Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009] See more...
Aliases for SLC2A10 Gene
Aliases for SLC2A10 Gene
External Ids for SLC2A10 Gene
- HGNC: 13444
- Entrez Gene: 81031
- Ensembl: ENSG00000197496
- OMIM: 606145
- UniProtKB: O95528
Previous GeneCards Identifiers for SLC2A10 Gene
- GC20P045066
- GC20P045976
- GC20P046023
- GC20P044771
- GC20P045338
- GC20P042079
Summaries for SLC2A10 Gene
-
This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]
GeneCards Summary for SLC2A10 Gene
SLC2A10 (Solute Carrier Family 2 Member 10) is a Protein Coding gene. Diseases associated with SLC2A10 include Arterial Tortuosity Syndrome and Familial Thoracic Aortic Aneurysm And Aortic Dissection. Among its related pathways are HIF1Alpha Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A12.
UniProtKB/Swiss-Prot Summary for SLC2A10 Gene
-
Facilitative glucose transporter required for the development of the cardiovascular system.
Additional gene information for SLC2A10 Gene
- HGNC(13444)
- Entrez Gene(81031)
- Ensembl(ENSG00000197496)
- OMIM(606145)
- UniProtKB(O95528)
- Open Targets Platform(ENSG00000197496)
- Monarch Initiative
- Search for SLC2A10 at DataMed
- Search for SLC2A10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A10 Gene
Genomics for SLC2A10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC2A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC2A10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC2A10
- Top Transcription factor binding sites by QIAGEN in the SLC2A10 gene promoter:
-
- FOXD3
- GR-alpha
- HSF2
- NCX
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- RFX1
Genomic Locations for SLC2A10 Gene
Genomic Locations for SLC2A10 Gene
- chr20:46,708,358-46,736,347
- (GRCh38/hg38)
- Size:
- 27,990 bases
- Orientation:
- Plus strand
- chr20:45,338,126-45,364,986
- (GRCh37/hg19)
- Size:
- 26,861 bases
- Orientation:
- Plus strand
Genomic View for SLC2A10 Gene
Genes around SLC2A10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by HGNC
- 20q13.12 by Entrez Gene
- 20q13.12 by Ensembl
SLC2A10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC2A10 Gene
Proteins for SLC2A10 Gene
-
Protein details for SLC2A10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95528-GTR10_HUMAN
- Recommended name:
- Solute carrier family 2, facilitated glucose transporter member 10
- Protein Accession:
- O95528
- A8K4J6
- Q3MIX5
- Q9H4I6
Protein attributes for SLC2A10 Gene
- Size:
- 541 amino acids
- Molecular mass:
- 56911 Da
- Quaternary structure:
- No Data Available
Protein Expression for SLC2A10 Gene
Post-translational modifications for SLC2A10 Gene
Other Protein References for SLC2A10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SLC2A10 / GLUT10 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SLC2A10
- Novus Biologicals Antibodies for SLC2A10
- Invitrogen Antibodies for SLC2A10 (AFLGC-SLC2A10)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC2A10
- Sino Biological Antibodies for SLC2A10
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC2A10
- Origene Custom Protein Services for SLC2A10
- Novus Biologicals proteins for SLC2A10
- antibodies-online: Show 3 available SLC2A10 Proteins ranked by validation data
- Compare Top SLC2A10 Proteins
-
Quality Products:
-
Abcam proteins for SLC2A10
No data available for DME Specific Peptides for SLC2A10 Gene
Domains & Families for SLC2A10 Gene
Gene Families for SLC2A10 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for SLC2A10 Gene
- InterPro:
- Blocks:
-
- Sugar transporter signature
- Sugar transporter superfamily
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC2A10 Gene
- GenScript: Design optimal peptide antigens:
-
- Glucose transporter type 10 (GTR10_HUMAN)
- Solute carrier family 2 facilitated glucose transporter member 10 (Q8TDC7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95528UniProtKB/Swiss-Prot:
GTR10_HUMAN :- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
- Family:
-
- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Function for SLC2A10 Gene
Molecular function for SLC2A10 Gene
- UniProtKB/Swiss-Prot Function:
- Facilitative glucose transporter required for the development of the cardiovascular system.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence={ECO:0000269|PubMed:11592815};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.28 mM for 2-deoxy-D-glucose {ECO:0000269|PubMed:11592815};
Phenotypes From GWAS Catalog for SLC2A10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005351 | carbohydrate:proton symporter activity | IBA,NAS | 11247674 |
