This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009] See more...

Aliases for SLC2A10 Gene

Aliases for SLC2A10 Gene

  • Solute Carrier Family 2 Member 10 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 10 2 3
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 10 3 4
  • Glucose Transporter Type 10 3 4
  • GLUT-10 3 4
  • GLUT10 3 4
  • ATORS 3
  • ATS 3

External Ids for SLC2A10 Gene

Previous GeneCards Identifiers for SLC2A10 Gene

  • GC20P045066
  • GC20P045976
  • GC20P046023
  • GC20P044771
  • GC20P045338
  • GC20P042079

Summaries for SLC2A10 Gene

Entrez Gene Summary for SLC2A10 Gene

  • This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

GeneCards Summary for SLC2A10 Gene

SLC2A10 (Solute Carrier Family 2 Member 10) is a Protein Coding gene. Diseases associated with SLC2A10 include Arterial Tortuosity Syndrome and Familial Thoracic Aortic Aneurysm And Dissection. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and HIF1Alpha Pathway. Gene Ontology (GO) annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A12.

UniProtKB/Swiss-Prot Summary for SLC2A10 Gene

  • Facilitative glucose transporter required for the development of the cardiovascular system.

Gene Wiki entry for SLC2A10 Gene

Additional gene information for SLC2A10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC2A10 Gene

Genomics for SLC2A10 Gene

GeneHancer (GH) Regulatory Elements for SLC2A10 Gene

Promoters and enhancers for SLC2A10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J046708 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 763.3 +1.2 1169 2.7 MLX RBPJ CREB1 L3MBTL2 MNT MTA3 ZNF652 CTCF ELF3 ZFX SLC2A10 HSALNG0130501 ENSG00000271784
GH20J046682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 -24.4 -24410 2.4 ZBTB40 SMARCE1 ETV6 ELF1 L3MBTL2 RBM39 MNT TEAD4 ZNF652 ZNF148 SLC13A3 ENSG00000273893 SLC12A5 CD40 NCOA5 PCIF1 ZNF335 SLC35C2 SLC2A10 OCSTAMP
GH20J046739 Enhancer 1 Ensembl ENCODE 16.7 +31.5 31516 1.2 E2F8 USF2 ZNF217 MNT MTA3 NCOA3 MYC HDGF CREB1 GATAD2B lnc-SLC2A10-13 NCOA5 ZNF335 SLC35C2 SLC2A10 TP53RK CD40 PCIF1 UBE2C ENSG00000271984
GH20J046568 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 10 -139.4 -139446 1.4 RBPJ MIXL1 ZNF362 RAD21 ELF3 SP1 TFE3 CEBPG ZSCAN21 PPARG SLC13A3 ZNF663P SLC2A10 ZNF334 lnc-SLC2A10-5 OCSTAMP
GH20J046606 Enhancer 0.9 ENCODE 14.3 -100.8 -100808 1.4 MLX RBPJ NR2F6 MIXL1 ZNF652 RERE ELF3 AHR SP1 TFE3 SLC2A10 SLC13A3 OCSTAMP NCOA5 piR-50437-408 lnc-TP53RK-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC2A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC2A10 gene promoter:
  • FOXD3
  • GR-alpha
  • HSF2
  • NCX
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RFX1

Genomic Locations for SLC2A10 Gene

Genomic Locations for SLC2A10 Gene
chr20:46,708,347-46,736,347
(GRCh38/hg38)
Size:
28,001 bases
Orientation:
Plus strand
chr20:45,338,126-45,364,986
(GRCh37/hg19)
Size:
26,861 bases
Orientation:
Plus strand

Genomic View for SLC2A10 Gene

Genes around SLC2A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A10 Gene

Proteins for SLC2A10 Gene

  • Protein details for SLC2A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95528-GTR10_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Protein Accession:
    O95528
    Secondary Accessions:
    • A8K4J6
    • Q3MIX5
    • Q9H4I6

    Protein attributes for SLC2A10 Gene

    Size:
    541 amino acids
    Molecular mass:
    56911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC2A10 Gene

Post-translational modifications for SLC2A10 Gene

  • Glycosylation at Asn334
  • Ubiquitination at Lys208
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A10 Gene

Domains & Families for SLC2A10 Gene

Gene Families for SLC2A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC2A10 Gene

GenScript: Design optimal peptide antigens:
  • Glucose transporter type 10 (GTR10_HUMAN)
  • Solute carrier family 2 facilitated glucose transporter member 10 (Q8TDC7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95528

UniProtKB/Swiss-Prot:

GTR10_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A10: view

Function for SLC2A10 Gene

Molecular function for SLC2A10 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter required for the development of the cardiovascular system.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376, ChEBI:CHEBI:4167; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.28 mM for 2-deoxy-D-glucose {ECO:0000269 PubMed:11592815};

Phenotypes From GWAS Catalog for SLC2A10 Gene

Gene Ontology (GO) - Molecular Function for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 carbohydrate:proton symporter activity IBA,NAS 11247674
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC2A10: view
genes like me logo Genes that share phenotypes with SLC2A10: view

Human Phenotype Ontology for SLC2A10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A10

CRISPR Products

miRNA for SLC2A10 Gene

miRTarBase miRNAs that target SLC2A10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A10 Gene

Localization for SLC2A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A10 Gene

Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A10 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A10: view

