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Aliases for SLC28A2 Gene

Aliases for SLC28A2 Gene

  • Solute Carrier Family 28 Member 2 2 3 4 5
  • Solute Carrier Family 28 (Sodium-Coupled Nucleoside Transporter), Member 2 2 3
  • Solute Carrier Family 28 (Concentrative Nucleoside Transporter), Member 2 2 3
  • Sodium-Coupled Nucleoside Transporter 2 3 4
  • Sodium/Purine Nucleoside Co-Transporter 3 4
  • Concentrative Nucleoside Transporter 2 3 4
  • Na(+)/Nucleoside Cotransporter 2 3 4
  • CNT 2 3 4
  • HCNT2 3 4
  • CNT2 3 4
  • SPNT 3 4
  • Sodium/Nucleoside Cotransporter 2 3
  • HsT17153 3
  • SPNT1 3

External Ids for SLC28A2 Gene

Previous GeneCards Identifiers for SLC28A2 Gene

  • GC15P041102
  • GC15P038591
  • GC15P043123
  • GC15P043260
  • GC15P043331
  • GC15P045544
  • GC15P022369

Summaries for SLC28A2 Gene

GeneCards Summary for SLC28A2 Gene

SLC28A2 (Solute Carrier Family 28 Member 2) is a Protein Coding gene. Among its related pathways are Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics and Transport of vitamins, nucleosides, and related molecules. Gene Ontology (GO) annotations related to this gene include nucleoside binding and purine nucleoside transmembrane transporter activity. An important paralog of this gene is SLC28A1.

UniProtKB/Swiss-Prot for SLC28A2 Gene

  • Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Gene Wiki entry for SLC28A2 Gene

Additional gene information for SLC28A2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC28A2 Gene

Genomics for SLC28A2 Gene

GeneHancer (GH) Regulatory Elements for SLC28A2 Gene

Promoters and enhancers for SLC28A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I045252 Promoter 0.5 EPDnew 550.8 +0.1 149 0.1 SLC28A2 LOC101928414
GH15I045253 Enhancer 0.3 ENCODE 550.8 +1.5 1452 0.2 CTCF SLC28A2 LOC101928414
GH15I045197 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 -52.1 -52140 4.3 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 NFYC MEF2D SHF ENSG00000259932 TRH-GTG1-8 TRH-GTG1-9 TRH-GTG1-7 CTDSPL2 SPATA5L1 SPG11 ENSG00000259563 DUOX1
GH15I045165 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 10.9 -84.2 -84214 4.7 HDGF PKNOX1 ATF1 SIN3A FEZF1 YY1 TCF12 POLR2B ZNF766 ZNF207 ENSG00000259539 DUOXA1 CTDSPL2 SPG11 SHF ENSG00000259563 DUOX1 SPATA5L1 SLC28A2 DUOX2
GH15I045278 Promoter/Enhancer 1.5 Ensembl ENCODE 11.3 +27.1 27136 2.1 HDGF FOXA2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 LOC101928414 CTDSPL2 SLC28A2 DUOX1 DUOXA1 SPATA5L1 ENSG00000259539
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC28A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC28A2 gene promoter:

Genomic Locations for SLC28A2 Gene

Genomic Locations for SLC28A2 Gene
chr15:45,252,066-45,277,845
(GRCh38/hg38)
Size:
25,780 bases
Orientation:
Plus strand
chr15:45,544,428-45,568,149
(GRCh37/hg19)

Genomic View for SLC28A2 Gene

Genes around SLC28A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC28A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC28A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC28A2 Gene

Proteins for SLC28A2 Gene

  • Protein details for SLC28A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43868-S28A2_HUMAN
    Recommended name:
    Sodium/nucleoside cotransporter 2
    Protein Accession:
    O43868
    Secondary Accessions:
    • A8K7F9
    • O43239
    • Q52LZ0

    Protein attributes for SLC28A2 Gene

    Size:
    658 amino acids
    Molecular mass:
    71926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC28A2 Gene

Post-translational modifications for SLC28A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC28A2 Gene

No data available for DME Specific Peptides for SLC28A2 Gene

Domains & Families for SLC28A2 Gene

Gene Families for SLC28A2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

O43868

UniProtKB/Swiss-Prot:

S28A2_HUMAN :
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
Family:
  • Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
genes like me logo Genes that share domains with SLC28A2: view

Function for SLC28A2 Gene

Molecular function for SLC28A2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by formycin B.
UniProtKB/Swiss-Prot Function:
Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Phenotypes From GWAS Catalog for SLC28A2 Gene

Gene Ontology (GO) - Molecular Function for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005415 nucleoside:sodium symporter activity IEA,TAS --
GO:0015211 purine nucleoside transmembrane transporter activity TAS 9435697
genes like me logo Genes that share ontologies with SLC28A2: view
genes like me logo Genes that share phenotypes with SLC28A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC28A2