| GO:0022857 | transmembrane transporter activity | IEA | -- |
| GO:0033300 | dehydroascorbic acid transmembrane transporter activity | IDA | 27153185 |
| GO:0055056 | D-glucose transmembrane transporter activity | IDA | 11592815 |
Phenotypes for SLC2A10 Gene
- MGI mutant phenotypes for SLC2A10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SLC2A10:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- shRNA abundance <= 25%
- Inconclusive
- Decreased viability with paclitaxel
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC2A10
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC2A10 - Select products 50% OFF >
- * SLC2A10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC2A10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A10
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A10
miRNA for SLC2A10 Gene
- miRTarBase miRNAs that target SLC2A10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A10
- Browse OriGene Inhibitory RNA Products For SLC2A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A10
Clone Products
- Applied Biological Materials (abm): Clones for SLC2A10 - Select products 50% OFF >
- * SLC2A10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC2A10
- Addgene plasmids for SLC2A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A10
Cell Line Products
-
Horizon Cell Lines for SLC2A10
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A10 Gene
Localization for SLC2A10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC2A10 Gene
- Endomembrane system. Multi-pass membrane protein. Cytoplasm, perinuclear region.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Vesicles (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA,RCA | 11592815 |
| GO:0012505 | endomembrane system | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SLC2A10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
.37
|
|
| 2 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
|
| 3 | HIF1Alpha Pathway |
HIF1Alpha Pathway
-
|
|
| 4 | NRF2 pathway | ||
Pathways by source for SLC2A10 Gene
1 BioSystems pathway for SLC2A10 Gene
2 Qiagen pathways for SLC2A10 Gene
- Antioxidant Action of Vitamin-C
- HIF1Alpha Pathway
Interacting Proteins for SLC2A10 Gene
GPS-Prot Interaction Network for SLC2A10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008643 | carbohydrate transport | IEA | -- |
| GO:0008645 | hexose transmembrane transport | TAS | -- |
| GO:0010628 | positive regulation of gene expression | IMP | 16550171 |
| GO:0010629 | negative regulation of gene expression | IMP | 16550171 |
| GO:0015757 | galactose transmembrane transport | TAS | 16550171 |
No data available for SIGNOR curated interactions for SLC2A10 Gene
Drugs & Compounds for SLC2A10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dextrose, unspecified form | Approved, Vet_approved | Pharma | Transporter, substrate | 0 | ||
| D-glucose | Approved, Investigational, Vet_approved | Pharma | Transporter, substrate | 0 | ||
| Fludeoxyglucose (18F) | Approved, Investigational | Pharma | Transporter, substrate | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for SLC2A10 Gene
mRNA/cDNA for SLC2A10 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000359271 4227 nts (view in UCSC)
- ENST00000486000 497 nts (view in UCSC)
- ENST00000611837 586 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC2A10 - Select products 50% OFF >
- * SLC2A10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC2A10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A10
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A10
- Browse OriGene Inhibitory RNA Products For SLC2A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A10
Clone Products
- Applied Biological Materials (abm): Clones for SLC2A10 - Select products 50% OFF >
- * SLC2A10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC2A10
- Addgene plasmids for SLC2A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A10
Relevant External Links for SLC2A10 Gene
- GeneLoc Exon Structure for
- SLC2A10
Expression for SLC2A10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for SLC2A10 Gene
This gene is overexpressed in Liver (x7.7).
This gene is overexpressed in Liver (51.9), Placenta (8.0), and Breast (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC2A10 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC2A10
SOURCE GeneReport for Unigene cluster for SLC2A10 Gene:
Hs.305971mRNA Expression by UniProt/SwissProt for SLC2A10 Gene:
O95528-GTR10_HUMAN
Tissue specificity:
Widely expressed; highest levels in liver and pancreas.
