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Aliases for SLC2A2 Gene

Aliases for SLC2A2 Gene

  • Solute Carrier Family 2 Member 2 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 2 2 3
  • Glucose Transporter Type 2, Liver 3 4
  • GLUT2 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 2 3
  • GLUT-2 4

External Ids for SLC2A2 Gene

Previous HGNC Symbols for SLC2A2 Gene

  • GLUT2

Previous GeneCards Identifiers for SLC2A2 Gene

  • GC03M167856
  • GC03M171763
  • GC03M172116
  • GC03M172035
  • GC03M172196
  • GC03M170714
  • GC03M168084
  • GC03M170996
  • GC03M170998
  • GC03M171000
  • GC03M171002
  • GC03M171004
  • GC03M171006
  • GC03M171008

Summaries for SLC2A2 Gene

Entrez Gene Summary for SLC2A2 Gene

  • This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC2A2 Gene

SLC2A2 (Solute Carrier Family 2 Member 2) is a Protein Coding gene. Diseases associated with SLC2A2 include Fanconi-Bickel Syndrome and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A1.

UniProtKB/Swiss-Prot for SLC2A2 Gene

  • Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Additional gene information for SLC2A2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A2 Gene

Genomics for SLC2A2 Gene

GeneHancer (GH) Regulatory Elements for SLC2A2 Gene

Promoters and enhancers for SLC2A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I171021 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.4 1420 8.9 HDAC1 ELF3 PKNOX1 FOXA2 RAD21 YY1 MIXL1 RXRA NFYC MXD4 SLC2A2 MIR569 TNIK RPL22L1 RNU1-70P GC03M171011
GH03I171013 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 19.5 +9.9 9856 7.4 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 GATA2 ATF7 RXRA SLC2A2 RPL22L1 RNU1-70P GC03M171011
GH03I171456 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 -432.7 -432655 6 HDGF PKNOX1 SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B ZNF766 E2F8 TNIK ENSG00000279673 LOC102724479 SLC2A2 ENSG00000222506
GH03I170996 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.8 +25.9 25943 8.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SLC2A2 GC03M171011 RNU1-70P
GH03I171165 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.6 -142.1 -142096 7.9 FOXA2 RAD21 ZNF143 FOS RXRA ZNF217 SSRP1 RCOR2 CEBPA KDM1A SLC2A2 TNIK MIR569 ENSG00000222506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC2A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC2A2 gene promoter:

Genomic Locations for SLC2A2 Gene

Genomic Locations for SLC2A2 Gene
31,615 bases
Minus strand

Genomic View for SLC2A2 Gene

Genes around SLC2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A2 Gene

Proteins for SLC2A2 Gene

  • Protein details for SLC2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 2
    Protein Accession:
    Secondary Accessions:
    • A8K481
    • B2R936
    • B7Z547
    • F8W8V8
    • Q9UCW9

    Protein attributes for SLC2A2 Gene

    524 amino acids
    Molecular mass:
    57490 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A2 Gene


neXtProt entry for SLC2A2 Gene

Post-translational modifications for SLC2A2 Gene

  • N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
  • Glycosylation at isoforms=62
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A2 Gene

No data available for DME Specific Peptides for SLC2A2 Gene

Domains & Families for SLC2A2 Gene

Gene Families for SLC2A2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A2: view

Function for SLC2A2 Gene

Molecular function for SLC2A2 Gene

GENATLAS Biochemistry:
solute carrier family 2,member A2,facilitated glucose transporter
UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

Phenotypes From GWAS Catalog for SLC2A2 Gene

Gene Ontology (GO) - Molecular Function for SLC2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005355 glucose transmembrane transporter activity IEA,EXP 7589840
GO:0015149 hexose transmembrane transporter activity TAS --
GO:0022857 transmembrane transporter activity IEA --
GO:0033300 dehydroascorbic acid transmembrane transporter activity IEA --
GO:0055056 D-glucose transmembrane transporter activity IEA,EXP 8457197
genes like me logo Genes that share ontologies with SLC2A2: view
genes like me logo Genes that share phenotypes with SLC2A2: view

Human Phenotype Ontology for SLC2A2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC2A2 Gene

MGI Knock Outs for SLC2A2:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SLC2A2 Gene

Localization for SLC2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 8027028
GO:0005903 brush border IEA --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with SLC2A2: view

Pathways & Interactions for SLC2A2 Gene

genes like me logo Genes that share pathways with SLC2A2: view

Gene Ontology (GO) - Biological Process for SLC2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 8027028
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transport TAS --
GO:0015758 glucose transport IEA,TAS --
genes like me logo Genes that share ontologies with SLC2A2: view

No data available for SIGNOR curated interactions for SLC2A2 Gene

Drugs & Compounds for SLC2A2 Gene

(21) Drugs for SLC2A2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Streptozocin Approved, Investigational Pharma Target, ligand Antibiotic and antitumor agent 11
glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved, Investigational Pharma Transporter, substrate 0
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1891
[<sup>3</sup>H]2-deoxyglucose Pharma 0

(19) Additional Compounds for SLC2A2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC2A2 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes 864070-44-0
genes like me logo Genes that share compounds with SLC2A2: view

Drug Products

Transcripts for SLC2A2 Gene

Unigene Clusters for SLC2A2 Gene

Solute carrier family 2 (facilitated glucose transporter), member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP2: -

Relevant External Links for SLC2A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC2A2 Gene

This gene is overexpressed in Liver (x46.4).