Pathways & Interactions for SLC2A10 Gene

genes like me logo Genes that share pathways with SLC2A10: view

Pathways by source for SLC2A10 Gene

2 Qiagen pathways for SLC2A10 Gene
  • Antioxidant Action of Vitamin-C
  • HIF1Alpha Pathway

Gene Ontology (GO) - Biological Process for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transmembrane transport TAS --
GO:0055085 transmembrane transport IEA --
GO:1902600 proton transmembrane transport IEA --
GO:1904659 glucose transmembrane transport NAS 11247674
genes like me logo Genes that share ontologies with SLC2A10: view

No data available for SIGNOR curated interactions for SLC2A10 Gene

Drugs & Compounds for SLC2A10 Gene

(3) Drugs for SLC2A10 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dextrose, unspecified form Approved, Vet_approved Pharma Transporter, substrate 0
D-glucose Approved, Investigational, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose (18F) Approved, Investigational Pharma Transporter, substrate 0

(1) Additional Compounds for SLC2A10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A10: view

Transcripts for SLC2A10 Gene

mRNA/cDNA for SLC2A10 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(104) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A10 Gene

No ASD Table

Relevant External Links for SLC2A10 Gene

GeneLoc Exon Structure for
SLC2A10
ECgene alternative splicing isoforms for
SLC2A10

Expression for SLC2A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A10 Gene

This gene is overexpressed in Liver (x7.7).

Protein differential expression in normal tissues from HIPED for SLC2A10 Gene

This gene is overexpressed in Liver (51.9), Placenta (8.0), and Breast (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC2A10 Gene



Protein tissue co-expression partners for SLC2A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC2A10 Gene:

SLC2A10

SOURCE GeneReport for Unigene cluster for SLC2A10 Gene:

Hs.305971

mRNA Expression by UniProt/SwissProt for SLC2A10 Gene:

O95528-GTR10_HUMAN
Tissue specificity: Widely expressed; highest levels in liver and pancreas.

Evidence on tissue expression from TISSUES for SLC2A10 Gene

  • Liver(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • skull
Thorax:
  • aorta
  • chest wall
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • sternum
Abdomen:
  • abdominal wall
  • intestine
  • large intestine
  • liver
  • small intestine
  • stomach
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with SLC2A10: view

Orthologs for SLC2A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A10 33 32
  • 98.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A10 33 32
  • 85.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A10 33 32
  • 84.51 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a10 32
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Slc2a10 17 33 32
  • 78.23 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC2A10 33
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A10 33
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A10 33 32
  • 64.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A10 33
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a10 32
  • 58.86 (n)
Str.16625 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.3328 32
zebrafish
(Danio rerio)
Actinopterygii slc2a10 33 32
  • 53.37 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 33
  • 21 (a)
ManyToMany
ITR1 33
  • 20 (a)
ManyToMany
ITR2 33
  • 19 (a)
ManyToMany
Species where no ortholog for SLC2A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A10 Gene

ENSEMBL:
Gene Tree for SLC2A10 (if available)
TreeFam:
Gene Tree for SLC2A10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC2A10: view image

Paralogs for SLC2A10 Gene

(9) SIMAP similar genes for SLC2A10 Gene using alignment to 2 proteins:

  • GTR10_HUMAN
  • Q8TDC7_HUMAN
genes like me logo Genes that share paralogs with SLC2A10: view

Variants for SLC2A10 Gene

Sequence variations from dbSNP and Humsavar for SLC2A10 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1015798796 pathogenic, Arterial tortuosity syndrome, Thoracic aortic aneurysm and aortic dissection 46,725,684(+) C/G coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs1059217 benign, Arterial tortuosity syndrome 46,736,010(+) T/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1060502311 uncertain-significance, Arterial tortuosity syndrome 46,725,347(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1060502312 uncertain-significance, Arterial tortuosity syndrome 46,725,553(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1060502313 uncertain-significance, Arterial tortuosity syndrome 46,725,101(+) T/G coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A10 Gene

Variant ID Type Subtype PubMed ID
nsv1061899 CNV loss 25217958
nsv1136547 CNV deletion 24896259

Variation tolerance for SLC2A10 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC2A10 Gene

Human Gene Mutation Database (HGMD)
SLC2A10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A10 Gene

Disorders for SLC2A10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SLC2A10 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
arterial tortuosity syndrome
  • ats
familial thoracic aortic aneurysm and dissection
  • annuloaortic ectasia
regular astigmatism
corneal ectasia
aortic aneurysm
  • abdominal aortic aneurysm, ruptured
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GTR10_HUMAN
  • Arterial tortuosity syndrome (ATORS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. {ECO:0000269 PubMed:16550171, ECO:0000269 PubMed:17935213}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for SLC2A10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC2A10: view

No data available for Genatlas for SLC2A10 Gene

Publications for SLC2A10 Gene

  1. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. (PMID: 12941788) Andersen G … Pedersen O (Diabetes 2003) 3 4 23 43 56
  2. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. (PMID: 16550171) Coucke PJ … De Paepe A (Nature genetics 2006) 3 4 23 56
  3. Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population. (PMID: 16586067) Lin WH … Chen YT (Diabetologia 2006) 3 23 43 56
  4. Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes. (PMID: 16336637) Bento JL … Segade F (BMC medical genetics 2005) 3 23 43 56
  5. Evaluation of SLC2A10 (GLUT10) as a candidate gene for type 2 diabetes and related traits in Finns. (PMID: 15936967) Mohlke KL … FUSION Study Group (Molecular genetics and metabolism 2005) 3 23 43 56

Products for SLC2A10 Gene

Sources for SLC2A10 Gene