Evidence on tissue expression from TISSUES for SLC2A10 Gene
- Liver(4.4)
- Muscle(2.2)
- Heart(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A10 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- chin
- ear
- eye
- eyelid
- face
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- skull
Thorax:
- aorta
- chest wall
- diaphragm
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
- sternum
Abdomen:
- abdominal wall
- intestine
- large intestine
- liver
- small intestine
- stomach
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
- skin
Primer Products
-
OriGene qPCR primer pairs for SLC2A10
-
OriGene qPCR primer pairs and template standards for SLC2A10
Gene Expression Assay Products
Orthologs for SLC2A10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC2A10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC2A10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC2A10 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc2a10 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc2a10 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC2A10 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC2A10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC2A10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC2A10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc2a10 30 |
|
||
| Str.16625 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3328 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | slc2a10 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
ManyToMany | |
| ITR1 31 |
|
ManyToMany | |||
| ITR2 31 |
|
ManyToMany |
- Species where no ortholog for SLC2A10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SLC2A10 Gene
- ENSEMBL:
- Gene Tree for SLC2A10 (if available)
- TreeFam:
- Gene Tree for SLC2A10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC2A10: view image
Paralogs for SLC2A10 Gene
Paralogs for SLC2A10 Gene
(9) SIMAP similar genes for SLC2A10 Gene using alignment to 2 proteins:
- GTR10_HUMAN
- Q8TDC7_HUMAN
Variants for SLC2A10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC2A10 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 161099 | Pathogenic: Arterial tortuosity syndrome | 46,727,443(+) | CCCGAGTAGCTGGGAC | SPLICE_ACCEPTOR_VARIANT,SPLICE_DONOR_VARIANT | |
| 643278 | Uncertain Significance: Arterial tortuosity syndrome | 46,729,488(+) | G/C | MISSENSE_VARIANT | |
| 643699 | Uncertain Significance: Arterial tortuosity syndrome | 46,733,794(+) | G/A | MISSENSE_VARIANT | |
| 644653 | Uncertain Significance: Arterial tortuosity syndrome | 46,729,488(+) | G/A | MISSENSE_VARIANT | |
| 647015 | Uncertain Significance: Arterial tortuosity syndrome | 46,725,469(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1061899 | CNV | loss | 25217958 |
| nsv1136547 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.16;
75.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC2A10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A10 Gene
Disorders for SLC2A10 Gene
(23) MalaCards diseases for SLC2A10 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| arterial tortuosity syndrome |
|
|
| familial thoracic aortic aneurysm and aortic dissection |
|
|
| aortic aneurysm |
|
|
| cutis laxa, autosomal dominant 1 |
|
|
| aneurysm |
|
|
Search SLC2A10 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GTR10_HUMAN- Arterial tortuosity syndrome (ATORS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. {ECO:0000269 PubMed:16550171, ECO:0000269 PubMed:17935213}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SLC2A10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for SLC2A10 Gene
Publications for SLC2A10 Gene
- Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. (PMID: 12941788) Andersen G … Pedersen O (Diabetes 2003) 3 4 23 41
- Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. (PMID: 16550171) Coucke PJ … De Paepe A (Nature genetics 2006) 3 4 23
- Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population. (PMID: 16586067) Lin WH … Chen YT (Diabetologia 2006) 3 23 41
- Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. (PMID: 15936967) Mohlke KL … FUSION Study Group (Molecular genetics and metabolism 2005) 3 23 41
- Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes. (PMID: 16336637) Bento JL … Segade F (BMC medical genetics 2005) 3 23 41
ExternalLinks
Products for SLC2A10 Gene
- Custom Antibody ServicesOriGene Antibodies for SLC2A10
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC2A10
- Origene Custom Protein Services for SLC2A10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC2A10
- Browse OriGene Inhibitory RNA Products For SLC2A10
- OriGene qPCR primer pairs for SLC2A10
- OriGene qPCR primer pairs and template standards for SLC2A10
- OriGene CRISPR knockouts for SLC2A10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SLC2A10
- Sino Biological Human cDNA Clone for SLC2A10
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for SLC2A10
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SLC2A10
- Novus Biologicals proteins for SLC2A10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for SLC2A10
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for SLC2A10
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for SLC2A10 (AFLGC-SLC2A10)
- VectorBuilder Custom and pre-made DNA vectors for SLC2A10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SLC2A10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SLC2A10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SLC2A10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SLC2A10
- Addgene plasmids for SLC2A10
- antibodies-online: Show 12 available SLC2A10 Antibodies ranked by validation data
- Compare Top SLC2A10 Antibodies
- antibodies-online: Search results for available SLC2A10 related products ranked by validation data
- antibodies-online: Show 3 available SLC2A10 Proteins ranked by validation data
- Compare Top SLC2A10 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SLC2A10
- Search Santa Cruz Biotechnology (SCBT) for SLC2A10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A10
- Horizon Cell Lines for SLC2A10
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC2A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC2A10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SLC2A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC2A10
Sources for SLC2A10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB