Aliases for SLC27A1 Gene
External Ids for SLC27A1 Gene
Previous GeneCards Identifiers for SLC27A1 Gene
GeneCards Summary for SLC27A1 Gene
SLC27A1 (Solute Carrier Family 27 Member 1) is a Protein Coding gene. Diseases associated with SLC27A1 include Ichthyosis Prematurity Syndrome and Platelet Glycoprotein Iv Deficiency. Among its related pathways are Transport of vitamins, nucleosides, and related molecules and Insulin resistance. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A4.
UniProtKB/Swiss-Prot Summary for SLC27A1 Gene
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed:28178239). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585).