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Aliases for SLC2A12 Gene

Aliases for SLC2A12 Gene

  • Solute Carrier Family 2 Member 12 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 12 2 3
  • Glucose Transporter Type 12 3 4
  • GLUT-12 3 4
  • GLUT12 3 4
  • GLUT8 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 12 3

External Ids for SLC2A12 Gene

Previous GeneCards Identifiers for SLC2A12 Gene

  • GC06M134155
  • GC06M134288
  • GC06M134292
  • GC06M134349
  • GC06M131877

Summaries for SLC2A12 Gene

Entrez Gene Summary for SLC2A12 Gene

  • SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC2A12 Gene

SLC2A12 (Solute Carrier Family 2 Member 12) is a Protein Coding gene. Among its related pathways are PAK Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A10.

UniProtKB/Swiss-Prot for SLC2A12 Gene

  • Facilitative glucose transporter.

Gene Wiki entry for SLC2A12 Gene

Additional gene information for SLC2A12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A12 Gene

Genomics for SLC2A12 Gene

GeneHancer (GH) Regulatory Elements for SLC2A12 Gene

Promoters and enhancers for SLC2A12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J134051 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.5 +0.2 220 2.5 ATF1 FOXA2 ARNT ZNF133 FEZF1 GLI4 ZNF2 POLR2B ARID2 ZNF143 SLC2A12 ENSG00000229722 LOC101928277 LOC100421250
GH06J133951 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 +97.3 97287 8.4 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 TBPL1 SLC2A12 GC06P133988
GH06J134015 Enhancer 1.1 ENCODE dbSUPER 18.3 +35.3 35253 2.9 HDGF PKNOX1 ATF1 ARNT ZFP64 NCOA2 TCF12 ZNF766 GATA2 FOS SLC2A12 TBPL1 LOC100421250
GH06J133887 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.1 +160.3 160298 8.8 PKNOX1 NFIB BMI1 ZNF2 YY1 ETS1 ZNF335 GLIS2 ZSCAN5C EGR2 TCF21 TARID TBPL1 SLC2A12
GH06J133972 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 +79.7 79744 1 HDAC1 PKNOX1 FEZF1 RAD21 CHAMP1 ZNF335 TCF12 ZFP91 RUNX3 MIXL1 SLC2A12 TBPL1 GC06P133988
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC2A12 gene promoter:
  • Hand1
  • E47
  • AP-1
  • c-Fos
  • FosB
  • Fra-1
  • JunB
  • JunD
  • c-Jun
  • STAT1beta

Genomic Locations for SLC2A12 Gene

Genomic Locations for SLC2A12 Gene
65,088 bases
Minus strand
65,071 bases
Minus strand

Genomic View for SLC2A12 Gene

Genes around SLC2A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A12 Gene

Proteins for SLC2A12 Gene

  • Protein details for SLC2A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 12
    Protein Accession:
    Secondary Accessions:
    • B3KV17
    • Q7Z6U3
    • Q96MR8

    Protein attributes for SLC2A12 Gene

    617 amino acids
    Molecular mass:
    66966 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71214.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC2A12 Gene

Post-translational modifications for SLC2A12 Gene

  • N-glycosylated.
  • Glycosylation at posLast=445445, posLast=432432, isoforms=401, isoforms=396, posLast=383383, and posLast=371371
  • Ubiquitination at posLast=254254
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A12 Gene

Domains & Families for SLC2A12 Gene

Gene Families for SLC2A12 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC2A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A12: view

Function for SLC2A12 Gene

Molecular function for SLC2A12 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter.

Phenotypes From GWAS Catalog for SLC2A12 Gene

Gene Ontology (GO) - Molecular Function for SLC2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 carbohydrate:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A12: view
genes like me logo Genes that share phenotypes with SLC2A12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A12

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A12 Gene

Localization for SLC2A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A12 Gene

Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily perinuclear region in the absence of insulin.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A12 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
lysosome 1
golgi apparatus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A12: view

Pathways & Interactions for SLC2A12 Gene

genes like me logo Genes that share pathways with SLC2A12: view

Gene Ontology (GO) - Biological Process for SLC2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transmembrane transport TAS --
GO:0046323 glucose import IBA --
GO:0055085 transmembrane transport IEA --
GO:1902600 proton transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC2A12: view

