Aliases for SLC28A3 Gene
- Solute Carrier Family 28 Member 3 2 3 3 5
- Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 3 2 3
- Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 3 2 3
- Concentrative Na(+)-Nucleoside Cotransporter 3 3 4
- CNT3 3 4
- Concentrative Na+-Nucleoside Cotransporter 3
- CNT 3 4
- HCNT3 4
External Ids for SLC28A3 Gene
Previous GeneCards Identifiers for SLC28A3 Gene
Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC28A3 Gene
SLC28A3 (Solute Carrier Family 28 Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include nucleoside binding and pyrimidine- and adenine-specific:sodium symporter activity. An important paralog of this gene is SLC28A1.
UniProtKB/Swiss-Prot for SLC28A3 Gene
Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3-azido-3-deoxythymidine (AZT), ribavirin and 3-deazauridine.