The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme act... See more...

Aliases for SLC27A2 Gene

Aliases for SLC27A2 Gene

  • Solute Carrier Family 27 Member 2 2 3 4 5
  • Solute Carrier Family 27 (Fatty Acid Transporter), Member 2 2 3
  • Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 1 3 4
  • Very Long-Chain-Fatty-Acid-CoA Ligase 3 4
  • Very Long-Chain Acyl-CoA Synthetase 3 4
  • Long-Chain-Fatty-Acid--CoA Ligase 3 4
  • Fatty Acid Transport Protein 2 3 4
  • Arachidonate--CoA Ligase 3 4
  • Phytanate--CoA Ligase 3 4
  • THCA-CoA Ligase 3 4
  • EC 6.2.1.7 4 52
  • FACVL1 3 4
  • ACSVL1 3 4
  • FATP-2 3 4
  • FATP2 3 4
  • VLACS 3 4
  • VLCS 3 4
  • Very Long-Chain Fatty-Acid-Coenzyme A Ligase 1 3
  • EC 6.2.1.15 4
  • EC 6.2.1.24 4
  • EC 6.2.1.- 4
  • EC 6.2.1.3 4
  • HsT17226 3
  • EC 6.2.1 52
  • HFACVL1 3

External Ids for SLC27A2 Gene

Previous HGNC Symbols for SLC27A2 Gene

  • FACVL1

Previous GeneCards Identifiers for SLC27A2 Gene

  • GC15U990072
  • GC15P043520
  • GC15P048053
  • GC15P048190
  • GC15P048261
  • GC15P050474
  • GC15P027305

Summaries for SLC27A2 Gene

Entrez Gene Summary for SLC27A2 Gene

  • The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for SLC27A2 Gene

SLC27A2 (Solute Carrier Family 27 Member 2) is a Protein Coding gene. Diseases associated with SLC27A2 include Adrenoleukodystrophy and Restrictive Dermopathy, Lethal. Among its related pathways are Innate Immune System and Synthesis of bile acids and bile salts. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A6.

UniProtKB/Swiss-Prot Summary for SLC27A2 Gene

  • Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10198260, PubMed:10749848, PubMed:11980911). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake (PubMed:20530735).
  • Isoform 1 exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:21768100). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100).
  • Isoform 2 exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.

Gene Wiki entry for SLC27A2 Gene

Additional gene information for SLC27A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC27A2 Gene

Genomics for SLC27A2 Gene

GeneHancer (GH) Regulatory Elements for SLC27A2 Gene

Promoters and enhancers for SLC27A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC27A2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC27A2

Top Transcription factor binding sites by QIAGEN in the SLC27A2 gene promoter:
  • AP-4
  • C/EBPalpha
  • CHOP-10
  • CUTL1
  • En-1
  • HEN1
  • Pax-5
  • SEF-1 (1)
  • Sp1
  • STAT5A

Genomic Locations for SLC27A2 Gene

Genomic Locations for SLC27A2 Gene
chr15:50,182,196-50,236,392
(GRCh38/hg38)
Size:
54,197 bases
Orientation:
Plus strand
chr15:50,474,393-50,528,592
(GRCh37/hg19)
Size:
54,200 bases
Orientation:
Plus strand

Genomic View for SLC27A2 Gene

Genes around SLC27A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC27A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC27A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC27A2 Gene

Proteins for SLC27A2 Gene

  • Protein details for SLC27A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14975-S27A2_HUMAN
    Recommended name:
    Very long-chain acyl-CoA synthetase
    Protein Accession:
    O14975
    Secondary Accessions:
    • A8K2J7
    • Q53FY6
    • Q6PF09

    Protein attributes for SLC27A2 Gene

    Size:
    620 amino acids
    Molecular mass:
    70312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC27A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC27A2 Gene

Selected DME Specific Peptides for SLC27A2 Gene

O14975:
  • RWKGENV
  • TSGTTGLPKA

Post-translational modifications for SLC27A2 Gene

  • Ubiquitination at Lys398
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC27A2 Gene

Domains & Families for SLC27A2 Gene

Gene Families for SLC27A2 Gene

Protein Domains for SLC27A2 Gene

Blocks:
  • AMP-binding signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC27A2 Gene

