Aliases for SLC27A1 Gene
External Ids for SLC27A1 Gene
Previous GeneCards Identifiers for SLC27A1 Gene
GeneCards Summary for SLC27A1 Gene
SLC27A1 (Solute Carrier Family 27 Member 1) is a Protein Coding gene. Diseases associated with SLC27A1 include Ichthyosis Prematurity Syndrome and Melkersson-Rosenthal Syndrome. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and PPAR signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is SLC27A4.
UniProtKB/Swiss-Prot Summary for SLC27A1 Gene
Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane (PubMed:28178239). Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity).