SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008] See more...

Aliases for SLC2A12 Gene

Aliases for SLC2A12 Gene

  • Solute Carrier Family 2 Member 12 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 12 2 3
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 12 3 4
  • Glucose Transporter Type 12 3 4
  • GLUT-12 3 4
  • GLUT12 3 4
  • GLUT8 3

External Ids for SLC2A12 Gene

Previous GeneCards Identifiers for SLC2A12 Gene

  • GC06M133933
  • GC06M134155
  • GC06M134288
  • GC06M134292
  • GC06M134349
  • GC06M131877

Summaries for SLC2A12 Gene

Entrez Gene Summary for SLC2A12 Gene

  • SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC2A12 Gene

SLC2A12 (Solute Carrier Family 2 Member 12) is a Protein Coding gene. Among its related pathways are NRF2 pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A10.

UniProtKB/Swiss-Prot Summary for SLC2A12 Gene

Gene Wiki entry for SLC2A12 Gene

Additional gene information for SLC2A12 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A12 Gene

Genomics for SLC2A12 Gene

GeneHancer (GH) Regulatory Elements for SLC2A12 Gene

Promoters and enhancers for SLC2A12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J134051 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 515.1 +0.4 421 2.9 NRF1 SP1 JUND PHF8 FOS ZNF639 ZBTB10 ZBTB26 MYC ZEB1 SLC2A12 piR-43106-178
GH06J133951 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +97.3 97287 8.4 FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C TCF12 NRF1 POLR2G GTF2E2 TBPL1 SLC2A12 lnc-SLC2A12-12 RF00017-5782
GH06J134015 Enhancer 1.3 Ensembl ENCODE dbSUPER 18.4 +35.3 35253 2.9 BCLAF1 GTF2E2 FOS AFF1 HES1 CUX1 NR3C1 MYC RUNX1 CTBP1 SLC2A12 TBPL1 piR-43106-178 ENSG00000278744
GH06J133887 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.1 +160.5 160476 9.2 ZSCAN5C CTCF ZIC2 FOXA1 ZBTB26 TRIM28 SKI EZH2 ATF2 HDAC2 TCF21 TBPL1 SLC2A12 TARID lnc-SLC2A12-6 lnc-TCF21-2
GH06J133995 Enhancer 0.9 Ensembl ENCODE dbSUPER 18.6 +56.6 56567 2.6 TCF12 RFX1 HDAC2 RBM25 KDM1A ZNF146 ZNF664 ZMYM3 NFE2L2 ZNF24 SLC2A12 TBPL1 lnc-TCF21-3 LOC100421250
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC2A12

Top Transcription factor binding sites by QIAGEN in the SLC2A12 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • E47
  • FosB
  • Fra-1
  • Hand1
  • JunB
  • JunD
  • STAT1beta

Genomic Locations for SLC2A12 Gene

Genomic Locations for SLC2A12 Gene
chr6:133,987,581-134,052,668
(GRCh38/hg38)
Size:
65,088 bases
Orientation:
Minus strand
chr6:134,308,719-134,373,789
(GRCh37/hg19)
Size:
65,071 bases
Orientation:
Minus strand

Genomic View for SLC2A12 Gene

Genes around SLC2A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A12 Gene

Proteins for SLC2A12 Gene

  • Protein details for SLC2A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD20-GTR12_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 12
    Protein Accession:
    Q8TD20
    Secondary Accessions:
    • B3KV17
    • Q7Z6U3
    • Q96MR8

    Protein attributes for SLC2A12 Gene

    Size:
    617 amino acids
    Molecular mass:
    66966 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71214.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC2A12 Gene

Post-translational modifications for SLC2A12 Gene

  • Glycosylation at Asn371, Asn383, Asn396, Asn401, Thr432, Thr433, Ser434, and Thr445
  • Ubiquitination at Lys254
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A12 Gene

Domains & Families for SLC2A12 Gene

Gene Families for SLC2A12 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC2A12 Gene

Blocks:
  • Sugar transporter superfamily
  • Sugar transporter signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC2A12 Gene

GenScript: Design optimal peptide antigens:
  • Glucose transporter type 12 (GTR12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TD20

UniProtKB/Swiss-Prot:

GTR12_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A12: view

Function for SLC2A12 Gene

Molecular function for SLC2A12 Gene

UniProtKB/Swiss-Prot Function:
Insulin-independent facilitative glucose transporter.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=. ;.

Phenotypes From GWAS Catalog for SLC2A12 Gene

Gene Ontology (GO) - Molecular Function for SLC2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 carbohydrate:proton symporter activity IBA 21873635
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC2A12: view
genes like me logo Genes that share phenotypes with SLC2A12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A12

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A12

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A12 Gene

Localization for SLC2A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A12 Gene

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily perinuclear region in the absence of insulin. {ECO:0000269 PubMed:11832379}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A12 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A12: view

Pathways & Interactions for SLC2A12 Gene

genes like me logo Genes that share pathways with SLC2A12: view

Pathways by source for SLC2A12 Gene

Gene Ontology (GO) - Biological Process for SLC2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transmembrane transport TAS --
GO:0055085 transmembrane transport IEA --
GO:1902600 proton transmembrane transport IEA --
GO:1904659 glucose transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC2A12: view

No data available for SIGNOR curated interactions for SLC2A12 Gene

Drugs & Compounds for SLC2A12 Gene

(3) Drugs for SLC2A12 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dextrose, unspecified form Approved, Vet_approved Pharma Transporter, substrate 0
D-glucose Approved, Investigational, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose (18F) Approved, Investigational Pharma Transporter, substrate 0

(1) Additional Compounds for SLC2A12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A12: view

Transcripts for SLC2A12 Gene

mRNA/cDNA for SLC2A12 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A12

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A12 Gene

No ASD Table

Relevant External Links for SLC2A12 Gene

GeneLoc Exon Structure for
SLC2A12

Expression for SLC2A12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC2A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A12 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for SLC2A12 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC2A12 Gene



Protein tissue co-expression partners for SLC2A12 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC2A12

SOURCE GeneReport for Unigene cluster for SLC2A12 Gene:

Hs.486508

mRNA Expression by UniProt/SwissProt for SLC2A12 Gene:

Q8TD20-GTR12_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.

Evidence on tissue expression from TISSUES for SLC2A12 Gene

  • Nervous system(4.7)
  • Skin(4)
genes like me logo Genes that share expression patterns with SLC2A12: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A12 Gene

Orthologs for SLC2A12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A12 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A12 31 30
  • 87.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A12 31 30
  • 87.45 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a12 30
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Slc2a12 17 31 30
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC2A12 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A12 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A12 31 30
  • 71.47 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A12 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a12 30
  • 64.38 (n)
zebrafish
(Danio rerio)
Actinopterygii slc2a12 31 30
  • 52.31 (n)
OneToOne
zgc66027 30
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ITR1 31
  • 22 (a)
ManyToMany
ITR2 31
  • 22 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17010 30
  • 49.11 (n)
rice
(Oryza sativa)
Liliopsida Os10g0579200 30
  • 47.15 (n)
Species where no ortholog for SLC2A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A12 Gene

ENSEMBL:
Gene Tree for SLC2A12 (if available)
TreeFam:
Gene Tree for SLC2A12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC2A12: view image

Paralogs for SLC2A12 Gene

(2) SIMAP similar genes for SLC2A12 Gene using alignment to 1 proteins:

  • GTR12_HUMAN
genes like me logo Genes that share paralogs with SLC2A12: view

Variants for SLC2A12 Gene

Additional dbSNP identifiers (rs#s) for SLC2A12 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC2A12 Gene

Variant ID Type Subtype PubMed ID
esv2659392 CNV deletion 23128226
esv2671195 CNV deletion 23128226
esv2732730 CNV deletion 23290073
esv2732731 CNV deletion 23290073
esv34122 CNV loss 18971310
esv3610869 CNV loss 21293372
nsv1140696 CNV deletion 24896259

Variation tolerance for SLC2A12 Gene

Residual Variation Intolerance Score: 6.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC2A12 Gene

Disorders for SLC2A12 Gene

Additional Disease Information for SLC2A12

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC2A12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A12 Gene

Publications for SLC2A12 Gene

  1. Identification of a novel glucose transporter-like protein-GLUT-12. (PMID: 11832379) Rogers S … Best JD (American journal of physiology. Endocrinology and metabolism 2002) 2 3 4 23 54
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41 54
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 41 54
  4. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. (PMID: 16803853) Stuart CA … Ferrando AA (American journal of physiology. Endocrinology and metabolism 2006) 3 23 54
  5. Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. (PMID: 16091581) Linden KC … Rogers S (American journal of physiology. Renal physiology 2006) 3 23 54

Products for SLC2A12 Gene

Sources for SLC2A12 Gene