GenScript: Design optimal peptide antigens:
  • Very long-chain-fatty-acid-CoA ligase (S27A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14975

UniProtKB/Swiss-Prot:

S27A2_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with SLC27A2: view

Function for SLC27A2 Gene

Molecular function for SLC27A2 Gene

UniProtKB/Swiss-Prot Function:
Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10198260, PubMed:10749848, PubMed:11980911). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake (PubMed:20530735).
UniProtKB/Swiss-Prot Function:
Isoform 1 exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:21768100). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100).
UniProtKB/Swiss-Prot Function:
Isoform 2 exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence={ECO:0000269 PubMed:10198260, ECO:0000269 PubMed:10749848, ECO:0000269 PubMed:11980911}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence={ECO:0000305 PubMed:10198260, ECO:0000305 PubMed:10749848, ECO:0000305 PubMed:11980911};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA; Xref=Rhea:RHEA:21380, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37257, ChEBI:CHEBI:57287, ChEBI:CHEBI:57391, ChEBI:CHEBI:456215; EC=6.2.1.24; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21381; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:22976, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58677, ChEBI:CHEBI:58734, ChEBI:CHEBI:456215; EC=6.2.1.7; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22977; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215; Evidence={ECO:0000269 PubMed:10198260, ECO:0000269 PubMed:10749848, ECO:0000269 PubMed:11980911, ECO:0000269 PubMed:21768100}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537; Evidence={ECO:0000305 PubMed:10198260, ECO:0000305 PubMed:10749848, ECO:0000305 PubMed:11980911};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a fatty acid(in) = a fatty acid(out); Xref=Rhea:RHEA:38879, ChEBI:CHEBI:28868; Evidence={ECO:0000269 PubMed:20530735, ECO:0000269 PubMed:21768100}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38881; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616, ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65052, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:44932, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:74298, ChEBI:CHEBI:77016, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44933; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:44936, ChEBI:CHEBI:30616, ChEBI:CHEBI:32387, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:74034, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44937; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence={ECO:0000269 PubMed:10198260, ECO:0000269 PubMed:10749848, ECO:0000269 PubMed:11980911}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence={ECO:0000305 PubMed:10198260, ECO:0000305 PubMed:10749848, ECO:0000305 PubMed:11980911};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA; Xref=Rhea:RHEA:47264, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:77250, ChEBI:CHEBI:77268, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47265; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=12 uM for palmitic acid {ECO:0000269 PubMed:11980911}; Vmax=1.4 nmol/min/mg enzyme for palmitic acid {ECO:0000269 PubMed:11980911};

Enzyme Numbers (IUBMB) for SLC27A2 Gene

Phenotypes From GWAS Catalog for SLC27A2 Gene

Gene Ontology (GO) - Molecular Function for SLC27A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity IEA --
GO:0003996 acyl-CoA ligase activity IEA --
GO:0004467 long-chain fatty acid-CoA ligase activity TAS,IEA --
GO:0005324 long-chain fatty acid transporter activity IBA,IDA 20530735
genes like me logo Genes that share ontologies with SLC27A2: view
genes like me logo Genes that share phenotypes with SLC27A2: view

Animal Models for SLC27A2 Gene

MGI Knock Outs for SLC27A2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC27A2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC27A2 Gene

Localization for SLC27A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC27A2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Peripheral membrane protein. Cell membrane; Multi-pass membrane protein. Microsome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC27A2 gene
Compartment Confidence
peroxisome 5
endoplasmic reticulum 5
plasma membrane 4
cytosol 4
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC27A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IBA,TAS --
GO:0005779 integral component of peroxisomal membrane IDA,IBA 10198260
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005788 endoplasmic reticulum lumen IDA,IBA 10198260
genes like me logo Genes that share ontologies with SLC27A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC27A2 Gene

Pathways & Interactions for SLC27A2 Gene

genes like me logo Genes that share pathways with SLC27A2: view

Gene Ontology (GO) - Biological Process for SLC27A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001561 fatty acid alpha-oxidation TAS --
GO:0001676 long-chain fatty acid metabolic process IEA,IDA 22022213
GO:0006625 protein targeting to peroxisome TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with SLC27A2: view