Protein differential expression in normal tissues from HIPED for SLC2A2 Gene

This gene is overexpressed in Liver (20.5), Uterus (17.1), Fetal Liver (15.8), and Gallbladder (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC2A2 Gene

Protein tissue co-expression partners for SLC2A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC2A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A2 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A2 Gene:

Tissue specificity: Liver, insulin-producing beta cell, small intestine and kidney.

Evidence on tissue expression from TISSUES for SLC2A2 Gene

  • Liver(4.8)
  • Kidney(4.6)
  • Blood(4.4)
  • Intestine(3.4)
  • Pancreas(3.2)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • ear
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
  • chest wall
  • clavicle
  • diaphragm
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
  • biliary tract
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • stomach
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with SLC2A2: view

Orthologs for SLC2A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A2 33 34
  • 99.43 (n)
(Canis familiaris)
Mammalia SLC2A2 33 34
  • 86.83 (n)
(Bos Taurus)
Mammalia SLC2A2 33 34
  • 85.68 (n)
(Mus musculus)
Mammalia Slc2a2 33 16 34
  • 81.77 (n)
(Rattus norvegicus)
Mammalia Slc2a2 33
  • 81.29 (n)
(Monodelphis domestica)
Mammalia SLC2A2 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia SLC2A2 34
  • 63 (a)
(Gallus gallus)
Aves SLC2A2 33 34
  • 66.54 (n)
(Anolis carolinensis)
Reptilia SLC2A2 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a2 33
  • 69.05 (n)
Str.10072 33
(Danio rerio)
Actinopterygii slc2a2 33 34
  • 62.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glut1 35 34
  • 41 (a)
sut1 35
  • 31 (a)
CG7882 35
  • 30 (a)
sut3 35
  • 29 (a)
sut2 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea H17B01.1a 35
  • 39 (a)
H17B01.1b 35
  • 39 (a)
fgt-1 34
  • 39 (a)
R09B5.11 35 34
  • 35 (a)
F53H8.3 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 27 (a)
VPS73 34
  • 26 (a)
SNF3 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 34
  • 41 (a)
Species where no ortholog for SLC2A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A2 Gene

Gene Tree for SLC2A2 (if available)
Gene Tree for SLC2A2 (if available)

Paralogs for SLC2A2 Gene

Paralogs for SLC2A2 Gene

genes like me logo Genes that share paralogs with SLC2A2: view

Variants for SLC2A2 Gene

Sequence variations from dbSNP and Humsavar for SLC2A2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1009976007 uncertain-significance, Fanconi-Bickel syndrome 170,996,739(-) A/G 3_prime_UTR_variant
rs111737375 likely-benign, Fanconi-Bickel syndrome, not specified 171,009,951(-) GA/GAGA/GAGAGA intron_variant
rs114710971 likely-benign, Fanconi-Bickel syndrome 170,997,429(-) T/C 3_prime_UTR_variant
rs121909741 pathogenic, uncertain-significance, Diabetes mellitus type 2, Monogenic diabetes 171,007,171(-) C/T coding_sequence_variant, missense_variant
rs121909742 pathogenic, Fanconi-Bickel syndrome 170,999,142(-) G/A/T coding_sequence_variant, stop_gained, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A2 Gene

Variant ID Type Subtype PubMed ID
dgv1427e212 CNV loss 25503493
dgv1428e212 CNV loss 25503493
dgv2839e59 CNV tandem duplication 20981092
esv3390925 CNV duplication 20981092
nsv236991 CNV deletion 16902084
nsv477726 CNV novel sequence insertion 20440878
nsv509866 OTHER sequence alteration 20534489
nsv7356 OTHER inversion 18451855

Variation tolerance for SLC2A2 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.17; 84.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A2 Gene

Disorders for SLC2A2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for SLC2A2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards


  • Fanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. {ECO:0000269 PubMed:10987651, ECO:0000269 PubMed:11044475}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for SLC2A2 Gene

glycogen storage disease,hepatorenal with tubular nephropathy and impaired utilization of glucose and galactose,Fanconi-Bickel syndrome

Additional Disease Information for SLC2A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC2A2: view

Publications for SLC2A2 Gene

  1. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. (PMID: 17636114) Kilpeläinen TO … Finnish Diabetes Prevention Study Group (Physiological genomics 2007) 3 22 44 58
  2. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. (PMID: 15983230) Laukkanen O … Finnish Diabetes Prevention Study (Diabetes 2005) 3 22 44 58
  3. Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity. (PMID: 12017192) Cha JY … Ahn YH (Annals of clinical and laboratory science 2002) 3 22 44 58
  4. Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus. (PMID: 11344224) Møller AM … Pedersen O (The Journal of clinical endocrinology and metabolism 2001) 3 22 44 58
  5. Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome. (PMID: 11044475) Sakamoto O … Iinuma K (Pediatric research 2000) 3 4 22 58

Products for SLC2A2 Gene

Sources for SLC2A2 Gene

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