activity IEA,TAS 2649253
GO:0005515 protein binding IPI 11842083
GO:0022857 transmembrane transporter activity IEA --
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A4: view
genes like me logo Genes that share phenotypes with SLC2A4: view

Animal Models for SLC2A4 Gene

MGI Knock Outs for SLC2A4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A4 Gene

Localization for SLC2A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A4 Gene

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A4 gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 3
cytosol 3
golgi apparatus 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005771 multivesicular body IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SLC2A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A4 Gene

Pathways & Interactions for SLC2A4 Gene

genes like me logo Genes that share pathways with SLC2A4: view

SIGNOR curated interactions for SLC2A4 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 2649253
GO:0008643 carbohydrate transport IEA --
GO:0010021 amylopectin biosynthetic process IEA --
GO:0032869 cellular response to insulin stimulus IDA,IEA 12556481
GO:0042593 glucose homeostasis IDA 14562105
genes like me logo Genes that share ontologies with SLC2A4: view

Drugs & Compounds for SLC2A4 Gene

(68) Drugs for SLC2A4 Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucose Approved, Vet_approved Pharma Transporter, substrate 0
D-glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved, Investigational Pharma Transporter, substrate 0
Glufosfamide Investigational Pharma inhibitor 0
[<sup>3</sup>H]2-deoxyglucose Pharma 0

(44) Additional Compounds for SLC2A4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A4: view

Transcripts for SLC2A4 Gene

mRNA/cDNA for SLC2A4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC2A4 Gene

Solute carrier family 2 (facilitated glucose transporter), member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for SLC2A4 Gene

GeneLoc Exon Structure for
SLC2A4
ECgene alternative splicing isoforms for
SLC2A4

Expression for SLC2A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A4 Gene

This gene is overexpressed in Muscle - Skeletal (x13.5), Heart - Left Ventricle (x5.9), Esophagus - Muscularis (x5.3), and Esophagus - Gastroesophageal Junction (x5.2).

Protein differential expression in normal tissues from HIPED for SLC2A4 Gene

This gene is overexpressed in Heart (32.0), Urinary Bladder (16.6), and Adipocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A4 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC2A4 Gene:

SLC2A4

SOURCE GeneReport for Unigene cluster for SLC2A4 Gene:

Hs.380691

mRNA Expression by UniProt/SwissProt for SLC2A4 Gene:

P14672-GTR4_HUMAN
Tissue specificity: Skeletal and cardiac muscles; brown and white fat.

Evidence on tissue expression from TISSUES for SLC2A4 Gene

  • Intestine(4.4)
  • Muscle(4.3)
  • Heart(3.5)
  • Liver(2.7)
  • Blood(2.4)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with SLC2A4: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A4 Gene

Orthologs for SLC2A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A4 34 33
  • 99.61 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A4 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A4 34 33
  • 90.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A4 34 33
  • 89.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a4 16 34 33
  • 87.88 (n)
rat
(Rattus norvegicus)
Mammalia Slc2a4 33
  • 87.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A4 34
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A4 34
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01043017.1 34
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta sut1 35
  • 36 (a)
CG7882 35
  • 34 (a)
sut4 35
  • 33 (a)
sut2 35
  • 33 (a)
Glut1 34 35
  • 31 (a)
OneToMany
sut3 35
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea H17B01.1a 35
  • 39 (a)
H17B01.1b 35
  • 39 (a)
fgt-1 34
  • 36 (a)
ManyToMany
R09B5.11 34 35
  • 34 (a)
ManyToMany
F53H8.3 34
  • 27 (a)
ManyToMany
Y37A1A.3 35
  • 26 (a)
K08F9.1 35
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 27 (a)
ManyToMany
VPS73 34
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 34
  • 45 (a)
OneToMany
Species where no ortholog for SLC2A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC2A4 Gene

ENSEMBL:
Gene Tree for SLC2A4 (if available)
TreeFam:
Gene Tree for SLC2A4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC2A4: view image

Paralogs for SLC2A4 Gene

Paralogs for SLC2A4 Gene

(10) SIMAP similar genes for SLC2A4 Gene using alignment to 5 proteins:

  • GTR4_HUMAN
  • F5H081_HUMAN
  • I3L1S2_HUMAN
  • I3L2R4_HUMAN
  • Q05BQ3_HUMAN
genes like me logo Genes that share paralogs with SLC2A4: view

Variants for SLC2A4 Gene

Sequence variations from dbSNP and Humsavar for SLC2A4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs121434581 uncertain-significance, Diabetes mellitus type 2, Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853] 7,285,729(+) G/A/C coding_sequence_variant, missense_variant
rs1000383151 -- 7,281,724(+) T/G upstream_transcript_variant
rs1000435440 -- 7,281,414(+) T/C upstream_transcript_variant
rs1000718694 -- 7,280,386(+) T/C upstream_transcript_variant
rs1001013141 -- 7,288,156(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639863 CNV loss 21293372
esv3639864 CNV loss 21293372
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for SLC2A4 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.60; 78.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A4 Gene

Human Gene Mutation Database (HGMD)
SLC2A4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A4 Gene

Disorders for SLC2A4 Gene

MalaCards: The human disease database

(13) MalaCards diseases for SLC2A4 Gene - From: HGMD, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GTR4_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:1521731, ECO:0000269 PubMed:1756912, ECO:0000269 PubMed:1918382}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLC2A4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC2A4: view

No data available for Genatlas for SLC2A4 Gene

Publications for SLC2A4 Gene

  1. Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4. (PMID: 17382906) Jeyaraj S … Palmada M (Biochemical and biophysical research communications 2007) 3 4 22 58
  2. Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. (PMID: 1756912) Choi WH … Moller DE (Diabetes 1991) 3 4 44 58
  3. Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. (PMID: 1918382) Kusari J … Olefsky JM (The Journal of clinical investigation 1991) 3 4 22 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for SLC2A4 Gene

Sources for SLC2A4 Gene

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