No data available for SIGNOR curated interactions for SLC27A2 Gene

Drugs & Compounds for SLC27A2 Gene

(5) Drugs for SLC27A2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
Coenzyme A Investigational Nutra 0

(35) Additional Compounds for SLC27A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with SLC27A2: view

Transcripts for SLC27A2 Gene

mRNA/cDNA for SLC27A2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC27A2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC27A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLC27A2 Gene

GeneLoc Exon Structure for
SLC27A2

Expression for SLC27A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC27A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC27A2 Gene

This gene is overexpressed in Liver (x29.1) and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for SLC27A2 Gene

This gene is overexpressed in Liver (26.8), Gallbladder (21.9), and Kidney (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC27A2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC27A2

SOURCE GeneReport for Unigene cluster for SLC27A2 Gene:

Hs.11729

mRNA Expression by UniProt/SwissProt for SLC27A2 Gene:

O14975-S27A2_HUMAN
Tissue specificity: Expressed in liver, kidney, placenta and pancreas.

Evidence on tissue expression from TISSUES for SLC27A2 Gene

  • Kidney(4.8)
  • Liver(4.7)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with SLC27A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC27A2 Gene

Orthologs for SLC27A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC27A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC27A2 31 30
  • 99.57 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC27A2 31 30
  • 86.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC27A2 31 30
  • 86.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc27a2 17 31 30
  • 82.42 (n)
rat
(Rattus norvegicus)
Mammalia Slc27a2 30
  • 82.1 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC27A2 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC27A2 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC27A2 30
  • 59.55 (n)
lizard
(Anolis carolinensis)
Reptilia SLC27A2 31
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494612 30
  • 63.36 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:101540 30
  • 60.08 (n)
slc27a2b 31
  • 55 (a)
OneToMany
SLC27A2 (3 of 3) 31
  • 54 (a)
OneToMany
SLC27A2 (2 of 3) 31
  • 51 (a)
OneToMany
Dr.19084 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.257 30
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAT1 33 31
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToMany
Species where no ortholog for SLC27A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC27A2 Gene

ENSEMBL:
Gene Tree for SLC27A2 (if available)
TreeFam:
Gene Tree for SLC27A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC27A2: view image

Paralogs for SLC27A2 Gene

(6) SIMAP similar genes for SLC27A2 Gene using alignment to 2 proteins:

  • S27A2_HUMAN
  • G3V1R7_HUMAN
genes like me logo Genes that share paralogs with SLC27A2: view

Variants for SLC27A2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC27A2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
730873 Likely Benign: not provided 50,227,053(+) G/A SYNONYMOUS_VARIANT
rs1648348 - p.Lys48Gln

Additional dbSNP identifiers (rs#s) for SLC27A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC27A2 Gene

Variant ID Type Subtype PubMed ID
esv3892693 CNV gain 25118596
nsv1531 CNV insertion 18451855
nsv507779 OTHER sequence alteration 20534489

Variation tolerance for SLC27A2 Gene

Residual Variation Intolerance Score: 9.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC27A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC27A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC27A2 Gene

Disorders for SLC27A2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC27A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adrenoleukodystrophy
  • sudanophilic cerebral sclerosis
restrictive dermopathy, lethal
  • rd
zellweger syndrome
  • zs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC27A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC27A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC27A2 Gene

Publications for SLC27A2 Gene

  1. Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. (PMID: 10198260) Steinberg SJ … Watkins PA (Biochemical and biophysical research communications 1999) 3 4 23 54
  2. Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization. (PMID: 9730624) Wakui K … Fukushima Y (Cytogenetics and cell genetics 1998) 2 3 23 54
  3. Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol. (PMID: 21768100) Melton EM … Black PN (The Journal of biological chemistry 2011) 3 4 54
  4. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. (PMID: 20530735) Falcon A … Stahl A (American journal of physiology. Endocrinology and metabolism 2010) 3 4 54
  5. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. (PMID: 17998437) Li H … Roses AD (Archives of neurology 2008) 3 41 54

Products for SLC27A2 Gene

  • Biorbyt antibodies for SLC27A2

Sources for SLC27A2 Gene