Aliases for SLC29A2 Gene
- Solute Carrier Family 29 Member 2 2 3 4 5
- DER12 2 3 4
- Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside Transporter 3 4
- Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2 2 3
- Equilibrative NBMPR-Insensitive Nucleoside Transporter 3 4
- Equilibrative Nucleoside Transporter 2 3 4
- Hydrophobic Nucleolar Protein, 36 KDa 3 4
External Ids for SLC29A2 Gene
Previous HGNC Symbols for SLC29A2 Gene
Previous GeneCards Identifiers for SLC29A2 Gene
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]
GeneCards Summary for SLC29A2 Gene
SLC29A2 (Solute Carrier Family 29 Member 2) is a Protein Coding gene. Diseases associated with SLC29A2 include Hepatic Adenomas, Familial and Histiocytosis-Lymphadenopathy Plus Syndrome. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A1.
UniProtKB/Swiss-Prot Summary for SLC29A2 Gene
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1, 2 and 3) display subtype-selective tissue expression patterns.