No data available for SIGNOR curated interactions for SLC2A12 Gene

Drugs & Compounds for SLC2A12 Gene

(3) Drugs for SLC2A12 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucose Approved, Vet_approved Pharma Transporter, substrate 0
D-glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved, Investigational Pharma Transporter, substrate 0
genes like me logo Genes that share compounds with SLC2A12: view

Transcripts for SLC2A12 Gene

mRNA/cDNA for SLC2A12 Gene

Unigene Clusters for SLC2A12 Gene

Solute carrier family 2 (facilitated glucose transporter), member 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A12

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A12 Gene

No ASD Table

Relevant External Links for SLC2A12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A12 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for SLC2A12 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A12 Gene

Protein tissue co-expression partners for SLC2A12 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A12 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A12 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A12 Gene:

Tissue specificity: Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.

Evidence on tissue expression from TISSUES for SLC2A12 Gene

  • Nervous system(4.7)
  • Skin(4)
genes like me logo Genes that share expression patterns with SLC2A12: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A12 Gene

Orthologs for SLC2A12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A12 34 33
  • 99.41 (n)
(Canis familiaris)
Mammalia SLC2A12 34 33
  • 87.46 (n)
(Bos Taurus)
Mammalia SLC2A12 34 33
  • 87.45 (n)
(Rattus norvegicus)
Mammalia Slc2a12 33
  • 83.52 (n)
(Mus musculus)
Mammalia Slc2a12 16 34 33
  • 82.87 (n)
(Ornithorhynchus anatinus)
Mammalia SLC2A12 34
  • 76 (a)
(Monodelphis domestica)
Mammalia SLC2A12 34
  • 76 (a)
(Gallus gallus)
Aves SLC2A12 34 33
  • 71.47 (n)
(Anolis carolinensis)
Reptilia SLC2A12 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a12 33
  • 64.38 (n)
(Danio rerio)
Actinopterygii slc2a12 34 33
  • 52.31 (n)
zgc66027 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ITR1 34
  • 22 (a)
ITR2 34
  • 22 (a)
-- 34
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17010 33
  • 49.11 (n)
(Oryza sativa)
Liliopsida Os10g0579200 33
  • 47.15 (n)
Species where no ortholog for SLC2A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A12 Gene

Gene Tree for SLC2A12 (if available)
Gene Tree for SLC2A12 (if available)
Evolutionary constrained regions (ECRs) for SLC2A12: view image

Paralogs for SLC2A12 Gene

Paralogs for SLC2A12 Gene

(2) SIMAP similar genes for SLC2A12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC2A12: view

Variants for SLC2A12 Gene

Sequence variations from dbSNP and Humsavar for SLC2A12 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000041630 -- 134,005,167(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000092196 -- 134,009,203(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000204824 -- 134,008,987(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000233069 -- 134,023,552(-) A/T intron_variant
rs1000271008 -- 134,014,917(-) A/G 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A12 Gene

Variant ID Type Subtype PubMed ID
esv2659392 CNV deletion 23128226
esv2671195 CNV deletion 23128226
esv2732730 CNV deletion 23290073
esv2732731 CNV deletion 23290073
esv34122 CNV loss 18971310
esv3610869 CNV loss 21293372
nsv1140696 CNV deletion 24896259

Variation tolerance for SLC2A12 Gene

Residual Variation Intolerance Score: 6.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A12 Gene

Disorders for SLC2A12 Gene

Additional Disease Information for SLC2A12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC2A12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A12 Gene

Publications for SLC2A12 Gene

  1. Identification of a novel glucose transporter-like protein-GLUT-12. (PMID: 11832379) Rogers S … Best JD (American journal of physiology. Endocrinology and metabolism 2002) 2 3 4 22 58
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 44 58
  4. Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. (PMID: 16091581) Linden KC … Rogers S (American journal of physiology. Renal physiology 2006) 3 22 58
  5. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. (PMID: 16803853) Stuart CA … Ferrando AA (American journal of physiology. Endocrinology and metabolism 2006) 3 22 58

Products for SLC2A12 Gene

Sources for SLC2A12 Gene

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