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC28A2 Gene

Localization for SLC28A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC28A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC28A2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IBA --
GO:0016020 membrane TAS,IEA 9435697
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC28A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC28A2 Gene

Pathways & Interactions for SLC28A2 Gene

genes like me logo Genes that share pathways with SLC28A2: view

Interacting Proteins for SLC28A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315006%0d%0a9606.ENSP00000356505%0d%0a
Selected Interacting proteins: ENSP00000315006 O43868-S28A2_HUMAN for SLC28A2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SLC28A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 9435697
GO:0006810 transport IEA --
GO:0015860 purine nucleoside transmembrane transport TAS 9435697
GO:1901642 nucleoside transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC28A2: view

No data available for SIGNOR curated interactions for SLC28A2 Gene

Drugs & Compounds for SLC28A2 Gene

(14) Drugs for SLC28A2 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2100
Ribavirin Approved Pharma 1017
Mercaptopurine Approved Pharma Transporter, substrate 0
Peginterferon alfa-2b Approved Pharma 309
protease inhibitors Pharma 5791

(10) Additional Compounds for SLC28A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC28A2: view

Transcripts for SLC28A2 Gene

mRNA/cDNA for SLC28A2 Gene

Unigene Clusters for SLC28A2 Gene

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC28A2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: -

Relevant External Links for SLC28A2 Gene

GeneLoc Exon Structure for
SLC28A2
ECgene alternative splicing isoforms for
SLC28A2

Expression for SLC28A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC28A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC28A2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.3), Colon - Transverse (x10.5), and Stomach (x8.4).

Protein differential expression in normal tissues from HIPED for SLC28A2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC28A2 Gene



Protein tissue co-expression partners for SLC28A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC28A2 Gene:

SLC28A2

SOURCE GeneReport for Unigene cluster for SLC28A2 Gene:

Hs.367833

mRNA Expression by UniProt/SwissProt for SLC28A2 Gene:

O43868-S28A2_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.

Evidence on tissue expression from TISSUES for SLC28A2 Gene

  • Intestine(4.4)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with SLC28A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC28A2 Gene

Orthologs for SLC28A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC28A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC28A2 33 34
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia SLC28A2 33 34
  • 88.84 (n)
mouse
(Mus musculus)
Mammalia Slc28a2 33 16 34
  • 82.98 (n)
Gm14085 34
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc28a2 33
  • 82.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia SLC28A2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC28A2 33
  • 65.33 (n)
-- 34
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc28a2 33
  • 63.52 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-24l11.1 33
  • 59.52 (n)
SLC28A2 34
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CNT1 33 34
  • 50.72 (n)
BEST:CK00459 35
  • 45 (a)
CG11778 35
  • 45 (a)
CG8083 34
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F27E11.1 35
  • 31 (a)
slc-28.1 34
  • 28 (a)
ManyToMany
slc-28.2 34
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
Species where no ortholog for SLC28A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC28A2 Gene

ENSEMBL:
Gene Tree for SLC28A2 (if available)
TreeFam:
Gene Tree for SLC28A2 (if available)

Paralogs for SLC28A2 Gene

Paralogs for SLC28A2 Gene

(2) SIMAP similar genes for SLC28A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC28A2: view

Variants for SLC28A2 Gene

Sequence variations from dbSNP and Humsavar for SLC28A2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000224601 -- 45,262,416(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000225543 -- 45,259,410(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000266068 -- 45,256,094(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000328976 -- 45,263,217(+) A/G coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000581802 -- 45,260,407(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC28A2 Gene

Variant ID Type Subtype PubMed ID
esv3636336 CNV gain 21293372
esv3636337 CNV gain 21293372
nsv569315 CNV gain 21841781

Variation tolerance for SLC28A2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.46; 92.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC28A2 Gene

Human Gene Mutation Database (HGMD)
SLC28A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC28A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC28A2 Gene

Disorders for SLC28A2 Gene

Additional Disease Information for SLC28A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC28A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC28A2 Gene

Publications for SLC28A2 Gene

  1. Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. (PMID: 9435697) Wang J … Giacomini KM (The American journal of physiology 1997) 2 3 4 22 58
  2. Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. (PMID: 17700367) Li L … Lee EJ (Pharmacogenetics and genomics 2007) 3 4 22 58
  3. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. (PMID: 15861032) Owen RP … Giacomini KM (Pharmacogenetics and genomics 2005) 3 4 22 58
  4. Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. (PMID: 10455109) Loewen SK … Young JD (The Journal of biological chemistry 1999) 3 4 22 58
  5. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. (PMID: 10087507) Ritzel MW … Young JD (Molecular membrane biology 1998) 3 4 22 58

Products for SLC28A2 Gene

Sources for SLC28A2 Gene

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